Commensal gut flora and brain autoimmunity: a love or hate affair? (original) (raw)
Abdollahi-Roodsaz S, Joosten LAB, Koenders MI et al (2008) Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis. J Clin Invest 118:205–216 ArticlePubMedCAS Google Scholar
Abreu MT, Fukata M, Arditi M (2005) TLR signaling in the gut in health and disease. J Immunol 174:4453–4460 PubMedCAS Google Scholar
Alam C, Bittoun E, Bhagwat D et al (2011) Effects of a germ-free environment on gut immune regulation and diabetes progression in non-obese diabetic (NOD) mice. Diabetologia 54:1398–1406 ArticlePubMedCAS Google Scholar
Atarashi K, Nishimura J, Shima T et al (2008) ATP drives lamina propria TH17 cell differentiation. Nature 455:808–812 ArticlePubMedCAS Google Scholar
Atarashi K, Tanoue T, Shima T et al (2011) Induction of colonic regulatory T cells by indigenous clostridium species. Science 331:337–341 ArticlePubMedCAS Google Scholar
Ayabe T, Satchell DP, Wilson CL, Parks WC, Selsted ME, Ouellette AJ (2000) Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria. Nat Immunol 1:113–118 ArticlePubMedCAS Google Scholar
Bäckhed F, Ley RE, Sonnenburg JL, Peterson DA, Gordon JI (2005) Host-bacterial mutualism in the human intestine. Science 307:1915–1920 ArticlePubMedCAS Google Scholar
Bain CC, Mowat AM (2011) Intestinal macrophages—specialised adaptation to a unique environment. Eur J Immunol 41:2494–2498 ArticlePubMedCAS Google Scholar
Baken KA, Ezendam J, Gremmer ER et al (2006) Evaluation of immunomodulation by Lactobacillus casei Shirota: immune function, autoimmunity and gene expression. Int J Food Microbiol 112:8–18 ArticlePubMedCAS Google Scholar
Bauer H, Horowitz RE, Popper H, Levenson SM (1963) Response of lymphatic tissue to microbial flora—studies on germfree mice. Am J Pathol 42:471–483 PubMedCAS Google Scholar
Benson A, Pifer R, Behrendt CL, Hooper LV, Yarovinsky F (2009) Gut commensal bacteria direct a protective immune response against Toxoplasma gondii. Cell Host Microbe 6:187–196 ArticlePubMedCAS Google Scholar
Benson AK, Kelly SA, Legge R et al (2010) Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors. Proc Natl Acad Sci USA 107:18933–18938 ArticlePubMedCAS Google Scholar
Berer K, Mues M, Koutroulos M et al (2011) Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature 479:538–541 ArticlePubMedCAS Google Scholar
Bergstrom KSB, Kissoon-Singh V, Gibson DL et al (2010) Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa. PLoS Pathogens 6:e1000902 ArticlePubMedCAS Google Scholar
Bettelli E, Carrier Y, Gao W et al (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441:235–238 ArticlePubMedCAS Google Scholar
Brandl K, Plitas G, Mihu CN et al (2008) Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits. Nature 455:804–807 ArticlePubMedCAS Google Scholar
Breban MA, Moreau MC, Fournier C, Ducluzeau R, Kahn MF (1993) Influence of the bacterial-flora on collagen-induced arthritis in susceptible and resistant strains of rats. Clin Exp Rheumatol 11:61–64 PubMedCAS Google Scholar
Burcelin R, Serino M, Chabo C, Blasco-Baque V, Amar J (2011) Gut microbiota and diabetes: from pathogenesis to therapeutic perspective. Acta Diabetol 48:257–273 ArticlePubMed Google Scholar
Bush WS, Sawcer SJ, De Jager PL et al (2010) Evidence for polygenic susceptibility to multiple sclerosis—the shape of things to come. Am J Hum Genet 86:621–625 ArticlePubMedCAS Google Scholar
Calcinaro F, Dionisi S, Marinaro M et al (2005) Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoimmune diabetes in the non-obese diabetic mouse. Diabetologia 48:1565–1575 ArticlePubMedCAS Google Scholar
Cash HL, Whitham CV, Behrendt CL, Hooper LV (2006) Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science 313:1126–1130 ArticlePubMedCAS Google Scholar
Cerutti A, Rescigno M (2008) The biology of intestinal immunoglobulin A responses. Immunity 28:740–750 ArticlePubMedCAS Google Scholar
Chieppa M, Rescigno M, Huang AYC, Germain RN (2006) Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement. J Exp Med 203:2841–2852 ArticlePubMedCAS Google Scholar
Clarke TB, Davis KM, Lysenko ES, Zhou AY, Yu YM, Weiser JN (2010) Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity. Nat Med 16:228–231 ArticlePubMedCAS Google Scholar
Coombes JL, Siddiqui KRR, Aranciba-Cárcamo CV et al (2007) A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β- and retinoic acid-dependent mechanism. J Exp Med 204:1757–1764 ArticlePubMedCAS Google Scholar
Cyster JG (2010) B cell follicles and antigen encounters of the third kind. Nat Immunol 11:989–996 ArticlePubMedCAS Google Scholar
De Filippo C, Cavalieri D, Di Paola M et al (2010) Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci USA 107:14691–14696 ArticlePubMed Google Scholar
De Vos AF, Van Meurs M, Brok HP et al (2002) Transfer of central nervous system autoantigens and presentation in secondary lymphoid organs. J Immunol 169:5415–5423 PubMed Google Scholar
Dicksved J, Halfvarson J, Rosenquist M et al (2008) Molecular analysis of the gut microbiota of identical twins with Crohn’s disease. ISME J 2:716–727 ArticlePubMedCAS Google Scholar
Duan JY, Chung H, Troy E, Kasper DL (2010) Microbial colonization drives expansion of IL-1 receptor 1-expressing and IL-17-producing γ/δ T cells. Cell Host Microbe 7:140–150 ArticlePubMedCAS Google Scholar
Eckburg PB, Bik EM, Bernstein CN et al (2005) Diversity of the human intestinal microbial flora. Science 308:1635–1638 ArticlePubMed Google Scholar
Ezendam J, de KA, Gremmer ER, van Loveren H (2008) Effects of Bifidobacterium animalis administered during lactation on allergic and autoimmune responses in rodents. Clin Exp Immunol 154:424–431 ArticlePubMedCAS Google Scholar
Ezendam J, van Loveren H (2008) Lactobacillus casei Shirota administered during lactation increases the duration of autoimmunity in rats and enhances lung inflammation in mice. Br J Nutr 99:83–90 ArticlePubMedCAS Google Scholar
Fagarasan S, Honjo T (2003) Intestinal IgA synthesis: regulation of front-line body defences. Nat Rev Immunol 3:63–72 ArticlePubMedCAS Google Scholar
Falk PG, Hooper LV, Midtvedt T, Gordon JI (1998) Creating and maintaining the gastrointestinal ecosystem: what we know and need to know from gnotobiology. Microbiol Mol Biol Rev 62:1157–1170 PubMedCAS Google Scholar
Fontenot JD, Rasmussen JP, Williams LM, Dooley JL, Farr AG, Rudensky AY (2005) Regulatory T cell lineage specification by the Forkhead transcription factor Foxp3. Immunity 22:329–341 ArticlePubMedCAS Google Scholar
Gaboriau-Routhiau V, Rakotobe S, Lévuyer E et al (2009) The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity 31:677–689 ArticlePubMedCAS Google Scholar
Goverman J, Woods A, Larson L, Weiner LP, Hood L, Zaller DM (1993) Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell 72:551–560 ArticlePubMedCAS Google Scholar
Gray DHD, Gavanescu I, Benoist C, Mathis D (2007) Danger-free autoimmune disease in Aire-deficient mice. Proc Natl Acad Sci USA 104:18193–18198 ArticlePubMedCAS Google Scholar
Hall JA, Bouladoux N, Sun CM et al (2008) Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses. Immunity 29:637–649 ArticlePubMedCAS Google Scholar
Hase K, Takahashi D, Ebisawa M, Kawano S, Itoh K, Ohno H (2009) Activation-induced cytidine deaminase deficiency causes organ-specific autoimmune disease. Plos One 3:e3033 ArticleCAS Google Scholar
Hehemann JH, Correc G, Barbeyron T, Helbert W, Czjzek M, Michel G (2010) Transfer of carbohydrate-active enzymes from marine bacteria to Japanese gut microbiota. Nature 464:908–912 ArticlePubMedCAS Google Scholar
Hill DA, Artis D (2010) Intestinal bacteria and the regulation of immune cell homeostasis. Annu Rev Immunol 28:623–667 ArticlePubMedCAS Google Scholar
Hill JA, Hall JA, Sun CM et al (2008) Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi cells. Immunity 29:758–770 ArticlePubMedCAS Google Scholar
Ivanov II, Atarashi K, Manel N et al (2009) Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139:485–498 ArticlePubMedCAS Google Scholar
Ivanov II, De Llanos Frutos R, Manel N et al (2008) Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe 4:337–349 ArticlePubMedCAS Google Scholar
Iwata M, Hirakiyama A, Eshima Y, Kageshima H, Kato C, Song S-Y (2004) Retinoic acid imprints gut-homing specificity on T cells. Immunity 21:527–538 ArticlePubMedCAS Google Scholar
Jia W, Li HK, Zhao LP, Nicholson JK (2008) Gut microbiota: a potential new territory for drug targeting. Nat Rev Drug Discov 7:123–129 ArticlePubMedCAS Google Scholar
Johansson ME, Hansson GC (2008) Mucus protects the colon by separating bacteria from the epithelium. Gastroenterology 134:A516 Article Google Scholar
Johansson ME, Phillipson M, Petersson J, Velcich A, Holm L, Hansson GC (2008) The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc Natl Acad Sci USA 105:15064–15069 ArticlePubMedCAS Google Scholar
Johansson-Lindbom B, Svensson M, Pabst O et al (2005) Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing. J Exp Med 202:1063–1073 ArticlePubMedCAS Google Scholar
King C, Sarvetnick N (2011) The incidence of type-1 diabetes in NOD mice is modulated by restricted flora not germ-free conditions. Plos One 6:e17049 ArticlePubMedCAS Google Scholar
Kira J-I, Yamasaki K, Horiuchi I, Ohyagi Y, Taniwaki T, Kawano Y (1999) Changes in the clinical phenotypes of multiple sclerosis during the past 50 years in Japan. J Neurol Sci 166:53–57 ArticlePubMedCAS Google Scholar
Kohashi O, Kuwata J, Umehara K, Uemura F, Takahashi T, Ozawa A (1979) Susceptibility to adjuvant-induced arthritis among germfree, specific-pathogen-free, and conventional rats. Infect Immun 26:791–794 PubMedCAS Google Scholar
Krishnamoorthy G, Holz A, Wekerle H (2007) Experimental models of spontaneous autoimmune disease in the central nervous system. J Mol Med 85:1161–1173 ArticlePubMedCAS Google Scholar
Krishnamoorthy G, Lassmann H, Wekerle H, Holz A (2006) Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell/B cell cooperation. J Clin Invest 116:2385–2392 ArticlePubMedCAS Google Scholar
Kuwahara T, Ogura Y, Oshima K et al (2011) The lifestyle of the segmented filamentous bacterium: a non-culturable gut-associated immunostimulating microbe inferred by whole-genome sequencing. DNA Res 18:291–303 ArticlePubMedCAS Google Scholar
Lampropoulou V, Hoehlig K, Roch T et al (2008) TLR-activated B cells suppress T cell-mediated autoimmunity. J Immunol 180:4763–4773 PubMedCAS Google Scholar
Lavasani S, Dzhambazov B, Nouri M et al (2010) A novel probiotic mixture exerts a therapeutic effect on experimental autoimmune encephalomyelitis mediated by IL-10 producing regulatory T cells. Plos One 5:e9009 ArticlePubMedCAS Google Scholar
Lee YK, Menezes JS, Umesaki Y, Mazmanian SK (2011) Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA 108:4615–4622 ArticlePubMedCAS Google Scholar
Ley RE, Peterson DA, Gordon JI (2006) Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell 124:837–848 ArticlePubMedCAS Google Scholar
Linden SK, Sutton P, Karlsson NG, Korolik V, McGuckin MA (2008) Mucins in the mucosal barrier to infection. Mucosal Immunol 1:183–197 ArticlePubMedCAS Google Scholar
MacPherson AJ, Harris NL (2004) Interactions between commensal intestinal bacteria and the immune system. Nat Rev Immunol 4:478–485 ArticlePubMedCAS Google Scholar
Maldonado MA, Kakkanaiah V, MacDonald GC et al (1999) The role of environmental antigens in the spontaneous development of autoimmunity in MRL-lpr mice. J Immunol 162:6322–6330 PubMedCAS Google Scholar
Manicassamy S, Reizis B, Ravindran R et al (2010) Activation of β-catenin in dendritic cells regulates immunity versus tolerance in the intestine. Science 329:849–853 ArticlePubMedCAS Google Scholar
Maslowski KM, Vieira AT, Ng AW et al (2009) Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 461:1282–1286 ArticlePubMedCAS Google Scholar
Matsushita T, Yanaba K, Bouaziz J-D, Fujimoto M, Tedder TF (2008) Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. J Clin Invest 118:3420–3430 PubMedCAS Google Scholar
Matsuzaki T, Nagata Y, Kado S et al (1997) Prevention of onset in an insulin-dependent diabetes mellitus model, NOD mice, by oral feeding of Lactobacillus casei. APMIS 105:643–649 ArticlePubMedCAS Google Scholar
Matteoli G, Mazzini E, Iliev ID et al (2010) Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction. Gut 59:595–604 ArticlePubMedCAS Google Scholar
Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL (2005) An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 122:107–118 ArticlePubMedCAS Google Scholar
Mazmanian SK, Round JL, Kasper DL (2008) A microbial symbiosis factor prevents intestinal inflammatory disease. Nature 453:620–625 ArticlePubMedCAS Google Scholar
Mezrich JD, Fechner JH, Zhang XJ, Johnson BP, Burlingham WJ, Bradfield CA (2010) An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory t cells. J Immunol 185:3190–3198 ArticlePubMedCAS Google Scholar
Mizutani A, Shaheen VM, Yoshida H et al (2005) Pristane-induced autoimmunity in germ-free mice. Clin Immunol 114:110–118 ArticlePubMedCAS Google Scholar
Mowat AM (2003) Anatomical basis of tolerance and immunity to intestinal antigens. Nat Rev Immunol 3:331–341 ArticlePubMedCAS Google Scholar
Nell S, Suerbaum S, Josenhans C (2010) The impact of the microbiota on the pathogenesis of IBD: lessons from mouse infection models. Nat Rev Microbiol 8:564–577 ArticlePubMedCAS Google Scholar
Niess JH, Leithauser F, Adler G, Reimann J (2008) Commensal gut flora drives the expansion of proinflammatory CD4 T cells in the colonic lamina propria under normal and inflammatory conditions. J Immunol 180:559–568 PubMedCAS Google Scholar
Nieuwenhuis EES, Matsumoto T, Lindenbergh D et al (2009) Cd1d-dependent regulation of bacterial colonization in the intestine of mice. J Clin Invest 119:1241–1250 ArticlePubMedCAS Google Scholar
O’Mahony C, Scully P, O’Mahony D et al (2008) Commensal-induced regulatory T cells mediate protection against pathogen-stimulated NF-κB activation. PLoS Pathogens 4:e1000112 ArticlePubMedCAS Google Scholar
Ochoa-Repáraz J, Mielcarz DW, Ditrio LE et al (2010) Central nervous system demyelinating disease protection by the human commensal Bacteroides fragilis depends on polysaccharide A expression. J Immunol 185:4101–4108 ArticlePubMedCAS Google Scholar
Ochoa-Repáraz J, Mielcarz DW, Ditrio LE et al (2009) Role of gut commensal microflora in the development of experimental autoimmune encephalomyelitis. J Immunol 183:6041–6050 ArticlePubMedCAS Google Scholar
Ochoa-Repáraz J, Mielcarz DW, Haque-Begum S, Kasper LH (2010) Induction of a regulatory B cell population in experimental allergic encephalomyelitis by alteration of the gut commensal microflora. Gut Microbes 1:103–108 ArticlePubMed Google Scholar
Ochoa-Repáraz J, Mielcarz DW, Wang Y et al (2010) A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease. Mucosal Immunol 3:487–495 ArticlePubMedCAS Google Scholar
Perdew GH, Babbs CF (1991) Production of Ah receptor ligands in rat fecal suspensions containing tryptophan or indole-3-carbinol. Nutr Cancer 16:209–218 ArticlePubMedCAS Google Scholar
Peterson DA, Frank DN, Pace NR, Gordon JI (2008) Metagenomic approaches for defining the pathogenesis of inflammatory bowel diseases. Cell Host Microbe 3:417–427 ArticlePubMedCAS Google Scholar
Petnicki-Ocwieja T, Hrncir T, Liu YJ et al (2009) Nod2 is required for the regulation of commensal microbiota in the intestine. Proc Natl Acad Sci USA 106:15813–15818 ArticlePubMedCAS Google Scholar
Pöllinger B, Krishnamoorthy G, Berer K et al (2009) Spontaneous relapsing–remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells. J Exp Med 206:1303–1316 ArticlePubMedCAS Google Scholar
Pomare EW, Branch WJ, Cummings JH (1985) Carbohydrate fermentation in the human-colon and its relation to acetate concentrations in venous-blood. J Clin Invest 75:1448–1454 ArticlePubMedCAS Google Scholar
Pozzilli P, Signore A, Williams AJK, Beales PE (1993) NOD mouse colonies around the world—recent facts and figures. Immunol Today 14:193–196 ArticlePubMedCAS Google Scholar
Prakash T, Oshima K, Morita H et al (2011) Complete genome sequences of rat and mouse segmented filamentous bacteria, a potent inducer of Th17 cell differentiation. Cell Host Microbe 10:273–284 ArticlePubMedCAS Google Scholar
Quintana FJ, Basso AS, Iglesias AH et al (2008) Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor. Nature 453:65–71 ArticlePubMedCAS Google Scholar
Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R (2004) Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis. Cell 118:229–241 ArticlePubMedCAS Google Scholar
Rehakova Z, Capkova J, Stepankova R et al (2000) Germ-free mice do not develop ankylosing enthesopathy, a spontaneous joint disease. Hum Immunol 61:555–558 ArticlePubMedCAS Google Scholar
Rescigno M, Urbano M, Valzasina B et al (2001) Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol 2:361–367 ArticlePubMedCAS Google Scholar
Rossini AA, Williams RM, Mordes JP, Appel MC, Like AA (1979) Spontaneous diabetes in the gnotobiotic BB-W rat. Diabetes 28:1031–1032 ArticlePubMedCAS Google Scholar
Round JL, Mazmanian SK (2009) The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol 9:313–323 ArticlePubMedCAS Google Scholar
Round JL, Mazmanian SK (2010) Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc Natl Acad Sci USA 107:12204–12209 ArticlePubMedCAS Google Scholar
Saleh M, Elson CO (2011) Experimental inflammatory bowel disease: insights into the host-microbiota dialog. Immunity 34:293–302 ArticlePubMedCAS Google Scholar
Salvetti M, Ristori G, Bomprezzi R, Pozzilli P, Leslie RDG (2000) Twins: mirrors of the immune system. Immunol Today 21:342–347 ArticlePubMedCAS Google Scholar
Salzman NH, Hung KC, Haribhai D et al (2010) Enteric defensins are essential regulators of intestinal microbial ecology. Nat Immunol 11:76–82 ArticlePubMedCAS Google Scholar
Sawcer S, Hellenthal G, Pirinen M et al (2011) Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 476:214–219 ArticlePubMedCAS Google Scholar
Scher JU, Abramson SB (2011) The microbiome and rheumatoid arthritis. Nat Rev Rheumatol 7:569–578 PubMedCAS Google Scholar
Schulz O, Jaensson E, Persson EK et al (2009) Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions. J Exp Med 206:3101–3114 ArticlePubMedCAS Google Scholar
Sczesnak A, Segata N, Qin X et al (2011) The genome of Th17 cell-inducing segmented filamentous bacteria reveals extensive auxotrophy and adaptations to the intestinal environment. Cell Host Microbe 10:260–272 ArticlePubMedCAS Google Scholar
Sinkorova Z, Capkova J, Niederlova J, Stepankova R, Sinkora J (2008) Commensal intestinal bacterial strains trigger ankylosing enthesopathy of the ankle in inbred B10.BR (H-2k) male mice. Hum Immunol 69:845–850 ArticlePubMedCAS Google Scholar
Slack E, Hapfelmeier S, Stecher B et al (2009) Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism. Science 325:617–620 ArticlePubMedCAS Google Scholar
Smith KD, McCoy KD, MacPherson AJ (2007) Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota. Semin Immunol 19:59–69 ArticlePubMedCAS Google Scholar
Sokol H, Pigneur B, Watterlot L et al (2008) Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci USA 105:16731–16736 ArticlePubMedCAS Google Scholar
Spor A, Koren O, Ley R (2011) Unravelling the effects of the environment and host genotype on the gut microbiome. Nat Rev Microbiol 9:279–290 ArticlePubMedCAS Google Scholar
Stecher B, Chaffron S, Kappeli R et al (2010) Like will to like: abundances of closely related species can predict susceptibility to intestinal colonization by pathogenic and commensal bacteria. PLoS Pathogens 6:e1000711 ArticlePubMedCAS Google Scholar
Suzuki K, Meek B, Doi Y et al (2004) Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut. Proc Natl Acad Sci USA 101:1981–1986 ArticlePubMedCAS Google Scholar
Takata K, Kinoshita M, Okuno T et al (2011) The lactic acid bacterium Pediococcus acidilactici Suppresses autoimmune encephalomyelitis by inducing IL-10-producing regulatory T cells. PLoS ONE 6:e27644 ArticlePubMedCAS Google Scholar
Talham GL, Jiang HQ, Bos NA, Cebra JJ (1999) Segmented filamentous bacteria are potent stimuli of a physiologically normal state of the murine gut mucosal immune system. Infect Immun 67:1992–2000 PubMedCAS Google Scholar
Taurog JD, Richardson JA, Croft JT et al (1994) The germ-free state prevents development of gut and joint jnflammatory disease in HLA-B27 transgenic rats. J Exp Med 180:2359–2364 ArticlePubMedCAS Google Scholar
Turnbaugh PJ, Hamady M, Yatsunenko T et al (2009) A core gut microbiome in obese and lean twins. Nature 457:480–484 ArticlePubMedCAS Google Scholar
Ubeda C, Taur Y, Jenq RR et al (2010) Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans. J Clin Invest 120:4332–4341 ArticlePubMedCAS Google Scholar
Umesaki Y, Okada Y, Matsumoto S, Imaoka A, Setoyama H (1995) Segmented filamentous bacteria are indigenous intestinal bacteria that activate intraepithelial lymphocytes and induce MHC class-II molecules and fucosyl asialo Gm1 glycolipids on the small-intestinal epithelial-cells in the ex-germ-free mouse. Microbiol Immunol 39:555–562 PubMedCAS Google Scholar
Vaahtovuo J, Munukka E, Korkeamaki M, Luukkainen R, Toivanen P (2008) Fecal microbiota in early rheumatoid arthritis. J Rheumatol 35:1500–1505 PubMedCAS Google Scholar
Vaishnava S, Behrendt CL, Ismail AS, Eckmann L, Hooper LV (2008) Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host–microbial interface. Proc Natl Acad Sci USA 105:20858–20863 ArticlePubMedCAS Google Scholar
Vaishnava S, Yamamoto M, Severson KM et al (2011) The antibacterial lectin RegIIIγ promotes the spatial segregation of microbiota and host in the intestine. Science 334:255–258 ArticlePubMedCAS Google Scholar
Van den Broek MF, van Bruggen MC, Koopman JP, Hazenberg MP, Van den Berg WB (1992) Gut flora induces and maintains resistance against streptococcal cell wall-induced arthritis in F344 rats. Clin Exp Immunol 88:313–317 ArticlePubMed Google Scholar
Van der Sluis M, De Koning BAE, De Bruijn ACJM et al (2006) Muc2-deficient mice spontaneously develop colitis, indicating that Muc2 is critical for colonic protection. Gastroenterology 131:117–129 ArticlePubMedCAS Google Scholar
Van Zwam M, Huizinga R, Heijmans N et al (2009) Surgical excision of CNS-draining lymph nodes reduces relapse severity in chronic-relapsing experimental autoimmune encephalomyelitis. J Pathol 217:543–551 ArticlePubMed Google Scholar
Veldhoen M, Hirota K, Westendorf AM et al (2008) The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins. Nature 453:106–109 ArticlePubMedCAS Google Scholar
Vijay-Kumar M, Aitken JD, Carvalho FA et al (2010) Metabolic syndrome and altered gut microbiota in mice lacking toll-like receptor 5. Science 328:228–231 ArticlePubMedCAS Google Scholar
Wen L, Ley RE, Volchkov PY et al (2008) Innate immunity and intestinal microbiota in the development of type 1 diabetes. Nature 455:1109–1113 ArticlePubMedCAS Google Scholar
Wikoff WR, Anfora AT, Liu J et al (2009) Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci USA 106:3698–3703 ArticlePubMedCAS Google Scholar
Willer CJ, Dyment DA, Risch NJ, Sadovnick AD, Ebers GC (2003) Twin concordance and sibling recurrence rates in multiple sclerosis. Proc Natl Acad Sci USA 100:12877–12882 ArticlePubMedCAS Google Scholar
Wolk K, Witte E, Wallace E et al (2006) IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur J Immunol 36:1309–1323 ArticlePubMedCAS Google Scholar
Wong JM, de SR, Kendall CW, Emam A, Jenkins DJ (2006) Colonic health: fermentation and short chain fatty acids. J Clin Gastroenterol 40:235–243 ArticlePubMedCAS Google Scholar
Wu GD, Chen J, Hoffmann C et al (2011) Linking long-term dietary patterns with gut microbial enterotypes. Science 334:105–108 ArticlePubMedCAS Google Scholar
Wu H-J, Ivanov II, Darce D et al (2010) Gut residing filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 32:815–823 ArticlePubMedCAS Google Scholar
Yokote H, Miyake S, Croxford JL, Oki S, Mizusawa H, Yamamura T (2008) NKT cell-dependent amelioration of a mouse model of multiple sclerosis by altering gut flora. Am J Pathol 173:1714–1723 ArticlePubMedCAS Google Scholar