Telomere dysfunction and the initiation of genome instability (original) (raw)
Mitelman, F. (ed. Bertil Johansson, F. M.) Catalog of Chromosome Aberrations in Cancer (Wiley–Liss, New York, 1994). Google Scholar
Loeb, L. A., Springgate, C. F. & Battula, N. Errors in DNA replication as a basis of malignant changes. Cancer Res.34, 2311–2321 (1974). CASPubMed Google Scholar
Shih, I. M. et al. Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis. Cancer Res.61, 818–822 (2001). CASPubMed Google Scholar
Lengauer, C., Kinzler, K. W. & Vogelstein, B. Genetic instability in colorectal cancers. Nature386, 623–627 (1997). ArticleCASPubMed Google Scholar
Phear, G., Bhattacharyya, N. P. & Meuth, M. Loss of heterozygosity and base substitution at the APRT locus in mismatch-repair-proficient and-deficient colorectal carcinoma cell lines. Mol. Cell. Biol.16, 6516–6523 (1996). ArticleCASPubMedPubMed Central Google Scholar
Cahill, D. P. et al. Mutations of mitotic checkpoint genes in human cancers. Nature392, 300–303 (1998). ArticleCASPubMed Google Scholar
Da Costa L. T. & Lengauer, C. Exploring and exploiting instability. Cancer Biol. Ther.1, 212–225 (2002). Article Google Scholar
Maser, R. S. & DePinho, R. A. Connecting chromosomes, crisis, and cancer. Science297, 565–569 (2002). ArticleCASPubMed Google Scholar
Muller, H. J. The remaking of chromosomes. Collecting Net.13, 181–198 (1938). Google Scholar
Blasco, M. A. et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell91, 25–34 (1997). ArticleCASPubMed Google Scholar
Hemann, M. T., Strong, M. A., Hao, L. Y. & Greider, C. W. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell107, 67–77 (2001). ArticleCASPubMed Google Scholar
Hackett, J. A., Feldser, D. M. & Greider, C. W. Telomere dysfunction increases mutation rate and genomic instability. Cell106, 275–286 (2001). ArticleCASPubMed Google Scholar
Gisselsson, D. et al. Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors. Proc. Natl Acad. Sci. USA98, 12683–12688 (2001). ArticleCASPubMedPubMed Central Google Scholar
Baumann, P. & Cech, T. R. Pot1, the putative telomere end-binding protein in fission yeast and humans. Science292, 1171–1175 (2001). ArticleCASPubMed Google Scholar
Carson, M. & Hartwell, L. CDC 17: an essential gene that prevents telomere elongation in yeast. Cell42, 249–257 (1985). ArticleCASPubMed Google Scholar
Garvik, B., Carson, M. & Hartwell, L. Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint. Mol. Cell. Biol.15, 6128–6138 (1995). ArticleCASPubMedPubMed Central Google Scholar
O'Hagan, R. C. et al. Telomere dysfunction provokes regional amplification and deletion in cancer genomes. Cancer Cell2, 149–155 (2002). ArticleCASPubMed Google Scholar
Artandi, S. E. et al. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature406, 641–645 (2000). ArticleCASPubMed Google Scholar
McClintock, B. The behavior in successive nuclear divisions of a chromosome broken at meiosis. Proc. Natl Acad. Sci. USA25, 405–416 (1939). ArticleCASPubMedPubMed Central Google Scholar
Rudolph, K. L. et al. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell96, 701–712 (1999). ArticleCASPubMed Google Scholar
Chin, L. et al. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell97, 527–538 (1999). ArticleCASPubMed Google Scholar
Rudolph, K. L., Millard, M., Bosenberg, M. W. & DePinho, R. A. Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nature Genet.28, 155–159 (2001). ArticleCASPubMed Google Scholar
Chang, S., Khoo, C. & DePinho, R. A. Modeling chromosomal instability and epithelial carcinogenesis in the telomerase-deficient mouse. Semin. Cancer Biol.11, 227–239 (2001). ArticleCASPubMed Google Scholar
Harley, C. B., Futcher, A. B. & Greider, C. W. Telomeres shorten during ageing of human fibroblasts. Nature345, 458–460 (1990). ArticleCASPubMed Google Scholar
de Lange, T. in Telomeres (eds. Blackburn, E. H. & Greider, C. W.) 265–293 (Cold Spring Harbor Laboratory Press, New York, 1995). Google Scholar
Meeker, A. K. et al. Telomere length assessment in human archival tissues: combined telomere fluorescence in situ hybridization and immunostaining. Am. J. Pathol.160, 1259–1268 (2002). ArticleCASPubMedPubMed Central Google Scholar
van Heek, N. T. et al. Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia. Am. J. Pathol.161, 1541–1547 (2002). ArticleCASPubMedPubMed Central Google Scholar
Meeker, A. K. et al. Telomere shortening is an early somatic DNA alteration in human prostate tumorigenesis. Cancer Res.62, 6405–6409 (2002). CASPubMed Google Scholar
Ekbom, A., Helmick, C., Zack, M. & Adami, H. O. Ulcerative colitis and colorectal cancer. A population-based study. N. Engl. J. Med.323, 1228–1233 (1990). ArticleCASPubMed Google Scholar
Kinouchi, Y. et al. Telomere shortening in the colonic mucosa of patients with ulcerative colitis. J. Gastroenterol.33, 343–348 (1998). ArticleCASPubMed Google Scholar
Kitada, T., Seki, S., Kawakita, N., Kuroki, T. & Monna, T. Telomere shortening in chronic liver diseases. Biochem. Biophys. Res. Commun.211, 33–39 (1995). ArticleCASPubMed Google Scholar
O'Sullivan, J. N. et al. Chromosomal instability in ulcerative colitis is related to telomere shortening. Nature Genet.32, 280–284 (2002). ArticleCASPubMed Google Scholar
Engelhardt, M., Drullinsky, P., Guillem, J. & Moore, M. A. Telomerase and telomere length in the development and progression of premalignant lesions to colorectal cancer. Clin. Cancer Res.3, 1931–1941 (1997). CASPubMed Google Scholar
Greider, C. W. Cellular responses to telomere shortening: cellular senescence as a tumor suppressor mechanism. Harvey Lect.96, 33–50 (2000). PubMed Google Scholar
Counter, C. M. et al. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J.11, 1921–1929 (1992). ArticleCASPubMedPubMed Central Google Scholar
Sherwood, S. W., Rush, D., Ellsworth, J. L. & Schimke, R. T. Defining cellular senescence in IMR-90 cells: a flow cytometric analysis. Proc. Natl Acad. Sci. USA85, 9086–9090 (1988). ArticleCASPubMedPubMed Central Google Scholar
Benn, P. A. Specific chromosome aberrations in senescent fibroblast cell lines derived from human embryos. Am. J. Hum. Genet.28, 465–473 (1976). CASPubMedPubMed Central Google Scholar
Cahill, D. P., Kinzler, K. W., Vogelstein, B. & Lengauer, C. Genetic instability and darwinian selection in tumours. Trends Cell Biol.9, M57–M60 (1999). ArticleCASPubMed Google Scholar
Hackett, J. A. & Greider, C. W. Balancing instability: dual roles for telomerase and telomere dysfunction in tumorigenesis. Oncogene21, 619–626 (2002). ArticleCASPubMed Google Scholar
Kim, N. W. et al. Specific association of human telomerase activity with immortal cells and cancer. Science266, 2011–2015 (1994). ArticleCASPubMed Google Scholar
Shay, J. W. & Bacchetti, S. A survey of telomerase activity in human cancer. Eur. J. Cancer33, 787–791 (1997). ArticleCASPubMed Google Scholar
Chadeneau, C., Hay, K., Hirte, H. W., Gallinger, S. & Bacchetti, S. Telomerase activity associated with acquisition of malignancy in human colorectal cancer. Cancer Res.55, 2533–2536 (1995). CASPubMed Google Scholar
Tang, R., Cheng, A. J., Wang, J. Y. & Wang, T. C. Close correlation between telomerase expression and adenomatous polyp progression in multistep colorectal carcinogenesis. Cancer Res.58, 4052–4054 (1998). CASPubMed Google Scholar
Bryan, T. M., Englezou, A., Dunham, M. A. & Reddel, R. R. Telomere length dynamics in telomerase-positive immortal human cell populations. Exp. Cell Res.239, 370–378 (1998). ArticleCASPubMed Google Scholar
Myung, K., Chen, C. & Kolodner, R. D. Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae. Nature411, 1073–1076 (2001). ArticleCASPubMed Google Scholar
Maringele, L. & Lydall, D. EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Delta mutants. Genes Dev.16, 1919–1933 (2002). ArticleCASPubMedPubMed Central Google Scholar
Lengauer, C., Kinzler, K. W. & Vogelstein, B. Genetic instabilities in human cancers. Nature396, 643–649 (1998). ArticleCASPubMed Google Scholar