A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl (original) (raw)
Yeaman, C., Grindstaff, K.K., Hansen, M.D. & Nelson, W.J. Cell polarity: versatile scaffolds keep things in place. Curr. Biol.9, R515–R517 (1999). ArticleCAS Google Scholar
Ohno, S. Intercellular junctions and cellular polarity: the PAR–aPKC complex, a conserved core cassette playing fundamental roles in cell polarity. Curr. Opin. Cell Biol.13, 641–648 (2001). ArticleCAS Google Scholar
Tepass, U., Tanentzapf, G., Ward, R. & Fehon, R. Epithelial cell polarity and cell junctions in Drosophila. Annu. Rev. Genet.35, 747–784 (2001). ArticleCAS Google Scholar
Guo, S. & Kemphues, K.J. Molecular genetics of asymmetric cleavage in the early Caenorhabditis elegans embryo. Curr. Opin. Genet. Dev.6, 408–415 (1996). ArticleCAS Google Scholar
Tabuse, Y. et al. Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans. Development125, 3607–3614 (1998). CASPubMed Google Scholar
Hung, T.J. & Kemphues, K.J. PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos. Development126, 127–135 (1999). CASPubMed Google Scholar
Wodarz, A., Ramrath, A., Grimm, A. & Knust, E. Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts. J. Cell Biol.150, 1361–1374 (2000). ArticleCAS Google Scholar
Petronczki, M. & Knoblich, J.A. DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila. Nature Cell Biol.3, 43–49 (2001). ArticleCAS Google Scholar
Gao, L., Joberty, G. & Macara, I.G. Assembly of epithelial tight junctions is negatively regulated by Par6. Curr. Biol.12, 221–225 (2002). ArticleCAS Google Scholar
Hirose, T. et al. Involvement of ASIP/PAR-3 in the promotion of epithelial tight junction formation. J. Cell Sci.115, 2485–2495 (2002). CASPubMed Google Scholar
Yamanaka, T. et al. PAR-6 regulates aPKC activity in a novel way and mediates cell–cell contact-induced formation of the epithelial junctional complex. Genes Cells6, 721–731 (2001). ArticleCAS Google Scholar
Suzuki, A. et al. Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia- specific junctional structures. J. Cell Biol.152, 1183–1196 (2001). ArticleCAS Google Scholar
Johansson, A., Driessens, M. & Aspenstrom, P. The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1. J. Cell Sci.113, 3267–3275 (2000). CASPubMed Google Scholar
Joberty, G., Petersen, C., Gao, L. & Macara, I.G. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nature Cell Biol.2, 531–539 (2000). ArticleCAS Google Scholar
Horne-Badovinac, S. et al. Positional cloning of heart and soul reveals multiple roles for PKC lambda in zebrafish organogenesis. Curr. Biol.11, 1492–1502 (2001). ArticleCAS Google Scholar
Peterson, R.T., Mably, J.D., Chen, J.N. & Fishman, M.C. Convergence of distinct pathways to heart patterning revealed by the small molecule concentramide and the mutation heart-and-soul. Curr. Biol.11, 1481–1491 (2001). ArticleCAS Google Scholar
Ponting, C.P. et al. OPR, PC and AID: all in the PB1 family. Trends Biochem. Sci.27, 10 (2002). ArticleCAS Google Scholar
Lin, D. et al. A mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity. Nature Cell Biol.2, 540–547 (2000). ArticleCAS Google Scholar
Qiu, R.G., Abo, A. & Martin, S.G. A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCζ signaling and cell transformation. Curr. Biol.10, 697–707 (2000). ArticleCAS Google Scholar
Kay, A.J. & Hunter, C.P. CDC-42 regulates PAR protein localization and function to control cellular and embryonic polarity in C. elegans. Curr. Biol.11, 474–481 (2001). ArticleCAS Google Scholar
Gotta, M., Abraham, M.C. & Ahringer, J. CDC-42 controls early cell polarity and spindle orientation in C. elegans. Curr. Biol.11, 482–488 (2001). ArticleCAS Google Scholar
Hall, A. Rho GTPases and the actin cytoskeleton. Science279, 509–514 (1998). ArticleCAS Google Scholar
Kaibuchi, K. Regulation of cytoskeleton and cell adhesion by Rho targets. Prog. Mol. Subcell. Biol.22, 23–38 (1999). ArticleCAS Google Scholar
Kroschewski, R., Hall, A. & Mellman, I. Cdc42 controls secretory and endocytic transport to the basolateral plasma membrane of MDCK cells. Nature Cell Biol.1, 8–13 (1999). ArticleCAS Google Scholar
Musch, A., Cohen, D., Kreitzer, G. & Rodriguez-Boulan, E. cdc42 regulates the exit of apical and basolateral proteins from the _trans_-Golgi network. EMBO J.20, 2171–2179 (2001). ArticleCAS Google Scholar
Etienne-Manneville, S. & Hall, A. Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCζ. Cell106, 489–498 (2001). ArticleCAS Google Scholar
Izumi, Y. et al. An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3. J. Cell Biol.143, 95–106 (1998). ArticleCAS Google Scholar
Coghlan, M.P., Chou, M.M. & Carpenter, C.L. Atypical protein kinases C λ and ζ associate with the GTP-binding protein Cdc42 and mediate stress fiber loss. Mol. Cell. Biol.20, 2880–2889 (2000). ArticleCAS Google Scholar
Bilder, D., Li, M. & Perrimon, N. Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science289, 113–116 (2000). ArticleCAS Google Scholar
Bilder, D. & Perrimon, N. Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature403, 676–680 (2000). ArticleCAS Google Scholar
Peng, C.Y., Manning, L., Albertson, R. & Doe, C.Q. The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts. Nature408, 596–600 (2000). ArticleCAS Google Scholar
Ohshiro, T., Yagami, T., Zhang, C. & Matsuzaki, F. Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast. Nature408, 593–596 (2000). ArticleCAS Google Scholar
Gateff, E. & Schneiderman, H.A. Neoplasms in mutant and cultured wild-type tissues of Drosophila. Natl Cancer Inst. Monogr.31, 365–397 (1969). CASPubMed Google Scholar
Mechler, B.M., McGinnis, W. & Gehring, W.J. Molecular cloning of lethal(2)giant larvae, a recessive oncogene of Drosophila melanogaster. EMBO J.4, 1551–1557 (1985). ArticleCAS Google Scholar
Lehman, K., Rossi, G., Adamo, J.E. & Brennwald, P. Yeast homologues of tomosyn and lethal giant larvae function in exocytosis and are associated with the plasma membrane SNARE, Sec9. J Cell. Biol.146, 125–140 (1999). CASPubMedPubMed Central Google Scholar
Musch, A. et al. Mammalian homolog of Drosophila tumor suppressor lethal (2) giant larvae interacts with basolateral exocytic machinery in Madin–Darby canine kidney cells. Mol. Biol. Cell13, 158–168 (2002). ArticleCAS Google Scholar
Fujita, Y. et al. Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process. Neuron20, 905–915 (1998). ArticleCAS Google Scholar
Kalmes, A., Merdes, G., Neumann, B., Strand, D. & Mechler, B.M. A serine-kinase associated with the p127-L(2)gl tumour suppressor of Drosophila may regulate the binding of p127 to nonmuscle myosin II heavy chain and the attachment of p127 to the plasma membrane. J. Cell Sci.109, 1359–1368 (1996). CASPubMed Google Scholar
Kulkarni, S.V., Gish, G., van der Geer, P., Henkemeyer, M. & Pawson, T. Role of p120 Ras-GAP in directed cell movement. J. Cell Biol.149, 457–470 (2000). ArticleCAS Google Scholar
Hurd, T.W., Gao, L., Roh, M.H., Macara, I.G. & Margolis, B. Binding of PALS1/Stardust to Par6 links two polarity complexes implicated in epithelial tight junction assembly. Nature Cell Biol.5, 137–142 (2003). ArticleCAS Google Scholar
Bilder, D., Schober, M. & Perrimon, N. Integrated activity of PDZ protein complexes regulates epithelial polarity. Nature Cell Biol.5, 53–58 (2003). ArticleCAS Google Scholar
Tanentzapf, G. & Tepass, U. Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization. Nature Cell Biol.5, 46–52 (2003). ArticleCAS Google Scholar
Strand, D. et al. A human homologue of the Drosophila tumour suppressor gene l(2)gl maps to 17p11.2–12 and codes for a cytoskeletal protein that associates with nonmuscle myosin II heavy chain. Oncogene11, 291–301 (1995). CASPubMed Google Scholar
Ebnet, K. et al. The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM). EMBO J.20, 3738–3748 (2001). ArticleCAS Google Scholar
Itoh, M. et al. Junctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the recruitment of PAR-3 to tight junctions. J. Cell Biol.154, 491–497 (2001). ArticleCAS Google Scholar
Arquier, N., Perrin, L., Manfruelli, P. & Semeriva, M. The Drosophila tumor suppressor gene lethal(2)giant larvae is required for the emission of the Decapentaplegic signal. Development128, 2209–2220 (2001). CASPubMed Google Scholar
Shevchenko, A., Wilm, M., Vorm, O. & Mann, M. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal. Chem.68, 850–858 (1996). ArticleCAS Google Scholar
Couchman, J.R. & Rees, D.A. The behavior of fibroblasts migrating from chick heart explants: changes in adhesion, locomotion, and growth in the distribution of actomyosin and fibronectin. J. Cell Sci.39, 149–165 (1979). CASPubMed Google Scholar
Cramer, L.P., Siebert, M. & Mitchison, T.J. Identification of novel graded polarity actin filament bundles in locomoting heart fibroblasts: Implication for the generation of motile force. J. Cell Biol.136, 1287–1305 (1997). ArticleCAS Google Scholar
Ettenson, D.S. & Gotlieb, A.I. Centrosomes microtubules and microfilaments in the reendothelialization and remodeling of double-sided in vitro wounds. Lab. Invest.66, 722–733 (1992). CASPubMed Google Scholar