| dbo:abstract |
Der hypergonadotrope Hypogonadismus ist eine seltene angeborene Erkrankung mit einer Unterfunktion der Keimdrüsen (Gonaden) und mit gleichzeitig erhöhter Konzentration der Gonadotropine aufgrund verminderten oder fehlenden Ansprechens der Gonaden auf Gonadotropine. Weitere Bezeichnungen sind: Gonadotropinresistenz; primärer Hypogonadismus (de) Hypergonadotropic hypogonadism (HH), also known as primary or peripheral/gonadal hypogonadism or primary gonadal failure, is a condition which is characterized by hypogonadism which is due to an impaired response of the gonads to the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH), and in turn a lack of sex steroid production. As compensation and the lack of negative feedback, gonadotropin levels are elevated. Individuals with HH have an intact and functioning hypothalamus and pituitary glands (of the hypothalamic-pituitary-gonadal (HPA) axis) so they are still able to produce FSH and LH. HH may present as either congenital or acquired, but the majority of cases are of the former nature. HH can be treated with hormone replacement therapy. (en) |
| dbo:synonym |
Peripheral/gonadal hypogonadism |
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| dbo:wikiPageWikiLink |
dbr:Pseudohypoparathyroidism dbr:Endocrine_disruptor dbr:Mosaic_(genetics) dbr:Androgen dbr:Anorchia dbr:Hypothalamus dbc:Gonadotropin-releasing_hormone_and_gonadotropins dbr:Delayed_puberty dbr:Leydig_cell_hypoplasia dbr:Complete_androgen_insensitivity_syndrome dbr:Cryptorchidism dbr:Medical_condition dbr:Estrogen dbr:Galactosemia dbr:Gene dbr:Genetic_mutation dbr:Myotonic_dystrophy dbr:Congenital_adrenal_hyperplasia dbc:Endocrine_gonad_disorders dbr:Antiandrogen dbr:Hormone_replacement_therapy dbr:Ovary dbr:Surgery dbr:Drug dbr:GNAS_complex_locus dbr:Ethanol dbr:Follicle-stimulating_hormone dbr:Follicle-stimulating_hormone_insensitivity dbr:Gonad dbr:Gonadotropin dbr:Gonadotropin-releasing_hormone dbr:Gonadotropin_receptor dbr:Testicle dbr:Hypergonadotropic_hypergonadism dbr:Hypogonadism dbr:Hypogonadotropic_hypogonadism dbr:Hypothalamic–pituitary–gonadal_axis dbr:Chemotherapy dbr:Ovarian_torsion dbr:Toxin dbr:Autoimmunity dbr:Azoospermia dbr:Polycystic_ovary_syndrome dbr:Infection dbr:Infertility dbr:Opioid dbr:Orchitis dbr:Radiation_therapy dbr:Sex_hormone dbr:Sex_steroid dbr:XX_gonadal_dysgenesis dbr:Luteinizing_hormone dbr:Oligospermia dbr:Pituitary_gland dbr:Turner's_syndrome dbr:Vanishing_testis dbr:Sexually-transmitted_disease dbr:Swyer's_syndrome dbr:Trauma_(medicine) dbr:Klinefelter's_syndrome dbr:Ovarian_resistance_syndrome dbr:Premature_ovarian_insufficiency |
| dbp:specialty |
endocrinology (en) |
| dbp:synonym |
Peripheral/gonadal hypogonadism (en) |
| dbp:wikiPageUsesTemplate |
dbt:Infobox_medical_condition_(new) dbt:Reflist dbt:See_also dbt:Gonadal_disorder |
| dcterms:subject |
dbc:Gonadotropin-releasing_hormone_and_gonadotropins dbc:Endocrine_gonad_disorders |
| gold:hypernym |
dbr:Condition |
| rdf:type |
owl:Thing wikidata:Q12136 yago:Abstraction100002137 yago:Attribute100024264 yago:Condition113920835 yago:Disorder114052403 yago:PhysicalCondition114034177 dbo:Disease yago:State100024720 yago:WikicatEndocrineGonadDisorders |
| rdfs:comment |
Der hypergonadotrope Hypogonadismus ist eine seltene angeborene Erkrankung mit einer Unterfunktion der Keimdrüsen (Gonaden) und mit gleichzeitig erhöhter Konzentration der Gonadotropine aufgrund verminderten oder fehlenden Ansprechens der Gonaden auf Gonadotropine. Weitere Bezeichnungen sind: Gonadotropinresistenz; primärer Hypogonadismus (de) Hypergonadotropic hypogonadism (HH), also known as primary or peripheral/gonadal hypogonadism or primary gonadal failure, is a condition which is characterized by hypogonadism which is due to an impaired response of the gonads to the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH), and in turn a lack of sex steroid production. As compensation and the lack of negative feedback, gonadotropin levels are elevated. Individuals with HH have an intact and functioning hypothalamus and pituitary glands (of the hypothalamic-pituitary-gonadal (HPA) axis) so they are still able to produce FSH and LH. HH may present as either congenital or acquired, but the majority of cases are of the former nature. HH can be treated with hormone replacement therapy. (en) |
| rdfs:label |
Hypergonadotroper Hypogonadismus (de) Hypergonadotropic hypogonadism (en) |
| rdfs:seeAlso |
dbr:Hypogonadism |
| owl:sameAs |
freebase:Hypergonadotropic hypogonadism yago-res:Hypergonadotropic hypogonadism wikidata:Hypergonadotropic hypogonadism dbpedia-de:Hypergonadotropic hypogonadism https://global.dbpedia.org/id/4nf73 |
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wikipedia-en:Hypergonadotropic_hypogonadism?oldid=1104816474&ns=0 |
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wikipedia-en:Hypergonadotropic_hypogonadism |
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dbr:Hypergonadotrophic_hypogonadism dbr:Hypergonadotrophism dbr:Hypergonadotropism dbr:Peripheral/gonadal_hypogonadism dbr:Primary_hypogonadism |
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dbr:Androgen_deficiency dbr:Delayed_puberty dbr:Leydig_cell_hypoplasia dbr:XXYY_syndrome dbr:Reproductive_medicine dbr:Aromatase_deficiency dbr:Late-onset_hypogonadism dbr:Follicle-stimulating_hormone_insensitivity dbr:Gonadal_dysgenesis dbr:Isolated_17,20-lyase_deficiency dbr:Isolated_hypogonadotropic_hypogonadism dbr:Hypergonadotropic_hypergonadism dbr:Hypoestrogenism dbr:Hypogonadism dbr:Hypogonadotropic_hypogonadism dbr:XXXY_syndrome dbr:Bone_morphogenetic_protein_15 dbr:Klinefelter_syndrome dbr:Luteinizing_hormone dbr:Malouf_syndrome dbr:Hypergonadotrophic_hypogonadism dbr:Hypergonadotrophism dbr:Hypergonadotropism dbr:Peripheral/gonadal_hypogonadism dbr:Primary_hypogonadism |
| is foaf:primaryTopic of |
wikipedia-en:Hypergonadotropic_hypogonadism |