Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 (original) (raw)

Change history

In the version of this article initially published, there were errors in the consortium membership list and the associated affiliations and in the acknowledgements and contributions sections. These errors and their corrections are detailed below by section. Consortium members: Janice M. Fullerton was omitted from the membership list and has now been added with affiliations 76 and 77. Phil H. Lee was listed incorrectly as Phil L. Hyoun. Fan Meng was listed incorrectly as Fan Guo Meng, and the associated affiliation has been changed from 51 to 54. Robert Thompson was assigned affiliation 50; the correct affiliation is 54. Marian Hamshere and Valentina Moskvina were assigned affiliation 26; the correct affiliation for both is 22. Richard Day was assigned affiliation 47; the correct affiliation is 46. Jun Li was assigned affiliation 24; the correct affiliation is 48. In addition to the affiliation originally listed for Sebastian Zöllner and Peng Zhang, both have now also been assigned affiliation 4. Howard Endenberg has now also been assigned affiliation 12, and Shaun Purcell has now also been assigned affiliation 1. Consortium affiliations: Affiliation 46 was originally given as the University of Dundee School of Medicine, Nethergate, Dundee, UK. The correct affiliation is the Division of Neuroscience, University of Dundee, Ninewells Hospital & Medical School, Dundee, UK. Affiliation 47 was originally given as the School of Neurology, Neurobiology and Psychiatry, Royal Victoria Infirmary, Newcastle upon Tyne, UK. The correct affiliation is the Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA. This affiliation was also listed out of order and has now been changed to affiliation 48. Affiliation 76 was originally given as the Prince of Wales Medical Institute, Sydney, Australia. The correct affiliation is Neuroscience Research Australia, Sydney, Australia. Acknowledgments: The Stanley Foundation for Medical Research was listed as a source of funding. The correct name is the Stanley Medical Research Institute, and the Merck Genome Research Institute has also been added as a source of support. Contributions: In four instances, the contribution of Sven Cichon was indicated with the incorrect spelling S. Chichon instead of S. Cichon. Manuel A. Ferreira (M.A.F.) was incorrectly listed as a contributor to manuscript preparation. Manuel A. Ferreira (M.A.F.) was listed as a contributor to primary study data at the NIMH/Pritzke; the correct contributor was Matthew Flickinger (M.F.). In the section listing contributors to replication data, Neuroscience Research Australia was named incorrectly as the Prince of Wales Medical Institute, and Janice M. Fullerton (J.M.F.) has been added as a contributor at this site and at the University of New South Wales. The errors detailed above have been corrected in the HTML and PDF versions of the article. In addition, the subsections of the contributions section detailing the individuals contributing to primary study data and replication data were omitted from the original HTML version of the article, and this error has now been corrected.

An Erratum to this paper has been published: https://doi.org/10.1038/ng0912-1072a

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Acknowledgements

We would like to recognize the contribution of thousands of subjects without whom this work would not be possible. T. Lehner (National Institute of Mental Health (NIMH)) was instrumental in initiating and planning the overall project. D. Posthuma and the Dutch Genetic Cluster Computer provided invaluable computational resources. We also thank the PGC schizophrenia group for allowing us to perform the combined analyses of six loci before publication. This work was supported by many grants from the US National Institutes of Health (NIH) (MH078151, MH081804, MH059567 supplement, MH59553, MH080372 and 1U54RR025204). Other sources of support include: the Genetic Association Information Network (GAIN), the NIMH Intramural Research Program, the Tzedakah Foundation, the American Philosophical Society, the Stardust foundation, the National Library of Medicine, the Stanley Medical Research Institute, the Merck Genome Research Institute and the Wellcome Trust, the Pritzker Neuropsychiatric Disorders Research Fund L.L.C., GlaxoSmithKline, as well as grants for individual studies (see the Supplemental Note for a full list of Acknowledgements). The TOP Study was supported by grants from the Research Council of Norway (167153/V50, 163070/V50 and 175345/V50), the South-East Norway Health Authority (123-2004) and the EU (ENBREC). Additional acknowledgments can be found in the Supplementary Note.

Genotype data from this manuscript for the 10,257 samples can be obtained from the Center on Collaborative Genetic Studies of Mental Disorders in accordance with NIMH data release policies (http://zork.wustl.edu/nimh/). Genotype data from the WTCCC sample can be obtained from https://www.wtccc.org.uk/info/access_to_data_samples.shtml. Genotype data from the BOMA-Bipolar Study can be obtained by contacting S. Cichon directly (sven.cichon@uni-bonn.de).

Author information

Authors and Affiliations

  1. Division of Psychiatric Genomics, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    Pamela Sklar & Shaun M Purcell
  2. Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Pamela Sklar, Stephan Ripke, Mark Daly, Manuel A Ferreira, Colm O'Dushlaine, Roy Perlis, Soumya Raychaudhuri, Douglas Ruderfer, Phil H Lee, Jordan W Smoller, Sarah E Bergen & Shaun M Purcell
  3. Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    Stephan Ripke, Mark Daly, Manuel A Ferreira, Colm O'Dushlaine, Roy Perlis, Soumya Raychaudhuri, Douglas Ruderfer, Jordan W Smoller, Kim Chambert, Jennifer Moran, Ed Scolnick, Sarah E Bergen & Shaun M Purcell
  4. Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA
    Laura J Scott, Matthew Flickinger, Weihua Guan, Phoenix Kwan, Sebastian Zöllner, Peng Zhang & Michael Boehnke
  5. Institute of Clinical Medicine, European Network of Bipolar Research Expert Centers (ENBREC) Group, University of Oslo, Oslo, Norway
    Ole A Andreassen, Morten Mattingsdal, Srdjan Djurovic & Ingrid Melle
  6. Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
    Ole A Andreassen & Ingrid Melle
  7. Institute of Human Genetics, University of Bonn, Bonn, Germany
    Sven Cichon, Thomas W Mühleisen, Franziska A Degenhardt, Manuel Mattheisen, Johannes Schumacher, Peter Propping & Markus M Nöthen
  8. Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    Sven Cichon, Thomas W Mühleisen, Franziska A Degenhardt & Markus M Nöthen
  9. Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany
    Sven Cichon
  10. Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Henry Wellcome Building, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Nick Craddock, Peter A Holmans, Marian L Hamshere, Katherine Gordon-Smith, Christine Fraser, Elaine K Green, Detelina Grozeva, Ian R Jones, George Kirov, Valentina Moskvina, Ivan Nikolov, Michael C O'Donovan & Michael J Owen
  11. Department of Biochemistry and Molecular Biology, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Howard J Edenberg
  12. Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Howard J Edenberg, John I Nurnberger Jr, Tatiana Foroud & Daniel L Koller
  13. Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA
    John I Nurnberger Jr
  14. Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health Mannheim, University of Heidelberg, Mannheim, Germany
    Marcella Rietschel, Thomas G Schulze, René Breuer, Sandra Meier, Jana Strohmaier & Stephanie H Witt
  15. Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Douglas Blackwood, Kevin McGhee, Andrew McIntosh, Alan W McLean, Walter J Muir & Benjamin S Pickard
  16. Medical Genetics Section, University of Edinburgh Molecular Medicine Centre, Western General Hospital, Edinburgh, UK
    Douglas Blackwood, Kevin McGhee, Andrew McIntosh, Alan W McLean, Walter J Muir & Benjamin S Pickard
  17. Department of Psychiatry and Institute of Molecular Medicine, Neuropsychiatric Genetics Research Group, Trinity College Dublin, Dublin, Ireland
    Aiden Corvin, Michael Gill, Derek Morris & Emma Quinn
  18. Sorlandet Hospital HF, Kristiansand, Norway
    Morten Mattingsdal
  19. Research Department of Mental Health Sciences, Molecular Psychiatry Laboratory, University College London, Rockefeller Building, London, UK
    Andrew McQuillin, Adebayo Anjorin, Nick Bass, Hugh Gurling, Radhika Kandaswamy & Jacob Lawrence
  20. Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
    Thomas F Wienker, Manuel Mattheisen & Michael Steffens
  21. London School of Hygiene and Tropical Medicine, University of London, London, UK
    Frank Dudbridge
  22. Biostatistics and Bioinformatics Unit, Cardiff University School of Medicine, Cardiff, UK
    Peter A Holmans, Marian L Hamshere & Valentina Moskvina
  23. Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, USA
    Danyu Lin
  24. Department of Human Genetics, Department of Psychiatry, Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan, USA
    Margit Burmeister
  25. Department of Psychiatry, University of California San Diego, La Jolla, California, USA
    Tiffany A Greenwood, Caroline M Nievergelt, Rebecca McKinney, Paul D Shilling & John R Kelsoe
  26. Neurosciences Centre of Excellence in Drug Discovery, GlaxoSmithKline Research and Development, Verona, Italy
    Pierandrea Muglia & Federica Tozzi
  27. The Scripps Translational Science Institute and Scripps Health, La Jolla, California, USA
    Erin N Smith & Cinnamon S Bloss
  28. Department of Mental Health, Johns Hopkins University and Hospital, Baltimore, Maryland, USA
    Peter P Zandi, James B Potash & Pamela B Mahon
  29. The Scripps Translational Science Institute and The Scripps Research Institute, La Jolla, California, USA
    Nicholas J Schork
  30. Department of Psychiatry, University of Chicago, Chicago, Illinois, USA
    Elliot S Gershon, Chunyu Liu & Judith A Badner
  31. Rush University Medical Center, Chicago, Illinois, USA
    William A Scheftner
  32. Department of Psychiatry and Behavioral Sciences, Howard University College of Medicine, Washington, DC, USA
    William B Lawson, Evaristus A Nwulia & Maria Hipolito
  33. Department of Psychiatry, University of Iowa, Iowa City, Iowa, USA
    William Coryell
  34. Washington University School of Medicine, St. Louis, Missouri, USA
    John Rice
  35. Department of Psychiatry, University of California San Francisco School of Medicine, San Francisco, California, USA
    William Byerley
  36. National Institute of Mental Health, US National Institutes of Health, Bethesda, Maryland, USA
    Francis J McMahon & Thomas G Schulze
  37. Department of Psychiatry, University Göttingen, Göttingen, Germany
    Thomas G Schulze
  38. Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Wade Berrettini & Falk W Lohoff
  39. Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA
    Melvin G McInnis, Sebastian Zöllner & Peng Zhang
  40. The Translational Genomics Research Institute, Phoenix, Arizona, USA
    David W Craig & Szabocls Szelinger
  41. Portland Veterans Affairs Medical Center, Portland, Oregon, USA
    Thomas B Barrett
  42. Social, Genetic and Developmental Psychiatry (SGDP) Centre, The Institute of Psychiatry, King's College London, De Crespigny Park Denmark Hill, London, UK
    Anne Farmer, Peter McGuffin, Gerome Breen, David A Collier, Amanda Elkin & Richard Williamson
  43. Molecular Neuropsychiatry and Development Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    John Strauss & John B Vincent
  44. Department of Biostatistics, Princess Margaret Hospital, Toronto, Ontario, Canada
    Wei Xu
  45. Psychiatric Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    James L Kennedy
  46. Divisin of Neuroscience, University of Dundee, Ninewells Hospital & Medical School, Dundee, UK
    Keith Matthews, Richard Day, Allan H Young & I Nicol Ferrier
  47. Queensland Institute of Medical Research, Brisbane, Australia
    Manuel A Ferreira, Nick Martin & Grant W Montgomery
  48. Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA
    Jun Li
  49. HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA
    Devin Absher & Richard M Myers
  50. Department of Psychiatry and Human Behavior, University of California, Irvine, California, USA
    William E Bunney
  51. Department of Psychiatry, Weill Medical College, Cornell University, New York, New York, USA
    Jack D Barchas
  52. Psychiatry and Behavioral Science, Stanford University School of Medicine, Palo Alto, California, USA
    Alan F Schatzberg
  53. Department of Psychiatry and Behavioral Sciences, Center for Neuroscience, University of California, Davis, California, USA
    Edward G Jones
  54. Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan, USA
    Fan Meng, Robert C Thompson, Stanley J Watson & Huda Akil
  55. Department of Medical Genetics, Oslo University Hospital, Oslo, Norway
    Srdjan Djurovic
  56. Department of Psychiatry, St. Olavs Hospital, Trondheim, Norway
    Gunnar Morken
  57. Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway
    Gunnar Morken
  58. Department of Psychiatry, University of Bonn, Bonn, Germany
    Wolfgang Maier
  59. University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, UK
    Gerome Breen & David St. Clair
  60. Department of Psychiatry, School of Clinical and Experimental Medicine, Birmingham University, Birmingham, UK
    Sian Caesar, Katherine Gordon-Smith & Lisa Jones
  61. University of British Columbia (UBC) Institute of Mental Health, Vancouver, British Columbia, Canada
    Allan H Young
  62. deCODE genetics, Reykjavík, Iceland
    Kari Stefansson, Hreinn Stefansson, Þorgeir Þorgeirsson, Stacy Steinberg & Ómar Gustafsson
  63. Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Vishwajit Nimgaonkar
  64. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Christina Hultman, Mikael Landén & Paul Lichtenstein
  65. Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
    Mikael Landén & Niklas Langstrom
  66. Department of Genetics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA
    Patrick Sullivan
  67. Department of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    Martin Schalling, Urban Osby & Louise Frisén
  68. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Lena Backlund
  69. INSERM, U955, Psychiatrie Génétique, Créteil, France
    Stéphane Jamain, Marion Leboyer, Bruno Etain & Frank Bellivier
  70. Université Paris Est, Faculté de Médecine, Créteil, France
    Stéphane Jamain, Marion Leboyer, Bruno Etain & Frank Bellivier
  71. Département de Psychiatrie, Assistance Publique–Hôpitaux de Paris (AP-HP), Hôpital H. Mondor–A. Chenevier, Créteil, France
    Stéphane Jamain, Marion Leboyer, Bruno Etain & Frank Bellivier
  72. ENBREC group, Fondation Fondamental, Créteil, France
    Stéphane Jamain, Marion Leboyer, Bruno Etain & Frank Bellivier
  73. Division of Psychiatry, Landspitali University Hospital, University of Iceland, Reykjavik, Iceland
    Hannes Petursson & Engilbert Sigur∂sson
  74. Max Planck Institute of Psychiatry, Munich, Germany
    Bertram Müller-Mysok & Susanne Lucae
  75. Psychiatric Center Nordbaden, Wiesloch, Germany
    Markus Schwarz
  76. Neuroscience Research Australia, Sydney, Australia
    Janice M Fullerton & Peter R Schofield
  77. University of New South Wales, Sydney, Australia
    Janice M Fullerton & Peter R Schofield
  78. Centre National de Génotypage, Evry, France
    Mark Lathrop
  79. Therapeia, Reykjavik, Iceland
    Högni Óskarsson
  80. Department of Psychiatry and Psychotherapy, ENBREC Group, University Hospital Carl Gustav Carus, Dresden, Germany
    Michael Bauer
  81. School of Psychiatry, University of New South Wales and Black Dog Institute, Sydney, New South Wales, Australia
    Adam Wright & Philip B Mitchell
  82. Department of Clinical and Developmental Psychology, Institute of Psychology, University of Tubingen, Tubingen, Germany
    Martin Hautzinger
  83. Department of Psychiatry, University of Würzburg, Würzburg, Germany
    Andreas Reif
  84. Department of Psychiatry, Special Treatment and Evaluation Program (STEP), Veterans Affairs San Diego Healthcare System, San Diego, California, USA
    John R Kelsoe

Consortia

Psychiatric GWAS Consortium Bipolar Disorder Working Group

Contributions

Manuscript preparation: P. Sklar. (chair), O.A.A., S. Cichon, N.C., H.J.E., J.R.K., J.I.N., S.M.P., M.R., S. Ripke, L.J.S. Analysis group: S.M.P. (chair), D.B., A.C., N.C., M.F., W.G., J.R.K., M. Mattingsdal, A. McQuillin, P.K., S. Ripke, L.J.S., P. Sklar, T.F.W. PGC central analysis group: S. Ripke (chair), M.D., F.D., P.A.H., D.L. Management group: J.R.K. (co-chair), P. Sklar. (co-chair), O.A.A., D.B., M. Burmeister, S. Cichon, N.C., T.A.G., M.L.H., S.M.P., P. Muglia, J.I.N., L.J.S., E.N.S., P.P.Z.

Primary study data was contributed from the following investigators: BiGS (Bipolar Genome Study) –University of California San Diego: J.R.K., T.A.G., C.M.N., R.M., P.D.S.; Scripps Translational Science Institute: N.J.S., E.N.S., C.S.B.; Indiana University: J.I.N., H.J.E., T.F., D.L.K.; University of Chicago: E.S.G., C.L., J.A.B.; Rush University Medical Center: W.A.S.; Howard University: W.B.L., E.A.N., M. Hipolito; University of Iowa: W.C.; Washington University: J.R.; University of California San Francisco: W. Byerley; National Institute of Mental Health: F.J.M., T.G.S.; University of Pennsylvania: W. Berrettini, F.W.L.; Johns Hopkins Hospital: J.B.P., P.P.Z., P.B. Mahon; University of Michigan: M.G.M., S.Z., P.Z.; The Translational Genomics Research Institute: D.W.C., S. Szelinger; Portland Veterans Affairs Medical Center: T.B.B.; Central Institute of Mental Health, Mannheim: R.B., S.M., M.R., T.G.S., J. Strohmaier, S.H.W.; GlaxoSmithKline, Institute of Psychiatry, Centre for Addiction & Mental Health, University of Dundee: F.T., P. Muglia, A.F., P. McGuffin, J. Strauss, W.X., J.L.K., J.B.V., K. Matthews, R.D.; Massachusetts General Hospital: M.A.F., C.O.'D., R.P., S.M.P., S. Raychaudhuri, P.L.H., D.R., P. Sklar, J.W.S.; NIMH/Pritzker: L.J.S., M.F., M. Burmeister, J. Li, W.G., P.K., D.A., R.C.T., F.G.M., A.F.S., W.E.B., J.D.B., E.G.J., S.J.W., R.M.M., H.A., M. Boehnke; Stanley Center Broad Institute: K.C., J.M., E. Scolnick; TOP Study Group: O.A.A., S.D., M. Mattingsdal, I.M., G.M.; Trinity College Dublin: A.C., M.G., D.M., E.Q.; University of Bonn: S. Cichon, T.W.M., F.A.D., M. Mattheisen, J. Schumacher, W.M., M. Steffens, T.F.W., P.P., M.M.N.; University College London: A.A., N.B., H.G., R.K., J. Lawrence, A. McQuillin; University of Edinburgh: D.B., K. McGhee, A. McIntosh, A.W.M., W.J.M., B.S.P.; Wellcome Trust Case Control Consortium Bipolar Disorder Group—Aberdeen: G.B., D.St.C.; Birmingham: S. Caesar, K.G.-S., L.J.; Cardiff: C.F., E.K.G., D.G., M.L.H., P.A.H., I.R.J., G.K., V.M., I.N., M.C.O., M.J.O., N.C.; London: D.A.C., A.E., A.F., R.W., P. McGuffin; Newcastle: A.H.Y., I.N.F. Replication data contributed by the following investigators: Central Institute of Mental Health, Mannheim: R.B., S.M., M.R., T.G.S., J. Strohmaier, S.H.W.; deCODE genetics: H.S., Þ.Þ., S. Steinberg, Ó.G., K.S.; FaST: S.E.B., K.C., J.M., V.N., S.M.P., P. Sklar, J.W.S.; ICCBD: C.H., M. Landén, P.L., P. Sullivan, M. Schalling, U.O., L.B., L.F., S.E.B., S.M.P., K.C., J.M., N.L., P. Sklar; INSERM U955: S.J., M. Leboyer, B.E., F.B.; Landspitali University: H.P., E. Sigurđsson; Max Planck Institute of Psychiatry, Munich: B.M.-M., S.L.; Psychiatric Center Nordbaden: M. Schwarz; Neuroscience Research Australia and University of New South Wales: P.R.S. and J.M.F.; Queensland Institute of Medical Research: N.M., G.W.M.; Centre National de Génotypage: M. Lathrop; Therapeia University Hospital, Reykjavík: H.Ó.; University of Bonn: S. Cichon, T.W.M., F.A.D., M. Mattheisen, J. Schumacher, W.M., M. Steffens, T.F.W., P.P., M.M.N.; University of Dresden: M. Bauer; University of New South Wales and Black Dog Institute: A.W., P.B. Mitchell; University of Tübingen: M. Hautzinger; University of Würzburg: A.R.

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Correspondence toPamela Sklar.

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Psychiatric GWAS Consortium Bipolar Disorder Working Group. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.Nat Genet 43, 977–983 (2011). https://doi.org/10.1038/ng.943

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