The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D) (original) (raw)

• Crespi B, Summers K, Dorus S . Adaptive evolution of genes underlying schizophrenia. Proc Biol Sci 2007; 274: 2801–2810.
  Article CAS PubMed PubMed Central Google Scholar
• Kuningas M, May L, Tamm R, van Bodegom D, van den Biggelaar AH, Meij JJ et al. Selection for genetic variation inducing pro-inflammatory responses under adverse environmental conditions in a Ghanaian population. PLoS One 2009; 4: e7795.
  Article CAS PubMed PubMed Central Google Scholar
• van Dissel JT, van Langevelde P, Westendorp RG, Kwappenberg K, Frolich M . Anti-inflammatory cytokine profile and mortality in febrile patients. Lancet 1998; 351: 950–953.
  Article CAS PubMed Google Scholar
• Bermejo-Martin JF, Martin-Loeches I, Rello J, Anton A, Almansa R, Xu L et al. Host adaptive immunity deficiency in severe pandemic influenza. Crit Care 2010; 14: R167.
  Article PubMed PubMed Central Google Scholar
• Westendorp RG, Langermans JA, Huizinga TW, Elouali AH, Verweij CL, Boomsma DI et al. Genetic influence on cytokine production and fatal meningococcal disease. Lancet 1997; 349: 170–173.
  Article CAS PubMed Google Scholar
• McDade TW . Life history theory and the immune system: steps toward a human ecological immunology. Am J Phys Anthropol 2003 (Suppl 37): 100–125.
  Article Google Scholar
• Pedron B, Guerin V, Cordeiro DJ, Masmoudi S, Dalle JH, Sterkers G . Development of cytomegalovirus and adenovirus-specific memory CD4 T-cell functions from birth to adulthood. Pediatr Res 2011; 69: 106–111.
  Article PubMed Google Scholar
• Nwachuku N, Gerba CP . Health risks of enteric viral infections in children. Rev Environ Contam Toxicol 2006; 186: 1–56.
  PubMed Google Scholar
• Chen LC, Rahman M, Sarder AM . Epidemiology and causes of death among children in a rural area of Bangladesh. Int J Epidemiol 1980; 9: 25–33.
  Article CAS PubMed Google Scholar
• Miller AH, Maletic V, Raison CL . Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry 2009; 65: 732–741.
  Article CAS PubMed PubMed Central Google Scholar
• Howren MB, Lamkin DM, Suls J . Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom Med 2009; 71: 171–186.
  Article CAS PubMed Google Scholar
• Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK et al. A meta-analysis of cytokines in major depression. Biol Psychiatry 2010; 67: 446–457.
  Article CAS PubMed Google Scholar
• Zorrilla EP, Luborsky L, McKay JR, Rosenthal R, Houldin A, Tax A et al. The relationship of depression and stressors to immunological assays: a meta-analytic review. Brain Behav Immun 2001; 15: 199–226.
  Article CAS PubMed Google Scholar
• Gimeno D, Kivimaki M, Brunner EJ, Elovainio M, De Vogli R, Steptoe A et al. Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study. Psychol Med 2008; 39: 1–11.
  Google Scholar
• van den Biggelaar AH, Gussekloo J, de Craen AJ, Frolich M, Stek ML, van der Mast RC et al. Inflammation and interleukin-1 signaling network contribute to depressive symptoms but not cognitive decline in old age. Exp Gerontol 2007; 42: 693–701.
  Article CAS PubMed Google Scholar
• Pasco JA, Nicholson GC, Williams LJ, Jacka FN, Henry MJ, Kotowicz MA et al. Association of high-sensitivity C-reactive protein with de novo major depression. Br J Psychiatry 2010; 197: 372–377.
  Article PubMed Google Scholar
• Finch CE . Evolution in health and medicine Sackler colloquium: Evolution of the human lifespan and diseases of aging: roles of infection, inflammation, and nutrition. Proc Natl Acad Sci USA 2010; 107 (Suppl 1): 1718–1724.
  Article CAS PubMed Google Scholar
• Dobson AP, Carper ER . Infectious diseases and human population history. Biosci 1996; 46: 115–126.
  Article Google Scholar
• Wolfe ND, Dunavan CP, Diamond J . Origins of major human infectious diseases. Nature 2007; 447: 279–283.
  Article CAS PubMed PubMed Central Google Scholar
• Lovel H . Targeted interventions and infant mortality. Trans R Soc Trop Med Hyg 1989; 83: 10–18.
  Article CAS PubMed Google Scholar
• Kavaliers M, Colwell DD, Choleris E . Parasites and behavior: an ethopharmacological analysis and biomedical implications. Neurosci Biobehav Rev 1999; 23: 1037–1045.
  Article CAS PubMed Google Scholar
• Goncalves GM, Zamboni DS, Camara NO . The role of innate immunity in septic acute kidney injuries. Shock 2010; 34 (Suppl 1): 22–26.
  Article CAS PubMed Google Scholar
• Oberholzer A, Oberholzer C, Moldawer LL . Sepsis syndromes: understanding the role of innate and acquired immunity. Shock 2001; 16: 83–96.
  Article CAS PubMed Google Scholar
• Klein SL . Parasite manipulation of the proximate mechanisms that mediate social behavior in vertebrates. Physiol Behav 2003; 79: 441–449.
  Article CAS PubMed Google Scholar
• Kinney DK, Tanaka M . An evolutionary hypothesis of depression and its symptoms, adaptive value, and risk factors. J Nerv Ment Dis 2009; 197: 561–567.
  Article PubMed Google Scholar
• Gershon ES, Alliey-Rodriguez N, Liu C . After GWAS: searching for genetic risk for schizophrenia and bipolar disorder. Am J Psychiatry 2011; 168: 253–256.
  Article PubMed PubMed Central Google Scholar
• Licinio J, Dong C, Wong ML . Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment response. Arch Gen Psychiatry 2009; 66: 488–497.
  Article CAS PubMed PubMed Central Google Scholar
• Keller MC, Miller G . Resolving the paradox of common, harmful, heritable mental disorders: which evolutionary genetic models work best? Behav Brain Sci 2006; 29: 385–404; discussion 405–452.
  Article PubMed Google Scholar
• Detera-Wadleigh SD, Akula N . A systems approach to the biology of mood disorders through network analysis of candidate genes. Pharmacopsychiatry 2011; 44 (Suppl 1): S35–S42.
  Article CAS PubMed Google Scholar
• Wong ML, Dong C, Maestre-Mesa J, Licinio J . Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response. Mol Psychiatry 2008; 13: 800–812.
  Article CAS PubMed PubMed Central Google Scholar
• Cerri AP, Arosio B, Viazzoli C, Confalonieri R, Vergani C, Annoni G . The −308 (G/A) single nucleotide polymorphism in the TNF-alpha gene and the risk of major depression in the elderly. Int J Geriatr Psychiatry 2010; 25: 219–223.
  Article PubMed Google Scholar
• Clerici M, Arosio B, Mundo E, Cattaneo E, Pozzoli S, Dell'osso B et al. Cytokine polymorphisms in the pathophysiology of mood disorders. CNS Spectr 2009; 14: 419–425.
  Article PubMed Google Scholar
• Jun TY, Pae CU, Hoon H, Chae JH, Bahk WM, Kim KS et al. Possible association between -G308A tumour necrosis factor-alpha gene polymorphism and major depressive disorder in the Korean population. Psychiatr Genet 2003; 13: 179–181.
  Article PubMed Google Scholar
• Pae CU, Lee KU, Han H, Serretti A, Jun TY . Tumor necrosis factor alpha gene-G308A polymorphism associated with bipolar I disorder in the Korean population. Psychiatry Res 2004; 125: 65–68.
  Article CAS PubMed Google Scholar
• Bosker FJ, Hartman CA, Nolte IM, Prins BP, Terpstra P, Posthuma D et al. Poor replication of candidate genes for major depressive disorder using genome-wide association data. Mol Psychiatry 2011; 16: 516–532.
  Article CAS PubMed Google Scholar
• Wheway J, Herzog H, Mackay F . NPY and receptors in immune and inflammatory diseases. Curr Top Med Chem 2007; 7: 1743–1752.
  Article CAS PubMed Google Scholar
• Ferreira R, Xapelli S, Santos T, Silva AP, Cristovao A, Cortes L et al. Neuropeptide Y modulation of interleukin-1{beta} (IL-1{beta})-induced nitric oxide production in microglia. J Biol Chem 2010; 285: 41921–41934.
  Article CAS PubMed PubMed Central Google Scholar
• Wheway J, Herzog H, Mackay F . The Y1 receptor for NPY: a key modulator of the adaptive immune system. Peptides 2007; 28: 453–458.
  Article CAS PubMed Google Scholar
• Heilig M, Zachrisson O, Thorsell A, Ehnvall A, Mottagui-Tabar S, Sjogren M et al. Decreased cerebrospinal fluid neuropeptide Y (NPY) in patients with treatment refractory unipolar major depression: preliminary evidence for association with preproNPY gene polymorphism. J Psychiatr Res 2004; 38: 113–121.
  Article PubMed Google Scholar
• Sjoholm LK, Melas PA, Forsell Y, Lavebratt C . PreproNPY Pro7 protects against depression despite exposure to environmental risk factors. J Affect Disord 2009; 118: 124–130.
  Article CAS PubMed Google Scholar
• Mickey BJ, Zhou Z, Heitzeg MM, Heinz E, Hodgkinson CA, Hsu DT et al. Emotion processing, major depression, and functional genetic variation of neuropeptide Y. Arch Gen Psychiatry 2011; 68: 158–166.
  Article CAS PubMed PubMed Central Google Scholar
• Morales-Medina JC, Dumont Y, Quirion R . A possible role of neuropeptide Y in depression and stress. Brain Res 2010; 1314: 194–205.
  Article CAS PubMed Google Scholar
• Kallio J, Pesonen U, Kaipio K, Karvonen MK, Jaakkola U, Heinonen OJ et al. Altered intracellular processing and release of neuropeptide Y due to leucine 7 to proline 7 polymorphism in the signal peptide of preproneuropeptide Y in humans. FASEB J 2001; 15: 1242–1244.
  Article CAS PubMed Google Scholar
• Wilson AG, di Giovine FS, Blakemore AI, Duff GW . Single base polymorphism in the human tumour necrosis factor alpha (TNF alpha) gene detectable by NcoI restriction of PCR product. Hum Mol Genet 1992; 1: 353.
  Article CAS PubMed Google Scholar
• Lotrich FE, Ferrell RE, Rabinovitz M, Pollock BG . Labile anger during interferon Alfa treatment is associated with a polymorphism in tumor necrosis factor alpha. Clin Neuropharmacol 2010; 33: 191–197.
  Article CAS PubMed PubMed Central Google Scholar
• Correa PA, Gomez LM, Cadena J, Anaya JM . Autoimmunity and tuberculosis. Opposite association with TNF polymorphism. J Rheumatol 2005; 32: 219–224.
  CAS PubMed Google Scholar
• Kerr JR, McCoy M, Burke B, Mattey DL, Pravica V, Hutchinson IV . Cytokine gene polymorphisms associated with symptomatic parvovirus B19 infection. J Clin Pathol 2003; 56: 725–727.
  Article CAS PubMed PubMed Central Google Scholar
• Chen DQ, Zeng Y, Zhou J, Yang L, Jiang S, Huang JD et al. Association of candidate susceptible loci with chronic infection with hepatitis B virus in a Chinese population. J Med Virol 2010; 82: 371–378.
  Article CAS PubMed Google Scholar
• Surbatovic M, Grujic K, Cikota B, Jevtic M, Filipovic N, Romic P et al. Polymorphisms of genes encoding tumor necrosis factor-alpha, interleukin-10, cluster of differentiation-14 and interleukin-1ra in critically ill patients. J Crit Care 2010; 25: 542 e541–548.
  Article CAS PubMed Google Scholar
• Larcombe LA, Orr PH, Lodge AM, Brown JS, Dembinski IJ, Milligan LC et al. Functional gene polymorphisms in Canadian aboriginal populations with high rates of tuberculosis. J Infect Dis 2008; 198: 1175–1179.
  Article PubMed Google Scholar
• Masuda M, Senju S, Fujii Si S, Terasaki Y, Takeya M, Hashimoto Si S et al. Identification and immunocytochemical analysis of DCNP1, a dendritic cell-associated nuclear protein. Biochem Biophys Res Commun 2002; 290: 1022–1029.
  Article CAS PubMed Google Scholar
• Zhou T, Wang S, Ren H, Qi XR, Luchetti S, Kamphuis W et al. Dendritic cell nuclear protein-1, a novel depression-related protein, upregulates corticotropin-releasing hormone expression. Brain 2010; 133: 3069–3079.
  Article PubMed Google Scholar
• Kim Y, Park CS, Shin HD, Choi JW, Cheong HS, Park BL et al. A promoter nucleotide variant of the dendritic cell-specific DCNP1 associates with serum IgE levels specific for dust mite allergens among the Korean asthmatics. Genes Immun 2007; 8: 369–378.
  Article CAS PubMed Google Scholar
• Lopez-Leon S, Janssens AC, Hofman A, Claes S, Breteler MM, Tiemeier H et al. No association between the angiotensin-converting enzyme gene and major depression: a case-control study and meta-analysis. Psychiatr Genet 2006; 16: 225–226.
  Article PubMed Google Scholar
• Virchow S, Ansorge N, Rosskopf D, Rubben H, Siffert W . The G protein beta3 subunit splice variant Gbeta3-s causes enhanced chemotaxis of human neutrophils in response to interleukin-8. Naunyn Schmiedebergs Arch Pharmacol 1999; 360: 27–32.
  Article CAS PubMed Google Scholar
• Lindemann M, Virchow S, Ramann F, Barsegian V, Kreuzfelder E, Siffert W et al. The G protein beta3 subunit 825T allele is a genetic marker for enhanced T cell response. FEBS Lett 2001; 495: 82–86.
  Article CAS PubMed Google Scholar
• Romundstad S, Melien O, Holmen J . The G protein beta3 subunit C825T polymorphism is associated with microalbuminuria in hypertensive women and cardiovascular disease in hypertensive men. Am J Hypertens 2010; 23: 1114–1120.
  Article CAS PubMed Google Scholar
• Holmen OL, Romundstad S, Melien O . Association between the G protein beta3 subunit C825T polymorphism and the occurrence of cardiovascular disease in hypertensives: The Nord-Trondelag Health Study (HUNT). Am J Hypertens 2010; 23: 1121–1127.
  Article CAS PubMed Google Scholar
• Hauge Opdal S, Melien O, Rootwelt H, Vege A, Arnestad M, Ole Rognum T . The G protein beta3 subunit 825C allele is associated with sudden infant death due to infection. Acta Paediatr 2006; 95: 1129–1132.
  Article PubMed Google Scholar
• Bagos PG, Elefsinioti AL, Nikolopoulos GK, Hamodrakas SJ . The GNB3 C825T polymorphism and essential hypertension: a meta-analysis of 34 studies including 14,094 cases and 17,760 controls. J Hypertens 2007; 25: 487–500.
  Article CAS PubMed Google Scholar
• Ahlenstiel G, Nischalke HD, Bueren K, Berg T, Vogel M, Biermer M et al. The GNB3 C825T polymorphism affects response to HCV therapy with pegylated interferon in HCV/HIV co-infected but not in HCV mono-infected patients. J Hepatol 2007; 47: 348–355.
  Article CAS PubMed Google Scholar
• Sarrazin C, Berg T, Weich V, Mueller T, Frey UH, Zeuzem S et al. GNB3 C825T polymorphism and response to interferon-alfa/ribavirin treatment in patients with hepatitis C virus genotype 1 (HCV-1) infection. J Hepatol 2005; 43: 388–393.
  Article CAS PubMed Google Scholar
• Brockmeyer NH, Potthoff A, Kasper A, Nabring C, Jockel KH, Siffert W . GNB3 C825T polymorphism and response to anti-retroviral combination therapy in HIV-1-infected patients--a pilot study. Eur J Med Res 2005; 10: 489–494.
  CAS PubMed Google Scholar
• Lindemann M, Barsegian V, Siffert W, Ferencik S, Roggendorf M, Grosse-Wilde H . Role of G protein beta3 subunit C825T and HLA class II polymorphisms in the immune response after HBV vaccination. Virology 2002; 297: 245–252.
  Article CAS PubMed Google Scholar
• Fodil-Cornu N, Kozij N, Wu Q, Rozen R, Vidal SM . Methylenetetrahydrofolate reductase (MTHFR) deficiency enhances resistance against cytomegalovirus infection. Genes Immun 2009; 10: 662–666.
  Article CAS PubMed Google Scholar
• Imamura A, Murakami R, Takahashi R, Cheng XW, Numaguchi Y, Murohara T et al. Low folate levels may be an atherogenic factor regardless of homocysteine levels in young healthy nonsmokers. Metabolism 2010; 59: 728–733.
  Article CAS PubMed Google Scholar
• Fujimaki C, Hayashi H, Tsuboi S, Matsuyama T, Kosuge K, Yamada H et al. Plasma total homocysteine level and methylenetetrahydrofolate reductase 677C>T genetic polymorphism in Japanese patients with rheumatoid arthritis. Biomarkers 2009; 14: 49–54.
  Article CAS PubMed Google Scholar
• Dedoussis GV, Panagiotakos DB, Pitsavos C, Chrysohoou C, Skoumas J, Choumerianou D et al. An association between the methylenetetrahydrofolate reductase (MTHFR) C677T mutation and inflammation markers related to cardiovascular disease. Int J Cardiol 2005; 100: 409–414.
  Article PubMed Google Scholar
• Chen AR, Zhang HG, Wang ZP, Fu SJ, Yang PQ, Ren JG et al. C-reactive protein, vitamin B12 and C677T polymorphism of N-5,10-methylenetetrahydrofolate reductase gene are related to insulin resistance and risk factors for metabolic syndrome in Chinese population. Clin Invest Med 2010; 33: E290–E297.
  Article CAS PubMed Google Scholar
• Hammons AL, Summers CM, Woodside JV, McNulty H, Strain JJ, Young IS et al. Folate/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with serum levels of monocyte chemoattractant protein-1. Clin Immunol 2009; 133: 132–137.
  Article CAS PubMed PubMed Central Google Scholar
• Lu ZY, Morales M, Khartulyari S, Mei M, Murphy KM, Stanislawska-Sachadyn A et al. Genetic and biochemical determinants of serum concentrations of monocyte chemoattractant protein-1, a potential neural tube defect risk factor. Birth Defects Res A Clin Mol Teratol 2008; 82: 736–741.
  Article CAS PubMed PubMed Central Google Scholar
• Bronowicki JP, Abdelmouttaleb I, Peyrin-Biroulet L, Venard V, Khiri H, Chabi N et al. Methylenetetrahydrofolate reductase 677T allele protects against persistent HBV infection in West Africa. J Hepatol 2008; 48: 532–539.
  Article CAS PubMed Google Scholar
• Simhan HN, Himes KP, Venkataramanan R, Bodnar LM . Maternal serum folate species in early pregnancy and lower genital tract inflammatory milieu. Am J Obstet Gynecol 2011; 205: 61. e1–e7.
  Article CAS Google Scholar
• Chillemi R, Zappacosta B, Simpore J, Persichilli S, Musumeci M, Musumeci S . Hyperhomocysteinemia in acute Plasmodium falciparum malaria: an effect of host-parasite interaction. Clin Chim Acta 2004; 348: 113–120.
  Article CAS PubMed Google Scholar
• Maeda M, Yamamoto I, Fukuda M, Motomura T, Nishida M, Nonen S et al. MTHFR gene polymorphism is susceptible to diabetic retinopathy but not to diabetic nephropathy in Japanese type 2 diabetic patients. J Diabetes Complications 2008; 22: 119–125.
  Article PubMed Google Scholar
• Khandanpour N, Willis G, Meyer FJ, Armon MP, Loke YK, Wright AJ et al. Peripheral arterial disease and methylenetetrahydrofolate reductase (MTHFR) C677T mutations: a case-control study and meta-analysis. J Vasc Surg 2009; 49: 711–718.
  Article PubMed Google Scholar
• Ferrara F, Novo S, Grimaudo S, Raimondi F, Meli F, Amato C et al. Methylenetetrahydrofolate reductase mutation in subjects with abdominal aortic aneurysm subdivided for age. Clin Hemorheol Microcirc 2006; 34: 421–426.
  CAS PubMed Google Scholar
• Pollex RL, Mamakeesick M, Zinman B, Harris SB, Hanley AJ, Hegele RA . Methylenetetrahydrofolate reductase polymorphism 677C>T is associated with peripheral arterial disease in type 2 diabetes. Cardiovasc Diabetol 2005; 4: 17.
  Article CAS PubMed PubMed Central Google Scholar
• Chen J, Ma J, Stampfer MJ, Palomeque C, Selhub J, Hunter DJ . Linkage disequilibrium between the 677C>T and 1298A>C polymorphisms in human methylenetetrahydrofolate reductase gene and their contributions to risk of colorectal cancer. Pharmacogenetics 2002; 12: 339–342.
  Article CAS PubMed Google Scholar
• Movva S, Alluri RV, Venkatasubramanian S, Vedicherla B, Vattam KK, Ahuja YR et al. Association of methylene tetrahydrofolate reductase C677T genotype with type 2 diabetes mellitus patients with and without renal complications. Genet Test Mol Biomarkers 2011; 15: 257–261.
  Article CAS PubMed Google Scholar
• Reyes-Engel A, Munoz E, Gaitan MJ, Fabre E, Gallo M, Dieguez JL et al. Implications on human fertility of the 677C → T and 1298A → C polymorphisms of the MTHFR gene: consequences of a possible genetic selection. Mol Hum Reprod 2002; 8: 952–957.
  Article CAS PubMed Google Scholar
• Gerdes LU . The common polymorphism of apolipoprotein E: geographical aspects and new pathophysiological relations. Clin Chem Lab Med 2003; 41: 628–631.
  Article CAS PubMed Google Scholar
• Urosevic N, Martins RN . Infection and Alzheimer's disease: the APOE epsilon4 connection and lipid metabolism. J Alzheimers Dis 2008; 13: 421–435.
  Article CAS PubMed Google Scholar
• Mahley RW, Rall Jr SC . Apolipoprotein E: far more than a lipid transport protein. Annu Rev Genomics Hum Genet 2000; 1: 507–537.
  Article CAS PubMed Google Scholar
• Jofre-Monseny L, Minihane AM, Rimbach G . Impact of apoE genotype on oxidative stress, inflammation and disease risk. Mol Nutr Food Res 2008; 52: 131–145.
  Article CAS PubMed Google Scholar
• Wozniak MA, Maude RJ, Innes JA, Hawkey PM, Itzhaki RF . Apolipoprotein E-epsilon2 confers risk of pulmonary tuberculosis in women from the Indian subcontinent--a preliminary study. J Infect 2009; 59: 219–222.
  Article PubMed Google Scholar
• Roy A, Karoum F, Pollack S . Marked reduction in indexes of dopamine metabolism among patients with depression who attempt suicide. Arch Gen Psychiatry 1992; 49: 447–450.
  Article CAS PubMed Google Scholar
• Meyer JH, Kruger S, Wilson AA, Christensen BK, Goulding VS, Schaffer A et al. Lower dopamine transporter binding potential in striatum during depression. NeuroReport 2001; 12: 4121–4125.
  Article CAS PubMed Google Scholar
• Lambert G, Johansson M, Agren H, Friberg P . Reduced brain norepinephrine and dopamine release in treatment-refractory depressive illness: evidence in support of the catecholamine hypothesis of mood disorders. Arch Gen Psychiatry 2000; 57: 787–793.
  Article CAS PubMed Google Scholar
• Klimek V, Schenck JE, Han H, Stockmeier CA, Ordway GA . Dopaminergic abnormalities in amygdaloid nuclei in major depression: a postmortem study. Biol Psychiatry 2002; 52: 740–748.
  Article CAS PubMed Google Scholar
• Kavelaars A, Cobelens PM, Teunis MA, Heijnen CJ . Changes in innate and acquired immune responses in mice with targeted deletion of the dopamine transporter gene. J Neuroimmunol 2005; 161: 162–168.
  Article CAS PubMed Google Scholar
• Alaniz RC, Thomas SA, Perez-Melgosa M, Mueller K, Farr AG, Palmiter RD et al. Dopamine beta-hydroxylase deficiency impairs cellular immunity. Proc Natl Acad Sci USA 1999; 96: 2274–2278.
  Article CAS PubMed PubMed Central Google Scholar
• Cobat A, Gallant CJ, Simkin L, Black GF, Stanley K, Hughes J et al. Two loci control tuberculin skin test reactivity in an area hyperendemic for tuberculosis. J Exp Med 2009; 206: 2583–2591.
  Article CAS PubMed PubMed Central Google Scholar
• Stein CM, Zalwango S, Malone LL, Won S, Mayanja-Kizza H, Mugerwa RD et al. Genome scan of M. tuberculosis infection and disease in Ugandans. PLoS One 2008; 3: e4094.
  Article CAS PubMed PubMed Central Google Scholar
• Mill J, Asherson P, Browes C, D'Souza U, Craig I . Expression of the dopamine transporter gene is regulated by the 3′ UTR VNTR: evidence from brain and lymphocytes using quantitative RT-PCR. Am J Med Genet 2002; 114: 975–979.
  Article PubMed Google Scholar
• van de Giessen E, de Win MM, Tanck MW, van den Brink W, Baas F, Booij J . Striatal dopamine transporter availability associated with polymorphisms in the dopamine transporter gene SLC6A3. J Nucl Med 2009; 50: 45–52.
  Article CAS PubMed Google Scholar
• Opdal SH, Vege A, Rognum TO . Serotonin transporter gene variation in sudden infant death syndrome. Acta Paediatr 2008; 97: 861–865.
  Article CAS PubMed Google Scholar
• Narita N, Narita M, Takashima S, Nakayama M, Nagai T, Okado N . Serotonin transporter gene variation is a risk factor for sudden infant death syndrome in the Japanese population. Pediatrics 2001; 107: 690–692.
  Article CAS PubMed Google Scholar
• Weese-Mayer DE, Berry-Kravis EM, Maher BS, Silvestri JM, Curran ME, Marazita ML . Sudden infant death syndrome: association with a promoter polymorphism of the serotonin transporter gene. Am J Med Genet A 2003; 117A: 268–274.
  Article PubMed Google Scholar
• Prandota J . Possible pathomechanisms of sudden infant death syndrome: key role of chronic hypoxia, infection/inflammation states, cytokine irregularities, and metabolic trauma in genetically predisposed infants. Am J Ther 2004; 11: 517–546.
  Article PubMed Google Scholar
• Fredericks CA, Drabant EM, Edge MD, Tillie JM, Hallmayer J, Ramel W et al. Healthy young women with serotonin transporter SS polymorphism show a pro-inflammatory bias under resting and stress conditions. Brain Behav Immun 2010; 24: 350–357.
  Article CAS PubMed Google Scholar
• Su S, Zhao J, Bremner JD, Miller AH, Tang W, Bouzyk M et al. Serotonin transporter gene, depressive symptoms, and interleukin-6. Circ Cardiovasc Genet 2009; 2: 614–620.
  Article CAS PubMed PubMed Central Google Scholar
• Murray DR, Schaller M . Historical prevalence of infectious diseases within 230 geopolitical regions: a tool for investigating origins of culture. J Cross Cult Psychol 2010; 41: 99–108.
  Article Google Scholar
• Chiao JY, Blizinsky KD . Culture-gene coevolution of individualism-collectivism and the serotonin transporter gene. Proc Biol Sci 2010; 277: 529–537.
  Article CAS PubMed Google Scholar
• Wray NR, Pergadia ML, Blackwood DH, Penninx BW, Gordon SD, Nyholt DR et al. Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned. Mol Psychiatry 2012; 17: 36–48.
  Article CAS PubMed Google Scholar
• Cattaneo M, Otsu M, Fagioli C, Martino S, Lotti LV, Sitia R et al. SEL1L and HRD1 are involved in the degradation of unassembled secretory Ig-mu chains. J Cell Physiol 2008; 215: 794–802.
  Article CAS PubMed Google Scholar
• Schelhaas M, Malmstrom J, Pelkmans L, Haugstetter J, Ellgaard L, Grunewald K et al. Simian Virus 40 depends on ER protein folding and quality control factors for entry into host cells. Cell 2007; 131: 516–529.
  Article CAS PubMed Google Scholar
• Oresic K, Ng CL, Tortorella D . TRAM1 participates in human cytomegalovirus US2- and US11-mediated dislocation of an endoplasmic reticulum membrane glycoprotein. J Biol Chem 2009; 284: 5905–5914.
  Article CAS PubMed PubMed Central Google Scholar
• Ban Y, Taniyama M, Tozaki T, Yanagawa T, Tomita M . SEL1L microsatellite polymorphism in Japanese patients with autoimmune thyroid diseases. Thyroid 2001; 11: 335–338.
  Article CAS PubMed Google Scholar
• Song J, Duncan MJ, Li G, Chan C, Grady R, Stapleton A et al. A novel TLR4-mediated signaling pathway leading to IL-6 responses in human bladder epithelial cells. Plos Pathog 2007; 3: e60.
  Article CAS PubMed PubMed Central Google Scholar
• Abera AB, Sales KJ, Catalano RD, Katz AA, Jabbour HN . EP2 receptor mediated cAMP release is augmented by PGF 2 alpha activation of the FP receptor via the calcium-calmodulin pathway. Cell Signal 2010; 22: 71–79.
  Article CAS PubMed PubMed Central Google Scholar
• Klempan TA, Rujescu D, Merette C, Himmelman C, Sequeira A, Canetti L et al. Profiling brain expression of the spermidine/spermine N1-acetyltransferase 1 (SAT1) gene in suicide. Am J Med Genet B Neuropsychiatr Genet 2009; 150B: 934–943.
  Article CAS PubMed Google Scholar
• Tabeta K, Hoebe K, Janssen EM, Du X, Georgel P, Crozat K et al. The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat Immunol 2006; 7: 156–164.
  Article CAS PubMed Google Scholar
• Koehn J, Huesken D, Jaritz M, Rot A, Zurini M, Dwertmann A et al. Assessing the function of human UNC-93B in Toll-like receptor signaling and major histocompatibility complex II response. Hum Immunol 2007; 68: 871–878.
  Article CAS PubMed Google Scholar
• Pifer R, Benson A, Sturge CR, Yarovinsky F . UNC93B1 is essential for TLR11 activation and IL-12-dependent host resistance to Toxoplasma gondii. J Biol Chem 2011; 286: 3307–3314.
  Article CAS PubMed Google Scholar
• Crozat K, Vivier E, Dalod M . Crosstalk between components of the innate immune system: promoting anti-microbial defenses and avoiding immunopathologies. Immunol Rev 2009; 227: 129–149.
  Article CAS PubMed Google Scholar
• Lang R, Kofler B . The galanin peptide family in inflammation. Neuropeptides 2011; 45: 1–8.
  Article CAS PubMed Google Scholar
• Matkowskyj KA, Danilkovich A, Marrero J, Savkovic SD, Hecht G, Benya RV . Galanin-1 receptor up-regulation mediates the excess colonic fluid production caused by infection with enteric pathogens. Nat Med 2000; 6: 1048–1051.
  Article CAS PubMed Google Scholar
• McDonald AC, Schuijers JA, Gundlach AL, Grills BL . Galanin treatment offsets the inhibition of bone formation and downregulates the increase in mouse calvarial expression of TNFalpha and GalR2 mRNA induced by chronic daily injections of an injurious vehicle. Bone 2007; 40: 895–903.
  Article CAS PubMed Google Scholar
• Su Y, Ganea D, Peng X, Jonakait GM . Galanin down-regulates microglial tumor necrosis factor-alpha production by a post-transcriptional mechanism. J Neuroimmunol 2003; 134: 52–60.
  Article CAS PubMed Google Scholar
• Christiansen SH, Olesen MV, Wortwein G, Woldbye DP . Fluoxetine reverts chronic restraint stress-induced depression-like behaviour and increases neuropeptide Y and galanin expression in mice. Behav Brain Res 2011; 216: 585–591.
  Article CAS PubMed Google Scholar
• Wardi Le Maitre T, Xia S, Le Maitre E, Dun XP, Lu J, Theodorsson E et al. Galanin receptor 2 overexpressing mice display an antidepressive-like phenotype: possible involvement of the subiculum. Neurosci 2011; 190: 270–288.
  Article CAS Google Scholar
• Davidson S, Lear M, Shanley L, Hing B, Baizan-Edge A, Herwig A et al. Differential activity by polymorphic variants of a remote enhancer that supports galanin expression in the hypothalamus and amygdala: implications for obesity, depression and alcoholism. Neuropsychopharmacology 2011; 36: 2211–2221.
  Article CAS PubMed PubMed Central Google Scholar
• Rauch I, Lundstrom L, Hell M, Sperl W, Kofler B . Galanin message-associated peptide suppresses growth and the budded-to-hyphal-form transition of Candida albicans. Antimicrob Agents Chemother 2007; 51: 4167–4170.
  Article CAS PubMed PubMed Central Google Scholar
• Ikegami K, Sato S, Nakamura K, Ostrowski LE, Setou M . Tubulin polyglutamylation is essential for airway ciliary function through the regulation of beating asymmetry. Proc Natl Acad Sci USA 2010; 107: 10490–10495.
  Article CAS PubMed PubMed Central Google Scholar
• Chen C, Han YH, Yang Z, Rodrigues AD . Effect of interferon-alpha2b on the expression of various drug-metabolizing enzymes and transporters in co-cultures of freshly prepared human primary hepatocytes. Xenobiotica 2011; 41: 476–485.
  Article CAS PubMed Google Scholar
• Crossland H, Constantin-Teodosiu D, Greenhaff PL, Gardiner SM . Low-dose dexamethasone prevents endotoxaemia-induced muscle protein loss and impairment of carbohydrate oxidation in rat skeletal muscle. J Physiol 2010; 588: 1333–1347.
  Article CAS PubMed PubMed Central Google Scholar
• Palomer X, Alvarez-Guardia D, Rodriguez-Calvo R, Coll T, Laguna JC, Davidson MM et al. TNF-alpha reduces PGC-1alpha expression through NF-kappaB and p38 MAPK leading to increased glucose oxidation in a human cardiac cell model. Cardiovasc Res 2009; 81: 703–712.
  Article CAS PubMed Google Scholar
• Zapata-Gonzalez F, Rueda F, Petriz J, Domingo P, Villarroya F, Diaz-Delfin J et al. Human dendritic cell activities are modulated by the omega-3 fatty acid, docosahexaenoic acid, mainly through PPAR(gamma):RXR heterodimers: comparison with other polyunsaturated fatty acids. J Leukoc Biol 2008; 84: 1172–1182.
  Article CAS PubMed Google Scholar
• Nawa Y, Kawahara K, Tancharoen S, Meng X, Sameshima H, Ito T et al. Nucleophosmin may act as an alarmin: implications for severe sepsis. J Leukoc Biol 2009; 86: 645–653.
  Article CAS PubMed Google Scholar
• Sarek G, Jarviluoma A, Moore HM, Tojkander S, Vartia S, Biberfeld P et al. Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency. Plos Pathog 2010; 6: e1000818.
  Article CAS PubMed PubMed Central Google Scholar
• Johnson JS, Samulski RJ . Enhancement of adeno-associated virus infection by mobilizing capsids into and out of the nucleolus. J Virol 2009; 83: 2632–2644.
  Article CAS PubMed Google Scholar
• Lee JJ, Seah JB, Chow VT, Poh CL, Tan EL . Comparative proteome analyses of host protein expression in response to Enterovirus 71 and Coxsackievirus A16 infections. J Proteomics 2011; 74: 2018–2024.
  Article CAS PubMed Google Scholar
• Zeng Y, Ye L, Zhu S, Zheng H, Zhao P, Cai W et al. The nucleocapsid protein of SARS-associated coronavirus inhibits B23 phosphorylation. Biochem Biophys Res Commun 2008; 369: 287–291.
  Article CAS PubMed PubMed Central Google Scholar
• Fankhauser C, Izaurralde E, Adachi Y, Wingfield P, Laemmli UK . Specific complex of human immunodeficiency virus type 1 rev and nucleolar B23 proteins: dissociation by the Rev response element. Mol Cell Biol 1991; 11: 2567–2575.
  Article CAS PubMed PubMed Central Google Scholar
• Lymberopoulos MH, Bourget A, Abdeljelil NB, Pearson A . Involvement of the UL24 protein in herpes simplex virus 1-induced dispersal of B23 and in nuclear egress. Virology 2011; 412: 341–348.
  Article CAS PubMed Google Scholar
• Garcia MA, Meurs EF, Esteban M . The dsRNA protein kinase PKR: virus and cell control. Biochimie 2007; 89: 799–811.
  Article CAS PubMed Google Scholar
• Burrows JF, McGrattan MJ, Johnston JA . The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence. Genomics 2005; 85: 524–529.
  Article CAS PubMed Google Scholar
• Burrows JF, McGrattan MJ, Rascle A, Humbert M, Baek KH, Johnston JA . DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation. J Biol Chem 2004; 279: 13993–14000.
  Article CAS PubMed Google Scholar
• Chen R, Zhang L, Zhong B, Tan B, Liu Y, Shu HB . The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling. Cell Res 2010; 20: 802–811.
  Article CAS PubMed Google Scholar
• Liu Y, Blackwood DH, Caesar S, de Geus EJ, Farmer A, Ferreira MA et al. Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. Mol Psychiatry 2011; 16: 2–4.
  Article CAS PubMed Google Scholar
• Green EK, Grozeva D, Jones I, Jones L, Kirov G, Caesar S et al. The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia. Mol Psychiatry 2010; 15: 1016–1022.
  Article CAS PubMed Google Scholar
• Erk S, Meyer-Lindenberg A, Schnell K, Opitz von Boberfeld C, Esslinger C, Kirsch P et al. Brain function in carriers of a genome-wide supported bipolar disorder variant. Arch Gen Psychiatry 2010; 67: 803–811.
  Article PubMed Google Scholar
• Bigos KL, Mattay VS, Callicott JH, Straub RE, Vakkalanka R, Kolachana B et al. Genetic variation in CACNA1C affects brain circuitries related to mental illness. Arch Gen Psychiatry 2010; 67: 939–945.
  Article PubMed PubMed Central Google Scholar
• Perrier E, Pompei F, Ruberto G, Vassos E, Collier D, Frangou S . Initial evidence for the role of CACNA1C on subcortical brain morphology in patients with bipolar disorder. Eur Psychiatry 2011; 26: 135–137.
  Article CAS PubMed Google Scholar
• Suzuki Y, Inoue T, Ra C . L-type Ca2+ channels: a new player in the regulation of Ca2+ signaling, cell activation and cell survival in immune cells. Mol Immunol 2010; 47: 640–648.
  Article CAS PubMed Google Scholar
• Badou A, Jha MK, Matza D, Mehal WZ, Freichel M, Flockerzi V et al. Critical role for the beta regulatory subunits of Cav channels in T lymphocyte function. Proc Natl Acad Sci USA 2006; 103: 15529–15534.
  Article CAS PubMed PubMed Central Google Scholar
• Matza D, Badou A, Kobayashi KS, Goldsmith-Pestana K, Masuda Y, Komuro A et al. A scaffold protein, AHNAK1, is required for calcium signaling during T cell activation. Immunity 2008; 28: 64–74.
  Article CAS PubMed PubMed Central Google Scholar
• Gupta S, Salam N, Srivastava V, Singla R, Behera D, Khayyam KU et al. Voltage gated calcium channels negatively regulate protective immunity to Mycobacterium tuberculosis. PLoS One 2009; 4: e5305.
  Article CAS PubMed PubMed Central Google Scholar
• Radermacher AN, Crabtree GR . Monster protein controls calcium entry and fights infection. Immunity 2008; 28: 13–14.
  Article CAS PubMed Google Scholar
• Suzuki Y, Yoshimaru T, Inoue T, Ra C . Ca v 1.2L-type Ca2+ channel protects mast cells against activation-induced cell death by preventing mitochondrial integrity disruption. Mol Immunol 2009; 46: 2370–2380.
  Article CAS PubMed Google Scholar
• Das R, Burke T, Van Wagoner DR, Plow EF . L-type calcium channel blockers exert an antiinflammatory effect by suppressing expression of plasminogen receptors on macrophages. Circ Res 2009; 105: 167–175.
  Article CAS PubMed PubMed Central Google Scholar
• Matza D, Badou A, Jha MK, Willinger T, Antov A, Sanjabi S et al. Requirement for AHNAK1-mediated calcium signaling during T lymphocyte cytolysis. Proc Natl Acad Sci USA 2009; 106: 9785–9790.
  Article CAS PubMed PubMed Central Google Scholar
• Liao P, Soong TW . CaV1.2 channelopathies: from arrhythmias to autism, bipolar disorder, and immunodeficiency. Pflugers Arch 2010; 460: 353–359.
  Article CAS PubMed Google Scholar
• Das R, Plow EF . A new function for old drugs. Cell Cycle 2010; 9: 638–639.
  Article CAS PubMed Google Scholar
• Balog Z, Kiss I, Keri S . CACNA1C risk allele for psychotic disorders is related to the activation of the AKT-pathway. Am J Psychiatry 2010; 167: 1276–1277.
  Article PubMed Google Scholar
• Li XQ, Cao W, Li T, Zeng AG, Hao LL, Zhang XN et al. Amlodipine inhibits TNF-alpha production and attenuates cardiac dysfunction induced by lipopolysaccharide involving PI3K/Akt pathway. Int Immunopharmacol 2009; 9: 1032–1041.
  Article CAS PubMed Google Scholar
• Splawski I, Timothy KW, Sharpe LM, Decher N, Kumar P, Bloise R et al. Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism. Cell 2004; 119: 19–31.
  Article CAS PubMed Google Scholar
• Okazaki R, Iwasaki YK, Miyauchi Y, Hirayama Y, Kobayashi Y, Katoh T et al. Lipopolysaccharide induces atrial arrhythmogenesis via down-regulation of L-type Ca2+ channel genes in rats. Int Heart J 2009; 50: 353–363.
  Article CAS PubMed Google Scholar
• Azenabor AA, Chaudhry AU . Effective macrophage redox defense against Chlamydia pneumoniae depends on L-type Ca2+ channel activation. Med Microbiol Immunol 2003; 192: 99–106.
  CAS PubMed Google Scholar
• Wieland H, Hechtel N, Faigle M, Neumeister B . Efficient intracellular multiplication of Legionella pneumophila in human monocytes requires functional host cell L-type calcium channels. FEMS Immunol Med Microbiol 2006; 47: 296–301.
  Article CAS PubMed Google Scholar
• Reichenberg A, Yirmiya R, Schuld A, Kraus T, Haack M, Morag A et al. Cytokine-associated emotional and cognitive disturbances in humans. Arch Gen Psychiatry 2001; 58: 445–452.
  CAS PubMed Google Scholar
• Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW . From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 2008; 9: 46–56.
  Article CAS PubMed PubMed Central Google Scholar
• Musselman DL, Lawson DH, Gumnick JF, Manatunga AK, Penna S, Goodkin RS et al. Paroxetine for the prevention of depression induced by high-dose interferon alfa. New Engl J Med 2001; 344: 961–966.
  Article CAS PubMed Google Scholar
• Raison CL, Borisov AS, Broadwell SD, Capuron L, Woolwine BJ, Jacobson IM et al. Depression during pegylated interferon-alpha plus ribavirin therapy: prevalence and prediction. J Clin Psychiatry 2005; 66: 41–48.
  Article CAS PubMed PubMed Central Google Scholar
• Kraus MR, Schafer A, Csef H, Scheurlen M . Psychiatric side effects of pegylated interferon alfa-2b as compared to conventional interferon alfa-2b in patients with chronic hepatitis C. World J Gastroenterol 2005; 11: 1769–1774.
  Article CAS PubMed PubMed Central Google Scholar
• Reichenberg A, Gorman JM, Dieterich DT . Interferon-induced depression and cognitive impairment in hepatitis C virus patients: a 72 week prospective study. AIDS 2005; 19 (Suppl 3): S174–S178.
  Article CAS PubMed Google Scholar
• Andreasson A, Arborelius L, Erlanson-Albertsson C, Lekander M . A putative role for cytokines in the impaired appetite in depression. Brain Behav Immun 2007; 21: 147–152.
  Article CAS PubMed Google Scholar
• Maier SF, Watkins LR . Cytokines for psychologists: implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition. Psychol Rev 1998; 105: 83–107.
  Article CAS PubMed Google Scholar
• Yirmiya R, Weidenfeld J, Pollak Y, Morag M, Morag A, Avitsur R et al. Cytokines, “depression due to a general medical condition,” and antidepressant drugs. Adv Exper Med Biol 1999; 461: 283–316.
  Article CAS Google Scholar
• Hayley S, Merali Z, Anisman H . Stress and cytokine-elicited neuroendocrine and neurotransmitter sensitization: implications for depressive illness. Stress 2003; 6: 19–32.
  Article CAS PubMed Google Scholar
• Gibb J, Audet MC, Hayley S, Anisman H . Neurochemical and behavioral responses to inflammatory immune stressors. Front Biosci (Schol Ed) 2009; 1: 275–295.
  Article Google Scholar
• Maes M, Yirmyia R, Noraberg J, Brene S, Hibbeln J, Perini G et al. The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression. Metab Brain Dis 2009; 24: 27–53.
  Article CAS PubMed Google Scholar
• Simon GE, Ludman EJ, Linde JA, Operskalski BH, Ichikawa L, Rohde P et al. Association between obesity and depression in middle-aged women. Gen Hosp Psychiatry 2008; 30: 32–39.
  Article PubMed PubMed Central Google Scholar
• Simon GE, Von Korff M, Saunders K, Miglioretti DL, Crane PK, van Belle G et al. Association between obesity and psychiatric disorders in the US adult population. Arch Gen Psychiatry 2006; 63: 824–830.
  Article PubMed PubMed Central Google Scholar
• Miller GE, Freedland KE, Carney RM, Stetler CA, Banks WA . Pathways linking depression, adiposity, and inflammatory markers in healthy young adults. Brain Behav Immun 2003; 17: 276–285.
  Article CAS PubMed Google Scholar
• Lampert R, Bremner JD, Su S, Miller A, Lee F, Cheema F et al. Decreased heart rate variability is associated with higher levels of inflammation in middle-aged men. Am Heart J 2008; 156: 759 e751–757.
  Article PubMed PubMed Central Google Scholar
• Ranjit N, Diez-Roux AV, Shea S, Cushman M, Seeman T, Jackson SA et al. Psychosocial factors and inflammation in the multi-ethnic study of atherosclerosis. Arch Int Med 2007; 167: 174–181.
  Article Google Scholar
• Kloiber S, Ising M, Reppermund S, Horstmann S, Dose T, Majer M et al. Overweight and obesity affect treatment response in major depression. Biol Psychiatry 2007; 62: 321–326.
  Article PubMed Google Scholar
• Himmerich H, Fulda S, Linseisen J, Seiler H, Wolfram G, Himmerich S et al. TNF-alpha, soluble TNF receptor and interleukin-6 plasma levels in the general population. Eur Cytokine Network 2006; 17: 196–201.
  CAS Google Scholar
• Suarez EC . C-reactive protein is associated with psychological risk factors of cardiovascular disease in apparently healthy adults. Psychosom Med 2004; 66: 684–691.
  Article CAS PubMed Google Scholar
• Douglas KM, Taylor AJ, O'Malley PG . Relationship between depression and C-reactive protein in a screening population. Psychosom Med 2004; 66: 679–683.
  Article CAS PubMed Google Scholar
• Roberts RE, Deleger S, Strawbridge WJ, Kaplan GA . Prospective association between obesity and depression: evidence from the Alameda County Study. Int J Obes Relat Metab Disord 2003; 27: 514–521.
  Article CAS PubMed Google Scholar
• Pine DS, Goldstein RB, Wolk S, Weissman MM . The association between childhood depression and adulthood body mass index. Pediatrics 2001; 107: 1049–1056.
  Article CAS PubMed Google Scholar
• Kern PA, Ranganathan S, Li C, Wood L, Ranganathan G . Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab 2001; 280: E745–E751.
  Article CAS PubMed Google Scholar
• Katz JR, Taylor NF, Goodrick S, Perry L, Yudkin JS, Coppack SW . Central obesity, depression and the hypothalamo-pituitary-adrenal axis in men and postmenopausal women. Int J Obesity Related Metab Disord 2000; 24: 246–251.
  Article CAS Google Scholar
• Haack M, Hinze-Selch D, Fenzel T, Kraus T, Kuhn M, Schuld A et al. Plasma levels of cytokines and soluble cytokine receptors in psychiatric patients upon hospital admission: effects of confounding factors and diagnosis. J Psychiatr Res 1999; 33: 407–418.
  Article CAS PubMed Google Scholar
• Vieira VJ, Valentine RJ, McAuley E, Evans E, Woods JA . Independent relationship between heart rate recovery and C-reactive protein in older adults. J Am Geriat Soc 2007; 55: 747–751.
  Article PubMed Google Scholar
• Moyna NM, Bodnar JD, Goldberg HR, Shurin MS, Robertson RJ, Rabin BS . Relation between aerobic fitness level and stress induced alterations in neuroendocrine and immune function. Int J Sports Med 1999; 20: 136–141.
  Article CAS PubMed Google Scholar
• Kohut ML, McCann DA, Russell DW, Konopka DN, Cunnick JE, Franke WD et al. Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of beta-blockers, BMI, and psychosocial factors in older adults. Brain Behav Immun 2006; 20: 201–209.
  Article CAS PubMed Google Scholar
• Balducci S, Zanuso S, Nicolucci A, Fernando F, Cavallo S, Cardelli P et al. Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss. Nutr Metab Cardiovasc Dis 2010; 20: 608–617.
  Article CAS PubMed Google Scholar
• Ghosh S, Khazaei M, Moien-Afshari F, Ang LS, Granville DJ, Verchere CB et al. Moderate exercise attenuates caspase-3 activity, oxidative stress, and inhibits progression of diabetic renal disease in db/db mice. Am J Physiol Renal Physiol 2009; 296: F700–F708.
  Article CAS PubMed PubMed Central Google Scholar
• Anton SD, Newton Jr RL, Sothern M, Martin CK, Stewart TM, Williamson DA . Association of depression with body mass index, sedentary behavior, and maladaptive eating attitudes and behaviors in 11 to 13-year old children. Eat Weight Disord 2006; 11: e102–e108.
  Article CAS PubMed Google Scholar
• Colditz GA . Economic costs of obesity and inactivity. Med Sci Sports Exerc 1999; 31: S663–S667.
  Article CAS PubMed Google Scholar
• Rajala U, Uusimaki A, Keinanen-Kiukaanniemi S, Kivela SL . Prevalence of depression in a 55-year-old Finnish population. Soc Psychiatry Psychiatr Epidemiol 1994; 29: 126–130.
  CAS PubMed Google Scholar
• Tanskanen A, Hibbeln JR, Tuomilehto J, Uutela A, Haukkala A, Viinamaki H et al. Fish consumption and depressive symptoms in the general population in Finland. Psychiatr Serv 2001; 52: 529–531.
  Article CAS PubMed Google Scholar
• Maes M, Christophe A, Delanghe J, Altamura C, Neels H, Meltzer HY . Lowered omega3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients. Psychiatry Res 1999; 85: 275–291.
  Article CAS PubMed Google Scholar
• Maes M, Smith R, Christophe A, Cosyns P, Desnyder R, Meltzer H . Fatty acid composition in major depression: decreased omega 3 fractions in cholesteryl esters and increased C20: 4 omega 6/C20:5 omega 3 ratio in cholesteryl esters and phospholipids. J Affect Disord 1996; 38: 35–46.
  Article CAS PubMed Google Scholar
• Williams LL, Kiecolt-Glaser JK, Horrocks LA, Hillhouse JT, Glaser R . Quantitative association between altered plasma esterified omega-6 fatty acid proportions and psychological stress. Prostaglandins Leukot Essent Fatty Acids 1992; 47: 165–170.
  Article CAS PubMed Google Scholar
• Dai J, Miller AH, Bremner JD, Goldberg J, Jones L, Shallenberger L et al. Adherence to the mediterranean diet is inversely associated with circulating interleukin-6 among middle-aged men: a twin study. Circulation 2008; 117: 169–175.
  Article CAS PubMed Google Scholar
• Zampelas A, Panagiotakos DB, Pitsavos C, Das UN, Chrysohoou C, Skoumas Y et al. Fish consumption among healthy adults is associated with decreased levels of inflammatory markers related to cardiovascular disease: the ATTICA study. J Am Coll Cardiol 2005; 46: 120–124.
  Article CAS PubMed Google Scholar
• Chrysohoou C, Panagiotakos DB, Pitsavos C, Das UN, Stefanadis C . Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults: The ATTICA Study. J Am Coll Cardiol 2004; 44: 152–158.
  Article PubMed Google Scholar
• Westover AN, Marangell LB . A cross-national relationship between sugar consumption and major depression? Depress Anxiety 2002; 16: 118–120.
  Article PubMed Google Scholar
• O'Keefe JH, Gheewala NM, O'Keefe JO . Dietary strategies for improving post-prandial glucose, lipids, inflammation, and cardiovascular health. J Am Coll Cardiol 2008; 51: 249–255.
  Article CAS PubMed Google Scholar
• Schulze MB, Hoffmann K, Manson JE, Willett WC, Meigs JB, Weikert C et al. Dietary pattern, inflammation, and incidence of type 2 diabetes in women. Am J Clin Nutr 2005; 82: 675–684; quiz 714–715.
  Article CAS PubMed Google Scholar
• Lee O, Bruce WR, Dong Q, Bruce J, Mehta R, O'Brien PJ . Fructose and carbonyl metabolites as endogenous toxins. Chem Biol Interact 2009; 178: 332–339.
  Article CAS PubMed Google Scholar
• O'Connor MF, Bower JE, Cho HJ, Creswell JD, Dimitrov S, Hamby ME et al. To assess, to control, to exclude: effects of biobehavioral factors on circulating inflammatory markers. Brain Behav Immun 2009; 23: 887–897.
  Article CAS PubMed PubMed Central Google Scholar
• Ford DE, Kamerow DB . Epidemiologic study of sleep disturbances and psychiatric disorders. An opportunity for prevention? JAMA 1989; 262: 1479–1484.
  Article CAS PubMed Google Scholar
• Livingston G, Blizard B, Mann A . Does sleep disturbance predict depression in elderly people? A study in inner London. Brit J Gen Pract 1993; 43: 445–448.
  CAS Google Scholar
• Breslau N, Roth T, Rosenthal L, Andreski P . Sleep disturbance and psychiatric disorders: a longitudinal epidemiological study of young adults. Biol Psychiatry 1996; 39: 411–418.
  Article CAS PubMed Google Scholar
• Gillin JC . Are sleep disturbances risk factors for anxiety, depressive and addictive disorders? Acta Psychiatr Scand Suppl 1998; 393: 39–43.
  Article CAS PubMed Google Scholar
• Irwin MR, Wang M, Ribeiro D, Cho HJ, Olmstead R, Breen EC et al. Sleep loss activates cellular inflammatory signaling. Biol Psychiatry 2008; 64: 538–540.
  Article CAS PubMed PubMed Central Google Scholar
• McDade TW, Hawkley LC, Cacioppo JT . Psychosocial and behavioral predictors of inflammation in middle-aged and older adults: the Chicago health, aging, and social relations study. Psychosom Med 2006; 68: 376–381.
  Article PubMed Google Scholar
• Irwin MR, Wang M, Campomayor CO, Collado-Hidalgo A, Cole S . Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation. Arch Int Med 2006; 166: 1756–1762.
  Article CAS Google Scholar
• Meier-Ewert HK, Ridker PM, Rifai N, Regan MM, Price NJ, Dinges DF et al. Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. J Am Coll Cardiol 2004; 43: 678–683.
  Article CAS PubMed Google Scholar
• Friedman EM, Hayney MS, Love GD, Urry HL, Rosenkranz MA, Davidson RJ et al. Social relationships, sleep quality, and interleukin-6 in aging women. Proc Natl Acad Sci USA 2005; 102: 18757–18762.
  Article CAS PubMed PubMed Central Google Scholar
• Irwin M, Rinetti G, Redwine L, Motivala S, Dang J, Ehlers C . Nocturnal proinflammatory cytokine-associated sleep disturbances in abstinent African American alcoholics. Brain Behav Immun 2004; 18: 349–360.
  Article CAS PubMed Google Scholar
• Vgontzas AN, Zoumakis M, Papanicolaou DA, Bixler EO, Prolo P, Lin HM et al. Chronic insomnia is associated with a shift of interleukin-6 and tumor necrosis factor secretion from nighttime to daytime. Metab Clin Exper 2002; 51: 887–892.
  Article CAS Google Scholar
• Redwine L, Hauger RL, Gillin JC, Irwin M . Effects of sleep and sleep deprivation on interleukin-6, growth hormone, cortisol, and melatonin levels in humans. J Clin Endocrinol Metab 2000; 85: 3597–3603.
  CAS PubMed Google Scholar
• Saules KK, Pomerleau CS, Snedecor SM, Mehringer AM, Shadle MB, Kurth C et al. Relationship of onset of cigarette smoking during college to alcohol use, dieting concerns, and depressed mood: results from the Young Women's Health Survey. Addict Behav 2004; 29: 893–899.
  Article PubMed Google Scholar
• Lenz BK . Tobacco, depression, and lifestyle choices in the pivotal early college years. J Am Coll Health 2004; 52: 213–219.
  Article PubMed Google Scholar
• Handwerker WP . Cultural diversity, stress, and depression: working women in the Americas. J Women Health Gend Based Med 1999; 8: 1303–1311.
  Article CAS Google Scholar
• Moussavi S, Chatterji S, Verdes E, Tandon A, Patel V, Ustun B . Depression, chronic diseases, and decrements in health: results from the World Health Surveys. Lancet 2007; 370: 851–858.
  Article PubMed Google Scholar
• Brown GW, Harris TO, Hepworth C . Life events and endogenous depression. A puzzle reexamined. Arch Gen Psychiat 1994; 51: 525–534.
  Article CAS PubMed Google Scholar
• Kendler KS, Thornton LM, Gardner CO . Stressful life events and previous episodes in the etiology of major depression in women: an evaluation of the “kindling” hypothesis. Am J Psychiatry 2000; 157: 1243–1251.
  Article CAS PubMed Google Scholar
• DiPietro LA . Wound healing: the role of the macrophage and other immune cells. Shock 1995; 4: 233–240.
  Article CAS PubMed Google Scholar
• Ross SR, Bloomsmith MA, Bettinger TL, Wagner KE . The influence of captive adolescent male chimpanzees on wounding: management and welfare implications. Zoo Biol 2009; 28: 623–634.
  Article CAS PubMed Google Scholar
• Eshed V, Gopher A, Pinhasi R, Hershkovitz I . Paleopathology and the origin of agriculture in the Levant. Am J Phys Anthropol 2010; 143: 121–133.
  Article PubMed Google Scholar
• Pinker S . The Better Angels of Our Nature: Why Violence Has Declined. Viking Adult: New York, NY, 2011.
  Google Scholar
• Dhabhar FS . Enhancing versus suppressive effects of stress on immune function: implications for immunoprotection and immunopathology. Neuroimmunomodulation 2009; 16: 300–317.
  Article CAS PubMed PubMed Central Google Scholar
• Herbert TB, Cohen S . Stress and immunity in humans: a meta-analytic review. Psychosom Med 1993; 55: 364–379.
  Article CAS PubMed Google Scholar
• Bailey MT, Kinsey SG, Padgett DA, Sheridan JF, Leblebicioglu B . Social stress enhances IL-1beta and TNF-alpha production by Porphyromonas gingivalis lipopolysaccharide-stimulated CD11b+ cells. Physiol Behav 2009; 98: 351–358.
  Article CAS PubMed PubMed Central Google Scholar
• Pace TW, Mletzko TC, Alagbe O, Musselman DL, Nemeroff CB, Miller AH et al. Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress. Am J Psychiatry 2006; 163: 1630–1633.
  Article PubMed Google Scholar
• Powell ND, Mays JW, Bailey MT, Hanke ML, Sheridan JF . Immunogenic dendritic cells primed by social defeat enhance adaptive immunity to influenza A virus. Brain Behav Immun 2011; 25: 46–52.
  Article CAS PubMed Google Scholar
• Mays JW, Bailey MT, Hunzeker JT, Powell ND, Papenfuss T, Karlsson EA et al. Influenza virus-specific immunological memory is enhanced by repeated social defeat. J Immunol 2010; 184: 2014–2025.
  Article CAS PubMed Google Scholar
• Steptoe A, Hamer M, Chida Y . The effect of acute psychological stress on circulating inflammatory factors in humans: a review and meta-analysis. Brain Behav Immun 2007; 7: 901–912.
  Article CAS Google Scholar
• Bierhaus A, Wolf J, Andrassy M, Rohleder N, Humpert PM, Petrov D et al. A mechanism converting psychosocial stress into mononuclear cell activation. Proc Natl Acad Sci USA 2003; 100: 1920–1925.
  Article CAS PubMed PubMed Central Google Scholar
• Avitsur R, Kavelaars A, Heijnen C, Sheridan JF . Social stress and the regulation of tumor necrosis factor-alpha secretion. Brain Behav Immun 2005; 19: 311–317.
  Article CAS PubMed Google Scholar
• Quan N, Avitsur R, Stark JL, He L, Shah M, Caligiuri M et al. Social stress increases the susceptibility to endotoxic shock. J Neuroimmunol 2001; 115: 36–45.
  Article CAS PubMed Google Scholar
• Rosenberger PH, Ickovics JR, Epel E, Nadler E, Jokl P, Fulkerson JP et al. Surgical stress-induced immune cell redistribution profiles predict short-term and long-term postsurgical recovery. A prospective study. J Bone Joint Surg Am 2009; 91: 2783–2794.
  Article PubMed PubMed Central Google Scholar
• Joachim RA, Handjiski B, Blois SM, Hagen E, Paus R, Arck PC . Stress-induced neurogenic inflammation in murine skin skews dendritic cells towards maturation and migration: key role of intercellular adhesion molecule-1/leukocyte function-associated antigen interactions. Am J Pathol 2008; 173: 1379–1388.
  Article PubMed PubMed Central Google Scholar
• Viswanathan K, Daugherty C, Dhabhar FS . Stress as an endogenous adjuvant: augmentation of the immunization phase of cell-mediated immunity. Int Immunol 2005; 17: 1059–1069.
  Article CAS PubMed Google Scholar
• Miller GE, Chen E . Harsh family climate in early life presages the emergence of a proinflammatory phenotype in adolescence. Psychol Sci 2010; 21: 848–856.
  Article PubMed Google Scholar
• Danese A, Moffitt TE, Pariante CM, Ambler A, Poulton R, Caspi A . Elevated inflammation levels in depressed adults with a history of childhood maltreatment. Arch Gen Psychiatry 2008; 65: 409–415.
  Article PubMed PubMed Central Google Scholar
• Miller GE, Rohleder N, Cole SW . Chronic interpersonal stress predicts activation of pro- and anti-inflammatory signaling pathways 6 months later. Psychosom Med 2009; 71: 57–62.
  Article PubMed Google Scholar
• Miller GE, Chen E, Sze J, Marin T, Arevalo JM, Doll R et al. A functional genomic fingerprint of chronic stress in humans: blunted glucocorticoid and increased NF-kappaB signaling. Biol Psychiatry 2008; 64: 266–272.
  Article CAS PubMed PubMed Central Google Scholar
• Miller GE, Chen E, Parker KJ . Psychological stress in childhood and susceptibility to the chronic diseases of aging: moving toward a model of behavioral and biological mechanisms. Psychol Bull 2011; 137: 959–997.
  Article PubMed PubMed Central Google Scholar
• Kiecolt-Glaser JK, Preacher KJ, MacCallum RC, Atkinson C, Malarkey WB, Glaser R . Chronic stress and age-related increases in the proinflammatory cytokine IL-6. Proc Natl Acad Sci USA 2003; 100: 9090–9095.
  Article CAS PubMed PubMed Central Google Scholar
• Nesse RM . The smoke detector principle. Natural selection and the regulation of defensive responses. Ann NY Acad Sci 2001; 935: 75–85.
  Article CAS PubMed Google Scholar
• Kiecolt-Glaser JK . Stress, food, and inflammation: psychoneuroimmunology and nutrition at the cutting edge. Psychosom Med 2010; 72: 365–369.
  Article CAS PubMed PubMed Central Google Scholar
• Haroon E, Raison CL, Miller AH . Psychoneuroimmunology meets neuropsychopharmacol: translational implications of the impact of inflammation on behavior. Neuropsychopharmacology 2012; 37: 137–162.
  Article CAS PubMed Google Scholar
• Irwin MR, Cole SW . Reciprocal regulation of the neural and innate immune systems. Nat Rev Immunol 2011; 11: 625–632.
  Article CAS PubMed PubMed Central Google Scholar
• Leutscher PD, Lagging M, Buhl MR, Pedersen C, Norkrans G, Langeland N et al. Evaluation of depression as a risk factor for treatment failure in chronic hepatitis C. Hepatology 2010; 52: 430–435.
  Article CAS PubMed Google Scholar
• Raison CL, Broadwell SD, Borisov AS, Manatunga AK, Woolwine BJ, Jacobson IM et al. Depressive symptoms and viral clearance in patients receiving interferon-alpha and ribavirin for hepatitis C. Brain Behav Immun 2005; 19: 23–27.
  Article CAS PubMed Google Scholar
• Doering LV, Martinez-Maza O, Vredevoe DL, Cowan MJ . Relation of depression, natural killer cell function, and infections after coronary artery bypass in women. Eur J Cardiovasc Nurs 2008; 7: 52–58.
  Article PubMed Google Scholar
• Faulkner S, Smith A . A longitudinal study of the relationship between psychological distress and recurrence of upper respiratory tract infections in chronic fatigue syndrome. Br J Health Psychol 2008; 13: 177–186.
  Article PubMed Google Scholar
• Cruess DG, Petitto JM, Leserman J, Douglas SD, Gettes DR, Ten Have TR et al. Depression and HIV infection: impact on immune function and disease progression. CNS Spectr 2003; 8: 52–58.
  Article PubMed Google Scholar
• Leserman J . Role of depression, stress, and trauma in HIV disease progression. Psychosom Med 2008; 70: 539–545.
  Article PubMed Google Scholar
• Evans DL, Ten Have TR, Douglas SD, Gettes DR, Morrison M, Chiappini MS et al. Association of depression with viral load, CD8T lymphocytes, and natural killer cells in women with HIV infection. Am J Psychiatry 2002; 159: 1752–1759.
  Article PubMed Google Scholar
• Zorrilla EP, McKay JR, Luborsky L, Schmidt K . Relation of stressors and depressive symptoms to clinical progression of viral illness. Am J Psychiatry 1996; 153: 626–635.
  Article CAS PubMed Google Scholar
• Herbert TB, Cohen S . Depression and immunity: a meta-analytic review. Psychol Bull 1993; 113: 472–486.
  Article CAS PubMed Google Scholar
• Castilla-Cortazar I, Castilla A, Gurpegui M . Opioid peptides and immunodysfunction in patients with major depression and anxiety disorders. J Physiol Biochem 1998; 54: 203–215.
  CAS PubMed Google Scholar
• Blume J, Douglas SD, Evans DL . Immune suppression and immune activation in depression. Brain Behav Immun 2011; 25: 221–229.
  Article CAS PubMed Google Scholar
• Vaknin I, Blinder L, Wang L, Gazit R, Shapira E, Genina O et al. A common pathway mediated through Toll-like receptors leads to T- and natural killer-cell immunosuppression. Blood 2008; 111: 1437–1447.
  Article CAS PubMed Google Scholar
• Moraska A, Campisi J, Nguyen KT, Maier SF, Watkins LR, Fleshner M . Elevated IL-1beta contributes to antibody suppression produced by stress. J Appl Physiol 2002; 93: 207–215.
  Article CAS PubMed Google Scholar
• Cope AP, Liblau RS, Yang XD, Congia M, Laudanna C, Schreiber RD et al. Chronic tumor necrosis factor alters T cell responses by attenuating T cell receptor signaling. J Exp Med 1997; 185: 1573–1584.
  Article CAS PubMed PubMed Central Google Scholar
• Cope AP . Exploring the reciprocal relationship between immunity and inflammation in chronic inflammatory arthritis. Rheumatology (Oxford) 2003; 42: 716–731.
  Article CAS Google Scholar
• Eleftheriadis T, Kartsios C, Yiannaki E, Antoniadi G, Kazila P, Pliakos K et al. Decreased CD3+CD16+ natural killer-like T-cell percentage and zeta-chain expression accompany chronic inflammation in haemodialysis patients. Nephrology (Carlton) 2009; 14: 471–475.
  Article CAS Google Scholar
• Muller AJ, Sharma MD, Chandler PR, Duhadaway JB, Everhart ME, Johnson III BA et al. Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase. Proc Natl Acad Sci USA 2008; 105: 17073–17078.
  Article CAS PubMed PubMed Central Google Scholar
• Clark J, Vagenas P, Panesar M, Cope AP . What does tumour necrosis factor excess do to the immune system long term? Ann Rheum Dis 2005; 64 (Suppl 4): iv70–iv76.
  CAS PubMed PubMed Central Google Scholar
• Doran MF, Crowson CS, Pond GR, O'Fallon WM, Gabriel SE . Frequency of infection in patients with rheumatoid arthritis compared with controls: a population-based study. Arthritis Rheum 2002; 46: 2287–2293.
  Article PubMed Google Scholar
• Armelagos GJ, Brown PJ, Turner B . Evolutionary, historical and political economic perspectives on health and disease. Soc Sci Med 2005; 61: 755–765.
  Article PubMed Google Scholar
• May L, van den Biggelaar AH, van Bodegom D, Meij HJ, de Craen AJ, Amankwa J et al. Adverse environmental conditions influence age-related innate immune responsiveness. Immun Ageing 2009; 6: 7.
  Article CAS PubMed PubMed Central Google Scholar
• Drenos F, Westendorp RG, Kirkwood TB . Trade-off mediated effects on the genetics of human survival caused by increasingly benign living conditions. Biogerontology 2006; 7: 287–295.
  Article PubMed Google Scholar
• Raison CL, Lowry CA, Rook GA . Inflammation, sanitation, and consternation: loss of contact with coevolved, tolerogenic microorganisms and the pathophysiology and treatment of major depression. Arch Gen Psychiatry 2010; 67: 1211–1224.
  Article CAS PubMed PubMed Central Google Scholar
• Joosten KF, de Kleijn ED, Westerterp M, de Hoog M, Eijck FC, Hop WCJ et al. Endocrine and metabolic responses in children with meningoccocal sepsis: striking differences between survivors and nonsurvivors. J Clin Endocrinol Metab 2000; 85: 3746–3753.
  Article CAS PubMed Google Scholar
• Pinto RA, Arredondo SM, Bono MR, Gaggero AA, Diaz PV . T helper 1/T helper 2 cytokine imbalance in respiratory syncytial virus infection is associated with increased endogenous plasma cortisol. Pediatrics 2006; 117: e878–e886.
  Article PubMed Google Scholar
• Gallagher PM, Lowe G, Fitzgerald T, Bella A, Greene CM, McElvaney NG et al. Association of IL-10 polymorphism with severity of illness in community acquired pneumonia. Thorax 2003; 58: 154–156.
  Article CAS PubMed PubMed Central Google Scholar
• Li J, Cowden LG, King JD, Briles DA, Schroeder Jr HW, Stevens AB et al. Effects of chronic stress and interleukin-10 gene polymorphisms on antibody response to tetanus vaccine in family caregivers of patients with Alzheimer's disease. Psychosom Med 2007; 69: 551–559.
  Article CAS PubMed Google Scholar
• Hohler T, Reuss E, Freitag CM, Schneider PM . A functional polymorphism in the IL-10 promoter influences the response after vaccination with HBsAg and hepatitis A. Hepatology 2005; 42: 72–76.
  Article CAS PubMed Google Scholar
• Corsini E, Vismara L, Lucchi L, Viviani B, Govoni S, Galli CL et al. High interleukin-10 production is associated with low antibody response to influenza vaccination in the elderly. J Leukoc Biol 2006; 80: 376–382.
  Article CAS PubMed Google Scholar
• Forte GI, Scola L, Misiano G, Milano S, Mansueto P, Vitale G et al. Relevance of gamma interferon, tumor necrosis factor alpha, and interleukin-10 gene polymorphisms to susceptibility to Mediterranean spotted fever. Clin Vaccine Immunol 2009; 16: 811–815.
  Article CAS PubMed PubMed Central Google Scholar
• Pravica V, Asderakis A, Perrey C, Hajeer A, Sinnott PJ, Hutchinson IV . In vitro production of IFN-gamma correlates with CA repeat polymorphism in the human IFN-gamma gene. Eur J Immunogenet 1999; 26: 1–3.
  Article CAS PubMed Google Scholar
• Pravica V, Perrey C, Stevens A, Lee JH, Hutchinson IV . A single nucleotide polymorphism in the first intron of the human IFN-gamma gene: absolute correlation with a polymorphic CA microsatellite marker of high IFN-gamma production. Hum Immunol 2000; 61: 863–866.
  Article CAS PubMed Google Scholar
• Pacheco AG, Cardoso CC, Moraes MO . IFNG +874T/A, IL10 −1082G/A and TNF −308G/A polymorphisms in association with tuberculosis susceptibility: a meta-analysis study. Hum Genet 2008; 123: 477–484.
  Article CAS PubMed Google Scholar
• Ansari A, Talat N, Jamil B, Hasan Z, Razzaki T, Dawood G et al. Cytokine gene polymorphisms across tuberculosis clinical spectrum in Pakistani patients. PLoS One 2009; 4: e4778.
  Article CAS PubMed PubMed Central Google Scholar
• Cardoso CC, Pereira AC, Brito-de-Souza VN, Dias-Baptista IM, Maniero VC, Venturini J et al. IFNG +874 T>A single nucleotide polymorphism is associated with leprosy among Brazilians. Hum Genet 2010; 128: 481–490.
  Article CAS PubMed Google Scholar
• Chong WP, Ip WK, Tso GH, Ng MW, Wong WH, Law HK et al. The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome. BMC Infect Dis 2006; 6: 82.
  Article CAS PubMed PubMed Central Google Scholar
• Torres OA, Calzada JE, Beraun Y, Morillo CA, Gonzalez A, Gonzalez CI et al. Role of the IFNG +874T/A polymorphism in Chagas disease in a Colombian population. Infect Genet Evol 2010; 10: 682–685.
  Article CAS PubMed PubMed Central Google Scholar
• Gao QJ, Liu DW, Zhang SY, Jia M, Wang LM, Wu LH et al. Polymorphisms of some cytokines and chronic hepatitis B and C virus infection. World J Gastroenterol 2009; 15: 5610–5619.
  Article CAS PubMed PubMed Central Google Scholar
• Yirmiya R, Pollak Y, Barak O, Avitsur R, Ovadia H, Bette M et al. Effects of antidepressant drugs on the behavioral and physiological responses to lipopolysaccharide (LPS) in rodents. Neuropsychopharmacology 2001; 24: 531–544.
  Article CAS PubMed Google Scholar
• Merali Z, Brennan K, Brau P, Anisman H . Dissociating anorexia and anhedonia elicited by interleukin-1beta: antidepressant and gender effects on responding for “free chow” and “earned” sucrose intake. Psychopharmacology (Berl) 2003; 165: 413–418.
  Article CAS Google Scholar
• Dunn AJ, Swiergiel AH . The reductions in sweetened milk intake induced by interleukin-1 and endotoxin are not prevented by chronic antidepressant treatment. Neuroimmunomodulation 2001; 9: 163–169.
  Article CAS PubMed Google Scholar
• Castanon N, Bluthe RM, Dantzer R . Chronic treatment with the atypical antidepressant tianeptine attenuates sickness behavior induced by peripheral but not central lipopolysaccharide and interleukin-1beta in the rat. Psychopharmacology 2001; 154: 50–60.
  Article CAS PubMed Google Scholar
• Shen Y, Connor TJ, Nolan Y, Kelly JP, Leonard BE . Differential effect of chronic antidepressant treatments on lipopolysaccharide-induced depressive-like behavioural symptoms in the rat. Life Sci 1999; 65: 1773–1786.
  Article CAS PubMed Google Scholar
• Raison CL, Demetrashvili M, Capuron L, Miller AH . Neuropsychiatric adverse effects of interferon-alpha: recognition and management. CNS Drugs 2005; 19: 105–123.
  Article CAS PubMed PubMed Central Google Scholar
• Capuron L, Fornwalt FB, Knight BT, Harvey PD, Ninan PT, Miller AH . Does cytokine-induced depression differ from idiopathic major depression in medically healthy individuals? J Affect Disord 2009; 119: 181–185.
  Article CAS PubMed PubMed Central Google Scholar
• Raison CL, Woolwine BJ, Demetrashvili MF, Borisov AS, Weinreib R, Staab JP et al. Paroxetine for prevention of depressive symptoms induced by interferon-alpha and ribavirin for hepatitis C. Aliment Pharm Ther 2007; 25: 1163–1174.
  Article CAS Google Scholar
• Kraus MR, Schafer A, Al-Taie O, Scheurlen M . Prophylactic SSRI during interferon alpha re-therapy in patients with chronic hepatitis C and a history of interferon-induced depression. J Viral Hepatitis 2005; 12: 96–100.
  Article CAS Google Scholar
• Kraus MR, Schafer A, Faller H, Csef H, Scheurlen M . Paroxetine for the treatment of interferon-alpha-induced depression in chronic hepatitis C. Aliment Pharm Ther 2002; 16: 1091–1099.
  Article CAS Google Scholar
• Hauser P, Khosla J, Aurora H, Laurin J, Kling MA, Hill J et al. A prospective study of the incidence and open-label treatment of interferon-induced major depressive disorder in patients with hepatitis C. Mol Psychiatry 2002; 7: 942–947.
  Article CAS PubMed Google Scholar
• Wichers MC, Koek GH, Robaeys G, Praamstra AJ, Maes M . Early increase in vegetative symptoms predicts IFN-alpha-induced cognitive-depressive changes. Psychol Med 2005; 35: 433–441.
  Article CAS PubMed Google Scholar
• Eisenberger NI, Berkman ET, Inagaki TK, Rameson LT, Mashal NM, Irwin MR . Inflammation-induced anhedonia: endotoxin reduces ventral striatum responses to reward. Biol Psychiatry 2010; 68: 748–754.
  Article CAS PubMed PubMed Central Google Scholar
• Harrison NA, Brydon L, Walker C, Gray MA, Steptoe A, Critchley HD . Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivity. Biol Psychiatry 2009; 66: 407–414.
  Article PubMed PubMed Central Google Scholar
• Raison CL, Rye DB, Woolwine BJ, Vogt GJ, Bautista BM, Spivey JR et al. Chronic interferon-alpha administration disrupts sleep continuity and depth in patients with Hepatitis C: association with fatigue, motor slowing, and increased evening cortisol. Biol Psychiatry 2010; 68: 942–949.
  Article CAS PubMed PubMed Central Google Scholar
• Raison CL, Dantzer R, Kelley KW, Lawson MA, Woolwine BJ, Vogt G et al. CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression. Mol Psychiatry 2010; 15: 393–403.
  Article CAS PubMed Google Scholar
• Raison CL, Borisov AS, Woolwine BJ, Massung B, Vogt G, Miller AH . Interferon-alpha effects on diurnal hypothalamic-pituitary-adrenal axis activity: relationship with proinflammatory cytokines and behavior. Mol Psychiatry 2010; 15: 535–547.
  Article CAS PubMed Google Scholar
• Raison CL, Borisov AS, Majer M, Drake DF, Pagnoni G, Woolwine BJ et al. Activation of central nervous system inflammatory pathways by interferon-alpha: relationship to monoamines and depression. Biol Psychiatry 2009; 65: 296–303.
  Article CAS PubMed Google Scholar
• Capuron L, Pagnoni G, Demetrashvili MF, Lawson DH, Fornwalt FB, Woolwine BJ et al. Basal ganglia hypermetabolism and symptoms of fatigue during interferon-alpha therapy. Neuropsychopharmacology 2007; 32: 2384–2392.
  Article CAS PubMed Google Scholar
• Capuron L, Pagnoni G, Demetrashvili M, Woolwine BJ, Nemeroff CB, Berns GS et al. Anterior cingulate activation and error processing during interferon-alpha treatment. Biol Psychiatry 2005; 58: 190–196.
  Article CAS PubMed PubMed Central Google Scholar
• Hanff TC, Furst SJ, Minor TR . Biochemical and anatomical substrates of depression and sickness behavior. Isr J Psychiatry Relat Sci 2010; 47: 64–71.
  PubMed Google Scholar
• Hart BL . Biological basis of the behavior of sick animals. Neurosci Biobehav Rev 1988; 12: 123–137.
  Article CAS PubMed Google Scholar
• Hart BL . Behavioral adaptations to pathogens and parasites: five strategies. Neurosci Biobehav Rev 1990; 14: 273–294.
  Article CAS PubMed Google Scholar
• Kluger MJ . Phylogeny of fever. Fed Proc 1979; 38: 30–34.
  CAS PubMed Google Scholar
• Kluger MJ, Kozak W, Conn CA, Leon LR, Soszynski D . Role of fever in disease. Ann NY Acad Sci 1998; 856: 224–233.
  Article CAS PubMed Google Scholar
• Sweet C, Cavanagh D, Collie MH, Smith H . Sensitivity to pyrexial temperatures: a factor contributing to virulence differences between two clones of influenza virus. Br J Exp Pathol 1978; 59: 373–380.
  CAS PubMed PubMed Central Google Scholar
• Dixon G, Booth C, Price E, Westran R, Turner M, Klein N . Fever as nature's engine. Part of beneficial host response? BMJ 2010; 340: c450.
  Article PubMed Google Scholar
• Tyrrell D, Barrow I, Arthur J . Local hyperthermia benefits natural and experimental common colds. BMJ 1989; 298: 1280–1283.
  Article CAS PubMed PubMed Central Google Scholar
• Ostberg JR, Taylor SL, Baumann H, Repasky EA . Regulatory effects of fever-range whole-body hyperthermia on the LPS-induced acute inflammatory response. J Leukoc Biol 2000; 68: 815–820.
  CAS PubMed Google Scholar
• Jiang Q, Detolla L, Singh IS, Gatdula L, Fitzgerald B, van Rooijen N et al. Exposure to febrile temperature upregulates expression of pyrogenic cytokines in endotoxin-challenged mice. Am J Physiol 1999; 276: R1653–R1660.
  Article CAS PubMed Google Scholar
• Ostberg JR, Dayanc BE, Yuan M, Oflazoglu E, Repasky EA . Enhancement of natural killer (NK) cell cytotoxicity by fever-range thermal stress is dependent on NKG2D function and is associated with plasma membrane NKG2D clustering and increased expression of MICA on target cells. J Leukoc Biol 2007; 82: 1322–1331.
  Article CAS PubMed Google Scholar
• Ostberg JR, Repasky EA . Emerging evidence indicates that physiologically relevant thermal stress regulates dendritic cell function. Cancer Immunol Immunother 2006; 55: 292–298.
  Article PubMed Google Scholar
• Evans SS, Wang WC, Bain MD, Burd R, Ostberg JR, Repasky EA . Fever-range hyperthermia dynamically regulates lymphocyte delivery to high endothelial venules. Blood 2001; 97: 2727–2733.
  Article CAS PubMed Google Scholar
• Swenson BR, Hedrick TL, Popovsky K, Pruett TL, Sawyer RG . Is fever protective in surgical patients with bloodstream infection? J Am Coll Surg 2007; 204: 815–821; discussion 822–823.
  Article PubMed Google Scholar
• Mizushima Y, Ueno M, Idoguchi K, Ishikawa K, Matsuoka T . Fever in trauma patients: friend or foe? J Trauma 2009; 67: 1062–1065.
  Article PubMed Google Scholar
• Ohsugi Y . Recent advances in immunopathophysiology of interleukin-6: an innovative therapeutic drug, tocilizumab (recombinant humanized anti-human interleukin-6 receptor antibody), unveils the mysterious etiology of immune-mediated inflammatory diseases. Biol Pharm Bull 2007; 30: 2001–2006.
  Article CAS PubMed Google Scholar
• Kung'u JK, Wright VJ, Haji HJ, Ramsan M, Goodman D, Tielsch JM et al. Adjusting for the acute phase response is essential to interpret iron status indicators among young Zanzibari children prone to chronic malaria and helminth infections. J Nutr 2009; 139: 2124–2131.
  Article CAS PubMed Google Scholar
• Cartwright GE, Lauritsen MA et al. The anemia of infection; hypoferremia, hypercupremia, and alterations in porphyrin metabolism in patients. J Clin Invest 1946; 25: 65–80.
  Article CAS PubMed PubMed Central Google Scholar
• Kochan I, Wagner SK, Wasynczuk J . Effect of iron on antibacterial immunity in vaccinated mice. Infect Immun 1984; 43: 543–548.
  CAS PubMed PubMed Central Google Scholar
• Weinberg ED . Survival advantage of the hemochromatosis C282Y mutation. Perspect Biol Med 2008; 51: 98–102.
  Article PubMed Google Scholar
• Foster SL, Richardson SH, Failla ML . Elevated iron status increases bacterial invasion and survival and alters cytokine/chemokine mRNA expression in Caco-2 human intestinal cells. J Nutr 2001; 131: 1452–1458.
  Article CAS PubMed Google Scholar
• Wander K, Shell-Duncan B, McDade TW . Evaluation of iron deficiency as a nutritional adaptation to infectious disease: an evolutionary medicine perspective. Am J Hum Biol 2009; 21: 172–179.
  Article PubMed PubMed Central Google Scholar
• Mitra AK, Akramuzzaman SM, Fuchs GJ, Rahman MM, Mahalanabis D . Long-term oral supplementation with iron is not harmful for young children in a poor community of Bangladesh. J Nutr 1997; 127: 1451–1455.
  Article CAS PubMed Google Scholar
• Smith AW, Hendrickse RG, Harrison C, Hayes RJ, Greenwood BM . The effects on malaria of treatment of iron-deficiency anaemia with oral iron in Gambian children. Ann Trop Paediatr 1989; 9: 17–23.
  Article CAS PubMed Google Scholar
• van den Hombergh J, Dalderop E, Smit Y . Does iron therapy benefit children with severe malaria-associated anaemia? A clinical trial with 12 weeks supplementation of oral iron in young children from the Turiani Division, Tanzania. J Trop Pediatr 1996; 42: 220–227.
  Article CAS PubMed Google Scholar
• Tielsch JM, Khatry SK, Stoltzfus RJ, Katz J, LeClerq SC, Adhikari R et al. Effect of routine prophylactic supplementation with iron and folic acid on preschool child mortality in southern Nepal: community-based, cluster-randomised, placebo-controlled trial. Lancet 2006; 367: 144–152.
  Article CAS PubMed PubMed Central Google Scholar
• Sazawal S, Black RE, Ramsan M, Chwaya HM, Stoltzfus RJ, Dutta A et al. Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial. Lancet 2006; 367: 133–143.
  Article CAS PubMed Google Scholar
• McEnany GW, Lee KA . Effects of light therapy on sleep, mood, and temperature in women with nonseasonal major depression. Issues Ment Health Nurs 2005; 26: 781–794.
  Article PubMed Google Scholar
• Rausch JL, Johnson ME, Corley KM, Hobby HM, Shendarkar N, Fei Y et al. Depressed patients have higher body temperature: 5-HT transporter long promoter region effects. Neuropsychobiology 2003; 47: 120–127.
  Article CAS PubMed Google Scholar
• Szuba MP, Guze BH, Baxter Jr LR . Electroconvulsive therapy increases circadian amplitude and lowers core body temperature in depressed subjects. Biol Psychiatry 1997; 42: 1130–1137.
  Article CAS PubMed Google Scholar
• Daimon K, Yamada N, Tsujimoto T, Takahashi S . Circadian rhythm abnormalities of deep body temperature in depressive disorders. J Affect Disord 1992; 26: 191–198.
  Article CAS PubMed Google Scholar
• Avery DH, Shah SH, Eder DN, Wildschiodtz G . Nocturnal sweating and temperature in depression. Acta Psychiatr Scand 1999; 100: 295–301.
  Article CAS PubMed Google Scholar
• Avery DH, Wildschiodtz G, Smallwood RG, Martin D, Rafaelsen OJ . REM latency and core temperature relationships in primary depression. Acta Psychiatr Scand 1986; 74: 269–280.
  Article CAS PubMed Google Scholar
• Avery DH, Wildschiodtz G, Rafaelsen OJ . Nocturnal temperature in affective disorder. J Affect Disord 1982; 4: 61–71.
  Article CAS PubMed Google Scholar
• Sugahara H, Akamine M, Kondo T, Fujisawa K, Yoshimasu K, Tokunaga S et al. Somatic symptoms most often associated with depression in an urban hospital medical setting in Japan. Psychiatry Res 2004; 128: 305–311.
  Article PubMed Google Scholar
• Rangan AM, Blight GD, Binns CW . Iron status and non-specific symptoms of female students. J Am Coll Nutr 1998; 17: 351–355.
  Article CAS PubMed Google Scholar
• Maes M, Van de Vyvere J, Vandoolaeghe E, Bril T, Demedts P, Wauters A et al. Alterations in iron metabolism and the erythron in major depression: further evidence for a chronic inflammatory process. J Affect Disord 1996; 40: 23–33.
  Article CAS PubMed Google Scholar
• Maes M, Vandewoude M, Scharpe S, De Clercq L, Stevens W, Lepoutre L et al. Anthropometric and biochemical assessment of the nutritional state in depression: evidence for lower visceral protein plasma levels in depression. J Affect Disord 1991; 23: 25–33.
  Article CAS PubMed Google Scholar
• Maes M, Scharpe S, Bosmans E, Vandewoude M, Suy E, Uyttenbroeck W et al. Disturbances in acute phase plasma proteins during melancholia: additional evidence for the presence of an inflammatory process during that illness. Prog Neuropsychopharmacol Biol Psychiatry 1992; 16: 501–515.
  Article CAS PubMed Google Scholar
• Albacar G, Sans T, Martin-Santos R, Garcia-Esteve L, Guillamat R, Sanjuan J et al. An association between plasma ferritin concentrations measured 48 h after delivery and postpartum depression. J Affect Disord 2011; 131: 136–142.
  Article CAS PubMed Google Scholar
• Engel GL, Schmale AH . Conservation-withdrawal: a primary regulatory process for organismic homeostasis. Ciba Found Symp 1972; 8: 57–75.
  CAS PubMed Google Scholar
• Majer M, Wellberg LAM, Capuron L, Pagnoni G, Raison CL, Miller AH . IFN-alpha-induced motor slowing is associated with increased depression and fatigue in patients with chronic hepatitis C. Brain Behav Immun 2008; 25: 870–880.
  Article CAS Google Scholar
• Capuron L, Gumnick JF, Musselman DL, Lawson DH, Reemsnyder A, Nemeroff CB et al. Neurobehavioral effects of interferon-alpha in cancer patients: phenomenology and paroxetine responsiveness of symptom dimensions. Neuropsychopharmacology 2002; 26: 643–652.
  Article CAS PubMed Google Scholar
• Schaller M, Murray DR . Pathogens, personality, and culture: disease prevalence predicts worldwide variability in sociosexuality, extraversion, and openness to experience. J Pers Soc Psychol 2008; 95: 212–221.
  Article PubMed Google Scholar
• Cole SW . The complexity of dynamic host networks. In: Deisboeck TS, Kresh JY (eds). Complex Systems Science in Biomedicine. Springer: New York, NY, 2006, pp 605–629.
  Chapter Google Scholar
• Eisenberger NI, Inagaki TK, Mashal NM, Irwin MR . Inflammation and social experience: an inflammatory challenge induces feelings of social disconnection in addition to depressed mood. Brain Behav Immun 2010; 24: 558–563.
  Article PubMed PubMed Central Google Scholar
• Slavich GM, Way BM, Eisenberger NI, Taylor SE . Neural sensitivity to social rejection is associated with inflammatory responses to social stress. Proc Natl Acad Sci USA 2010; 107: 14817–14822.
  Article CAS PubMed PubMed Central Google Scholar
• Nguyen KB, Biron CA . Synergism for cytokine-mediated disease during concurrent endotoxin and viral challenges: roles for NK and T cell IFN-gamma production. J Immunol 1999; 162: 5238–5246.
  CAS PubMed Google Scholar
• Jakab GJ, Dick EC . Synergistic effect in viral-bacterial infection: combined infection of the murine respiratory tract with Sendai virus and Pasteurella pneumotropica. Infect Immun 1973; 8: 762–768.
  CAS PubMed PubMed Central Google Scholar
• Degre M, Glasgow LA . Synergistic effect in viral-bacterial infection. I. Combined infection of the respiratory tract in mice with parainfluenza virus and Hemophilus influenza. J Infect Dis 1968; 118: 449–462.
  Article CAS PubMed Google Scholar
• Jones WT, Menna JH, Wennerstrom DE . Lethal synergism induced in mice by influenza type A virus and type Ia group B streptococci. Infect Immun 1983; 41: 618–623.
  CAS PubMed PubMed Central Google Scholar
• Beadling C, Slifka MK . How do viral infections predispose patients to bacterial infections? Curr Opin Infect Dis 2004; 17: 185–191.
  Article PubMed Google Scholar
• Molyneux EM, Tembo M, Kayira K, Bwanaisa L, Mweneychanya J, Njobvu A et al. The effect of HIV infection on paediatric bacterial meningitis in Blantyre, Malawi. Arch Dis Child 2003; 88: 1112–1118.
  Article CAS PubMed PubMed Central Google Scholar
• McCullers JA, McAuley JL, Browall S, Iverson AR, Boyd KL, Henriques Normark B . Influenza enhances susceptibility to natural acquisition of and disease due to Streptococcus pneumoniae in ferrets. J Infect Dis 2010; 202: 1287–1295.
  Article PubMed Google Scholar
• Thornhill R, Fincher CL, Aran D . Parasites, democratization, and the liberalization of values across contemporary countries. Biol Rev Camb Philos Soc 2009; 84: 113–131.
  Article PubMed Google Scholar
• Diagnostic and Statistical Manual of Mental Disorders, 4th edn Text Revision: DSM-IV--4--TR. American Psychiatric Association: Washington, DC, 2000.
• Schmidt WD, O'Connor PJ, Cochrane JB, Cantwell M . Resting metabolic rate is influenced by anxiety in college men. J Appl Physiol 1996; 80: 638–642.
  Article CAS PubMed Google Scholar
• Blaza SE, Garrow JS . The effect of anxiety on metabolic rate. Proc Nutr Soc 1980; 39: 13A.
  Article CAS PubMed Google Scholar
• Bonnet MH, Arand DL . Insomnia, metabolic rate and sleep restoration. J Intern Med 2003; 254: 23–31.
  Article CAS PubMed Google Scholar
• Bonnet MH, Arand DL . 24-h metabolic rate in insomniacs and matched normal sleepers. Sleep 1995; 18: 581–588.
  Article CAS PubMed Google Scholar
• Miller GE, Cohen S . Infectious disease and psychoneuroimmunology. In: Vedhara K, Irwin MR (eds). Human Psychoneuroimmunology. Oxford University Press: Oxford, UK, 2005, pp 219–242.
  Chapter Google Scholar
• Constant A, Castera L, Dantzer R, Couzigou P, de Ledinghen V, Demotes-Mainard J et al. Mood alterations during interferon-alfa therapy in patients with chronic hepatitis C: evidence for an overlap between manic/hypomanic and depressive symptoms. J Clin Psychiatry 2005; 66: 1050–1057.
  Article CAS PubMed Google Scholar
• Critchley HD, Mathias CJ, Josephs O, O'Doherty J, Zanini S, Dewar BK et al. Human cingulate cortex and autonomic control: converging neuroimaging and clinical evidence. Brain 2003; 126: 2139–2152.
  Article PubMed Google Scholar
• Eisenberger NI, Lieberman MD, Williams KD . Does rejection hurt? An FMRI study of social exclusion. Science 2003; 302: 290–292.
  Article CAS PubMed Google Scholar
• Brydon L, Harrison NA, Walker C, Steptoe A, Critchley HD . Peripheral inflammation is associated with altered substantia nigra activity and psychomotor slowing in humans. Biol Psychiatry 2008; 63: 1022–1029.
  Article CAS PubMed PubMed Central Google Scholar
• Harrison NA, Brydon L, Walker C, Gray MA, Steptoe A, Dolan RJ et al. Neural origins of human sickness in interoceptive responses to inflammation. Biol Psychiatry 2009; 66: 415–422.
  Article PubMed PubMed Central Google Scholar
• Wing EJ, Barczynski LK, Boehmer SM . Effect of acute nutritional deprivation on immune function in mice. I. Macrophages. Immunol 1983; 48: 543–550.
  CAS Google Scholar
• Murray MJ, Murray AB . Anorexia of infection as a mechanism of host defense. Am J Clin Nutr 1979; 32: 593–596.
  Article CAS PubMed Google Scholar
• Heuer JG, Bailey DL, Sharma GR, Zhang T, Ding C, Ford A et al. Cecal ligation and puncture with total parenteral nutrition: a clinically relevant model of the metabolic, hormonal, and inflammatory dysfunction associated with critical illness. J Surg Res 2004; 121: 178–186.
  Article CAS PubMed Google Scholar
• Sena MJ, Utter GH, Cuschieri J, Maier RV, Tompkins RG, Harbrecht BG et al. Early supplemental parenteral nutrition is associated with increased infectious complications in critically ill trauma patients. J Am Coll Surg 2008; 207: 459–467.
  Article PubMed PubMed Central Google Scholar
• Heyland DK . Parenteral nutrition in the critically-ill patient: more harm than good? Proc Nutr Soc 2000; 59: 457–466.
  Article CAS PubMed Google Scholar
• Casaer MP, Mesotten D, Hermans G, Wouters PJ, Schetz M, Meyfroidt G et al. Early versus late parenteral nutrition in critically ill adults. N Engl J Med 2011; 365: 506–517.
  Article CAS PubMed Google Scholar
• Carter JD, Joyce PR, Mulder RT, Luty SE, McKenzie J . Gender differences in the presentation of depressed outpatients: a comparison of descriptive variables. J Affect Disord 2000; 61: 59–67.
  Article CAS PubMed Google Scholar
• Adamo SA, Fidler TL, Forestell CA . Illness-induced anorexia and its possible function in the caterpillar, Manduca sexta. Brain Behav Immun 2007; 21: 292–300.
  Article CAS PubMed Google Scholar
• Heyland DK, MacDonald S, Keefe L, Drover JW . Total parenteral nutrition in the critically ill patient: a meta-analysis. JAMA 1998; 280: 2013–2019.
  Article CAS PubMed Google Scholar
• Amprey JL, Spath GF, Porcelli SA . Inhibition of CD1 expression in human dendritic cells during intracellular infection with Leishmania donovani. Infect Immun 2004; 72: 589–592.
  Article CAS PubMed PubMed Central Google Scholar
• Roura-Mir C, Wang L, Cheng TY, Matsunaga I, Dascher CC, Peng SL et al. Mycobacterium tuberculosis regulates CD1 antigen presentation pathways through TLR-2. J Immunol 2005; 175: 1758–1766.
  Article CAS PubMed Google Scholar
• Raison CL, Miller AH . Is depression an inflammatory disorder? Curr Psychiatry Rep 2011; 13: 467–475.
  Article PubMed PubMed Central Google Scholar
• Nesse RM . Is depression an adaptation? Arch Gen Psychiatry 2000; 57: 14–20.
  Article CAS PubMed Google Scholar
• Sloman L, Gilbert P, Hasey G . Evolved mechanisms in depression: the role and interaction of attachment and social rank in depression. J Affect Disord 2003; 74: 107–121.
  Article CAS PubMed Google Scholar
• Andrews PW, Thomson Jr JA . The bright side of being blue: depression as an adaptation for analyzing complex problems. Psychol Rev 2009; 116: 620–654.
  Article PubMed PubMed Central Google Scholar
• Raison CL, Miller AH . When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. Am J Psychiatry 2003; 160: 1554–1565.
  Article PubMed Google Scholar
• Norbiato G, Bevilacqua M, Vago T, Taddei A, Clerici M . Glucocorticoids and the immune function in the human immunodeficiency virus infection: a study in hypercortisolemic and cortisol-resistant patients. J Clin Endocrinol Metab 1997; 82: 3260–3263.
  CAS PubMed Google Scholar
• Huff GR, Huff WE, Balog JM, Rath NC . The effects of behavior and environmental enrichment on disease resistance of turkeys. Brain Behav Immun 2003; 17: 339–349.
  Article CAS PubMed Google Scholar
• Schaller M . The behavioural immune system and the psychology of human sociality. Philos Trans R Soc London B Biol Sci 2011; 366: 3418–3426.
  Article PubMed PubMed Central Google Scholar
• Fincher CL, Thornhill R, Murray DR, Schaller M . Pathogen prevalence predicts human cross-cultural variability in individualism/collectivism. Proc Biol Sci 2008; 275: 1279–1285.
  Article PubMed PubMed Central Google Scholar
• Kim YK, Suh IB, Kim H, Han CS, Lim CS, Choi SH et al. The plasma levels of interleukin-12 in schizophrenia, major depression, and bipolar mania: effects of psychotropic drugs. Mol Psychiatry 2002; 7: 1107–1114.
  Article CAS PubMed Google Scholar
• Foster R, Kandanearatchi A, Beasley C, Williams B, Khan N, Fagerhol MK et al. Calprotectin in microglia from frontal cortex is up-regulated in schizophrenia: evidence for an inflammatory process? Eur J Neurosci 2006; 24: 3561–3566.
  Article PubMed Google Scholar
• Weigelt K, Carvalho LA, Drexhage RC, Wijkhuijs A, de Wit H, van Beveren NJ et al. TREM-1 and DAP12 expression in monocytes of patients with severe psychiatric disorders. EGR3, ATF3 and PU.1 as important transcription factors. Brain Behav Immun 2011; 25: 1162–1169.
  Article CAS PubMed Google Scholar
• Maes M, Delange J, Ranjan R, Meltzer HY, Desnyder R, Cooremans W et al. Acute phase proteins in schizophrenia, mania and major depression: modulation by psychotropic drugs. Psychiatry Res 1997; 66: 1–11.
  Article CAS PubMed Google Scholar