Meta-analysis identifies common variants associated with body mass index in east Asians (original) (raw)

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Acknowledgements

The Shanghai Genome Wide Associations Studies (SGWAS) would like to thank the dedicated investigators and staff members from the research teams at Vanderbilt University, the Shanghai Cancer Institute and the Shanghai Institute of Preventive Medicine and, most of all, the study participants for their contributions to this work. Genotyping assays and statistical analyses for the SGWAS were primarily supported by grants from the US National Institutes of Health (NIH; R01 CA064277, R37 CA070867, R01 CA090899, R01 CA118229, R01 CA092585 and R01 CA122756), as well as by Ingram professorship funds, Allen Foundation funds and a Vanderbilt Clinical and Translational Science Award (CTSA; 1 UL1 RR024975) from the National Center for Research Resources (NCRR) at the NIH. NIH grants provided support for the participating studies, including the Shanghai Breast Cancer Study (R01 CA064277), the Shanghai Breast Cancer Survival Study (R01 CA118229) and the Shanghai Endometrial Cancer Study (R01 CA092585). The KARE project was supported by grants from the Korea Centers for Disease Control and Prevention (4845-301, 4851-302 and 4851-307). The Singapore Prospective Study Program (SP2) was funded through grants from the Biomedical Research Council of Singapore (BMRC; 05/1/36/19/413 and 03/1/27/18/216) and the National Medical Research Council of Singapore (NMRC; NMRC/1174/2008). E.S.T. also received support from the NMRC through a clinician scientist award (NMRC/CSA/008/2009). The Singapore Malay Eye Study (SiMES) was funded by the NMRC (NMRC/0796/2003 and NMRC/STaR/0003/2008) and the BMRC (09/1/35/19/616). The CAGE Network Studies were supported by grants for the Core Research for Evolutional Science and Technology (CREST) from the Japan Science Technology Agency, the Program for Promotion of Fundamental Studies in Health Sciences, the National Institute of Biomedical Innovation Organization (NIBIO) and the National Center for Global Health and Medicine (NCGM). L.Q. is supported by a grant from the NIH (HL071981), an American Heart Association Scientist Development Award and the Boston Obesity Nutrition Research Center (DK46200). The Genetic Epidemiology Network of Salt Sensitivity (GenSalt) is supported by research grants from the National Heart, Lung, and Blood Institute at the NIH (HL072507, HL087263 and HL090682). SINDI was funded by grants from the BMRC (09/1/35/19/616 and 08/1/35/19/550) and the NMRC (NMRC/STaR/0003/2008). SCORM was funded by the NMRC (NMRC/0975/2005), the BMRC (06/1/21/19/466) and the Centre for Molecular Epidemiology at the National University of Singapore. The SIH was supported by the Chinese National Key Program for Basic Research (973:2004CB518603) and the Chinese National High Tech Program (863:2009AA022703). The MEC was supported by grants from the National Cancer Institute (NCI; CA063464, CA054281 and CA132839) and from the NIH Genes, Environment and Health Initiative (GEI; HG004726). Assistance with genotype cleaning for the MEC Japanese prostate cancer study was provided by the Gene Environment Association Studies (GENEVA) Coordinating Center (HG004446). Assistance with data cleaning was provided by the National Center for Biotechnology Information. Funding support for genotyping, which was performed at the Broad Institute of MIT and Harvard University, was provided by the GEI (HG04424).

Author information

Author notes

1. Wanqing Wen, Yoon-Shin Cho, Wei Zheng, Rajkumar Dorajoo, Norihiro Kato, Lu Qi, Chien-Hsiun Chen and E Shyong Tai: These authors contributed equally to this work.
2. Jer-Yuarn Wu, Jong-Young Lee, Frank B Hu, Toshihiro Tanaka, E Shyong Tai and Xiao-Ou Shu: These authors jointly directed this work.

Authors and Affiliations

1. Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
   Wanqing Wen, Wei Zheng, Ryan J Delahanty, Jirong Long, Qiuyin Cai, Jiajun Shi & Xiao-Ou Shu
2. Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
   Wanqing Wen, Wei Zheng, Ryan J Delahanty, Jirong Long, Qiuyin Cai, Jiajun Shi & Xiao-Ou Shu
3. Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
   Wanqing Wen, Wei Zheng, Ryan J Delahanty, Jirong Long, Qiuyin Cai, Jiajun Shi & Xiao-Ou Shu
4. Center for Genome Science, National Institute of Health, Cheongwon-gun, Republic of Korea
   Yoon-Shin Cho, Min-Jin Go, Bok-Ghee Han & Jong-Young Lee
5. Department of Biomedical Science, Hallym University, Chuncheon, Republic of Korea
   Yoon-Shin Cho
6. Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore
   Rajkumar Dorajoo, Rick T H Ong, Jian-Jun Liu & Mark Seielstad
7. Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK
   Rajkumar Dorajoo
8. Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
   Norihiro Kato & Fumihiko Takeuchi
9. Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
   Lu Qi & Frank B Hu
10. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Chien-Hsiun Chen, Li-Ching Chang, Mei-Hsin Su, Cathy S J Fann & Jer-Yuarn Wu
11. School of Chinese Medicine, China Medical University, Taichung, Taiwan
    Chien-Hsiun Chen, Fuu-Jen Tsai & Jer-Yuarn Wu
12. Laboratory for Statistical Analysis, Center for Genomic Medicine (CGM), RIKEN, Yokohama, Japan
    Yukinori Okada & Naoyuki Kamatani
13. Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Yukinori Okada
14. Department of Basic Medical Research and Education, Ehime University Graduate School of Medicine, Toon, Japan
    Yasuharu Tabara
15. Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Dongfeng Gu
16. State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Dingliang Zhu & Yi Zhang
17. Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Dingliang Zhu & Yi Zhang
18. Sino-French Research Center for Life Science and Genomics, Shanghai, China
    Dingliang Zhu & Yi Zhang
19. Shanghai Key Laboratory of Vascular Biology, Shanghai, China
    Dingliang Zhu
20. Department of Preventive Medicine, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Christopher A Haiman, Brian E Henderson & Gary K Chen
21. Institute of Urology and Nephrology, First Affiliated Hospital of Guangxi Medical University, Nanning, China
    Zengnan Mo
22. Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China
    Yu-Tang Gao & Yong-Bing Xiang
23. Saw Swee Hock School of Public Health, National University of Singapore, Singapore
    Seang-Mei Saw, Daniel P-K Ng & E Shyong Tai
24. Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, Suita, Japan
    Yoshihiro Kokubo
25. Department of Endocrinology, The Central Hospital of Xuzhou, Affiliated Hospital of Southeast University, Xuzhou, China
    Jun Liang
26. Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA
    Mei Hao & Jiang He
27. Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, Hawaii, USA
    Loïc Le Marchand
28. Medical Scientific Research Center, Guangxi Medical University, Nanning, China
    Yanling Hu
29. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Tien-Yin Wong & Tin Aung
30. Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Tien-Yin Wong & Tin Aung
31. Center for Eye Research Australia, The University of Melbourne, East Melbourne, Victoria, Australia
    Tien-Yin Wong
32. Laboratory for Genotyping Development, CGM, RIKEN, Yokohama, Japan
    Michiaki Kubo
33. Division of Genome Analysis, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Ken Yamamoto
34. Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, Japan
    Tetsuro Miki
35. State Key Laboratory of Medical Genomics, Molecular Medical Center, Shanghai Institute of Endocrinology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Huaidong Song
36. Center for Metabolic Disease and Diabetes, First Affiliated Hospital of Guangxi Medical University, Nanning, China
    Aihua Tan
37. Laboratory for Medical Informatics, CGM, RIKEN, Yokohama, Japan
    Tatsuhiko Tsunoda
38. Department of Genomic Medicine, National Cerebral and Cardiovascular Center, Suita, Japan
    Naoharu Iwai
39. Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA
    Jianfeng Xu
40. Centre for Molecular Epidemiology, National University of Singapore, Singapore
    Xueling Sim
41. Laboratory for Endocrinology and Metabolism, CGM, RIKEN, Yokohama, Japan
    Shiro Maeda
42. National University of Singapore Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore
    Rick T H Ong
43. Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Chun Li
44. Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Yusuke Nakamura
45. Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China
    Wei Lu
46. Department of Genome Science, Aichi-Gakuin University, School of Dentistry, Nagoya, Japan
    Mitsuhiro Yokota
47. Institute for Human Genetics, University of California, San Francisco, San Francisco, California, USA
    Mark Seielstad
48. Department of Epidemiology, Harvard University School of Public Health, Boston, Massachusetts, USA
    Frank B Hu
49. Laboratory for Cardiovascular Diseases, CGM, RIKEN, Yokohama, Japan
    Toshihiro Tanaka
50. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    E Shyong Tai
51. Duke–National University of Singapore Graduate Medical School, Singapore
    E Shyong Tai

Authors

1. Wanqing Wen
2. Yoon-Shin Cho
3. Wei Zheng
4. Rajkumar Dorajoo
5. Norihiro Kato
6. Lu Qi
7. Chien-Hsiun Chen
8. Ryan J Delahanty
9. Yukinori Okada
10. Yasuharu Tabara
11. Dongfeng Gu
12. Dingliang Zhu
13. Christopher A Haiman
14. Zengnan Mo
15. Yu-Tang Gao
16. Seang-Mei Saw
17. Min-Jin Go
18. Fumihiko Takeuchi
19. Li-Ching Chang
20. Yoshihiro Kokubo
21. Jun Liang
22. Mei Hao
23. Loïc Le Marchand
24. Yi Zhang
25. Yanling Hu
26. Tien-Yin Wong
27. Jirong Long
28. Bok-Ghee Han
29. Michiaki Kubo
30. Ken Yamamoto
31. Mei-Hsin Su
32. Tetsuro Miki
33. Brian E Henderson
34. Huaidong Song
35. Aihua Tan
36. Jiang He
37. Daniel P-K Ng
38. Qiuyin Cai
39. Tatsuhiko Tsunoda
40. Fuu-Jen Tsai
41. Naoharu Iwai
42. Gary K Chen
43. Jiajun Shi
44. Jianfeng Xu
45. Xueling Sim
46. Yong-Bing Xiang
47. Shiro Maeda
48. Rick T H Ong
49. Chun Li
50. Yusuke Nakamura
51. Tin Aung
52. Naoyuki Kamatani
53. Jian-Jun Liu
54. Wei Lu
55. Mitsuhiro Yokota
56. Mark Seielstad
57. Cathy S J Fann
58. Jer-Yuarn Wu
59. Jong-Young Lee
60. Frank B Hu
61. Toshihiro Tanaka
62. E Shyong Tai
63. Xiao-Ou Shu

Consortia

The Genetic Investigation of ANthropometric Traits (GIANT) Consortium

Contributions

T.A., Y.-S.C., Y.-T.G., D.G., B.-G.H., J.H., F.B.H., N. Kamatani, N. Kato, L.-L.-M., J.-Y.L., W.L., Z.M., Y.N., D.P.-K.N., L.Q., S.-M.S., X.-O.S., E.-S.T., F.-J.T., T. Tanaka, F.J.T., T.-Y.W., J.-Y.W., Y.-B.X., J.X., W.Z. and D.Z. supervised the research. Y.-S.C., D.G., J.H., Y.H., N. Kato, J. Liang, Z.M., Y.N., L.Q., M.S., X.-O.S., H.S., E.S.T., T. Tanaka, T.-Y.W., W.Z. and D.Z. conceived and designed the experiments. J.H., Y.H., M.K., J. Liang, M.S., J.S., M.Y. and Y.Z. performed the experiments. L.-C.C., C.-H.C., G.K.C., R.D., M.-J.G., M.H., Y.H., C.L., J. Long, Y.O., L.Q., M.-H.S., Y.T., A.T., T. Tsunoda and W.W. performed the statistical analyses. The GIANT Consortium, Q.C., L.-C.C., C.-H.C., R.J.D., R.D., M.-J.G., M.H., Y.H., N.I., J. Long, T.M., Y.O., R.T.H.O., L.Q., X.S., M.-H.S. and Y.T. analyzed the data. T.A., Q.C., Y.-T.G., C.A.H., B.E.H., N.I., N. Kato, Y.K., L.L.-M., J. Liang, J.-J.L., W.L., D.P.-K.N., L.Q., S.-M.S., M.S., X.-O.S., H.S., E.S.T., F.-J.T., T.-Y.W., J.-Y.W., Y.-B.X., K.Y., M.Y., C.S.J.F. and W.Z. contributed reagents, materials and/or analysis tools. R.J.D., Y.O., X.-O.S., E.S.T., T. Tanaka, W.W. and W.Z. wrote the manuscript. S.M. reviewed the manuscript for important intellectual content. All authors reviewed and approved the final version of the manuscript.

Corresponding author

Correspondence toXiao-Ou Shu.

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The authors declare no competing financial interests.

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Wen, W., Cho, YS., Zheng, W. et al. Meta-analysis identifies common variants associated with body mass index in east Asians.Nat Genet 44, 307–311 (2012). https://doi.org/10.1038/ng.1087

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• Received: 20 December 2011
• Accepted: 28 December 2011
• Published: 19 February 2012
• Issue date: March 2012
• DOI: https://doi.org/10.1038/ng.1087