Mechanistic links between COPD and lung cancer (original) (raw)

• Peto, R., Chen, Z. M. & Boreham, J. Tobacco-the growing epidemic. Nature Med. 5, 15–17 (1999).
  Article CAS PubMed Google Scholar
• Youlden, D. R., Cramb, S. M. & Baade, P. D. The International Epidemiology of Lung Cancer: geographical distribution and secular trends. J. Thorac. Oncol. 3, 819–831 (2008).
  Article PubMed Google Scholar
• Wasswa-Kintu, S., Gan, W. Q., Man, S. F., Pare, P. D. & Sin, D. D. Relationship between reduced forced expiratory volume in one second and the risk of lung cancer: a systematic review and meta-analysis. Thorax 60, 570–575 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Skillrud, D. M., Offord, K. P. & Miller, R. D. Higher risk of lung cancer in chronic obstructive pulmonary disease. A prospective, matched, controlled study. Ann. Intern. Med. 105, 503–507 (1986). The first study to show increased lung cancer incidence in patients with COPD.
  Article CAS PubMed Google Scholar
• Tockman, M. S., Anthonisen, N. R., Wright, E. C. & Donithan, M. G. Airways obstruction and the risk for lung cancer. Ann. Intern. Med. 106, 512–518 (1987).
  Article CAS PubMed Google Scholar
• Lange, P., Nyboe, J., Appleyard, M., Jensen, G. & Schnohr, P. Ventilatory function and chronic mucus hypersecretion as predictors of death from lung cancer. Am. Rev. Respir. Dis. 141, 613–617 (1990).
  Article CAS PubMed Google Scholar
• Speizer, F. E., Fay, M. E., Dockery, D. W. & Ferris, B. G. Jr. Chronic obstructive pulmonary disease mortality in six U.S. cities. Am. Rev. Respir. Dis. 140, S49–S55 (1989).
  Article CAS PubMed Google Scholar
• Sin, D. D., Anthonisen, N. R., Soriano, J. B. & Agusti, A. G. Mortality in COPD: role of comorbidities. Eur. Respir. J. 28, 1245–1257 (2006).
  Article CAS PubMed Google Scholar
• Young, R. P. et al. COPD prevalence is increased in lung cancer, independent of age, sex and smoking history. Eur. Respir. J. 34, 380–386 (2009).
  Article CAS PubMed Google Scholar
• Pauwels, R. A., Buist, A. S., Calverley, P. M., Jenkins, C. R. & Hurd, S. S. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am. J. Respir. Crit. Care Med. 163, 1256–1276 (2001).
  Article CAS PubMed Google Scholar
• Shapiro, S. D. & Ingenito, E. P. The pathogenesis of chronic obstructive pulmonary disease: advances in the past 100 years. Am. J. Respir. Cell. Mol. Biol. 32, 367–372 (2005).
  Article CAS PubMed Google Scholar
• Mannino, D. M. Epidemiology and global impact of chronic obstructive pulmonary disease. Semin. Respir. Crit. Care Med. 26, 204–210 (2005).
  Article PubMed Google Scholar
• Jemal, A. et al. Global cancer statistics. CA Cancer J. Clin. 61, 69–90 (2011).
  Article PubMed Google Scholar
• Travis, W. D. et al. International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society: international multidisciplinary classification of lung adenocarcinoma: executive summary. Proc. Am. Thorac. Soc. 8, 381–385 (2011).
  Article PubMed Google Scholar
• Sun, S., Schiller, J. H. & Gazdar, A. F. Lung cancer in never smokers--a different disease. Nature Rev. Cancer 7, 778–790 (2007).
  Article CAS Google Scholar
• Punturieri, A., Szabo, E., Croxton, T. L., Shapiro, S. D. & Dubinett, S. M. Lung cancer and chronic obstructive pulmonary disease: needs and opportunities for integrated research. J. Natl Cancer Inst. 101, 554–559 (2009).
  Article PubMed PubMed Central Google Scholar
• Wilson, D. O. et al. Association of radiographic emphysema and airflow obstruction with lung cancer. Am. J. Respir. Crit. Care Med. 178, 738–744 (2008). Definitive study showing that the presence of radiographic emphysema confers lung cancer risk.
  Article PubMed PubMed Central Google Scholar
• Ueda, K. et al. Computed tomography-diagnosed emphysema, not airway obstruction, is associated with the prognostic outcome of early-stage lung cancer. Clin. Cancer Res. 12, 6730–6736 (2006).
  Article PubMed Google Scholar
• de Torres, J. P. et al. Assessing the relationship between lung cancer risk and emphysema detected on low-dose CT of the chest. Chest 132, 1932–1938 (2007).
  Article PubMed Google Scholar
• Li, Y. et al. Effect of emphysema on lung cancer risk in smokers: a computed tomography-based assessment. Cancer Prev. Res. 4, 43–50 (2011).
  Article Google Scholar
• Zulueta, J. J. et al. Emphysema scores predict death from COPD and lung cancer. Chest 141, 1216–1223 (2012).
  Article PubMed Google Scholar
• Wilson, D. O. et al. Quantitative computed tomography analysis, airflow obstruction, and lung cancer in the pittsburgh lung screening study. J. Thorac. Oncol. 6, 1200–1205 (2011).
  Article PubMed PubMed Central Google Scholar
• Maldonado, F. et al. Are airflow obstruction and radiographic evidence of emphysema risk factors for lung cancer? A nested case-control study using quantitative emphysema analysis. Chest 138, 1295–1302 (2010).
  Article PubMed Google Scholar
• Taraseviciene-Stewart, L. & Voelkel, N. F. Molecular pathogenesis of emphysema. J. Clin. Invest. 118, 394–402 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Barnes, P. J. Chronic obstructive pulmonary disease. N. Engl. J. Med. 343, 269–280 (2000).
  Article CAS PubMed Google Scholar
• Berk, D. R., Bentley, D. D., Bayliss, S. J., Lind, A. & Urban, Z. Cutis laxa: a review. J. Am. Acad. Dermatol. 66, 842.e1–842.e17 (2012).
  Article Google Scholar
• Brantly, M., Nukiwa, T. & Crystal, R. G. Molecular basis of α-1-antitrypsin deficiency. Am. J. Med. 84, 13–31 (1988).
  Article PubMed Google Scholar
• Shapiro, S. D., Endicott, S. K., Province, M. A., Pierce, J. A. & Campbell, E. J. Marked longevity of human lung parenchymal elastic fibers deduced from prevalence of D-aspartate and nuclear weapons-related radiocarbon. J. Clin. Invest. 87, 1828–1834 (1991).
  Article CAS PubMed PubMed Central Google Scholar
• Heidelberger, K. P. α-1-antitrypsin deficiency: a review; 1963–1975. Ann. Clin. Lab Sci. 6, 110–117 (1976).
  CAS PubMed Google Scholar
• Shapiro, S. D. The pathogenesis of emphysema: the elastase:antielastase hypothesis 30 years later. Proc. Assoc. Am. Physicians 107, 346–352 (1995).
  CAS PubMed Google Scholar
• Gross, P., Pfitzer, E. A., Tolker, E., Babyak, M. A. & Kaschak, M. Experimental emphysema: its production with papain in normal and silicotic rats. Arch. Environ. Health 11, 50–58 (1965).
  Article CAS PubMed Google Scholar
• Larsson, C. Natural history and life expectancy in severe α1-antitrypsin deficiency, Pi Z. Acta Med. Scand. 204, 345–351 (1978).
  Article CAS PubMed Google Scholar
• Yang, P. et al. α1-antitrypsin deficiency carriers, tobacco smoke, chronic obstructive pulmonary disease, and lung cancer risk. Arch. Intern. Med. 168, 1097–1103 (2008).
  Article PubMed PubMed Central Google Scholar
• Yang, P. et al. α1-antitrypsin and neutrophil elastase imbalance and lung cancer risk. Chest 128, 445–452 (2005).
  Article CAS PubMed Google Scholar
• Petrache, I. et al. A novel antiapoptotic role for α1-antitrypsin in the prevention of pulmonary emphysema. Am. J. Respir. Crit. Care Med. 173, 1222–1228 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Demeo, D. L. et al. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am. J. Hum. Genet. 78, 253–264 (2006).
  Article CAS PubMed Google Scholar
• Cho, M. H. et al. Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nature Genet. 42, 200–202 (2010).
  Article CAS PubMed Google Scholar
• Pillai, S. G. et al. Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 182, 1498–1505 (2010).
  Article PubMed PubMed Central Google Scholar
• Thorgeirsson, T. E. et al. A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature 452, 638–642 (2008). One of the original studies linking polymorphisms in CHRNA3 and CHRNA5 to cigarette consumption, nicotine dependence and lung cancer.
  Article CAS PubMed PubMed Central Google Scholar
• Hung, R. J. et al. A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature 452, 633–637 (2008).
  Article CAS PubMed Google Scholar
• Amos, C. I. et al. Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nature Genet. 40, 616–622 (2008).
  Article CAS PubMed Google Scholar
• Belinsky, S. A. et al. Aberrant promoter methylation in bronchial epithelium and sputum from current and former smokers. Cancer Res. 62, 2370–2377 (2002).
  CAS PubMed Google Scholar
• Belinsky, S. A. Silencing of genes by promoter hypermethylation: key event in rodent and human lung cancer. Carcinogenesis 26, 1481–1487 (2005).
  Article CAS PubMed Google Scholar
• Zhang, H. T. et al. Defective expression of transforming growth factor β receptor type II is associated with CpG methylated promoter in primary non-small cell lung cancer. Clin. Cancer Res. 10, 2359–2367 (2004).
  Article CAS PubMed Google Scholar
• Zochbauer-Muller, S. et al. Aberrant promoter methylation of multiple genes in non-small cell lung cancers. Cancer Res. 61, 249–255 (2001).
  CAS PubMed Google Scholar
• Ohtani-Fujita, N. et al. CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene. Oncogene 8, 1063–1067 (1993).
  CAS PubMed Google Scholar
• Dammann, R., Takahashi, T. & Pfeifer, G. P. The CpG island of the novel tumor suppressor gene RASSF1A is intensely methylated in primary small cell lung carcinomas. Oncogene 20, 3563–3567 (2001).
  Article CAS PubMed Google Scholar
• Belinsky, S. A. et al. Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis. Proc. Natl Acad. Sci. USA 95, 11891–11896 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Qiu, W. et al. Variable DNA methylation is associated with chronic obstructive pulmonary disease and lung function. Am. J. Respir. Crit. Care Med. 185, 373–381 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Kasahara, Y. et al. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J. Clin. Invest. 106, 1311–1319 (2000). The semimal report highlighting the importance of cellular apoptosis in the pathogenesis of emphysema.
  Article CAS PubMed PubMed Central Google Scholar
• Aoshiba, K., Yokohori, N. & Nagai, A. Alveolar wall apoptosis causes lung destruction and emphysematous changes. Am. J. Respir. Cell. Mol. Biol. 28, 555–562 (2003).
  Article CAS PubMed Google Scholar
• Shapiro, S. D. Vascular atrophy and VEGFR-2 signaling: old theories of pulmonary emphysema meet new data. J. Clin. Invest. 106, 1309–1310 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646–674 (2011). The definitive review on the key features that define malignancy.
  Article CAS PubMed Google Scholar
• Steiling, K., Ryan, J., Brody, J. S. & Spira, A. The field of tissue injury in the lung and airway. Cancer Prev. Res. 1, 396–403 (2008).
  Article CAS Google Scholar
• Slaughter, D. P., Southwick, H. W. & Smejkal, W. Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer 6, 963–968 (1953).
  Article CAS PubMed Google Scholar
• Franklin, W. A. et al. Widely dispersed p53 mutation in respiratory epithelium. A novel mechanism for field carcinogenesis. J. Clin. Invest. 100, 2133–2137 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Chang, Y. L. et al. Clonality and prognostic implications of p53 and epidermal growth factor receptor somatic aberrations in multiple primary lung cancers. Clin. Cancer Res. 13, 52–58 (2007).
  Article CAS PubMed Google Scholar
• Wistuba, I. I. et al. Molecular damage in the bronchial epithelium of current and former smokers. J. Natl Cancer Inst. 89, 1366–1373 (1997).
  Article CAS PubMed Google Scholar
• Tang, X. et al. EGFR tyrosine kinase domain mutations are detected in histologically normal respiratory epithelium in lung cancer patients. Cancer Res. 65, 7568–7572 (2005).
  Article CAS PubMed Google Scholar
• Ji, H. et al. K-ras activation generates an inflammatory response in lung tumors. Oncogene 25, 2105–2112 (2006).
  Article CAS PubMed Google Scholar
• Sparmann, A. & Bar-Sagi, D. Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis. Cancer Cell 6, 447–458 (2004). This is the seminal report of RAS-induced expression of IL-8. This work confirms that cancers have the ability to manipulate host immune cell function to their benefit.
  Article CAS PubMed Google Scholar
• Spira, A. et al. Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer. Nature Med. 13, 361–366 (2007). This study validates the concept that cells residing in the field of risk can predict the presence of distal cancers on the basis of their genetic profiles.
  Article CAS PubMed Google Scholar
• Gustafson, A. M. et al. Airway PI3K pathway activation is an early and reversible event in lung cancer development. Sci. Transl. Med. 2, 26ra25 (2010).
  Article PubMed PubMed Central CAS Google Scholar
• Jackson, E. L. et al. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev. 15, 3243–3248 (2001). This is the initial report of the LSL- Kras mouse that develops lung adenoma and adenocarcinoma. It is the mouse model that is most commonly used to study lung cancer.
  Article CAS PubMed PubMed Central Google Scholar
• Kim, C. F. et al. Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell 121, 823–835 (2005).
  Article CAS PubMed Google Scholar
• Yatabe, Y., Borczuk, A. C. & Powell, C. A. Do all lung adenocarcinomas follow a stepwise progression? Lung Cancer 74, 7–11 (2011).
  Article PubMed Google Scholar
• Karimi, R., Tornling, G., Grunewald, J., Eklund, A. & Skold, C. M. Cell recovery in bronchoalveolar lavage fluid in smokers is dependent on cumulative smoking history. PLoS ONE 7, e34232 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Merchant, R. K., Schwartz, D. A., Helmers, R. A., Dayton, C. S. & Hunninghake, G. W. Bronchoalveolar lavage cellularity. The distribution in normal volunteers. Am. Rev. Respir. Dis. 146, 448–453 (1992).
  Article CAS PubMed Google Scholar
• Hogg, J. C. et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N. Engl. J. Med. 350, 2645–2653 (2004). Definitive study characterizing the quality and quantity of airway inflammation in patients with COPD.
  Article CAS PubMed Google Scholar
• Coussens, L. M. & Werb, Z. Inflammation and cancer. Nature 420, 860–867 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Grumelli, S. et al. An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema. PLoS Med. 1, e8 (2004). Seminal study providing a mechanistic basis for the role of lymphocytes in COPD pathogenesis in humans.
  Article PubMed PubMed Central CAS Google Scholar
• Shaykhiev, R. et al. Smoking-dependent reprogramming of alveolar macrophage polarization: implication for pathogenesis of chronic obstructive pulmonary disease. J. Immunol. 183, 2867–2883 (2009).
  Article CAS PubMed Google Scholar
• Kunz, L. I. et al. Smoking status and anti-inflammatory macrophages in bronchoalveolar lavage and induced sputum in COPD. Respir. Res. 12, 34 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Maeno, T. et al. CD8+ T Cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice. J. Immunol. 178, 8090–8096 (2007).
  Article CAS PubMed Google Scholar
• Mio, T. et al. Cigarette smoke induces interleukin-8 release from human bronchial epithelial cells. Am. J. Respir. Crit. Care Med. 155, 1770–1776 (1997).
  Article CAS PubMed Google Scholar
• Shan, M. et al. Lung myeloid dendritic cells coordinately induce TH1 and TH17 responses in human emphysema. Sci. Transl. Med. 1, 4ra10 (2009).
  Article PubMed CAS Google Scholar
• Chen, K. et al. IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke. PLoS ONE 6, e20333 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• de Visser, K. E., Eichten, A. & Coussens, L. M. Paradoxical roles of the immune system during cancer development. Nature Rev. Cancer 6, 24–37 (2006).
  Article CAS Google Scholar
• Mantovani, A., Sozzani, S., Locati, M., Allavena, P. & Sica, A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 23, 549–555 (2002).
  Article CAS PubMed Google Scholar
• Gabrilovich, D. I. & Nagaraj, S. Myeloid-derived suppressor cells as regulators of the immune system. Nature Rev. Immunol. 9, 162–174 (2009).
  Article CAS Google Scholar
• Fridlender, Z. G. et al. Polarization of tumor-associated neutrophil phenotype by TGF-β: “N1” versus “N2” TAN. Cancer Cell 16, 183–194 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Moghaddam, S. J. et al. Promotion of lung carcinogenesis by chronic obstructive pulmonary disease-like airway inflammation in a K-ras-induced mouse model. Am. J. Respir. Cell. Mol. Biol. 40, 443–453 (2009).
  Article CAS PubMed Google Scholar
• Gallina, G. et al. Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells. J. Clin. Invest. 116, 2777–2790 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Chen, M. L. et al. Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signals in vivo. Proc. Natl Acad. Sci. USA 102, 419–424 (2005).
  Article CAS PubMed Google Scholar
• Whiteside, T. L. Immune suppression in cancer: effects on immune cells, mechanisms and future therapeutic intervention. Semin. Cancer Biol. 16, 3–15 (2006).
  Article CAS PubMed Google Scholar
• Wang, L. et al. IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway. J. Exp. Med. 206, 1457–1464 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Martin-Orozco, N. et al. T helper 17 cells promote cytotoxic T cell activation in tumor immunity. Immunity 31, 787–798 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Haqqani, A. S., Sandhu, J. K. & Birnboim, H. C. Expression of interleukin-8 promotes neutrophil infiltration and genetic instability in mutatect tumors. Neoplasia 2, 561–568 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Dinarello, C. A. The paradox of pro-inflammatory cytokines in cancer. Cancer Metastasis Rev. 25, 307–313 (2006).
  Article CAS PubMed Google Scholar
• Takahashi, H., Ogata, H., Nishigaki, R., Broide, D. H. & Karin, M. Tobacco smoke promotes lung tumorigenesis by triggering IKKβ- and JNK1-dependent inflammation. Cancer Cell 17, 89–97 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Zhang, J. Y., Wang, Y. & Prakash, C. Xenobiotic-metabolizing enzymes in human lung. Curr. Drug Metab. 7, 939–948 (2006).
  Article CAS PubMed Google Scholar
• Dix, T. A. & Marnett, L. J. Metabolism of polycyclic aromatic hydrocarbon derivatives to ultimate carcinogens during lipid peroxidation. Science 221, 77–79 (1983).
  Article CAS PubMed Google Scholar
• Feyler, A. et al. Point: myeloperoxidase −463G ⊠ a polymorphism and lung cancer risk. Cancer Epidemiol. Biomarkers Prev. 11, 1550–1554 (2002).
  CAS PubMed Google Scholar
• Nguyen, T., Nioi, P. & Pickett, C. B. The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J. Biol. Chem. 284, 13291–13295 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Rangasamy, T. et al. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J. Clin. Invest. 114, 1248–1259 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Satoh, H. et al. Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung. Carcinogenesis 31, 1833–1843 (2010).
  Article CAS PubMed Google Scholar
• Kensler, T. W. et al. Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China. Carcinogenesis 33, 101–107 (2012).
  Article CAS PubMed Google Scholar
• Shureiqi, I. & Baron, J. A. Curcumin chemoprevention: the long road to clinical translation. Cancer Prev. Res. 4, 296–298 (2011).
  Article CAS Google Scholar
• DeNicola, G. M. et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature 475, 106–109 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Sporn, M. B. & Liby, K. T. NRF2 and cancer: the good, the bad and the importance of context. Nature Rev. Cancer 12, 564–571 (2012).
  Article CAS Google Scholar
• Solis, L. M. et al. Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features. Clin. Cancer Res. 16, 3743–3753 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Liu, Z. et al. The serpin α1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo. Cell 102, 647–655 (2000).
  Article CAS PubMed Google Scholar
• Atkinson, J. J. et al. The role of matrix metalloproteinase-9 in cigarette smoke-induced emphysema. Am. J. Respir. Crit. Care Med. 183, 876–884 (2011).
  Article CAS PubMed Google Scholar
• Russell, R. E. et al. Release and activity of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 by alveolar macrophages from patients with chronic obstructive pulmonary disease. Am. J. Respir. Cell. Mol. Biol. 26, 602–609 (2002).
  Article CAS PubMed Google Scholar
• Russell, R. E. et al. Alveolar macrophage-mediated elastolysis: roles of matrix metalloproteinases, cysteine, and serine proteases. Am. J. Physiol. Lung Cell. Mol. Physiol. 283, L867–L873 (2002).
  Article CAS PubMed Google Scholar
• Vignola, A. M. et al. Sputum metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio correlates with airflow obstruction in asthma and chronic bronchitis. Am. J. Respir. Crit. Care Med. 158, 1945–1950 (1998).
  Article CAS PubMed Google Scholar
• Nozawa, H., Chiu, C. & Hanahan, D. Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis. Proc. Natl Acad. Sci. USA 103, 12493–12498 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Bergers, G. et al. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nature Cell Biol. 2, 737–744 (2000).
  Article CAS PubMed Google Scholar
• Coussens, L. M., Tinkle, C. L., Hanahan, D. & Werb, Z. MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell 103, 481–490 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Itoh, T. et al. Reduced angiogenesis and tumor progression in gelatinase A-deficient mice. Cancer Res. 58, 1048–1051 (1998).
  CAS PubMed Google Scholar
• Gupta, G. P. et al. Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. Nature 446, 765–770 (2007).
  Article CAS PubMed Google Scholar
• Lu, X. et al. ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis. Genes Dev. 23, 1882–1894 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Minn, A. J. et al. Genes that mediate breast cancer metastasis to lung. Nature 436, 518–524 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• D'Armiento, J., Dalal, S. S., Okada, Y., Berg, R. A. & Chada, K. Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema. Cell 71, 955–961 (1992).
  Article CAS PubMed Google Scholar
• Joos, L. et al. The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function. Hum. Mol. Genet. 11, 569–576 (2002).
  Article CAS PubMed Google Scholar
• Hautamaki, R. D., Kobayashi, D. K., Senior, R. M. & Shapiro, S. D. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science 277, 2002–2004 (1997). This was the first study to combine cigarette smoke exposure and gene-targeted mice, which is now commonplace. It was also the first study to demonstrate a key role for MMP12 in cigarette smoke-induced emphysema.
  Article CAS PubMed Google Scholar
• Hunninghake, G. M. et al. MMP12, lung function, and COPD in high-risk populations. N. Engl. J. Med. 361, 2599–2608 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Acuff, H. B. et al. Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer. Cancer Res. 66, 7968–7975 (2006).
  Article CAS PubMed Google Scholar
• Houghton, A. M. et al. Macrophage elastase (matrix metalloproteinase-12) suppresses growth of lung metastases. Cancer Res. 66, 6149–6155 (2006).
  Article CAS PubMed Google Scholar
• Cornelius, L. A. et al. Matrix metalloproteinases generate angiostatin: effects on neovascularization. J. Immunol. 161, 6845–6852 (1998).
  CAS PubMed Google Scholar
• Kuhn, C., Yu, S. Y., Chraplyvy, M., Linder, H. E. & Senior, R. M. The induction of emphysema with elastase. II. Changes in connective tissue. Lab Invest. 34, 372–380 (1976).
  CAS PubMed Google Scholar
• Shapiro, S. D. et al. Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice. Am. J. Pathol. 163, 2329–2335 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Houghton, A. M. et al. Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth. Nature Med. 16, 219–223 (2010).
  Article CAS PubMed Google Scholar
• Foekens, J. A. et al. The prognostic value of polymorphonuclear leukocyte elastase in patients with primary breast cancer. Cancer Res. 63, 337–341 (2003).
  CAS PubMed Google Scholar
• Akizuki, M. et al. Prognostic significance of immunoreactive neutrophil elastase in human breast cancer: long-term follow-up results in 313 patients. Neoplasia 9, 260–264 (2007).
  Article PubMed PubMed Central Google Scholar
• Houghton, A. M. et al. Elastin fragments drive disease progression in a murine model of emphysema. J. Clin. Invest. 116, 753–759 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Mydel, P. et al. Neutrophil elastase cleaves laminin-332 (laminin-5) generating peptides that are chemotactic for neutrophils. J. Biol. Chem. 283, 9513–9522 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Weathington, N. M. et al. A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation. Nature Med. 12, 317–323 (2006). Seminal study demonstrating the importance of matrix fragments (independently of cytokines and chemokines) on the recruitment and maintenance of inflammatory cell infiltrates in the setting of lung injury.
  Article CAS PubMed Google Scholar
• Aberle, D. R. et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N. Engl. J. Med. 365, 395–409 (2011). This study reports the results of a large, multi-centre, randomized, placebo-controlled clinical trial, which demonstrated a 20% reduction in lung cancer mortality from the use of chest CT screening.
  Article PubMed Google Scholar
• Tammemagi, C. M. et al. Lung cancer risk prediction: prostate, lung, colorectal and ovarian cancer screening trial models and validation. J. Natl Cancer Inst. 103, 1058–1068 (2011).
  Article PubMed PubMed Central Google Scholar
• Parimon, T. et al. Inhaled corticosteroids and risk of lung cancer among patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 175, 712–719 (2007).
  Article CAS PubMed Google Scholar
• Calverley, P. M. et al. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N. Engl. J. Med. 356, 775–789 (2007).
  Article CAS PubMed Google Scholar
• Stolina, M. et al. Specific inhibition of cyclooxygenase 2 restores antitumor reactivity by altering the balance of IL-10 and IL-12 synthesis. J. Immunol. 164, 361–370 (2000).
  Article CAS PubMed Google Scholar
• Khuri, F. R. et al. Cyclooxygenase-2 overexpression is a marker of poor prognosis in stage I non-small cell lung cancer. Clin. Cancer Res. 7, 861–867 (2001).
  CAS PubMed Google Scholar
• Greenhough, A. et al. The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. Carcinogenesis 30, 377–386 (2009).
  Article CAS PubMed Google Scholar
• Mao, J. T. et al. Lung cancer chemoprevention with celecoxib in former smokers. Cancer Prev. Res. 4, 984–993 (2011).
  Article CAS Google Scholar
• Solomon, S. D. et al. Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention. N. Engl. J. Med. 352, 1071–1080 (2005).
  Article CAS PubMed Google Scholar
• Heasley, L. E. et al. Induction of cytosolic phospholipase A2 by oncogenic Ras in human non-small cell lung cancer. J. Biol. Chem. 272, 14501–14504 (1997).
  Article CAS PubMed Google Scholar
• Keith, R. L. et al. Pulmonary prostacyclin synthase overexpression chemoprevents tobacco smoke lung carcinogenesis in mice. Cancer Res. 64, 5897–5904 (2004).
  Article CAS PubMed Google Scholar
• Keith, R. L. et al. Oral iloprost improves endobronchial dysplasia in former smokers. Cancer Prev. Res. 4, 793–802 (2011).
  Article CAS Google Scholar
• Nocturnal Oxygen Therapy Trial Group. Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: a clinical trial. Ann. Intern. Med. 93, 391–398 (1980).
• Ito, K. et al. Decreased histone deacetylase activity in chronic obstructive pulmonary disease. N. Engl. J. Med. 352, 1967–1976 (2005).
  Article CAS PubMed Google Scholar
• Adcock, I. M., Chung, K. F., Caramori, G. & Ito, K. Kinase inhibitors and airway inflammation. Eur. J. Pharmacol. 533, 118–132 (2006).
  Article CAS PubMed Google Scholar
• Shepherd, F. A. et al. Erlotinib in previously treated non-small-cell lung cancer. N. Engl. J. Med. 353, 123–132 (2005).
  Article CAS PubMed Google Scholar
• Soda, M. et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 448, 561–566 (2007).
  Article CAS PubMed Google Scholar
• Woodruff, P. G. et al. Safety and efficacy of an inhaled epidermal growth factor receptor inhibitor (BIBW 2948 BS) in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 181, 438–445 (2010).
  Article CAS PubMed Google Scholar
• Hammerman, P. S. et al. Comprehensive genomic characterization of squamous cell lung cancers. Nature 489, 519–525 (2012).
  Article CAS Google Scholar
• Imielinski, M. et al. Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell 150, 1107–1120 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Witschi, H. et al. The carcinogenicity of environmental tobacco smoke. Carcinogenesis 18, 575–586 (1997).
  Article CAS PubMed Google Scholar
• Hubbard, R., Venn, A., Lewis, S. & Britton, J. Lung cancer and cryptogenic fibrosing alveolitis. A population-based cohort study. Am. J. Respir. Crit. Care Med. 161, 5–8 (2000).
  Article CAS PubMed Google Scholar
• Sandford, A. J., Weir, T. D., Spinelli, J. J. & Pare, P. D. Z and S mutations of the α1-antitrypsin gene and the risk of chronic obstructive pulmonary disease. Am. J. Respir. Cell. Mol. Biol. 20, 287–291 (1999).
  Article CAS PubMed Google Scholar
• Yang, P. et al. α1-antitrypsin deficiency allele carriers among lung cancer patients. Cancer Epidemiol. Biomarkers Prev. 8, 461–465 (1999).
  CAS PubMed Google Scholar
• Zhu, Y., Spitz, M. R., Lei, L., Mills, G. B. & Wu, X. A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter enhances lung cancer susceptibility. Cancer Res. 61, 7825–7829 (2001).
  CAS PubMed Google Scholar
• Cheng, S. L., Yu, C. J. & Yang, P. C. Genetic polymorphisms of cytochrome p450 and matrix metalloproteinase in chronic obstructive pulmonary disease. Biochem. Genet. 47, 591–601 (2009).
  Article CAS PubMed Google Scholar
• Dialyna, I. A., Miyakis, S., Georgatou, N. & Spandidos, D. A. Genetic polymorphisms of CYP1A1, GSTM1 and GSTT1 genes and lung cancer risk. Oncol. Rep. 10, 1829–1835 (2003).
  CAS PubMed Google Scholar
• Xiao, D. et al. Relationship between polymorphisms of genes encoding microsomal epoxide hydrolase and glutathione S-transferase P1 and chronic obstructive pulmonary disease. Chin. Med. J. 117, 661–667 (2004).
  CAS PubMed Google Scholar
• Park, J. Y., Chen, L., Wadhwa, N. & Tockman, M. S. Polymorphisms for microsomal epoxide hydrolase and genetic susceptibility to COPD. Int. J. Mol. Med. 15, 443–448 (2005).
  CAS PubMed Google Scholar
• Benhamou, S., Reinikainen, M., Bouchardy, C., Dayer, P. & Hirvonen, A. Association between lung cancer and microsomal epoxide hydrolase genotypes. Cancer Res. 58, 5291–5293 (1998).
  CAS PubMed Google Scholar
• Kao, R. C., Wehner, N. G., Skubitz, K. M., Gray, B. H. & Hoidal, J. R. Proteinase 3. A distinct human polymorphonuclear leukocyte proteinase that produces emphysema in hamsters. J. Clin. Invest. 82, 1963–1973 (1988).
  Article CAS PubMed PubMed Central Google Scholar
• Zheng, T. et al. Role of cathepsin S-dependent epithelial cell apoptosis in IFN-γ-induced alveolar remodeling and pulmonary emphysema. J. Immunol. 174, 8106–8115 (2005).
  Article CAS PubMed Google Scholar
• Yang, Y. et al. Cathepsin S mediates gastric cancer cell migration and invasion via a putative network of metastasis-associated proteins. J. Proteome Res. 9, 4767–4778 (2010).
  Article CAS PubMed Google Scholar
• Yang, Z. & Cox, J. L. Cathepsin L increases invasion and migration of B16 melanoma. Cancer Cell Int. 7, 8 (2007).
  Article PubMed PubMed Central CAS Google Scholar
• Golovatch, P. et al. Role for cathepsin K in emphysema in smoke-exposed guinea pigs. Exp. Lung Res. 35, 631–645 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Brooks, P. C. et al. Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin α v β 3. Cell 85, 683–693 (1996).
  Article CAS PubMed Google Scholar
• Radisky, D. C. et al. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature 436, 123–127 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Balbin, M. et al. Loss of collagenase-2 confers increased skin tumor susceptibility to male mice. Nature Genet. 35, 252–257 (2003).
  Article CAS PubMed Google Scholar
• Kudo, Y. et al. Matrix Metalloproteinase-13 (MMP-13) Directly and indirectly promotes tumor angiogenesis. J. Biol. Chem. 287, 38716–38728 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Deshmukh, H. S. et al. Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production. Am. J. Respir. Crit. Care Med. 180, 834–845 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Hotary, K., Li, X. Y., Allen, E., Stevens, S. L. & Weiss, S. J. A cancer cell metalloprotease triad regulates the basement membrane transmigration program. Genes Dev. 20, 2673–2686 (2006).
  Article CAS PubMed PubMed Central Google Scholar