Phosphoinositide 3-kinase (original) (raw)
Fosfatidylinositol-3-kináza (PI3 kináza, PI3K) je enzym ze skupiny kináz, který katalyzuje navázání fosfátové skupiny na D3 pozici inositolového kruhu . PI3K jsou významnými regulátory hladiny jednotlivých fosfatidylinositidů. Snižováním či zvyšováním hladiny těchto fosfolipidů následně dochází k změnám vlastností membrán i proteinů a signálních drah, jež jsou k těmto membránám ukotveny. Zvýšená aktivita PI-3 kináz (např. následkem mutace ) může vést k nádorovému bujení.
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| dbo:abstract | Fosfatidylinositol-3-kináza (PI3 kináza, PI3K) je enzym ze skupiny kináz, který katalyzuje navázání fosfátové skupiny na D3 pozici inositolového kruhu . PI3K jsou významnými regulátory hladiny jednotlivých fosfatidylinositidů. Snižováním či zvyšováním hladiny těchto fosfolipidů následně dochází k změnám vlastností membrán i proteinů a signálních drah, jež jsou k těmto membránám ukotveny. Zvýšená aktivita PI-3 kináz (např. následkem mutace ) může vést k nádorovému bujení. (cs) فوسفينوسيتايد 3-كينازات (PI3Ks)، وتسمى أيضًا الفوسفاتيدلينوسيتول 3 كيناز ، هي عائلة من الإنزيمات المشاركة في الوظائف الخلوية مثل نمو الخلايا، والتكاثر، والتمايز، والحركة، والبقاء، والاتجار داخل الخلايا، والتي بدورها تشارك في السرطان. PI3Ks أسرة مكونة من الخلايا ذات الصلة إشارة محول الانزيمات قادرة على الفسفرة 3 موقف الهيدروكسيل مجموعة من إينوزيتول حلقة من فوسفتيدلينوستول (PtdIns). المسار، مع الجين الورمي PIK3CA والقامع الورم PTEN ، وتورط في حساسية الأورام السرطانية الأنسولين و IGF1 ، و الحد من السعرات الحرارية . (ar) Phosphoinositid-3-Kinasen (PI3-Kinase, PI3K) sind Enzyme, deren Aktivität in sämtlichen eukaryotischen Zellen zu finden ist. Sie spielen eine wichtige Rolle in der Signaltransduktion und sind an einer Vielzahl von zellulären Schlüsselfunktionen, wie Zellwachstum, Zellproliferation, Migration, Differenzierung, Überleben und Zelladhäsion beteiligt. Beim Menschen können Veränderungen der Struktur, Aktivität oder Regulation der PI3K zu Krankheiten, wie Allergien, Entzündungsprozessen, Herzkrankheiten sowie Krebs führen. PI3K katalysiert die Phosphorylierung der 3’-OH Position am Inositolring von bestimmten Phospholipiden in der Zellmembran, sogenannten Phosphatidylinositolen. Diese Phosphoinositide, vor allem Phosphatidylinositol-3,4,5-trisphosphat (PIP3), dienen als Andockstellen für weitere Proteine, wie Proteinkinase B (auch Akt genannt) und . Der wichtigste Signalweg, den die PI3K so aktiviert ist der . Ein Gegenspieler der PI3K ist die Phosphatase PTEN, die ein wichtiger Tumorsuppressor ist. Die PI3-Kinase-Superfamilie besteht aus mehreren strukturell verwandten Enzymen, die nach der Proteindomänenstruktur der katalytischen Untereinheiten in die drei funktionellen Klassen IA, IB, II und III eingeteilt werden und aus insgesamt acht Isoformen bestehen: * Phosphorylierung von Phosphatidylinositol (PtdIns), PtdIns4P und PtdIns(4,5)P2 (bevorzugt): * Klasse IA-PI3K (EC 2.7.1.153): p110α, p110β, p110δ * Klasse IB-PI3K: p110γ * Phosphorylierung von PtdIns4P und PtdIns (bevorzugt): * Klasse II-PI3K (EC 2.7.1.154): PI3K-C2α, PI3K-C2β, PI3K-C2γ * Phosphorylierung von PtdIns: * Klasse III-PI3K (EC 2.7.1.137): Vps34 Ein Beispiel für einen PI3K-Inhibitor ist Wortmannin. Die PI-3 Kinase wurde 1985 von Lewis C. Cantley und Kollegen entdeckt. (de) La phosphoinositide 3-kinase (PI 3-kinase, PI3K, PI(3)K, or PI-3K) est une enzyme permettant la transformation des phosphoinositides en phosphatidylinositol-3-phosphate. (fr) Las fosfoinositol 3-cinasas o fosfoinosítido-3-cinasas (PI 3-cinasas o PI3K o P110δ), son una familia de enzimas capaces de fosforilar el grupo hidroxilo de la posición 3' del anillo inositol de las moléculas llamadas en conjunto fosfatidilinositol -enzima que en humanos está códificada por el gen PIK3CD-. (es) Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. PI3Ks are a family of related intracellular signal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns). The pathway, with oncogene PIK3CA and tumor suppressor gene PTEN, is implicated in the sensitivity of cancer tumors to insulin and IGF1, and in calorie restriction. (en) Kinase fosfatidil inositol-3 (bahasa Inggris: phosphatidyl inositol-3 kinase, Phosphoinositide 3-kinases, PI3K) merupakan enzim kinase lipid yang berperan dalam perkembangan sel, proliferasi, diferensiasi, motility, transduksi sinyal intraselular, termasuk GLUT12. Enzim ini pertama kali ditemukan oleh . PI3K diaktivasi oleh hormon tri-iodotironina dengan bantuan dalam sintesis transporter ion yang disebut ATP sintase. Banyak orang berpendapat bahwa respon biologis yang distimulasi oleh insulin, dikendalikan oleh enzim ini, termasuk proses penyerapan gula darah, sintesis glikogen dan protein. Enzim ini memiliki koenzim (PKB/c-Akt/Rac) yang menghambat enzim dan mengaktivasi yang meningkatkan laju sintesis glikogen dan protein, menginduksi produksi yang merupakan molekul sinyal yang menyebabkan translokasi Akt menuju membran plasma guna proses fosforilasi dan aktivasi oleh enzim PDK-1 dan PDK-2. (in) La fosfoinositide 3-chinasi o fosfatidilinositolo-3-chinasi o PI 3-chinasi o PI3K è una famiglia di enzimi coinvolti in complessi meccanismi cellulari come la crescita cellulare, la proliferazione, la differenziazione, la motilità e la sopravvivenza intracellulare; meccanismi questi coinvolti, anche, nello sviluppo del cancro. Le PI3K sono enzimi che trasducono i segnali intracellulari che sono in grado di fosforilare l'idrossile in posizione 3 presente sull'anello inositolico del fosfatidilinositolo (PtdIns).Questa classe di enzimi è anche nota come fosfatidilinositolo-3-chinasi. La via metabolica, con oncogene PIK3CA e con il gene oncosoppressore , è implicata nei fenomeni di insensibilità dei tumori all'insulina e di IGF1, in soggetti sottoposti alla. (it) PI3キナーゼ（英: Phosphoinositide 3-kinase, PI3K、EC 2.7.1.137）は、イノシトールリン脂質のイノシトール環3位のヒドロキシル基（-OH基）のリン酸化を行う酵素である。イノシトールリン脂質は真核生物の細胞膜を構成する成分の一つであり、PI3Kをはじめとしたキナーゼ（リン酸化酵素）の触媒作用を受けてホスファチジルイノシトール-3,4,5-三リン酸 PtdIns(3,4,5)P3となり、プロテインキナーゼB（PKB）/Aktを活性化する。このシグナル伝達経路はPI3キナーゼ-Akt経路と呼ばれ、様々な生理作用の発現に関与する。特にインスリンの分泌促進に深く関与することから、新たな糖尿病薬の開発が示唆されている。 (ja) A fosfoinositídeo 3-quinase ou fosfatidilinositol 3-quinases (PI 3-quinases ou PI3Ks) são uma família de enzimas envolvidas em funções celulares tais como crescimento celular, proliferação, diferenciação, mobilidade, sobrevivência e tráfego intracelular, os quais em alteração pode estar envolvidos em câncer, atuando no desenvolvimento de tumores. (pt) Фосфоинозитид-3-киназы, или фосфатидилинозитол-3-киназы (КФ 2.7.1; англ. Phosphoinositide 3-kinases, PI 3-kinases, PI3Ks) — семейство ферментов, фосфорилирующих фосфатидилинозитол в положении 3D инозитольного кольца. Являются ключевым элементом PI3K сигнального пути. (ru) 磷酸肌醇3-激酶（英語：Phosphoinositide 3-kinase, PI3Ks）又叫磷脂醯環己六醇3-激酶（英語：英語：phosphatidylinositol 3-kinases），是一個參與諸如細胞生長、增殖、分化、移動、存活和胞內運輸等細胞功能的酶家族，從而也參與癌症。 磷酸肌醇3-激酶是由細胞內能夠磷酸化磷脂醯環己六醇的肌醇環3號位置羟基基團的相關信号转导酶組成的一個家族。擁有癌基因PIK3CA（P110α）和抑癌基因PTEN的途徑不僅影響腫瘤細胞對胰岛素和胰岛素样生长因子1的敏感性，還影響攝熱量限制。 (zh) |
| dbo:symbol | PI3K |
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| dbp:altsymbols | PIK, PIK, PI-3K, PI-4K, PIK3, PI4K (en) |
| dbp:caption | PIK-93 inhibitor bound to the PI3K 110 gamma subunit . (en) |
| dbp:casNumber | 115926 (xsd:integer) |
| dbp:ecNumber | 2.700000 (xsd:double) |
| dbp:interpro | IPR000403 (en) |
| dbp:iubmbEcNumber | 2 (xsd:integer) |
| dbp:name | Phosphatidylinositol-4,5-bisphosphate 3-kinase (en) Phosphoinositide 3-kinase (en) |
| dbp:opmFamily | 265 (xsd:integer) |
| dbp:opmProtein | 3 (xsd:integer) |
| dbp:pfam | PF00454 (en) |
| dbp:prosite | PDOC00710 (en) |
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| dbp:smart | SM00146 (en) |
| dbp:symbol | PI3K (en) |
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| rdfs:comment | Fosfatidylinositol-3-kináza (PI3 kináza, PI3K) je enzym ze skupiny kináz, který katalyzuje navázání fosfátové skupiny na D3 pozici inositolového kruhu . PI3K jsou významnými regulátory hladiny jednotlivých fosfatidylinositidů. Snižováním či zvyšováním hladiny těchto fosfolipidů následně dochází k změnám vlastností membrán i proteinů a signálních drah, jež jsou k těmto membránám ukotveny. Zvýšená aktivita PI-3 kináz (např. následkem mutace ) může vést k nádorovému bujení. (cs) فوسفينوسيتايد 3-كينازات (PI3Ks)، وتسمى أيضًا الفوسفاتيدلينوسيتول 3 كيناز ، هي عائلة من الإنزيمات المشاركة في الوظائف الخلوية مثل نمو الخلايا، والتكاثر، والتمايز، والحركة، والبقاء، والاتجار داخل الخلايا، والتي بدورها تشارك في السرطان. PI3Ks أسرة مكونة من الخلايا ذات الصلة إشارة محول الانزيمات قادرة على الفسفرة 3 موقف الهيدروكسيل مجموعة من إينوزيتول حلقة من فوسفتيدلينوستول (PtdIns). المسار، مع الجين الورمي PIK3CA والقامع الورم PTEN ، وتورط في حساسية الأورام السرطانية الأنسولين و IGF1 ، و الحد من السعرات الحرارية . (ar) La phosphoinositide 3-kinase (PI 3-kinase, PI3K, PI(3)K, or PI-3K) est une enzyme permettant la transformation des phosphoinositides en phosphatidylinositol-3-phosphate. (fr) Las fosfoinositol 3-cinasas o fosfoinosítido-3-cinasas (PI 3-cinasas o PI3K o P110δ), son una familia de enzimas capaces de fosforilar el grupo hidroxilo de la posición 3' del anillo inositol de las moléculas llamadas en conjunto fosfatidilinositol -enzima que en humanos está códificada por el gen PIK3CD-. (es) PI3キナーゼ（英: Phosphoinositide 3-kinase, PI3K、EC 2.7.1.137）は、イノシトールリン脂質のイノシトール環3位のヒドロキシル基（-OH基）のリン酸化を行う酵素である。イノシトールリン脂質は真核生物の細胞膜を構成する成分の一つであり、PI3Kをはじめとしたキナーゼ（リン酸化酵素）の触媒作用を受けてホスファチジルイノシトール-3,4,5-三リン酸 PtdIns(3,4,5)P3となり、プロテインキナーゼB（PKB）/Aktを活性化する。このシグナル伝達経路はPI3キナーゼ-Akt経路と呼ばれ、様々な生理作用の発現に関与する。特にインスリンの分泌促進に深く関与することから、新たな糖尿病薬の開発が示唆されている。 (ja) A fosfoinositídeo 3-quinase ou fosfatidilinositol 3-quinases (PI 3-quinases ou PI3Ks) são uma família de enzimas envolvidas em funções celulares tais como crescimento celular, proliferação, diferenciação, mobilidade, sobrevivência e tráfego intracelular, os quais em alteração pode estar envolvidos em câncer, atuando no desenvolvimento de tumores. (pt) Фосфоинозитид-3-киназы, или фосфатидилинозитол-3-киназы (КФ 2.7.1; англ. Phosphoinositide 3-kinases, PI 3-kinases, PI3Ks) — семейство ферментов, фосфорилирующих фосфатидилинозитол в положении 3D инозитольного кольца. Являются ключевым элементом PI3K сигнального пути. (ru) 磷酸肌醇3-激酶（英語：Phosphoinositide 3-kinase, PI3Ks）又叫磷脂醯環己六醇3-激酶（英語：英語：phosphatidylinositol 3-kinases），是一個參與諸如細胞生長、增殖、分化、移動、存活和胞內運輸等細胞功能的酶家族，從而也參與癌症。 磷酸肌醇3-激酶是由細胞內能夠磷酸化磷脂醯環己六醇的肌醇環3號位置羟基基團的相關信号转导酶組成的一個家族。擁有癌基因PIK3CA（P110α）和抑癌基因PTEN的途徑不僅影響腫瘤細胞對胰岛素和胰岛素样生长因子1的敏感性，還影響攝熱量限制。 (zh) Phosphoinositid-3-Kinasen (PI3-Kinase, PI3K) sind Enzyme, deren Aktivität in sämtlichen eukaryotischen Zellen zu finden ist. Sie spielen eine wichtige Rolle in der Signaltransduktion und sind an einer Vielzahl von zellulären Schlüsselfunktionen, wie Zellwachstum, Zellproliferation, Migration, Differenzierung, Überleben und Zelladhäsion beteiligt. Beim Menschen können Veränderungen der Struktur, Aktivität oder Regulation der PI3K zu Krankheiten, wie Allergien, Entzündungsprozessen, Herzkrankheiten sowie Krebs führen. Ein Beispiel für einen PI3K-Inhibitor ist Wortmannin. (de) Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. (en) Kinase fosfatidil inositol-3 (bahasa Inggris: phosphatidyl inositol-3 kinase, Phosphoinositide 3-kinases, PI3K) merupakan enzim kinase lipid yang berperan dalam perkembangan sel, proliferasi, diferensiasi, motility, transduksi sinyal intraselular, termasuk GLUT12. Enzim ini pertama kali ditemukan oleh . (in) La fosfoinositide 3-chinasi o fosfatidilinositolo-3-chinasi o PI 3-chinasi o PI3K è una famiglia di enzimi coinvolti in complessi meccanismi cellulari come la crescita cellulare, la proliferazione, la differenziazione, la motilità e la sopravvivenza intracellulare; meccanismi questi coinvolti, anche, nello sviluppo del cancro. (it) |
| rdfs:label | فوسفوينوسيتيد 3 كيناز (ar) Fosfatidylinositol-3-kináza (cs) Phosphoinositid-3-Kinasen (de) Fosfoinositol 3-cinasa (es) Fosfatidil inositol-3 kinase (in) Phosphoinositide 3-kinase (fr) Fosfoinositide 3-chinasi (it) PI3キナーゼ (ja) Phosphoinositide 3-kinase (en) Fosfoinositídeo 3-quinase (pt) Фосфоинозитид-3-киназа (ru) 磷酸肌醇3-激酶 (zh) |
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