The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals (original) (raw)

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Acknowledgements

We thank all the participants of this study for their contributions. Detailed acknowledgment of funding sources by study is provided in the Supplementary Note.

Author information

Author notes

1. Andrew P Morris: A list of members and affiliations appears in the Supplementary Note.
2. Georg B Ehret and Teresa Ferreira: These authors contributed equally to this work.
3. Andrew P Morris, Christopher Newton-Cheh and Patricia B Munroe: These authors jointly directed this work.

Authors and Affiliations

1. Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
   Georg B Ehret, Vasyl Pihur, Dan E Arking, Maria X Sosa & Aravinda Chakravarti
2. Department of Medicine, Cardiology, Geneva University Hospital, Geneva, Switzerland
   Georg B Ehret, Li Lin & François Mach
3. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
   Teresa Ferreira, Martin Farrall, Anuj Goel, Mark I McCarthy, N William Rayner, Hugh Watkins & Andrew P Morris
4. Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA
   Daniel I Chasman, Franco Giulianini, Lynda M Rose & Paul M Ridker
5. Harvard Medical School, Boston, Massachusetts, USA
   Daniel I Chasman & Paul M Ridker
6. Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA
   Anne U Jackson, Michael Boehnke, Hyun Min Kang, Xueling Sim & Heather M Stringham
7. Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA
   Anne U Jackson, Michael Boehnke, Hyun Min Kang, Xueling Sim & Heather M Stringham
8. Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA
   Ellen M Schmidt & Cristen J Willer
9. Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK
   Toby Johnson, Kate Witkowska, Helen Warren, Claudia P Cabrera, Mark J Caulfield & Patricia B Munroe
10. GlaxoSmithKline, Stevenage, UK
    Toby Johnson
11. deCODE Genetics/Amgen, Inc., Reykjavik, Iceland
    Gudmar Thorleifsson, Gyda Bjornsdottir, Unnur Thorsteinsdottir & Kari Stefansson
12. MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK
    Jian'an Luan, Ken K Ong, Nicholas J Wareham, Jing Hua Zhao, Claudia Langenberg & Ruth J F Loos
13. Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    Louise A Donnelly, Alex S F Doney, Andrew D Morris & Colin N A Palmer
14. William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Stavroula Kanoni, Lazaros Lataniotis, Michael R Barnes, Eirini Marouli, Kathleen E Stirrups, Tsun-Po Yang & Panos Deloukas
15. Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany
    Ann-Kristin Petersen & Martina Müller-Nurasyid
16. Department of Medicine, Cardiovascular Research Unit, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    Rona J Strawbridge, Lasse Folkersen, Per Eriksson, Karl Gertow & Anders Hamsten
17. Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden
    Rona J Strawbridge, Karl Gertow & Anders Hamsten
18. Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
    Dmitry Shungin, Göran Hallmans, Frida Renström & Paul W Franks
19. Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund Universityö, Malmö, Sweden
    Dmitry Shungin, Frida Renström & Paul W Franks
20. Department of Odontology, Umeå University, Umeå, Sweden
    Dmitry Shungin
21. Centre of Excellence for Public Health, Queens University Belfast, Belfast, UK
    Maria F Hughes & Alun Evans
22. Laboratory of Genetics, Intramural Research Program, National Institute on Aging, US National Institutes of Health, Baltimore, Maryland, USA
    Osorio Meirelles & Ramaiah Nagaraja
23. Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK
    Marika Kaakinen
24. INSERM UMR 970, Paris Cardiovascular Research Center (PARCC), Paris, France
    Nabila Bouatia-Naji
25. University Paris-Descartes, Sorbonne Paris Cité, Paris, France
    Nabila Bouatia-Naji
26. National Institute for Health and Welfare, Helsinki, Finland
    Kati Kristiansson, Aki S Havulinna, Jaana Lindström, Satu Männistö, Markus Perola, Jarmo Virtamo, Jaakko Tuomilehto, Veikko Salomaa & Kari Kuulasmaa
27. Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
    Kati Kristiansson & Markus Perola
28. Department of Epidemiology and Public Health, Genetic Epidemiology Group, University College London, London, UK
    Sonia Shah, Aroon D Hingorani, Mika Kivimaki & Meena Kumari
29. Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Marcus E Kleber & Graciela Delgado
30. Los Angeles Biomedical Research Institute and Department of Pediatrics at Harbor-UCLA Medical Center, Institute for Translational Genomics and Population Sciences, Torrance, California, USA
    Xiuqing Guo, Eric Kim, Xiaohui Li, Jie Yao, Kent D Taylor, Yii-Der I Chen & Jerome I Rotter
31. Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland
    Leo-Pekka Lyytikäinen & Terho Lehtimäki
32. Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland
    Leo-Pekka Lyytikäinen & Terho Lehtimäki
33. Department of Internal Medicine, University of Lund, Malmö, Sweden
    Cristiano Fava & Olle Melander
34. Department of Medicine, University of Verona, Verona, Italy
    Cristiano Fava
35. Uppsala University, Uppsala Clinical Research Center, Uppsala, Sweden
    Niclas Eriksson
36. Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
    Ilja M Nolte, Ahmad Vaez & Harold Snieder
37. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Patrik K Magnusson & Nancy L Pedersen
38. Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
    Elias L Salfati, Thomas Quertermous, Themistocles L Assimes & Erik Ingelsson
39. Second Department of Cardiology, Attikon Hospital, School of Medicine, University of Athens, Athens, Greece
    Loukianos S Rallidis
40. Children's Hospital Oakland Research Institute, Oakland, California, USA
    Elizabeth Theusch
41. Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, UK
    Andrew J P Smith, Fotios Drenos & Phil Howard
42. NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK
    Kate Witkowska, Helen Warren, Michael R Barnes, Claudia P Cabrera, Mark J Caulfield & Patricia B Munroe
43. Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA
    Tune H Pers, Tonu Esko, Joel N Hirschhorn & Cameron D Palmer
44. Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, USA
    Tune H Pers & Joel N Hirschhorn
45. Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    Tune H Pers, Joel N Hirschhorn, Sekar Kathiresan, Cameron D Palmer, Benjamin F Voight & Christopher Newton-Cheh
46. Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic, Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    Tune H Pers
47. Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    Tune H Pers
48. National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA
    Roby Joehanes, Andrew D Johnson, John D Eicher, Daniel Levy, Honghuang Lin, Christopher J O'Donnell & Ramachandran S Vasan
49. Department of Developmental Biology and Genetics, Stanford University Medical Center, Stanford, California, USA
    Stuart K Kim & Hinco J Gierman
50. Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands
    Rick Jansen
51. National Heart, Lung, and Blood Institute, Cardiovascular Epidemiology and Human Genomics Branch, Bethesda, Maryland, USA
    Andrew D Johnson & John D Eicher
52. Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea
    Young Jin Kim, Yun Kyoung Kim, Young-Ah Shin & Jong-Young Lee
53. Division of Translational Medicine and Human Genetics, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Wei Zhao
54. Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Ying Wu & Karen L Mohlke
55. Department of Public Health Sciences, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA
    Bamidele O Tayo & Richard S Cooper
56. Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Murielle Bochud, Fred Paccaud & Pascal Bovet
57. HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA
    Devin Absher
58. Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Linda S Adair
59. Department of Epidemiology, Genetic Epidemiology Unit, Erasmus MC, Rotterdam, the Netherlands.,
    Najaf Amin
60. Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Tomas Axelsson, Johan Sundstrom, Ann-Christine Syvänen & Lars Lind
61. Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy
    Damiano Baldassarre & Elena Tremoli
62. Centro Cardiologico Monzino, IRCCS, Milan, Italy
    Damiano Baldassarre & Elena Tremoli
63. INSERM U1018, Centre for Research in Epidemiology and Population Health, University Paris-Sud, URMS 1018, Villejuif, France
    Beverley Balkau
64. Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy
    Stefania Bandinelli
65. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK
    Inês Barroso, John Danesh, Sarah Edkins & N William Rayner
66. University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK
    Inês Barroso
67. NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK
    Inês Barroso
68. School of Life Science, University of Lincoln, Joseph Banks Laboratories, Lincoln, UK
    Stephen Bevan
69. Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
    Joshua C Bis, Richard A Jensen & Bruce M Psaty
70. Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA
    Eric Boerwinkle
71. Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA
    Lori L Bonnycastle, Peter S Chines, Francis S Collins, Narisu Narisu & Amy J Swift
72. Department of Biological Psychology, VU University, Amsterdam, the Netherlands
    Dorret I Boomsma & Jouke-Jan Hottenga
73. Department of Medicine III, University of Dresden, Medical Faculty Carl Gustav Carus, Dresden, Germany
    Stefan R Bornstein & Peter E H Schwarz
74. Barts Heart Centre, William Harvey Research Institute, Queen Mary University of London, London, UK
    Morris J Brown
75. Nephrology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Michel Burnier
76. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
    John C Chambers, Evangelos Evangelou, He Gao, Weihua Zhang & Paul Elliott
77. Department of Cardiology, Ealing Hospital NHS Trust, Southall, UK
    John C Chambers, Jaspal S Kooner & Weihua Zhang
78. Imperial College Healthcare NHS Trust, London, UK
    John C Chambers & Jaspal S Kooner
79. National Institute of Cancer Research, National Health Research Institutes, Zhunan Town, Taiwan
    I-Shou Chang
80. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Ching-Yu Cheng & Tien Y Wong
81. Duke-NUS Graduate Medical School Singapore, Singapore
    Ching-Yu Cheng, E-Shyong Tai & Tien Y Wong
82. Department of Ophthalmology, National University of Singapore and National University Health System, Singapore
    Ching-Yu Cheng & Tien Y Wong
83. Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan Town, Taiwan
    Ren-Hua Chung & Chao A Hsiung
84. University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    John M Connell
85. Institute of Epidemiology I, Helmholtz Zentrum München, Neuherberg, Germany
    Angela Döring & H-Erich Wichmann
86. Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, Germany
    Angela Döring & Annette Peters
87. INSERM UMR 1167, Lille 2 University, Institut Pasteur Lille, Lille, France
    Jean Dallongeville
88. Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    John Danesh
89. Department of Public Health and Primary Care, NIHR Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK
    John Danesh
90. Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Ulf de Faire & Bruna Gigante
91. BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    Anna F Dominiczak
92. Medical Research Council Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK
    Fotios Drenos
93. Cardiovascular Epidemiology and Genetics, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain
    Roberto Elosua
94. Department of Immunology, Genetics and Pathology, University of Uppsala, Biomedical Center, Uppsala, Sweden
    Stefan Enroth & Ulf Gyllensten
95. Science for Life Laboratory, University of Uppsala, Biomedical Center, Uppsala, Sweden
    Stefan Enroth & Ulf Gyllensten
96. Institut für Integrative und Experimentelle Genomik, Universiät zu Lübeck, Lübeck, Germany
    Jeanette Erdmann
97. Deutsches Zentrum für Herz Kreislauf Forschung (DZHK), partner site Hamburg, Lübeck, Kiel, Germany
    Jeanette Erdmann
98. Estonian Genome Center, University of Tartu, Tartu, Estonia
    Andres Metspalu & Markus Perola
99. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    Tonu Esko, Gulum Kosova & Christopher Newton-Cheh
100. Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece
     Evangelos Evangelou
101. Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
     Tove Fall & Erik Ingelsson
102. Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK
     Martin Farrall, Anuj Goel & Hugh Watkins
103. Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands
     Janine F Felix, Oscar H Franco, Albert Hofman, M Arfan Ikram, Andre G Uitterlinden, Cornelia M van Duijn & Germaine C Verwoert
104. Toulouse University School of Medicine, Rangueil University Hospital, INSERM UMR 1027, Toulouse, France
     Jean Ferrières
105. Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, USA
     Luigi Ferrucci & Toshiko Tanaka
106. Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA
     Myriam Fornage
107. Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston, Jamaica.,
     Terrence Forrester & Colin A McKenzie
108. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
     Nora Franceschini
109. Department of Molecular Medicine and Surgery, Cardiothoracic Surgery Unit, Karolinska Institutet, Stockholm, Sweden
     Anders Franco-Cereceda
110. Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK
     Ross M Fraser & James F Wilson
111. Synpromics, Ltd, Edinburgh, UK
     Ross M Fraser
112. Department of Cardiology, University of Michigan Medical School, Ann Arbor, Michigan, USA
     Santhi K Ganesh
113. Department of Clinical and Experimental Medicine, Epidemiology and Preventive Medicine (EPIMED) Research Centre, University of Insubria, Varese, Italy
     Francesco Gianfagna
114. Department of Epidemiology and Prevention, IRCCS, Istituto Neurologico Mediterraneo (NEUROMED), Pozzilli, Italy
     Francesco Gianfagna
115. Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK
     Alison H Goodall & Nilesh J Samani
116. NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK
     Alison H Goodall & Nilesh J Samani
117. Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, California, USA
     Mark O Goodarzi
118. Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany
     Mathias Gorski
119. Department of Nephrology, University Hospital Regensburg, Regensburg, Germany
     Mathias Gorski
120. Division of Pathobiochemistry, Department of Medicine III, Technische Universität Dresden, Dresden, Germany
     Jürgen Gräßler
121. Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK
     Christopher J Groves, Mark I McCarthy & N William Rayner
122. Icelandic Heart Association, Kopavogur, Iceland
     Vilmundur Gudnason, Albert V Smith & Philippe Froguel
123. Faculty of Medicine, University of Iceland, Reykjavik, Iceland
     Vilmundur Gudnason, Albert V Smith, Unnur Thorsteinsdottir & Kari Stefansson
124. Institute of Clinical Medicine/Obstetrics and Gynaecology, University of Oulu, Oulu, Finland
     Anna-Liisa Hartikainen
125. Medical Research Center, Oulu University Hospital, Oulu, Finland
     Anna-Liisa Hartikainen
126. Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
     Maija Hassinen, Pirjo Komulainen, Timo A Lakka & Rainer Rauramaa
127. Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK
     Caroline Hayward, Veronique Vitart & James F Wilson
128. UREN, INSERM U557, INRA U1125, CNAM, SMBH, Sorbonne Paris Cité, Université Paris 13, Bobigny, France
     Serge Hercberg
129. Institute of Biomedicine, University of Oulu, Medical Research Center Oulu and Oulu University Hospital, Oulu, Finland
     Karl-Heinz Herzig
130. Biocenter Oulu, University of Oulu, Oulu, Finland
     Karl-Heinz Herzig, Sylvain Sebert & Marjo-Riitta Jarvelin
131. Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland
     Karl-Heinz Herzig
132. Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy (affiliated institute of the University of Lübeck, Lübeck, Germany).,
     Andrew A Hicks & Peter P Pramstaller
133. Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
     Joel N Hirschhorn
134. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
     Albert Hofman
135. Department of Public Health and General Practice, HUNT Research Centre, Norwegian University of Science and Technology, Levanger, Norway
     Jostein Holmen, Oddgeir Lingaas Holmen, Kirsti Kvaløy & Kristian Hveem
136. St. Olav Hospital, Trondheim University Hospital, Trondheim, Norway
     Oddgeir Lingaas Holmen
137. Cardiovascular Genetics Division, University of Utah School of Medicine, Salt Lake City, Utah, USA
     Steven C Hunt
138. Department of Genetic Medicine, Weill Cornell Medical College Qatar, Doha, Qatar
     Steven C Hunt
139. Department of Radiology, Erasmus MC, Rotterdam, the Netherlands
     M Arfan Ikram
140. Department of Neurology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands
     M Arfan Ikram
141. Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany
     Thomas Illig & Norman Klopp
142. Hannover Unified Biobank, Hannover Medical School, Hannover, Germany
     Thomas Illig & Norman Klopp
143. Hannover Medical School, Institute for Human Genetics, Hanover, Germany
     Thomas Illig
144. Division of Research, Kaiser Permanente, Oakland, California, USA
     Carlos Iribarren
145. Department of Medicine, University of Washington, Seattle, Washington, USA
     Richard A Jensen
146. Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland
     Mika Kähönen
147. Department of Clinical Physiology, University of Tampere School of Medicine, Tampere, Finland
     Mika Kähönen & Christopher Newton-Cheh
148. Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA
     Sekar Kathiresan & Gulum Kosova
149. Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA
     Sekar Kathiresan, Gulum Kosova & Christopher Newton-Cheh
150. Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
     Sekar Kathiresan
151. Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
     Sekar Kathiresan & Christopher J O'Donnell
152. Division of Transplantation, Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
     Brendan J Keating
153. Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
     Brendan J Keating
154. Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK
     Kay-Tee Khaw
155. 1st Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece
     Genovefa Kolovou
156. National Heart and Lung Institute, Imperial College London, Hammersmith Hospital Campus, London, UK
     Jaspal S Kooner
157. Department of Medicine, Children's Hospital Oakland Research Institute, Oakland, California, USA
     Ronald M Krauss
158. MRC Unit for Lifelong Health and Ageing at UCL, London, UK
     Diana Kuh & Andrew Wong
159. Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland
     Zoltan Kutalik
160. Swiss Institute of Bioinformatics, Lausanne, Switzerland
     Zoltan Kutalik
161. Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
     Johanna Kuusisto & Markku Laakso
162. Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio, Finland
     Timo A Lakka
163. Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland
     Timo A Lakka, Sylvain Sebert & Rainer Rauramaa
164. Office of Population Studies Foundation, Inc., Talamban, Cebu City, Philippines
     Nanette R Lee
165. Department of Anthropology, Sociology and History, University of San Carlos, Talamban, Cebu City, Philippines.,
     Nanette R Lee
166. Division of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
     I-Te Lee & Wayne H-H Sheu
167. School of Medicine, National Yang-Ming University, Taipei, Taiwan
     I-Te Lee & Wayne H-H Sheu
168. Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan
     Wen-Jane Lee
169. Population Sciences Branch, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, Maryland, USA
     Daniel Levy
170. Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan
     Kae-Woei Liang
171. Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan
     Kae-Woei Liang
172. Department of Medicine, Section of Computational Biomedicine, Boston University School of Medicine, Boston, Massachusetts, USA
     Honghuang Lin
173. European Genomic Institute for Diabetes (EGID), Lille, France
     Stéphane Lobbens, Loic Yengo & Philippe Froguel
174. CNRS UMR 8199, Lille Pasteur Institute, Lille, France
     Stéphane Lobbens, Loic Yengo & Philippe Froguel
175. Lille 2 University, Lille, France
     Stéphane Lobbens, Loic Yengo & Philippe Froguel
176. Center for Evidence-Based Healthcare, University of Dresden, Medical Faculty Carl Gustav Carus, Dresden, Germany
     Gabriele Müller
177. Department of Medicine I, University Hospital Großhadern, Ludwig Maximilians University, Munich, Germany
     Martina Müller-Nurasyid
178. Institute of Medical Informatics, Biometry and Epidemiology, Ludwig Maximilians Universität, Munich, Germany
     Martina Müller-Nurasyid & H-Erich Wichmann
179. Neurology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK
     Hugh S Markus
180. Department of Dietetics-Nutrition, Harokopio University, Athens, Greece
     Eirini Marouli & George Dedoussis
181. INSERM U1142, LIMICS, UMRS 1142, Sorbonne Universités, UPMC Université Paris 06, Université Paris 13, Paris, France
     Pierre Meneton
182. Department of Twin Research and Genetic Epidemiology, King's College London, London, UK
     Cristina Menni & Tim D Spector
183. Department of Life and Reproduction Sciences, University of Verona, Verona, Italy
     Vladan Mijatovic
184. Department of Medicine, Kuopio University Hospital, Kuopio, Finland
     Leena Moilanen
185. Unit of General Practice, Oulu University Hospital, Oulu, Finland
     Leena Moilanen
186. Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
     May E Montasser & Afshin Parsa
187. Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA
     Alanna C Morrison
188. Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cittadella Universitaria di Monseratto, Monserrato, Cagliari, Italy.,
     Antonella Mulas & Serena Sanna
189. Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland
     Kjell Nikus
190. Department of Cardiology, University of Tampere School of Medicine, Tampere, Finland
     Kjell Nikus
191. Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
     Christopher J O'Donnell & Jacques Rossouw
192. Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
     Paul F O'Reilly
193. Genetics and Program in Genomics, Children's Hospital Boston, Boston, Massachusetts, USA
     Cameron D Palmer
194. Department of Psychiatry, EMGO Institute, Neuroscience Campus, VU University Medical Centre, Amsterdam, the Netherlands
     Brenda W Penninx & Johannes H Smit
195. Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
     Brenda W Penninx
196. Department of Psychiatry, Leiden University Medical Centre, Leiden, the Netherlands
     Brenda W Penninx
197. International Centre for Circulatory Health, Imperial College London, London, UK
     Neil Poulter & Peter Sever
198. Department of Neurology, General Central Hospital, Bolzano, Italy
     Peter P Pramstaller
199. Department of Neurology, University of Lübeck, Lübeck, Germany
     Peter P Pramstaller
200. Department of Epidemiology, University of Washington, Seattle, Washington, USA
     Bruce M Psaty
201. Department of Health Services, University of Washington, Seattle, Washington, USA
     Bruce M Psaty
202. Group Health Research Institute, Group Health Cooperative, Seattle, Washington, USA
     Bruce M Psaty
203. Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA
     Dabeeru C Rao
204. Center for Non-Communicable Diseases, Karachi, Pakistan
     Asif Rasheed & Danish Saleheen
205. Department of Biobank Research, Umeå University, Umeå, Sweden
     Frida Renström
206. Institute of Physiology, University Medicine Greifswald, Greifswald, Germany
     Rainer Rettig
207. Department of Biostatistics, University of Washington, Seattle, Washington, USA
     Kenneth M Rice
208. University of Ottawa Heart Institute, Cardiovascular Research Methods Centre Ontario, Ottawa, Ontario, Canada
     Robert Roberts
209. Ruddy Canadian Cardiovascular Genetics Centre, Ottawa, Ontario, Canada
     Robert Roberts
210. South Karelia Central Hospital, Lappeenranta, Finland
     Jouko Saramies
211. Deutsches Herzzentrum München, Munich, Germany
     Heribert Schunkert
212. Technische Universität München, Munich, Germany
     Heribert Schunkert
213. Deutsches Zentrum für Herz Kreislauf Forschung (DZHK), Munich, Germany
     Heribert Schunkert
214. Munich Heart Alliance, Munich, Germany
     Heribert Schunkert
215. Center For Lifecourse Health Research, University of Oulu, Oulu, Finland
     Sylvain Sebert & Marjo-Riitta Jarvelin
216. College of Medicine, National Defense Medical Center, Taipei, Taiwan
     Wayne H-H Sheu
217. Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore
     Xueling Sim & E-Shyong Tai
218. University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
     Alena Stančáková
219. Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
     Alice V Stanton
220. Department of Haematology, University of Cambridge, Cambridge, UK
     Kathleen E Stirrups
221. Department of Medicine, National University of Singapore and National University Health System, Singapore
     E-Shyong Tai
222. Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, US National Institutes of Health, Baltimore, Maryland, USA
     Kirill V Tarasov & Edward G Lakatta
223. Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
     Alexander Teumer
224. Department of Health Sciences, University of Leicester, Leicester, UK
     Martin D Tobin & Louise V Wain
225. Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands
     Andre G Uitterlinden
226. Department of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
     Matti Uusitupa
227. Research Unit, Kuopio University Hospital, Kuopio, Finland
     Matti Uusitupa
228. Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
     Ahmad Vaez
229. Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
     Dhananjay Vaidya
230. Centre of Medical Systems Biology (CMSB 1-2), NGI Erasmus Medical Center, Rotterdam, the Netherlands
     Cornelia M van Duijn
231. Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, the Netherlands
     Erik P A van Iperen
232. Durrer Center for Cardiogenetic Research, ICIN–Netherlands Heart Institute, Utrecht, the Netherlands
     Erik P A van Iperen
233. Department of Medicine, Section of Preventive Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
     Ramachandran S Vasan
234. Department of Medicine, Cardiology, Boston University School of Medicine, Boston, Massachusetts, USA
     Ramachandran S Vasan
235. Department of Systems Pharmacology and Translational Therapeutics, Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
     Benjamin F Voight
236. Department of Internal Medicine, University Hospital Lausanne, Lausanne, Switzerland
     Peter Vollenweider
237. Department of Epidemiology and Public Health, EA3430, University of Strasbourg, Strasbourg, France
     Aline Wagner
238. Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
     Alan B Weder & Cristen J Willer
239. University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
     Harm-Jan Westra
240. Epidemiology Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston, Jamaica.,
     Rainford Wilks
241. Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway
     Tom Wilsgaard & Inger Njølstad
242. Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway
     Tom Wilsgaard & Inger Njølstad
243. MRC Cancer Unit, University of Cambridge, Cambridge, UK
     Tsun-Po Yang
244. Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
     Xiaofeng Zhu
245. Ministry of Health, Victoria, Seychelles
     Pascal Bovet
246. Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
     Danish Saleheen
247. MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK
     Paul Elliott & Marjo-Riitta Jarvelin
248. Enterprise Informatics, Illumina, Inc., Santa Clara, California, USA
     Hinco J Gierman
249. Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA
     Cristen J Willer
250. Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
     Lude Franke
251. Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands
     G Kees Hovingh
252. Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany
     Peter E H Schwarz
253. German Center for Diabetes Research (DZD), Neuherberg, Germany
     Peter E H Schwarz
254. Department of Medicine, Central Finland Health Care District, Jyväskylä, Finland
     Juha Saltevo
255. Dasman Diabetes Institute, Dasman, Kuwait
     Jaakko Tuomilehto
256. Saudi Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia
     Jaakko Tuomilehto
257. Centre for Vascular Prevention, Danube University Krems, Krems, Austria
     Jaakko Tuomilehto
258. Department of Medicine, Columbia University, New York, New York, USA
     Walter Palmas
259. Synlab Academy, Synlab Services, Mannheim, Germany
     Winfried März
260. Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
     Winfried März
261. Unit of Primary Care, Oulu University Hospital, Oulu, Finland
     Marjo-Riitta Jarvelin
262. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
     Paul W Franks
263. Institute of Medical Statistics and Epidemiology, Technical University Munich, Munich, Germany
     H-Erich Wichmann
264. Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York,, New York, USA
     Ruth J F Loos
265. Mindich Child Health Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA
     Ruth J F Loos
266. Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia
     Panos Deloukas
267. Department of Biostatistics, University of Liverpool, Liverpool, UK
     Andrew P Morris

Authors

1. Georg B Ehret
2. Teresa Ferreira
3. Daniel I Chasman
4. Anne U Jackson
5. Ellen M Schmidt
6. Toby Johnson
7. Gudmar Thorleifsson
8. Jian'an Luan
9. Louise A Donnelly
10. Stavroula Kanoni
11. Ann-Kristin Petersen
12. Vasyl Pihur
13. Rona J Strawbridge
14. Dmitry Shungin
15. Maria F Hughes
16. Osorio Meirelles
17. Marika Kaakinen
18. Nabila Bouatia-Naji
19. Kati Kristiansson
20. Sonia Shah
21. Marcus E Kleber
22. Xiuqing Guo
23. Leo-Pekka Lyytikäinen
24. Cristiano Fava
25. Niclas Eriksson
26. Ilja M Nolte
27. Patrik K Magnusson
28. Elias L Salfati
29. Loukianos S Rallidis
30. Elizabeth Theusch
31. Andrew J P Smith
32. Lasse Folkersen
33. Kate Witkowska
34. Tune H Pers
35. Roby Joehanes
36. Stuart K Kim
37. Lazaros Lataniotis
38. Rick Jansen
39. Andrew D Johnson
40. Helen Warren
41. Young Jin Kim
42. Wei Zhao
43. Ying Wu
44. Bamidele O Tayo
45. Murielle Bochud
46. Devin Absher
47. Linda S Adair
48. Najaf Amin
49. Dan E Arking
50. Tomas Axelsson
51. Damiano Baldassarre
52. Beverley Balkau
53. Stefania Bandinelli
54. Michael R Barnes
55. Inês Barroso
56. Stephen Bevan
57. Joshua C Bis
58. Gyda Bjornsdottir
59. Michael Boehnke
60. Eric Boerwinkle
61. Lori L Bonnycastle
62. Dorret I Boomsma
63. Stefan R Bornstein
64. Morris J Brown
65. Michel Burnier
66. Claudia P Cabrera
67. John C Chambers
68. I-Shou Chang
69. Ching-Yu Cheng
70. Peter S Chines
71. Ren-Hua Chung
72. Francis S Collins
73. John M Connell
74. Angela Döring
75. Jean Dallongeville
76. John Danesh
77. Ulf de Faire
78. Graciela Delgado
79. Anna F Dominiczak
80. Alex S F Doney
81. Fotios Drenos
82. Sarah Edkins
83. John D Eicher
84. Roberto Elosua
85. Stefan Enroth
86. Jeanette Erdmann
87. Per Eriksson
88. Tonu Esko
89. Evangelos Evangelou
90. Alun Evans
91. Tove Fall
92. Martin Farrall
93. Janine F Felix
94. Jean Ferrières
95. Luigi Ferrucci
96. Myriam Fornage
97. Terrence Forrester
98. Nora Franceschini
99. Oscar H Franco
100. Anders Franco-Cereceda
101. Ross M Fraser
102. Santhi K Ganesh
103. He Gao
104. Karl Gertow
105. Francesco Gianfagna
106. Bruna Gigante
107. Franco Giulianini
108. Anuj Goel
109. Alison H Goodall
110. Mark O Goodarzi
111. Mathias Gorski
112. Jürgen Gräßler
113. Christopher J Groves
114. Vilmundur Gudnason
115. Ulf Gyllensten
116. Göran Hallmans
117. Anna-Liisa Hartikainen
118. Maija Hassinen
119. Aki S Havulinna
120. Caroline Hayward
121. Serge Hercberg
122. Karl-Heinz Herzig
123. Andrew A Hicks
124. Aroon D Hingorani
125. Joel N Hirschhorn
126. Albert Hofman
127. Jostein Holmen
128. Oddgeir Lingaas Holmen
129. Jouke-Jan Hottenga
130. Phil Howard
131. Chao A Hsiung
132. Steven C Hunt
133. M Arfan Ikram
134. Thomas Illig
135. Carlos Iribarren
136. Richard A Jensen
137. Mika Kähönen
138. Hyun Min Kang
139. Sekar Kathiresan
140. Brendan J Keating
141. Kay-Tee Khaw
142. Yun Kyoung Kim
143. Eric Kim
144. Mika Kivimaki
145. Norman Klopp
146. Genovefa Kolovou
147. Pirjo Komulainen
148. Jaspal S Kooner
149. Gulum Kosova
150. Ronald M Krauss
151. Diana Kuh
152. Zoltan Kutalik
153. Johanna Kuusisto
154. Kirsti Kvaløy
155. Timo A Lakka
156. Nanette R Lee
157. I-Te Lee
158. Wen-Jane Lee
159. Daniel Levy
160. Xiaohui Li
161. Kae-Woei Liang
162. Honghuang Lin
163. Li Lin
164. Jaana Lindström
165. Stéphane Lobbens
166. Satu Männistö
167. Gabriele Müller
168. Martina Müller-Nurasyid
169. François Mach
170. Hugh S Markus
171. Eirini Marouli
172. Mark I McCarthy
173. Colin A McKenzie
174. Pierre Meneton
175. Cristina Menni
176. Andres Metspalu
177. Vladan Mijatovic
178. Leena Moilanen
179. May E Montasser
180. Andrew D Morris
181. Alanna C Morrison
182. Antonella Mulas
183. Ramaiah Nagaraja
184. Narisu Narisu
185. Kjell Nikus
186. Christopher J O'Donnell
187. Paul F O'Reilly
188. Ken K Ong
189. Fred Paccaud
190. Cameron D Palmer
191. Afshin Parsa
192. Nancy L Pedersen
193. Brenda W Penninx
194. Markus Perola
195. Annette Peters
196. Neil Poulter
197. Peter P Pramstaller
198. Bruce M Psaty
199. Thomas Quertermous
200. Dabeeru C Rao
201. Asif Rasheed
202. N William Rayner
203. Frida Renström
204. Rainer Rettig
205. Kenneth M Rice
206. Robert Roberts
207. Lynda M Rose
208. Jacques Rossouw
209. Nilesh J Samani
210. Serena Sanna
211. Jouko Saramies
212. Heribert Schunkert
213. Sylvain Sebert
214. Wayne H-H Sheu
215. Young-Ah Shin
216. Xueling Sim
217. Johannes H Smit
218. Albert V Smith
219. Maria X Sosa
220. Tim D Spector
221. Alena Stančáková
222. Alice V Stanton
223. Kathleen E Stirrups
224. Heather M Stringham
225. Johan Sundstrom
226. Amy J Swift
227. Ann-Christine Syvänen
228. E-Shyong Tai
229. Toshiko Tanaka
230. Kirill V Tarasov
231. Alexander Teumer
232. Unnur Thorsteinsdottir
233. Martin D Tobin
234. Elena Tremoli
235. Andre G Uitterlinden
236. Matti Uusitupa
237. Ahmad Vaez
238. Dhananjay Vaidya
239. Cornelia M van Duijn
240. Erik P A van Iperen
241. Ramachandran S Vasan
242. Germaine C Verwoert
243. Jarmo Virtamo
244. Veronique Vitart
245. Benjamin F Voight
246. Peter Vollenweider
247. Aline Wagner
248. Louise V Wain
249. Nicholas J Wareham
250. Hugh Watkins
251. Alan B Weder
252. Harm-Jan Westra
253. Rainford Wilks
254. Tom Wilsgaard
255. James F Wilson
256. Tien Y Wong
257. Tsun-Po Yang
258. Jie Yao
259. Loic Yengo
260. Weihua Zhang
261. Jing Hua Zhao
262. Xiaofeng Zhu
263. Pascal Bovet
264. Richard S Cooper
265. Karen L Mohlke
266. Danish Saleheen
267. Jong-Young Lee
268. Paul Elliott
269. Hinco J Gierman
270. Cristen J Willer
271. Lude Franke
272. G Kees Hovingh
273. Kent D Taylor
274. George Dedoussis
275. Peter Sever
276. Andrew Wong
277. Lars Lind
278. Themistocles L Assimes
279. Inger Njølstad
280. Peter E H Schwarz
281. Claudia Langenberg
282. Harold Snieder
283. Mark J Caulfield
284. Olle Melander
285. Markku Laakso
286. Juha Saltevo
287. Rainer Rauramaa
288. Jaakko Tuomilehto
289. Erik Ingelsson
290. Terho Lehtimäki
291. Kristian Hveem
292. Walter Palmas
293. Winfried März
294. Meena Kumari
295. Veikko Salomaa
296. Yii-Der I Chen
297. Jerome I Rotter
298. Philippe Froguel
299. Marjo-Riitta Jarvelin
300. Edward G Lakatta
301. Kari Kuulasmaa
302. Paul W Franks
303. Anders Hamsten
304. H-Erich Wichmann
305. Colin N A Palmer
306. Kari Stefansson
307. Paul M Ridker
308. Ruth J F Loos
309. Aravinda Chakravarti
310. Panos Deloukas
311. Andrew P Morris
312. Christopher Newton-Cheh
313. Patricia B Munroe

Consortia

CHARGE-EchoGen Consortium

CHARGE-HF Consortium

Wellcome Trust Case Control Consortium

Contributions

Analysis group. Design of secondary analyses: G.B.E., T. Ferreira, T.J., A.P.M., P.B.M., C.N.-C. Computation of secondary analyses: G.B.E., T. Ferreira, T.J., A.P.M., P.B.M., C.N.-C. Manuscript writing: A.C., G.B.E., T. Ferreira, T.J., A.P.M., P.B.M., C.N.-C. Study management: P.B.M., C.N.-C.

Cardio-MetaboChip or new GWAS. WGHS. Study phenotyping: P.M.R., D.I.C., L.M.R. Genotyping or analysis: P.M.R., D.I.C., L.M.R., F. Giulianini. Study PI: P.M.R. JUPITER. Study phenotyping: P.M.R., D.I.C., L.M.R. Genotyping or analysis: D.I.C., L.M.R., F. Giulianini. Study PI: P.M.R., D.I.C. deCODE. Study phenotyping: G.B. Genotyping or analysis: G.T. Study PI: K.S., U.T. GoDARTS. Study phenotyping: C.N.A.P., L.A.D., A.D.M., A.S.F.D. Genotyping or analysis: C.N.A.P., L.A.D., A.D.M., M.I.M., C.J.G., N.W.R. Study PI: C.N.A.P., A.D.M. KORA F3/F4. Study phenotyping: A.D., H. Schunkert, J.E. Genotyping or analysis: A.-K.P., M.M.-N., N.K., T.I. Study PI: H.-E.W., A. Peters. GLACIER. Study phenotyping: F.R., G.H. Genotyping or analysis: P.W.F., D. Shungin, I.B., S. Edkins, F.R. Study PI: P.W.F. B58C. Genotyping or analysis: S. Kanoni, K.E.S., Wellcome Trust Case Control Consortium, E.M., T. Ferreira, T.J. Study PI: P.D. MORGAM. Study phenotyping: K. Kuulasmaa, F. Gianfagna, A. Wagner, J. Dallongeville. Genotyping or analysis: M.F.H., F. Gianfagna. Study PI: J.V., J.F., A.E. SardiNIA. Study phenotyping: E.G.L. Genotyping or analysis: E.G.L., O. Meirelles, S. Sanna, R.N., A. Mulas, K.V.T. NFBC1986. Study phenotyping: M.-R.J., S. Sebert, K.-H.H., A.-L.H. Genotyping or analysis: M. Kaakinen, A.-L.H. Study PI: M.-R.J. DESIR. Genotyping or analysis: N.B.-N., L.Y., S.L. Study PI: P.F., N.B.-N., B.B. DILGOM. Study phenotyping: S.M. Genotyping or analysis: K. Kristiansson, M.P., A.S.H. Study PI: V.S. IMPROVE. Study phenotyping: D.B. Genotyping or analysis: R.J.S., K.G. Study PI: A. Hamsten, E. Tremoli. HyperGEN. Study phenotyping: S.C.H., D.C.R. Genotyping or analysis: A.C., V.P., G.B.E. Study PI: S.C.H. FENLAND (MetaboChip). Study phenotyping: R.J.F.L., J. Luan, N.J.W., K.K.O. Genotyping or analysis: R.J.F.L., J. Luan, N.J.W., K.K.O. Study PI: N.J.W. Whitehall II. Study phenotyping: M. Kumari. Genotyping or analysis: M. Kumari, S. Shah, C.L. Study PI: A.D.H., M. Kivimaki. LURIC. Genotyping or analysis: M.E.K., G. Delgado. Study PI: W.M. MESA. Study phenotyping: W.P. Genotyping or analysis: W.P., X.G., J.Y., D.V., K.D.T., J.I.R., Y.-D.C. Study PI: W.P. HUNT2. Study phenotyping: K. Kvaløy, J.H., O.L.H. Genotyping or analysis: A.U.J. Study PI: K.H. FINCAVAS. Genotyping or analysis: T.L., L.-P.L., K.N., M. Kähönen. Study PI: T.L., M. Kähönen. GenNet. Study phenotyping: R.S.C., A.B.W. Genotyping or analysis: A.C., V.P., M.X.S., D.E.A., G.B.E. Study PI: A.C., R.S.C., A.B.W. SCARFSHEEP. Study phenotyping: B.G. Genotyping or analysis: R.J.S. Study PI: A. Hamsten, U.d.F. DPS. Study phenotyping: J. Lindström. Genotyping or analysis: A.U.J., P.S.C. Study PI: J.T., M.U. DR's EXTRA. Study phenotyping: P.K. Genotyping or analysis: A.U.J., M.H. Study PI: R. Rauramaa, T.A.L. FIN-D2D 2007. Genotyping or analysis: A.U.J., L.L.B. Study PI: J. Saltevo, L.M. METSIM. Study phenotyping: H.M.S. Genotyping or analysis: A.U.J., A.S. Study PI: M.L., J.K. MDC-CVA. Study phenotyping: O. Melander. Genotyping or analysis: O. Melander, C.F. Study PI: O. Melander. BRIGHT. Study phenotyping: A.F.D., M.J.B., N.J.S., J.M.C. Genotyping or analysis: T.J., P.B.M. Study PI: M.J.C., A.F.D., M.J.B., N.J.S., J.M.C., P.B.M. NESDA. Study phenotyping: J.H.S. Genotyping or analysis: H. Snieder, I.M.N. Study PI: B.W.P. EPIC (MetaboChip). Study phenotyping: R.J.F.L., J. Luan, N.J.W. Genotyping or analysis: J. Luan, N.J.W. Study PI: N.J.W., K.-T.K. ELY. Study phenotyping: C.L., J. Luan, N.J.W. Genotyping or analysis: C.L., J. Luan, N.J.W. Study PI: N.J.W. DIAGEN. Study phenotyping: J.G., G.M. Genotyping or analysis: A.U.J., G.M. Study PI: P.E.H.S., S.R.B. GOSH. Study phenotyping: P.K.M., N.L.P. Genotyping or analysis: E.I., P.K.M., N.L.P., T. Fall. Study PI: E.I. Tromsø. Study phenotyping: T.W. Genotyping or analysis: A.U.J., A.J.S., N.N. Study PI: I.N.N. ADVANCE. Study phenotyping: T.L.A., C.I. Genotyping or analysis: T.L.A., E.L.S., T.Q. Study PI: T.L.A., T.Q., C.I. ULSAM. Study phenotyping: E.I., J. Sundstrom. Genotyping or analysis: E.I., N.E., J. Sundstrom, A.-C.S. Study PI: J. Sundstrom. PIVUS. Study phenotyping: L. Lind, J. Sundstrom. Genotyping or analysis: L. Lind, N.E., J. Sundstrom, T.A. Study PI: L. Lind, J. Sundstrom. MRC NSHD. Study phenotyping: D.K. Genotyping or analysis: A. Wong, J. Luan, D.K., K.K.O. Study PI: D.K. ASCOT. Study phenotyping: A.V. Stanton, N.P. Genotyping or analysis: T.J., M.J.C., P.B.M., E.P.A.v.I. Study PI: P.S., M.J.C. THISEAS. Genotyping or analysis: L.S.R., S. Kanoni, E.M., G. Kolovou. Study PI: G. Dedoussis, P.D. PARC. Study phenotyping: R.M.K. Genotyping or analysis: K.D.T., E. Theusch, J.I.R., X.L., M.O.G., Y.-D.I.C. Study PI: R.M.K. AMC-PAS. Genotyping or analysis: G.K.H., P.D., E.P.A.v.I. Study PI: G.K.H. CARDIOGENICS. Genotyping or analysis: S. Kanoni, A.H.G. Study PI: P.D., A.H.G., J.E., N.J.S., H. Schunkert.

Secondary analyses. Allele-specific FAIRE. Design of secondary analysis: A.J.P.S. Computation of secondary analysis: A.J.P.S., F.D., P.H. ASAP eQTL. Design of secondary analysis: A.F.-C. Computation of secondary analysis: L. Folkersen, P. Eriksson. CARDIOGENICS eQTL. Computation of secondary analysis: L. Lataniotis. Cardio-MetaboChip design. P.B.M., C.N.-C., T.J., B.F.V., H.M.K. Comprehensive literature review. Design of secondary analysis: P.B.M. Computation of secondary analysis: K.W., P.B.M. DEPICT. Design of secondary analysis: L. Franke, T.H.P., J.N.H. Computation of secondary analysis: T.H.P. DHS and methylation analysis by tissue. Design of secondary analysis: C.J.W. Computation of secondary analysis: E.M.S. DHS and methylation by cell line. Design of secondary analysis: D.I.C. Computation of secondary analysis: D.I.C., F. Giulianini. FHS eSNP. Design of secondary analysis: R. Joehanes. Computation of secondary analysis: R. Joehanes. ICBP SC. C.N.-C., M.J.C., P.B.M., A.C., K.M.R., P.F.O'R., W.P., D.L., M.D.T., B.M.P., A.D.J., P. Elliott, C.M.v.D., D.I.C., A.V. Smith, M. Bochud, L.V.W., H. Snieder, G.B.E. Kidney eQTL. Computation of secondary analysis: H.J.G., S.K.K. MAGENTA. Design of secondary analysis: D.I.C. Computation of secondary analysis: D.I.C. Miscellaneous. Computation of secondary analysis: H. Warren. MuTHER eQTL. Design of secondary analysis: P.D. Computation of secondary analysis: L. Lataniotis, T.-P.Y. NESDA eQTL. Design of secondary analysis: R. Jansen. Computation of secondary analysis: R. Jansen, A.V. NTR eQTL. Design of secondary analysis: R. Jansen. Computation of secondary analysis: R. Jansen, J.-J.H. Study PI: D.I.B. eQTL, EGCUT. Design of secondary analysis: A. Metspalu. Computation of secondary analysis: T.E., A. Metspalu. eQTL, Groningen. Design of secondary analysis: L. Franke. Computation of secondary analysis: H.-J.W., L. Franke. Public eSNP and methylation. Design of secondary analysis: A.D.J., J.D.E. Computation of secondary analysis: A.D.J., J.D.E. PubMed search. Design of secondary analysis: G.B.E. Computation of secondary analysis: G.B.E., L. Lin. WGHS conditional. Design of secondary analysis: D.I.C. Computation of secondary analysis: D.I.C., F. Giulianini, L.M.R.

Lookup of Cardio-MetaboChip variants. HEXA. Genotyping or analysis: Y.J.K., Y.K.K., Y.-A.S. Study PI: J.-Y.L. RACe. Study phenotyping: D. Saleheen, W. Zhao, A.R. Genotyping or analysis: W. Zhao, A.R. Study PI: D. Saleheen. HALST. Study phenotyping: C.A.H. Genotyping or analysis: J.I.R., Y.-D.C., C.A.H., R.-H.C., I.-S.C. Study PI: C.A.H. CLHNS. Study phenotyping: N.R.L., L.S.A. Genotyping or analysis: Y.W., N.R.L., L.S.A. Study PI: K.L.M., L.S.A. GxE/Spanish Town. Study phenotyping: B.O.T., C.A.M., R.W. Genotyping or analysis: C.D.P. Study PI: R.S.C., C.A.M., R.W., T. Forrester, J.N.H. DRAGON. Study phenotyping: W.-J.L., W.H.-H.S., K.-W.L., I.-T.L. Genotyping or analysis: J.I.R., Y.-D.C., E.K., D.A., K.D.T., X.G. Study PI: W.H.-H.S. SEY: study phenotyping: P.B. Genotyping or analysis: M. Bochud, G.B.E., F.M. Study PI: P.B., M. Bochud, M. Burnier, F.P. TUDR: study phenotyping: W.H.-H.S., I.-T.L., W.-J.L. Genotyping or analysis: J.I.R., Y.-D.C., E.K., K.D.T., X.G. Study PI: W.H.-H.S. TANDEM. Study phenotyping: P.B., M. Bochud. Genotyping or analysis: G.B.E., F.M. Study PI: P.B., M. Bochud, M. Burnier, F.P.

Imputed genotypes. FHS. Study phenotyping: D.L. Genotyping or analysis: D.L. Study PI: D.L. ARIC. Study phenotyping: E.B. Genotyping or analysis: G.B.E., E.B., A.C.M., A.C., S.K.G. Study PI: E.B., A.C. RS. Genotyping or analysis: G.C.V., A.G.U. Study PI: A. Hofman, A.G.U., O.H.F. CoLaus. Study phenotyping: P.V. Genotyping or analysis: Z.K. Study PI: P.V. NFBC1966. Study phenotyping: M.-R.J. Genotyping or analysis: P.F.O'R. Study PI: M.-R.J. SHIP. Study phenotyping: R. Rettig. Genotyping or analysis: A.T. CHS. Study phenotyping: B.M.P. Genotyping or analysis: K.M.R. Study PI: B.M.P. EPIC (GWAS). Study phenotyping: N.J.W., R.J.F.L., J. Luan. Genotyping or analysis: N.J.W., J.H.Z., J. Luan. Study PI: N.J.W., K.-T.K. SU.VI.MAX. Study phenotyping: S.H. Genotyping or analysis: S.H., P.M. Study PI: P.M. Amish. Genotyping or analysis: M.E.M. Study PI: A. Parsa. FENLAND (GWAS). Study phenotyping: N.J.W., J. Luan, R.J.F.L., K.K.O. Genotyping or analysis: N.J.W., J. Luan, R.J.F.L., K.K.O. Study PI: N.J.W. DGI. Study phenotyping: C.N.-C. Genotyping or analysis: C.N.-C., G. Kosova. Study PI: C.N.-C. ERF (EUROSPAN). Genotyping or analysis: N.A. Study PI: C.M.v.D. MIGEN. Study phenotyping: S. Kathiresan, R.E. Genotyping or analysis: S. Kathiresan, R.E. Design of secondary analysis: S. Kathiresan, R.E. MICROS. Study phenotyping: P.P.P. Genotyping or analysis: A.A.H. Study PI: A.A.H., P.P.P. FUSION. Genotyping or analysis: A.U.J. Study PI: M. Boehnke, F.S.C., K.L.M., J. Saramies. TwinsUK. Genotyping or analysis: C.M. Study PI: T.D.S. PROCARDIS. Genotyping or analysis: M. Farrall, A.G. Study PI: M. Farrall. BLSA. Study phenotyping: L. Ferrucci. Genotyping or analysis: T.T. Study PI: L. Ferrucci. ORCADES. Study phenotyping: J.F.W. Genotyping or analysis: R.M.F. Study PI: J.F.W. Croatia-Vis. Genotyping or analysis: V.V., C.H. Study PI: V.V., C.H. NSPHS. Genotyping or analysis: S. Enroth. Study PI: U.G. InCHIANTI. Genotyping or analysis: T.T. Study PI: S. Bandinelli. AGES Reykjavik. Study phenotyping: V.G. Genotyping or analysis: A.V. Smith. Study PI: V.G.

Lookup. CARDIoGRAMplusC4D. Genotyping or analysis: P.D. Study PI: J. Danesh, H. Schunkert, T.L.A., J.E., S. Kathiresan, R. Roberts, N.J.S., P.D., H. Watkins. CHARGE cIMT. Genotyping or analysis: C.J.O'D., J.C.B. CHARGE EYE. Genotyping or analysis: T.Y.W., X.S., R.A.J. Study PI: T.Y.W. CHARGE-HF Consortium. Study phenotyping: R.S.V., J.F.F. Genotyping or analysis: H.L., J.F.F. Study PI: R.S.V. CKDGen. Genotyping or analysis: M.G., V.M. COGENT-BP. Study phenotyping: N.F., J.R. Genotyping or analysis: N.F., X.Z., B.J.K., B.O.T., J.R. EchoGen Consortium. Study phenotyping: R.S.V., J.F.F. Genotyping or analysis: H.L., J.F.F. Study PI: R.S.V. KidneyGen Consortium. Study phenotyping: J.C.C., J.S.K., P. Elliott. Genotyping or analysis: W. Zhang, J.C.C., J.S.K. Study PI: J.C.C., J.S.K. MetaStroke. Genotyping or analysis: S. Bevan, H.S.M. NeuroCHARGE. Genotyping or analysis: M. Fornage, M.A.I. Study PI: M.A.I. PROMIS. Study phenotyping: D. Saleheen, W. Zhao, J. Danesh. Genotyping or analysis: W. Zhao. Study PI: D. Saleheen. SEED. Study phenotyping: T.Y.W., C.-Y.C. Genotyping or analysis: E.-S.T., C.-Y.C., C.-Y.C. Study PI: C.-Y.C., T.Y.W. UK Biobank. BP group leaders: M.J.C., P. Elliott. Genotyping or analysis: M.R.B., H. Warren, C.P.C., E.E., H.G.

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Correspondence toChristopher Newton-Cheh or Patricia B Munroe.

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Competing interests

I.B. owns stock in Incyte and GlaxoSmithKline. A.C. is a paid member of the Scientific Advisory Board of Biogen Idec. These potential conflicts of interest are managed by the policies of Johns Hopkins University School of Medicine. D.I.C. receives genotyping and collaborative scientific support from Amgen and receives support for genetic analysis from AstraZeneca. J.F.F. worked until 2013 in ErasmusAGE, a center for ageing research across the life course funded by Nestlé Nutrition (Nestec, Ltd), Metagenics, Inc., and AXA. H.J.G. currently works for Illumina. T.J. is an employee of and owns stock in GlaxoSmithKline. B.M.P. serves on the DSMB for a clinical trial funded by the manufacturer (Zoll LifeCor) and on the Steering Committee for the Yale Open Data Access Project funded by Johnson & Johnson. P.M.R. receives genotyping and collaborative scientific support from Amgen and receives support for genetic analysis from AstraZeneca. N.P. has received financial support from several pharmaceutical companies that manufacture blood pressure–lowering or lipid-lowering agents, or both, and consultancy fees. P.S. has received research awards from Pfizer. M.J.C. is Chief Scientist for Genomics England, a UK government company.

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A list of members and affiliations appears in the Supplementary Note.

A list of members and affiliations appears in the Supplementary Note.

A list of members and affiliations appears in the Supplementary Note.

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Ehret, G., Ferreira, T., Chasman, D. et al. The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.Nat Genet 48, 1171–1184 (2016). https://doi.org/10.1038/ng.3667

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• Received: 09 July 2015
• Accepted: 15 August 2016
• Published: 12 September 2016
• Issue date: October 2016
• DOI: https://doi.org/10.1038/ng.3667