PTPN22 (original) (raw)
Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a cytoplasmatic protein encoded by gene PTPN22 and a member of PEST family of protein tyrosine phosphatases. This protein is also called "PEST-domain Enriched Phosphatase" ("PEP") or "Lymphoid phosphatase" ("LYP"). The name LYP is used strictly for the human protein encoded by PTPN22, but the name PEP is used only for its mouse homolog. However, both proteins have similar biological functions and show 70% identity in amino acid sequence. PTPN22 functions as a negative regulator of T cell receptor (TCR) signaling, which maintains homeostasis of T cell compartment.
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| dbo:abstract | Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a cytoplasmatic protein encoded by gene PTPN22 and a member of PEST family of protein tyrosine phosphatases. This protein is also called "PEST-domain Enriched Phosphatase" ("PEP") or "Lymphoid phosphatase" ("LYP"). The name LYP is used strictly for the human protein encoded by PTPN22, but the name PEP is used only for its mouse homolog. However, both proteins have similar biological functions and show 70% identity in amino acid sequence. PTPN22 functions as a negative regulator of T cell receptor (TCR) signaling, which maintains homeostasis of T cell compartment. (en) PTPN22 pour « Protein tyrosine phosphatase, non receptor type 22 », est une protéine tyrosine phosphatase (LYP) exprimée dans les tissus lymphoïdes et codée par le gène PTPN22 situé sur le chromosome 1 humain. (fr) La protein-tirosin-fosfatasi non recettoriale 22, anche nota con l'acronimo PTPN22, è una proteina con proprietà enzimatiche codificata dal gene PTPN22. Tale gene può essere espresso in varie forme. Essendo coinvolto nella responsività dei recettori dei linfociti B e T, le sue mutazioni possono essere responsabili dell'insorgenza di malattie autoimmuni. (it) PTPN22 (англ. Protein tyrosine phosphatase, non-receptor type 22) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. Довжина поліпептидного ланцюга білка становить 807 амінокислот, а молекулярна маса — 91 705. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функціями належить до гідролаз, . Задіяний у таких біологічних процесах як імунітет, автофагія. Локалізований у цитоплазмі. (uk) |
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| dbo:wikiPageWikiLink | dbr:Proline dbr:Protein_tyrosine_phosphatase dbr:Enzyme_inhibitor dbr:Mutation dbr:Meta-analysis dbr:Tyrosine-protein_kinase_CSK dbr:Allele dbr:Antigen dbr:Antigen-presenting_cell dbr:Homeostasis dbr:House_mouse dbr:Human dbr:Peptide dbr:Rheumatoid_arthritis dbr:Cytokine dbr:Cytoplasm dbr:Cytosol dbr:Ulcerative_colitis dbr:Vasculitis dbr:Dephosphorylation dbr:Interaction dbr:Spleen dbr:Peyer's_patch dbr:KDa dbr:ZAP70 dbr:Gene_expression dbr:Naive_T_cell dbr:Gene dbr:Graves'_disease dbr:Multiple_sclerosis dbr:Myasthenia_gravis dbr:Antibody dbr:Lupus dbr:Lymph_node dbr:Lymphocytopenia dbr:Pemphigus_vulgaris dbr:Protein_kinase_C dbr:Protein_structure dbr:T-cell_receptor dbc:Proteins dbr:Addison's_disease dbr:Cell_(biology) dbr:Thymine dbr:Tryptophan dbr:Type_1_diabetes dbr:Tyrosine dbr:Codon dbr:Jurkat_cells dbr:Juvenile_idiopathic_arthritis dbr:Lipid_raft dbr:Amino_acid dbc:Molecular_biology dbr:Cytosine dbr:Base_pair dbr:Cell_adhesion dbr:Cell_membrane dbr:Cell_proliferation dbr:Cell_signaling dbr:Cellular_differentiation dbr:Chromosome dbr:Disease dbr:Germinal_center dbr:Protein_domain dbr:Protein_family dbr:Transcription_factor dbr:Protein dbr:Half-life dbr:TRAF3 dbr:Arginine dbc:Immune_system dbc:T_cells dbr:Affinity_(pharmacology) dbr:Lck dbr:Binding_site dbr:Co-stimulation dbr:Homology_(biology) dbr:Regulatory_T_cell dbr:Dissociation_(chemistry) dbr:Autoantibody dbr:Autoimmune_disease dbr:C-terminus dbr:CD3_(immunology) dbr:CD44 dbr:CD69 dbr:Phenotype dbr:Splenomegaly dbr:Src_family_kinase dbr:Catalysis dbr:Serine dbr:Single-nucleotide_polymorphism dbr:Tyrosine-protein_kinase_SYK dbr:Wild_type dbr:Exon dbr:Extracellular_signal-regulated_kinases dbr:Immune_tolerance dbr:Lymphadenopathy dbr:Lymphatic_system dbr:N-terminus dbr:Motility dbr:T_cell dbr:Phosphorylation dbr:SH2_domain dbr:Rap1 dbr:SH3_domain dbr:LFA-1 dbr:Protein_degradation dbr:Protein_motif dbr:GITR dbr:Ca²⁺ dbr:Polyubiquitination dbr:CD62L dbr:CD40L |
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| rdfs:comment | Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a cytoplasmatic protein encoded by gene PTPN22 and a member of PEST family of protein tyrosine phosphatases. This protein is also called "PEST-domain Enriched Phosphatase" ("PEP") or "Lymphoid phosphatase" ("LYP"). The name LYP is used strictly for the human protein encoded by PTPN22, but the name PEP is used only for its mouse homolog. However, both proteins have similar biological functions and show 70% identity in amino acid sequence. PTPN22 functions as a negative regulator of T cell receptor (TCR) signaling, which maintains homeostasis of T cell compartment. (en) PTPN22 pour « Protein tyrosine phosphatase, non receptor type 22 », est une protéine tyrosine phosphatase (LYP) exprimée dans les tissus lymphoïdes et codée par le gène PTPN22 situé sur le chromosome 1 humain. (fr) La protein-tirosin-fosfatasi non recettoriale 22, anche nota con l'acronimo PTPN22, è una proteina con proprietà enzimatiche codificata dal gene PTPN22. Tale gene può essere espresso in varie forme. Essendo coinvolto nella responsività dei recettori dei linfociti B e T, le sue mutazioni possono essere responsabili dell'insorgenza di malattie autoimmuni. (it) PTPN22 (англ. Protein tyrosine phosphatase, non-receptor type 22) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. Довжина поліпептидного ланцюга білка становить 807 амінокислот, а молекулярна маса — 91 705. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk) |
| rdfs:label | PTPN22 (en) PTPN22 (it) PTPN22 (fr) PTPN22 (uk) |
| owl:sameAs | freebase:PTPN22 http://www4.wiwiss.fu-berlin.de/diseasome/resource/genes/LYP http://www4.wiwiss.fu-berlin.de/diseasome/resource/genes/PTPN22 yago-res:PTPN22 wikidata:PTPN22 dbpedia-cy:PTPN22 dbpedia-fr:PTPN22 dbpedia-it:PTPN22 http://tt.dbpedia.org/resource/PTPN22 dbpedia-uk:PTPN22 https://global.dbpedia.org/id/3av6c |
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