MTORC2 (original) (raw)
mTORC2 (mTOR complex 2) je proteinový komplex tvořený serin/threoninovou kinázou mTOR. Je necitlivý vůči účinkům a reguluje buněčnou proliferaci, migraci a remodelaci cytoskeletu. Samotný komplex se skládá ze sedmi proteinových podjednotek. Katalytickou mTOR podjednotku, (DEP domain containing mTOR-interacting protein), (mammalian lethal with sec-13 protein 8, někdy také známou pod názvem ) a komplex lze nalézt jak u mTORC2, tak u . (Rapamycin-insensitive companion of mTOR), (mammalian stress-activated protein kinase interacting protein 1) a (protein observed with rictor 1 and 2) jsou pak pouze součástí mTORC2. Vazba substrátu na mTORC2 je zprostředkována přes Rictor.
| Property | Value |
|---|---|
| dbo:abstract | mTORC2 (mTOR complex 2) je proteinový komplex tvořený serin/threoninovou kinázou mTOR. Je necitlivý vůči účinkům a reguluje buněčnou proliferaci, migraci a remodelaci cytoskeletu. Samotný komplex se skládá ze sedmi proteinových podjednotek. Katalytickou mTOR podjednotku, (DEP domain containing mTOR-interacting protein), (mammalian lethal with sec-13 protein 8, někdy také známou pod názvem ) a komplex lze nalézt jak u mTORC2, tak u . (Rapamycin-insensitive companion of mTOR), (mammalian stress-activated protein kinase interacting protein 1) a (protein observed with rictor 1 and 2) jsou pak pouze součástí mTORC2. Vazba substrátu na mTORC2 je zprostředkována přes Rictor. (cs) mTOR Complex 2 (mTORC2) is an acutely rapamycin-insensitive protein complex formed by serine/threonine kinase mTOR that regulates cell proliferation and survival, cell migration and cytoskeletal remodeling. The complex itself is rather large, consisting of seven protein subunits. The catalytic mTOR subunit, DEP domain containing mTOR-interacting protein (DEPTOR), mammalian lethal with sec-13 protein 8 (mLST8, also known as GβL), and TTI1/TEL2 complex are shared by both mTORC2 and mTORC1. Rapamycin-insensitive companion of mTOR (RICTOR), mammalian stress-activated protein kinase interacting protein 1 (mSIN1), and protein observed with rictor 1 and 2 (/2) can only be found in mTORC2. Rictor has been shown to be the scaffold protein for substrate binding to mTORC2. (en) |
| dbo:arm | p q |
| dbo:band | 36 13.1 13.3 34.11 |
| dbo:chromosome | 1 5 16 9 |
| dbo:ecNumber | 2.7.11.1 |
| dbo:entrezgene | 2475 64223 253260 79109 |
| dbo:hgncid | 3942 18752 24825 28611 |
| dbo:omim | 601231 (xsd:integer) 610558 (xsd:integer) 612190 (xsd:integer) |
| dbo:refseq | NM_001006617.1 NM_004958 NM_022372 NM_152756 |
| dbo:symbol | FRAP, FRAP2, FRAP1 MAPKAP1 MLST8 MTOR RICTOR |
| dbo:uniprot | P42345 Q9BPZ7 Q9BVC4 |
| dbo:wikiPageID | 38403936 (xsd:integer) |
| dbo:wikiPageLength | 32966 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1098283410 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Protein_kinase_A dbr:Sapanisertib dbr:Endomembrane_system dbr:F-actin dbr:MTORC1 dbr:MAPKAP1 dbr:Cytoskeleton dbr:CDC42 dbr:Insulin_resistance dbr:GRB10 dbr:Proline_rich_5_like dbr:MLST8 dbr:Macroautophagy dbc:EC_2.7.11 dbc:Human_proteins dbr:SGK dbr:Mitochondrion dbr:MTOR dbr:Mammalian_target_of_rapamycin dbr:Sirolimus dbc:Tor_signaling_pathway dbr:Protein_kinase_B dbr:Protein_kinase_C dbr:Threonine dbr:Type_2_diabetes dbr:Tyrosine dbr:G_protein dbr:DEPTOR dbr:Lipogenesis dbr:PKC_alpha dbr:RAC1 dbc:Protein_complexes dbr:Curcumin dbr:Cell_growth dbr:Cell_membrane dbr:Cell_migration dbr:Glycerophospholipid dbr:Protein_complex dbr:Systemic_lupus_erythematosus dbr:Autophagy dbr:Glucose_homeostasis dbr:HDAC dbr:InsR dbr:RHOA dbr:Rapamycin dbr:Chaperone-mediated_autophagy dbr:Serine dbr:Serine/threonine-specific_protein_kinase dbr:Warburg_effect_(oncology) dbr:Sphingolipid dbr:RICTOR dbr:Torin-1 dbr:SGK1 dbr:AKT dbr:Paxillin dbr:Tyrosine_kinase dbr:TELO2 dbr:Stress_fiber dbr:Pancreatic_beta_cell dbr:Protein_kinase_G dbr:IGF1R dbr:PDPK1 dbr:PH_domain dbr:PI3K dbr:PIP3 dbr:Glucose_intolerance dbr:Lung_fibrosis dbr:Hepatic_steatosis dbr:Protor1 |
| dbp:altsymbols | FRAP, FRAP2, FRAP1 (en) |
| dbp:arm | p (en) q (en) |
| dbp:band | 13.100000 (xsd:double) 13.300000 (xsd:double) 34.110000 (xsd:double) 36 (xsd:integer) |
| dbp:chromosome | 1 (xsd:integer) 5 (xsd:integer) 9 (xsd:integer) 16 (xsd:integer) |
| dbp:ecnumber | 2.700000 (xsd:double) |
| dbp:entrezgene | 2475 (xsd:integer) 64223 (xsd:integer) 79109 (xsd:integer) 253260 (xsd:integer) |
| dbp:hgncid | 3942 (xsd:integer) 18752 (xsd:integer) 24825 (xsd:integer) 28611 (xsd:integer) |
| dbp:name | dbr:MAPKAP1 dbr:MLST8 dbr:Mammalian_target_of_rapamycin dbr:RICTOR |
| dbp:omim | 601231 (xsd:integer) 610558 (xsd:integer) 612190 (xsd:integer) |
| dbp:refseq | NM_001006617.1 (en) NM_004958 (en) NM_022372 (en) NM_152756 (en) |
| dbp:symbol | dbr:MAPKAP1 dbr:MLST8 dbr:Mammalian_target_of_rapamycin dbr:RICTOR |
| dbp:uniprot | P42345 (en) Q9BPZ7 (en) Q9BVC4 (en) |
| dbp:wikiPageUsesTemplate | dbt:Enzymes dbt:Lowercase_title dbt:MeshName dbt:Portal_bar dbt:Reflist dbt:Serine/threonine-specific_protein_kinases dbt:Short_description dbt:Infobox_protein |
| dct:subject | dbc:EC_2.7.11 dbc:Human_proteins dbc:Tor_signaling_pathway dbc:Protein_complexes |
| rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:Abstraction100002137 yago:Chemical114806838 yago:Compound114818238 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 yago:WikicatHumanProteins dbo:Protein yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 |
| rdfs:comment | mTORC2 (mTOR complex 2) je proteinový komplex tvořený serin/threoninovou kinázou mTOR. Je necitlivý vůči účinkům a reguluje buněčnou proliferaci, migraci a remodelaci cytoskeletu. Samotný komplex se skládá ze sedmi proteinových podjednotek. Katalytickou mTOR podjednotku, (DEP domain containing mTOR-interacting protein), (mammalian lethal with sec-13 protein 8, někdy také známou pod názvem ) a komplex lze nalézt jak u mTORC2, tak u . (Rapamycin-insensitive companion of mTOR), (mammalian stress-activated protein kinase interacting protein 1) a (protein observed with rictor 1 and 2) jsou pak pouze součástí mTORC2. Vazba substrátu na mTORC2 je zprostředkována přes Rictor. (cs) mTOR Complex 2 (mTORC2) is an acutely rapamycin-insensitive protein complex formed by serine/threonine kinase mTOR that regulates cell proliferation and survival, cell migration and cytoskeletal remodeling. The complex itself is rather large, consisting of seven protein subunits. The catalytic mTOR subunit, DEP domain containing mTOR-interacting protein (DEPTOR), mammalian lethal with sec-13 protein 8 (mLST8, also known as GβL), and TTI1/TEL2 complex are shared by both mTORC2 and mTORC1. Rapamycin-insensitive companion of mTOR (RICTOR), mammalian stress-activated protein kinase interacting protein 1 (mSIN1), and protein observed with rictor 1 and 2 (/2) can only be found in mTORC2. Rictor has been shown to be the scaffold protein for substrate binding to mTORC2. (en) |
| rdfs:label | MTORC2 (cs) MTORC2 (en) |
| owl:sameAs | freebase:MTORC2 yago-res:MTORC2 wikidata:MTORC2 dbpedia-cs:MTORC2 https://global.dbpedia.org/id/VWRM |
| prov:wasDerivedFrom | wikipedia-en:MTORC2?oldid=1098283410&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:MTORC2 |
| foaf:name | MAPKAP1 (en) MLST8 (en) RICTOR (en) mTOR (en) |
| is dbo:wikiPageRedirects of | dbr:Mechanistic_target_of_rapamycin_complex_2 dbr:MTOR_Complex_2 |
| is dbo:wikiPageWikiLink of | dbr:Sapanisertib dbr:Paul_Mischel dbr:MTORC1 dbr:MAPKAP1 dbr:David_M._Sabatini dbr:DDIT4L dbr:STK11 dbr:MLST8 dbr:Mechanistic_target_of_rapamycin_complex_2 dbr:WYE-687 dbr:MTOR dbr:MTOR_Complex_2 dbr:MTOR_inhibitors dbr:Sirolimus dbr:Protein_kinase_B dbr:HY-124798 dbr:DEPTOR dbr:Everolimus dbr:Folliculin dbr:XL-388 dbr:Immunometabolism dbr:RICTOR dbr:Torin-1 dbr:RPTOR dbr:NV-5440 dbr:SGK1 |
| is foaf:primaryTopic of | wikipedia-en:MTORC2 |