Bell JT, Tsai PC, Yang TP, Pidsley R, Nisbet J, Glass D, Mangino M, Zhai G, Zhang F, Valdes A, Shin SY, Dempster EL, Murray RM, Grundberg E, Hedman AK, Nica A, Small KS, The MuTHER Consortium, Dermitzakis ET, McCarthy MI, Mill J, Spector TD, Deloukas P (2012) Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population. PLoS Genet 8:e1002629. https://doi.org/10.1371/journal.pgen.1002629 ArticlePubMedPubMed CentralCAS Google Scholar
Bollati V, Schwartz J, Wright R, Litonjua A, Tarantini L, Suh H, Sparrow D, Vokonas P, Baccarelli A (2009) Decline in genomic DNA methylation through aging in a cohort of elderly subjects. Mech Ageing Dev 130:234–239. https://doi.org/10.1016/j.mad.2008.12.003 ArticlePubMedCAS Google Scholar
Borghol N, Suderman M, McArdle W, Racine A, Hallett M, Pembrey M, Hertzman C, Power C, Szyf M (2012) Associations with early-life socio-economic position in adult DNA methylation. Int J Epidemiol 41:62–74. https://doi.org/10.1093/ije/dyr147 ArticlePubMed Google Scholar
Chen YA, Lemire M, Choufani S, Butcher DT, Grafodatskaya D, Zanke BW, Gallinger S, Hudson TJ, Weksberg R (2013) Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray. Epigenetics 8:203–209. https://doi.org/10.4161/epi.23470 ArticlePubMedPubMed CentralCAS Google Scholar
Christensen BC, Houseman EA, Marsit CJ, Zheng S, Wrensch MR, Wiemels JL, Nelson HH, Karagas MR, Padbury JF, Bueno R, Sugarbaker DJ, Yeh RF, Wiencke JK, Kelsey KT (2009) Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genet 5:e1000602. https://doi.org/10.1371/journal.pgen.1000602 ArticlePubMedPubMed CentralCAS Google Scholar
Dallosso AR, Hancock AL, Szemes M, Moorwood K, Chilukamarri L, Tsai HH, Sarkar A, Barasch J, Vuononvirta R, Jones C, Pritchard-Jones K, Royer-Pokora B, Lee SB, Owen C, Malik S, Feng Y, Frank M, Ward A, Brown KW, Malik K (2009) Frequent long-range epigenetic silencing of protocadherin gene clusters on chromosome 5q31 in Wilms’ tumor. PLoS Genet 5:e1000745. https://doi.org/10.1371/journal.pgen.1000745 ArticlePubMedPubMed CentralCAS Google Scholar
Ernst J, Kheradpour P, Mikkelsen TS, Shoresh N, Ward LD, Epstein CB, Zhang X, Wang L, Issner R, Coyne M, Ku M, Durham T, Kellis M, Bernstein BE (2011) Mapping and analysis of chromatin state dynamics in nine human cell types. Nature 473:43–49. https://doi.org/10.1038/nature09906 ArticlePubMedPubMed CentralCAS Google Scholar
Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML, Heine-Suner D, Cigudosa JC, Urioste M, Benitez J, Boix-Chornet M, Sanchez-Aguilera A, Ling C, Carlsson E, Poulsen P, Vaag A, Stephan Z, Spector TD, Wu YZ, Plass C, Esteller M (2005) Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A 102:10604–10609. https://doi.org/10.1073/pnas.0500398102 ArticlePubMedPubMed CentralCAS Google Scholar
Gentilini D, Mari D, Castaldi D, Remondini D, Ogliari G, Ostan R, Bucci L, Sirchia SM, Tabano S, Cavagnini F, Monti D, Franceschi C, di Blasio AM, Vitale G (2013) Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians’ offspring. Age (Dordr) 35:1961–1973. https://doi.org/10.1007/s11357-012-9463-1 ArticleCAS Google Scholar
Halder R, Hennion M, Vidal RO, Shomroni O, Rahman RU, Rajput A, Centeno TP, van Bebber F, Capece V, Vizcaino JCG, Schuetz AL, Burkhardt S, Benito E, Sala MN, Javan SB, Haass C, Schmid B, Fischer A, Bonn S (2016) DNA methylation changes in plasticity genes accompany the formation and maintenance of memory. Nat Neurosci 19:102–110. https://doi.org/10.1038/nn.4194 ArticlePubMedCAS Google Scholar
Hannum G, Guinney J, Zhao L, Zhang L, Hughes G, Sadda SV, Klotzle B, Bibikova M, Fan JB, Gao Y, Deconde R, Chen M, Rajapakse I, Friend S, Ideker T, Zhang K (2013) Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol Cell 49:359–367. https://doi.org/10.1016/j.molcel.2012.10.016 ArticlePubMedCAS Google Scholar
Herskind AM, McGue M, Holm NV, Sorensen TI, Harvald B, Vaupel JW (1996) The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870-1900. Hum Genet 97:319–323 ArticleCASPubMed Google Scholar
Heyn H, Li N, Ferreira HJ, Moran S, Pisano DG, Gomez A, Diez J, Sanchez-Mut JV, Setien F, Carmona FJ, Puca AA, Sayols S, Pujana MA, Serra-Musach J, Iglesias-Platas I, Formiga F, Fernandez AF, Fraga MF, Heath SC, Valencia A, Gut IG, Wang J, Esteller M (2012) Distinct DNA methylomes of newborns and centenarians. Proc Natl Acad Sci U S A 109:10522–10527. https://doi.org/10.1073/pnas.1120658109 ArticlePubMedPubMed Central Google Scholar
Kaminsky ZA, Tang T, Wang SC, Ptak C, Oh GHT, Wong AHC, Feldcamp LA, Virtanen C, Halfvarson J, Tysk C, McRae AF, Visscher PM, Montgomery GW, Gottesman II, Martin NG, Petronis A (2009) DNA methylation profiles in monozygotic and dizygotic twins. Nat Genet 41:240–245. https://doi.org/10.1038/ng.286 ArticlePubMedCAS Google Scholar
Kawaguchi M, Toyama T, Kaneko R, Hirayama T, Kawamura Y, Yagi T (2008) Relationship between DNA methylation states and transcription of individual isoforms encoded by the protocadherin-alpha gene cluster. J Biol Chem 283:12064–12075. https://doi.org/10.1074/jbc.M709648200 ArticlePubMedCAS Google Scholar
Kerber RA, O’Brien E, Smith KR, Cawthon RM (2001) Familial excess longevity in Utah genealogies. J Gerontol A Biol Sci Med Sci 56:B130–B139 ArticleCASPubMed Google Scholar
Kim S, Welsh DA, Myers L, Cherry KE, Wyckoff J, Jazwinski SM (2015) Non-coding genomic regions possessing enhancer and silencer potential are associated with healthy aging and exceptional survival. Oncotarget 6:3600–3612 PubMedPubMed Central Google Scholar
Levine ME et al. (2018) An epigenetic biomarker of aging for lifespan and healthspan. Aging (Albany NY) 10:573–591 https://doi.org/10.18632/aging.101414
Lister R, Mukamel EA, Nery JR, Urich M, Puddifoot CA, Johnson ND, Lucero J, Huang Y, Dwork AJ, Schultz MD, Yu M, Tonti-Filippini J, Heyn H, Hu S, Wu JC, Rao A, Esteller M, He C, Haghighi FG, Sejnowski TJ, Behrens MM, Ecker JR (2013) Global epigenomic reconfiguration during mammalian brain development. Science 341:1237905. https://doi.org/10.1126/science.1237905 ArticlePubMedPubMed CentralCAS Google Scholar
McClay JL et al (2014) A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects. Hum Mol Genet 23:1175–1185. https://doi.org/10.1093/hmg/ddt511 ArticlePubMedCAS Google Scholar
Meissner A, Mikkelsen TS, Gu H, Wernig M, Hanna J, Sivachenko A, Zhang X, Bernstein BE, Nusbaum C, Jaffe DB, Gnirke A, Jaenisch R, Lander ES (2008) Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature 454:766–770. https://doi.org/10.1038/nature07107 ArticlePubMedPubMed CentralCAS Google Scholar
Mitchell BD, Hsueh WC, King TM, Pollin TI, Sorkin J, Agarwala R, Schäffer AA, Shuldiner AR (2001) Heritability of life span in the Old Order Amish. Am J Med Genet 102:346–352 https://doi.org/10.1002/ajmg.1483 [pii]
Monahan K, Rudnick ND, Kehayova PD, Pauli F, Newberry KM, Myers RM, Maniatis T (2012) Role of CCCTC binding factor (CTCF) and cohesin in the generation of single-cell diversity of protocadherin-alpha gene expression. Proc Natl Acad Sci U S A 109:9125–9130. https://doi.org/10.1073/pnas.1205074109 ArticlePubMedPubMed Central Google Scholar
Moore AZ, Hernandez DG, Tanaka T, Pilling LC, Nalls MA, Bandinelli S, Singleton AB, Ferrucci L (2016) Change in epigenome-wide DNA methylation over 9 years and subsequent mortality: results from the InCHIANTI Study. J Gerontol A Biol Sci Med Sci 71:1029–1035. https://doi.org/10.1093/gerona/glv118 ArticlePubMedCAS Google Scholar
Nitzsche A, Paszkowski-Rogacz M, Matarese F, Janssen-Megens EM, Hubner NC, Schulz H, de Vries I, Ding L, Huebner N, Mann M, Stunnenberg HG, Buchholz F (2011) RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity. PLoS One 6:e19470. https://doi.org/10.1371/journal.pone.0019470 ArticlePubMedPubMed CentralCAS Google Scholar
Ortega A et al. (2016) New cell adhesion molecules in human ischemic cardiomyopathy. PCDHGA3 implications in decreased stroke volume and ventricular dysfunction. PLoS One 11:e0160168 https://doi.org/10.1371/journal.pone.0160168
Rakyan VK, Down TA, Maslau S, Andrew T, Yang TP, Beyan H, Whittaker P, McCann OT, Finer S, Valdes AM, Leslie RD, Deloukas P, Spector TD (2010) Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains. Genome Res 20:434–439. https://doi.org/10.1101/gr.103101.109 ArticlePubMedPubMed CentralCAS Google Scholar
Rockwood K, Andrew M, Mitnitski A (2007) A comparison of two approaches to measuring frailty in elderly people. J Gerontol A Biol Sci Med Sci 62:738–743 doi:62/7/738 [pii]
Sandovici I, Smith NH, Nitert MD, Ackers-Johnson M, Uribe-Lewis S, Ito Y, Jones RH, Marquez VE, Cairns W, Tadayyon M, O'Neill LP, Murrell A, Ling C, Constancia M, Ozanne SE (2011) Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets. Proc Natl Acad Sci U S A 108:5449–5454. https://doi.org/10.1073/pnas.1019007108 ArticlePubMedPubMed Central Google Scholar
Saunderson EA, Spiers H, Mifsud KR, Gutierrez-Mecinas M, Trollope AF, Shaikh A, Mill J, Reul JMHM (2016) Stress-induced gene expression and behavior are controlled by DNA methylation and methyl donor availability in the dentate gyrus. Proc Natl Acad Sci U S A 113:4830–4835. https://doi.org/10.1073/pnas.1524857113 ArticlePubMedPubMed CentralCAS Google Scholar
Straussman R, Nejman D, Roberts D, Steinfeld I, Blum B, Benvenisty N, Simon I, Yakhini Z, Cedar H (2009) Developmental programming of CpG island methylation profiles in the human genome. Nat Struct Mol Biol 16:564–571. https://doi.org/10.1038/nsmb.1594 ArticlePubMedCAS Google Scholar
Svane AM, Soerensen M, Lund J, Tan Q, Jylhävä J, Wang Y, Pedersen N, Hägg S, Debrabant B, Deary I, Christensen K, Christiansen L, Hjelmborg J (2018) DNA methylation and all-cause mortality in middle-aged and elderly Danish twins Genes (Basel) 9 https://doi.org/10.3390/genes9020078
Talens RP, Christensen K, Putter H, Willemsen G, Christiansen L, Kremer D, Suchiman HED, Slagboom PE, Boomsma DI, Heijmans BT (2012) Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs. Aging Cell 11:694–703. https://doi.org/10.1111/j.1474-9726.2012.00835.x ArticlePubMedCAS Google Scholar
Toyoda S, Kawaguchi M, Kobayashi T, Tarusawa E, Toyama T, Okano M, Oda M, Nakauchi H, Yoshimura Y, Sanbo M, Hirabayashi M, Hirayama T, Hirabayashi T, Yagi T (2014) Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity. Neuron 82:94–108. https://doi.org/10.1016/j.neuron.2014.02.005 ArticlePubMedCAS Google Scholar
Wang H, Maurano MT, Qu H, Varley KE, Gertz J, Pauli F, Lee K, Canfield T, Weaver M, Sandstrom R, Thurman RE, Kaul R, Myers RM, Stamatoyannopoulos JA (2012) Widespread plasticity in CTCF occupancy linked to DNA methylation. Genome Res 22:1680–1688. https://doi.org/10.1101/gr.136101.111 ArticlePubMedPubMed CentralCAS Google Scholar