PSMB5 (original) (raw)
Proteasome subunit beta type-5 as known as 20S proteasome subunit beta-5 is a protein that in humans is encoded by the PSMB5 gene. This protein is one of the 17 essential subunits (alpha subunits 1–7, constitutive beta subunits 1–7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex. In particular, proteasome subunit beta type-5, along with other beta subunits, assemble into two heptameric rings and subsequently a proteolytic chamber for substrate degradation. This protein contains "chymotrypsin-like" activity and is capable of cleaving after large hydrophobic residues of peptide. The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key regulatory
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| dbo:abstract | Proteasome subunit beta type-5 as known as 20S proteasome subunit beta-5 is a protein that in humans is encoded by the PSMB5 gene. This protein is one of the 17 essential subunits (alpha subunits 1–7, constitutive beta subunits 1–7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex. In particular, proteasome subunit beta type-5, along with other beta subunits, assemble into two heptameric rings and subsequently a proteolytic chamber for substrate degradation. This protein contains "chymotrypsin-like" activity and is capable of cleaving after large hydrophobic residues of peptide. The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key regulatory protein components for dynamic biological processes. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. (en) PSMB5 (англ. Proteasome subunit beta 5) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 14-ї хромосоми. Довжина поліпептидного ланцюга білка становить 263 амінокислот, а молекулярна маса — 28 480. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функціями належить до гідролаз, протеаз, . Задіяний у таких біологічних процесах, як взаємодія хазяїн-вірус, альтернативний сплайсинг. Локалізований у цитоплазмі, ядрі. (uk) |
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| dbo:wikiPageWikiLink | dbr:Prostaglandins dbr:Proteasome dbr:Androgen_receptors dbr:C-Myc dbr:Non-small_cell_lung_carcinomas dbr:Dementia dbr:Huntington's_disease dbr:Retinoblastoma dbr:Rheumatoid_arthritis dbr:Cyclin-dependent_kinase dbr:Interleukin_8 dbr:P53 dbr:Creutzfeldt–Jakob_disease dbr:PSMB10 dbr:ICAM-1 dbr:Proteolysis dbr:Gene dbr:NF-κB dbr:Myc dbr:Proteasome_subunit_beta_type-2 dbr:Apoptosis dbr:Major_histocompatibility_complex dbr:Sjögren_syndrome dbr:PSMA1 dbr:Pick's_disease dbr:C-Fos dbr:C-jun dbr:Adenomatous_polyposis_coli dbr:Transcription_factors dbr:Heart_failure dbr:Amyotrophic_lateral_sclerosis dbr:Cytokines dbr:Alzheimer's_disease dbr:Fanconi_anemia dbr:Nitric_oxide dbr:Parkinson's_disease dbr:Cell_cycle dbr:Cell_growth dbr:Chymotrypsin dbr:Protein dbr:Raf_kinase dbr:PSMB8 dbr:STAT3 dbr:ABL_(gene) dbr:Systemic_lupus_erythematosus dbr:PSMB9 dbr:Autoimmune_disease dbr:Src_(gene) dbr:Radiation_therapy dbr:MOS_(gene) dbr:MYB_(gene) dbr:VCAM-1 dbr:Von_Hippel–Lindau_tumor_suppressor dbr:Ischemic dbr:Ventricular_hypertrophy dbr:P-selectin dbr:Muscular_dystrophies dbr:Proto-oncogenes dbr:Ubiquitination dbr:Ubiquitin–proteasome_system dbr:Adhesion_molecules dbr:Malignancies dbr:TNF-α |
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| rdfs:comment | Proteasome subunit beta type-5 as known as 20S proteasome subunit beta-5 is a protein that in humans is encoded by the PSMB5 gene. This protein is one of the 17 essential subunits (alpha subunits 1–7, constitutive beta subunits 1–7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex. In particular, proteasome subunit beta type-5, along with other beta subunits, assemble into two heptameric rings and subsequently a proteolytic chamber for substrate degradation. This protein contains "chymotrypsin-like" activity and is capable of cleaving after large hydrophobic residues of peptide. The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key regulatory (en) PSMB5 (англ. Proteasome subunit beta 5) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 14-ї хромосоми. Довжина поліпептидного ланцюга білка становить 263 амінокислот, а молекулярна маса — 28 480. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk) |
| rdfs:label | PSMB5 (en) PSMB5 (uk) |
| owl:sameAs | freebase:PSMB5 http://www4.wiwiss.fu-berlin.de/drugbank/resource/targets/4102 wikidata:PSMB5 dbpedia-cy:PSMB5 dbpedia-uk:PSMB5 https://global.dbpedia.org/id/k9Jz |
| prov:wasDerivedFrom | wikipedia-en:PSMB5?oldid=1116500514&ns=0 |
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| is dbo:wikiPageRedirects of | dbr:Proteasome_subunit_beta_type-5 dbr:PSMB5_(gene) |
| is dbo:wikiPageWikiLink of | dbr:PSMB4 dbr:Housekeeping_gene dbr:List_of_human_protein-coding_genes_3 dbr:PSMB10 dbr:PSMB6 dbr:Proteasome_subunit_beta_type-5 dbr:PSMA3 dbr:PSMA5 dbr:PSMD11 dbr:PSMB8 dbr:PSMB9 dbr:PSMD12 dbr:PSMB7 dbr:Thymoproteasome dbr:Oprozomib dbr:PSMD9 dbr:PSMB5_(gene) dbr:PSMD13 |
| is foaf:primaryTopic of | wikipedia-en:PSMB5 |