| dbo:abstract |
Neonatal diabetes mellitus (NDM) is a disease that affects an infant and their body's ability to produce or use insulin. NDM is a monogenic (controlled by a single gene) form of diabetes that occurs in the first 6 months of life. Infants do not produce enough insulin, leading to an increase in glucose accumulation. It is a rare disease, occurring in only one in 100,000 to 500,000 live births. NDM can be mistaken for the much more common type 1 diabetes, but type 1 diabetes usually occurs later than the first 6 months of life. There are two types of NDM: permanent neonatal diabetes mellitus (PNDM) is a lifelong condition. Transient neonatal diabetes mellitus (TNDM) is diabetes that disappears during the infant stage but may reappear later in life. Specific genes that can cause NDM have been identified. The onset of NDM can be caused by abnormal pancreatic development, beta cell dysfunction or accelerated beta cell dysfunction. Individuals with monogenic diabetes can pass it on to their children or future generations. Each gene associated with NDM has a different inheritance pattern. (en) Le diabète néonatal est un diabète insulino-dépendant qui apparaît durant les premiers mois de vie. Il existe sous deux formes : * Diabète néonatal transitoire * (fr) Не́оната́льный са́харный диабе́т — редко встречающееся гетерогенное по этиологии заболевание, проявляющееся в первые 6 месяцев жизни. Различают две основные клинические группы: * транзито́рный (преходящий) неонатальный сахарный диабет и * пермане́нтный (персистирующий) неонатальный сахарный диабет. На долю транзиторного приходится около 50% случаев неонатального сахарного диабета. Симптомы транзиторного неонатального сахарного диабета спонтанно исчезают в среднем к возрасту 12 недель жизни. Дети в последующем не требуют лечения, хотя считается, что у половины из них сахарный диабет может проявиться повторно в старшем возрасте – чаще на втором и третьем десятке жизни как сахарный диабет 1-го типа. В противоположность ему перманентный неонатальный сахарный диабет требует назначения инсулина. Так, в 2004 г. в Австралии наблюдали 5-летнюю девочку, которая нуждалась в инсулинотерапии, начиная с 6 недель жизни. (ru) |
| dbo:icd10 |
P70.2 |
| dbo:orpha |
224 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Monitores.jpg?width=300 |
| dbo:wikiPageID |
23754109 (xsd:integer) |
| dbo:wikiPageLength |
28941 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1094365727 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Pregnancy dbr:Puberty dbr:Endoplasmic_reticulum dbr:Mutation dbr:Nucleotide dbr:MNX1 dbr:Methylation dbr:PLAGL1 dbr:Euglycemic_clamp dbr:SUR1 dbr:Dehydration dbr:Developmental_delay dbr:Homozygous dbr:Beta_cell dbr:DNA_methylation dbr:EIF2AK3 dbr:Insulin_resistance dbr:Intrauterine_growth_restriction dbr:Polymerase_chain_reaction dbr:Potassium_channel dbr:Maturity_onset_diabetes_of_the_young dbr:Gene_expression dbr:Genomic_imprinting dbr:Second_messenger_system dbr:Rare_disease dbr:Gene dbr:Glibenclamide dbr:Congenital_hyperinsulinism dbr:Sulfonylurea dbr:Apoptosis dbr:Diabetes_mellitus_type_1 dbr:Ketone dbr:PLAG1 dbr:Pathogen dbr:Subcutaneous_tissue dbr:Autosomal_dominant dbr:Adenylyl_cyclase dbr:Transcriptional_regulation dbr:Type_1_diabetes dbr:Type_2_diabetes dbr:GATA4 dbr:GATA6 dbr:HYMAI dbr:Fasting_plasma_glucose dbr:Locus_(genetics) dbr:NKX2-2 dbr:5-Methylcytosine dbr:Cyclic_adenosine_monophosphate dbr:Pancreatic dbr:Cell_cycle dbr:Chromosome dbr:Chromosome_6 dbr:Diabetic_ketoacidosis dbr:Differentially_methylated_region dbr:Fasting dbr:Glycosuria dbr:Epigenetic dbr:Differentially_methylated_regions dbr:Permanent_neonatal_diabetes_mellitus dbr:Transient_neonatal_diabetes_mellitus dbr:Transcription_factor dbr:Promoter_(genetics) dbr:RFX6 dbr:Respiratory_tract_infection dbc:Rare_diseases dbr:ATP-sensitive_potassium_channel dbr:Heterogeneous dbr:Heterozygous dbr:Hypomethylating_agent dbr:Attention_deficit_hyperactivity_disorder dbr:ABCC8 dbc:Diabetes dbc:Neonatology dbr:KATP dbr:Kilogram dbr:Signal_transduction dbr:Wolfram_syndrome dbr:Zinc-activated_ion_channel dbr:Missense_mutation dbr:Monogenic_(genetics) dbr:Diabetes dbr:Diabetes_mellitus dbr:Endoplasmic_reticulum_stress dbr:Enlarged_tongue dbr:Insulin dbr:Metabolic_acidosis dbr:Candida_albicans dbr:Seizure dbr:CNOT1 dbr:Kir6.2 dbr:Methyl_group dbr:Microsatellite dbr:Umbilical_hernia dbr:White_blood_cell dbr:Wolcott-Rallison_syndrome dbr:FOXP3 dbr:IPEX_syndrome dbr:Pleomorphic_adenoma dbr:NEUROD1 dbr:NEUROG3 dbr:Sporosarcina_ureae dbr:Pituitary_adenylate_cyclase-activating_peptide dbr:Polyuria dbr:Intermediate-acting_insulin dbr:Insulin_therapy dbr:Intravenous dbr:ZFP57 dbr:Uniparental_disomy dbr:PDX1 dbr:PTF1A dbr:Chromosome_6_(human) dbr:Oral_glucose_tolerance_test dbr:Intravenous_glucose_challenge_test dbr:Secretory dbr:Short-acting_insulin dbr:Imprinted_gene dbr:KCNJ11 dbr:Polymorphic_marker dbr:Polypeptide dbr:Zinc-finger_protein dbr:Glyburide dbr:Glycemic_control dbr:ER_stress dbr:Genetic_disease dbr:Insulin-secreting_cells dbr:Subcutaneous_fat dbr:GLIS3 dbr:File:Monitores.jpg |
| dbp:caption |
Neonatal Diabetes Mellitus (en) |
| dbp:icd |
P70.2 (en) |
| dbp:orphanet |
224 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:Citation_needed dbt:Cite_book dbt:Cite_journal dbt:Diabetes dbt:Infobox_medical_condition_(new) dbt:Medical_resources dbt:Reflist dbt:Sfn |
| dct:subject |
dbc:Rare_diseases dbc:Diabetes dbc:Neonatology |
| rdf:type |
owl:Thing wikidata:Q12136 dbo:Disease |
| rdfs:comment |
Le diabète néonatal est un diabète insulino-dépendant qui apparaît durant les premiers mois de vie. Il existe sous deux formes : * Diabète néonatal transitoire * (fr) Neonatal diabetes mellitus (NDM) is a disease that affects an infant and their body's ability to produce or use insulin. NDM is a monogenic (controlled by a single gene) form of diabetes that occurs in the first 6 months of life. Infants do not produce enough insulin, leading to an increase in glucose accumulation. It is a rare disease, occurring in only one in 100,000 to 500,000 live births. NDM can be mistaken for the much more common type 1 diabetes, but type 1 diabetes usually occurs later than the first 6 months of life. There are two types of NDM: permanent neonatal diabetes mellitus (PNDM) is a lifelong condition. Transient neonatal diabetes mellitus (TNDM) is diabetes that disappears during the infant stage but may reappear later in life. (en) Не́оната́льный са́харный диабе́т — редко встречающееся гетерогенное по этиологии заболевание, проявляющееся в первые 6 месяцев жизни. Различают две основные клинические группы: * транзито́рный (преходящий) неонатальный сахарный диабет и * пермане́нтный (персистирующий) неонатальный сахарный диабет. На долю транзиторного приходится около 50% случаев неонатального сахарного диабета. В противоположность ему перманентный неонатальный сахарный диабет требует назначения инсулина. Так, в 2004 г. в Австралии наблюдали 5-летнюю девочку, которая нуждалась в инсулинотерапии, начиная с 6 недель жизни. (ru) |
| rdfs:label |
Diabète néonatal (fr) Neonatal diabetes (en) Неонатальный сахарный диабет (ru) |
| owl:sameAs |
wikidata:Neonatal diabetes dbpedia-fr:Neonatal diabetes dbpedia-he:Neonatal diabetes dbpedia-ru:Neonatal diabetes dbpedia-simple:Neonatal diabetes https://global.dbpedia.org/id/2gv5f |
| prov:wasDerivedFrom |
wikipedia-en:Neonatal_diabetes?oldid=1094365727&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Monitores.jpg |
| foaf:isPrimaryTopicOf |
wikipedia-en:Neonatal_diabetes |
| is dbo:wikiPageRedirects of |
dbr:Neonatal_diabetes_mellitus |
| is dbo:wikiPageWikiLink of |
dbr:Glucokinase dbr:Maturity-onset_diabetes_of_the_young dbr:Transient_neonatal_diabetes dbr:Frances_Ashcroft dbr:Neonatal_diabetes_mellitus dbr:L'Oréal-UNESCO_For_Women_in_Science_Awards dbr:Permanent_neonatal_diabetes |
| is foaf:primaryTopic of |
wikipedia-en:Neonatal_diabetes |
