Translational control of cell growth and malignancy by the CPEBs (original) (raw)

• Groppo, R. & Richter, J. D. Translational control from head to tail. Curr. Opin. Cell Biol. 21, 444–451 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Sonenberg, N. & Hinnebusch, A. G. Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell 136, 731–745 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Dever, T. E. Gene-specific regulation by general translation factors. Cell 108, 545–556 (2002).
  Article CAS PubMed Google Scholar
• Ruggero, D. & Pandolfi, P. P. Does the ribosome translate cancer? Nature Rev. Cancer 3, 179–192 (2003).
  Article CAS Google Scholar
• Wendel, H. G. et al. Dissecting eIF4E action in tumorigenesis. Genes Dev. 21, 3232–3237 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Richter, J. D. & Sonenberg, N. Regulation of cap-dependent translation by eIF4E inhibitory proteins. Nature 433, 477–480 (2005).
  Article CAS PubMed Google Scholar
• Sonenberg, N. Translation factors as effectors of cell growth and tumorigenesis. Curr. Opin. Cell Biol. 5, 955–960 (1993).
  Article CAS PubMed Google Scholar
• Lazaris-Karatzas, A. et al. Ras mediates translation initiation factor 4E-induced malignant transformation. Genes Dev. 6, 1631–1642 (1992).
  Article CAS PubMed Google Scholar
• Ruggero, D. et al. The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Nature Med. 10, 484–486 (2004).
  Article CAS PubMed Google Scholar
• Shamji, A. F., Nghiem, P. & Schreiber, S. L. Integration of growth factor and nutrient signaling. Mol. Cell 12, 271–280 (2003).
  Article CAS PubMed Google Scholar
• Guertin, D. A. & Sabatini, D. M. The Pharmacology of mTOR Inhibition. Sci. Signal. 2, pe24 (2009).
  Article PubMed Google Scholar
• Hsieh, A. C. et al. The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature 485, 55–61 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Hake, L. E. & Richter, J. D. CPEB is a specificity factor that mediates cytoplasmic polyadenylation during Xenopus oocyte maturation. Cell 79, 617–627 (1994).
  Article CAS PubMed Google Scholar
• Stebbins-Boaz, L. E. et al. CPEB controls the cytoplasmic polyadenylation of cyclin, Cdk2 and c-mos mRNAs and is necessary for oocyte maturation in Xenopus. EMBO J. 15, 2582–2592 (1996).
  Article CAS PubMed PubMed Central Google Scholar
• Liu, J. & Maller, J. L. Xenopus Polo-like kinase Plx1: a multifunctional mitotic kinase. Nature 24, 238–247 (2005).
  CAS Google Scholar
• Peng, A. & Maller, J. L. Serine/threonine phosphatases in the DNA damage response and cancer. Oncogene 29, 5977–5988 (2010).
  Article CAS PubMed Google Scholar
• Groisman, I., Jung, M. Y., Sarkissian, M., Cao, Q. & Richter, J. D. Translational control of the embryonic cell cycle. Cell 109, 473–483 (2002).
  Article CAS PubMed Google Scholar
• Groisman, I. et al. Control of cellular senescence by CPEB. Genes Dev. 20, 2701–2712 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Novoa, I., Gallego, J., Ferreira, P. G. & Mendez, R. Mitotic cell-cycle progression is regulated by CPEB1 and CPEB4-dependent translational control. Nature Cell Biol. 12, 447–456 (2010).
  Article CAS PubMed Google Scholar
• Di Giammartino, D. C., Nishida, K. & Manley, J. L. Mechanisms and consequences of alternative polyadenylation. Mol. Cell 43, 853–866 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Barnard, D. C., Ryan, K., Manley, J. L. & Richter, J. D. Symplekin and xGLD-2 are required for CPEB-mediated cytoplasmic polyadenylation. Cell 119, 641–651 (2004).
  Article CAS PubMed Google Scholar
• Cao, Q., Kim, J. H. & Richter, J. D. CDK1 and calcineurin regulate Maskin association with eIF4E and translational control of cell cycle progression. Nature Struct. Mol. Biol. 13, 1128–1134 (2006).
  Article CAS Google Scholar
• Sarkissian, M. et al. Progesterone and insulin stimulation of CPEB-dependent polyadenylation is regulated by Aurora A and glycogen synthase kinase-3. Genes Dev. 18, 48–61 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Mendez, R. et al. Phosphorylation of CPE binding factor by Eg2 regulates translation of c-mos mRNA. Nature 404, 302–307 (2000).
  Article CAS PubMed Google Scholar
• Kim, J. H. & Richter, J. D. Opposing polymerase-deadenylase activities regulate cytoplasmic polyadenylation. Mol. Cell 24, 173–183 (2006).
  Article CAS PubMed Google Scholar
• Kim, J. H. & Richter, J. D. RINGO/cdk1 and CPEB mediate poly(A) tail stabilization and translational regulation by ePAB. Genes Dev. 21, 2571–2579 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Minshall, N. et al. CPEB interacts with an ovary-specific eIF4E and 4E-T in early Xenopus oocytes. J. Biol. Chem. 282, 37389–37401 (2007).
  Article CAS PubMed Google Scholar
• Jung, M. Y., Lorenz, L. & Richter, J. D. Translational control by neuroguidin, a eukaryotic initiation factor 4E and CPEB binding protein. Mol. Cell. Biol. 26, 4277–4287 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Mendez, R. et al. Phosphorylation of CPEB by Eg2 mediates the recruitment of CPSF into an active cytoplasmic polyadenylation complex. Mol. Cell 6, 1253–1259 (2000).
  Article CAS PubMed Google Scholar
• Colgan, D. F. & Manley, J. L. Mechanism and regulation of mRNA polyadenylation. Genes Dev. 11, 2755–2766 (1997).
  Article CAS PubMed Google Scholar
• McGrew, L. L. & Richter, J. D. Translational control by cytoplasmic polyadenylation during Xenopus oocyte maturation: characterization of cis and trans elements and regulation by cyclin/MPF. EMBO J. 9, 3743–3751 (1990).
  Article CAS PubMed PubMed Central Google Scholar
• McGrew, L. L. et al. Poly(A) elongation during Xenopus oocyte maturation is required for translational recruitment and is mediated by a short sequence element. Genes Dev. 3, 803–815 (1989).
  Article CAS PubMed Google Scholar
• Fox, C. A. et al. Poly(A) addition during maturation of frog oocytes: distinct nuclear and cytoplasmic activities and regulation by the sequence UUUUUAU. Genes Dev. 3, 2151–2162 (1989).
  Article CAS PubMed Google Scholar
• Kuge, H. & Richter, J. D. Cytoplasmic 3′ poly(A) addition induces 5′ cap ribose methylation: implications for translational control of maternal mRNA. EMBO J. 14, 6301–6310 (1995).
  Article CAS PubMed PubMed Central Google Scholar
• Kuge, H. et al. Cap ribose methylation of c-mos mRNA stimulates translation and oocyte maturation in Xenopus laevis. Nucleic Acids Res. 26, 3208–3214 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Lantz, V. et al. The Drosophila orb gene is predicted to encode sex-specific germline RNA-binding proteins and has localized transcripts in ovaries and early embryos. Development 115, 75–88 (1992).
  CAS PubMed Google Scholar
• Lantz, V. et al. The Drosophila orb RNA-binding protein is required for the formation of the egg chamber and establishment of polarity. Genes Dev. 8, 598–613 (1994).
  Article CAS PubMed Google Scholar
• Christerson, L. B. & McKearin, D. M. orb is required for anteroposterior and dorsoventral patterning during Drosophila oogenesis. Genes Dev. 8, 614–628 (1994).
  Article CAS PubMed Google Scholar
• Zhang, J. H. et al. Cytoplasmic polyadenylation element binding protein is a conserved target of tumor suppressor HRPT2/CDC73. Cell Death Differ. 17, 1551–15565 (2010).
  Article CAS PubMed Google Scholar
• Wang, L. et al. A regulatory cytoplasmic poly(A) polymerase in Caenorhabditis elegans. Nature 419, 312–316 (2002).
  Article CAS PubMed Google Scholar
• Read, R. L. et al. Cytoplasmic poly(A) polymerases mediate cellular responses to S phase arrest. Proc. Natal. Acad. Sci. USA 99, 12079–12084 (2002).
  Article CAS Google Scholar
• Saitoh, S. et al. Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA. Cell 109, 563–573 (2002).
  Article CAS PubMed Google Scholar
• Kadyk, L. C. & Kimble, J. Genetic regulation of entry into meiosis in Caenorhabditis elegans. Development 125, 1803–1813 (1998).
  CAS PubMed Google Scholar
• Tay, J., Hodgman, R. & Richter, J. D. The Control of cyclin B1 mRNA translation during mouse oocyte maturation. Dev. Biol. 221, 1–9 (2000).
  Article CAS PubMed Google Scholar
• Tay, J. et al. Regulated CPEB phosphorylation during meiotic progression suggests a mechanism for temporal control of maternal mRNA translation. Genes Dev. 17, 1457–1462 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Burns, D. M. & Richter, J. D. CPEB regulation of human cellular senescence, energy metabolism, and p53 mRNA translation. Genes Dev. 22, 3449–3460 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Udagawa, T. et al. Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex. Mol. Cell 47, 253–266 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Burns, D. M., D'Ambrogio, A., Nottrott, S. & Richter, J. D. CPEB and two poly(A) polymerases control miR-122 stability and p53 mRNA translation. Nature 473, 105–108 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Mendez, R. & Richter, J. D. Translational control by CPEB: a means to the end. Nature Rev. Mol. Cell. Biol. 2, 521–529 (2001).
  Article CAS Google Scholar
• Huang, Y. S., Kan, M. C., Lin, C. L. & Richter, J. D. CPEB3 and CPEB4 in neurons: analysis of RNA-binding specificity and translational control of AMPA receptor GluR2 mRNA. EMBO J. 25, 4865–4876 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Igea, A. et al. Meiosis requires a translational positive loop where CPEB1 ensues its replacement by CPEB4. EMBO J. 29, 2182–2193 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Chen, P. J. & Huang, Y. S. CPEB2–eEF2 interaction impedes HIF-1α RNA translation. EMBO J. 31, 959–971 (2011).
  Article PubMed PubMed Central CAS Google Scholar
• Hosoda, N. et al. Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase. EMBO J. 30, 1311–1323 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Pavlopoulos, E. et al. Neuralized1 activates CPEB3: a function for nonproteolytic ubiquitin in synaptic plasticity and memory storage. Cell 147, 1369–1383 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Ortiz-Zapater, E. et al. Key contribution of CPEB4-mediated translational control to cancer progression. Nature Med. 18, 83–90 (2011).
  Article PubMed CAS Google Scholar
• Groppo, R. & Richter, J. D. CPEB control of NF- B nuclear localization and interleukin-6 production mediates cellular senescence. Mol. Cell. Biol. 31, 2707–2714 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Rhodes, D. R. et al. Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles. Neoplasia 9, 166–180 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Tay, J. & Richter, J. D. Germ cell differentiation and synaptonemal complex formation are disrupted in CPEB knockout mice. Dev. Cell 1, 201–213 (2001).
  Article CAS PubMed Google Scholar
• Wu, L. et al. CPEB-mediated cytoplasmic polyadenylation and the regulation of experience-dependent translation of α-CaMKII mRNA at synapses. Neuron 21, 1129–1139 (1998).
  Article CAS PubMed Google Scholar
• Silvera, D., Formenti, S. C. & Schneider, R. J. Translational control in cancer. Nature Rev. Cancer 10, 254–266 (2010).
  Article CAS Google Scholar
• Katoh, T. et al. Selective stabilization of mammalian microRNAs by 3′ adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2. Genes Dev. 23, 433–438 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• D'Ambrogio, A. et al. Specific miRNA stabilization by Gld2-catalyzed monoadenylation. Cell Rep. 2, 1537–1345 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Thomson, J. M. et al. Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev. 20, 2202–2207 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Piqué, M., López, J. M., Foissac, S., Guigó, R. & Mendez, R. A. Combinatorial code for CPE-mediated translational control. Cell 132, 434–448 (2008).
  Article PubMed CAS Google Scholar
• Belloc, E. & Méndez, R. A deadenylation negative feedback mechanism governs meiotic metaphase arrest. Nature 452, 1017–1021 (2008).
  Article CAS PubMed Google Scholar
• Hayflick, L. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37, 614–636 (1965).
  Article CAS PubMed Google Scholar
• Evan, G. I. & d'Adda di Fagagna, F. Cellular senescence: hot or what? Mol. Cell 19, 25–31 (2009).
  CAS Google Scholar
• Collado, M., Blasco, M. A. & Serrano, M. Cellular senescence in cancer and aging. Cell 130, 223–233 (2007).
  Article CAS PubMed Google Scholar
• Cairns, R. A., Harris, I. S. & Mak, T. W. Regulation of cancer cell metabolism. Nature Rev. Cancer 11, 85–95 (2011).
  Article CAS Google Scholar
• Chen, M., David, C. J. & Manley, J. L. Concentration-dependent control of pyruvate kinase M mutually exclusive splicing by hnRNP proteins. Nature Struct. Mol. Biol. 19, 346–354 (2012).
  Article CAS Google Scholar
• Christofk, H. R. et al. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 452, 230–233 (2008).
  Article CAS PubMed Google Scholar
• Lin, C. L., Evans, V., Shen, S., Xing, Y. & Richter, J. D. The nuclear experience of CPEB: implications for RNA processing and translational control. RNA 16, 338–348 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Kuilman, T. et al. Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell 133, 1019–1031 (2008).
  Article CAS PubMed Google Scholar
• Braig, M. et al. Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 436, 660–665 (2005).
  Article CAS PubMed Google Scholar
• Prieur, A. & Peeper, D. S. Cellular senescence in vivo: a barrier to tumorigenesis. Curr. Opin. Cell Biol. 20, 150–155 (2008).
  Article CAS PubMed Google Scholar
• Michaloglou, C. et al. BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 436, 720–724 (2005).
  Article CAS PubMed Google Scholar
• Chen, Z. et al. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 436, 725–730 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Jing, H. et al. Opposing roles of NF- B in anti-cancer treatment outcome unveiled by cross-species investigations. Genes Dev. 25, 2137–2146 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Nagaoka, K., Udagawa, T. & Richter, J. D. CPEB-mediated ZO-1 mRNA localization is required for epithelial tight-junction assembly and cell polarity. Nature Commun. 3, 675 (2012).
  Article CAS Google Scholar
• Kalluri, R. & Weinberg, R. A. The basics of epithelial-mesenchymal transition. J. Clin. Invest. 119, 1420–1428 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• McCaffrey, L. M., Montalbano, J., Mihai, C. & Macara, I. G. Loss of the Par3 polarity protein promotes breast tumorigenesis and metastasis. Cancer Cell 22, 601–614 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Sullivan, N. J. et al. Interleukin-6 induces an epithelial–mesenchymal transition phenotype in human breast cancer cells. Oncogene 28, 2940–2947 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Nairismägi, M. L. et al. Translational control of TWIST1 expression in MCF-10A cell lines recapitulating breast cancer progression. Oncogene 31, 4960–4966 (2012).
  Article PubMed CAS Google Scholar
• Huang, Y. S. Facilitation of dendritic mRNA transport by CPEB. Genes Dev. 17, 638–653 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Wang, H. et al. Dexamethasone as a chemosensitizer for breast cancer chemotherapy: potentiation of the antitumor activity of adriamycin, modulation of cytokine expression, and pharmacokinetics. Int. J. Oncol. 30, 947–953 (2007).
  CAS PubMed Google Scholar
• McClellan, M. et al. An accelerated pathway for targeted cancer therapies. Nature Rev. Drug Discov. 10, 79–80 (2011).
  Article CAS Google Scholar
• Ule, J. CLIP identifies Nova-regulated RNA networks in the brain. Science 302, 1212–1215 (2003).
  Article CAS PubMed Google Scholar
• König, J., Zarnack, K., Luscombe, N. M. & Ule, J. Protein–RNA interactions: new genomic technologies and perspectives. Nature Rev. Genet. 13, 77–83 (2012).
  Article CAS PubMed Google Scholar
• Ingolia, N. T., Brar, G. A., Rouskin, S., McGeachy, A. M. & Weissman, J. S. The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments. Nature Protoc. 7, 1534–1550 (2012).
  Article CAS Google Scholar
• Du, L. & Richter, J. D. Activity-dependent polyadenylation in neurons. RNA 11, 1340–1347 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Beilharz, T. H. & Preiss, T. Polyadenylation state microarray (PASTA) analysis. Methods Mol. Biol. 759, 133–148 (2011).
  Article CAS PubMed Google Scholar
• Page, R. D. M. in Current Protocols in Bioinformatics (John Wiley & Sons, Inc., USA).