Bers, D. M. Excitation–Contraction Coupling and Cardiac Contractile Force edn 2 (Kluwer Academic, Dordrecht, Netherlands, 2001). Google Scholar
Pogwizd, S. M., Schlotthauer, K., Li, L., Yuan, W. & Bers, D.M. Arrhythmogenesis and contractile dysfunction in heart failure: roles of sodium–calcium exchange, inward rectifier potassium current and residual β-adrenergic responsiveness. Circ. Res.88, 1159–1167 (2001). CASPubMed Google Scholar
Solaro, R. J. & Rarick, H. M. Troponin and tropomyosin—proteins that switch on and tune in the activity of cardiac myofilaments. Circ. Res.83, 471–480 (1998). CASPubMed Google Scholar
Moss, R. L. & Buck, S. H. in Handbook of Physiology (eds Page, E., Fozzard, H. A. & Solaro, R. J.) 420–454 (Oxford Univ. Press, New York, 2001). Google Scholar
Fukuda, N., Sasaki, D., Ishiwata, S. & Kurihara, S. Length dependence of tension generation in rat skinned cardiac muscle. Circ. Res.104, 1639–1645 (2001). CAS Google Scholar
Bassani, J. W. M., Bassani, R. A. & Bers, D. M. Relaxation in rabbit and rat cardiac cells: species-dependent differences in cellular mechanisms. J. Physiol.476, 279–293 (1994). CASPubMedPubMed Central Google Scholar
Brandes, R. & Bers, D. M. Intracellular Ca2+ increases the mitochondrial NADH concentration during elevated work in intact cardiac muscle. Circ. Res.80, 82–87 (1997). CASPubMed Google Scholar
Hove-Madsen, L., & Bers, D. M. Sarcoplasmic reticulum Ca2+ uptake and thapsigargin sensitivity in permeabilized rabbit and rat ventricular myocytes. Circ. Res.73, 820–828 (1993). CASPubMed Google Scholar
Li, L., Chu, G., Kranias, E. G. & Bers, D. M. Cardiac myocyte calcium transport in phospholamban knockout mouse: relaxation and endogenous CaMKII effects. Am. J. Physiol.274, H1335–H1347 (1998). CASPubMed Google Scholar
Hasenfuss, G. Alterations of calcium-regulatory proteins in heart failure. Cardiovasc. Res.37, 279–289 (1998). CASPubMed Google Scholar
Delbridge, L. M., Bassani, J. W. M. & Bers, D. M. Steady-state twitch Ca2+ fluxes and cytosolic Ca2+ buffering in rabbit ventricular myocytes. Am. J. Physiol.270, C192–C199 (1996). CASPubMed Google Scholar
Trafford, A. W., Díaz, M. E., Negretti, N. & Eisner, D. A. Enhanced Ca2+ current and decreased Ca2+ efflux restore sarcoplasmic reticulum Ca2+ content after depletion. Circ. Res.81, 477–484 (1997). CASPubMed Google Scholar
Peterson, B. Z., DeMaria, C. D. & Yue, D. T. Calmodulin is the Ca2+ sensor for Ca2+-dependent inactivation of L-type calcium channels. Neuron22, 549–558 (1999). CASPubMed Google Scholar
Zühlke, R. D., Pitt, G. S., Deisseroth, K., Tsien, R. W. & Reuter, H. Calmodulin supports both inactivation and facilitation of L-type calcium channels. Nature399, 159–162 (1999). ArticleADSPubMed Google Scholar
Scriven, D. R. L., Dan, P. & Moore, E. D. W. Distribution of proteins implicated in excitation-contraction coupling in rat ventricular myocytes. Biophys. J.79, 2682–2691 (2000). CASPubMedPubMed Central Google Scholar
Sipido, K. R., Callewaert, G. & Carmeliet, E. Inhibition and rapid recovery of Ca2+ current during Ca2+ release from sarcoplasmic reticulum in guinea pig ventricular myocytes. Circ. Res.76, 102–109 (1995). CASPubMed Google Scholar
Sham, J. S. K. et al. Termination of Ca2+ release by a local inactivation of ryanodine receptors in cardiac myocytes. Proc. Natl Acad. Sci. USA95, 15096–15101 (1998). ADSCASPubMedPubMed Central Google Scholar
Puglisi, J. L., Yuan, W., Bassani, J. W. M. & Bers, D. M. Ca2+ influx through Ca2+ channels in rabbit ventricular myocytes during action potential clamp: influence of temperature. Circ. Res.85, e7–e16 (1999). CASPubMed Google Scholar
Langer, G. A. & Peskoff, A. Calcium concentration and movement in the diadic cleft space of the cardiac ventricular cell. Biophys. J.70, 1169–1182 (1996). ADSCASPubMedPubMed Central Google Scholar
Zahradníková, A., Zahradník, I., Györke, I. & Györke, S. Rapid activation of the cardiac ryanodine receptor by submillisecond calcium stimuli. J. Gen. Physiol.114, 787–798 (1999). PubMedPubMed Central Google Scholar
Fujioka, Y., Komeda, M. & Matsuoka, S. Stoichiometry of Na+-Ca2+ exchange in inside-out patches excised from guinea-pig ventricular myocytes. J. Physiol.523, 339–351 (2000). CASPubMedPubMed Central Google Scholar
Egger, M. & Niggli, E. Paradoxical block of the Na+-Ca2+ exchanger by extracellular protons in guinea-pig ventricular myocytes. J. Physiol.523, 353–366 (2000). CASPubMedPubMed Central Google Scholar
Trafford, A. W., Díaz, M. E. O'., Neill, S. C. & Eisner, D. A. Comparison of subsarcolemmal and bulk calcium concentration during spontaneous calcium release in rat ventricular myocytes. J. Physiol.488, 577–586 (1995). CASPubMedPubMed Central Google Scholar
Leblanc, N. & Hume, J. R. Sodium current-induced release of calcium from cardiac sarcoplasmic reticulum. Science248, 372–376 (1990). ADSCASPubMed Google Scholar
Weber, C. R., Piacentino, V. III., Ginsburg, K. S. Houser, S. R. & Bers, D. M. Na/Ca exchange current and submembrane [Ca] during cardiac action potential. Circ. Res. (in the press).
Dipla, K., Mattiello, J. A., Margulies, K. B., Jeevanandam, V. & Houser, S. R. The sarcoplasmic reticulum and the Na+/Ca2+ exchanger both contribute to the Ca2+ transient of failing human ventricular myocytes. Circ. Res.84, 435–444 (1999). CASPubMed Google Scholar
Bassani, J. W. M., Yuan, W. & Bers, D. M. Fractional SR Ca release is regulated by trigger Ca and SR Ca content in cardiac myocytes. Am. J. Physiol.268, C1313–C1319 (1995). CASPubMed Google Scholar
Shannon, T. R., Ginsburg, K. S. & Bers, D. M. Potentiation of fractional SR Ca release by total and free intra-SR Ca concentration. Biophys. J.78, 334–343 (2000). CASPubMedPubMed Central Google Scholar
Sitsapesan, R. & Williams, A. J. Regulation of the gating of the sheep cardiac sarcoplasmic reticulum Ca2+-release channel by luminal Ca2+. J. Membr. Biol.137, 215–226 (1994). CASPubMed Google Scholar
Lukyanenko, V., Györke, I. & Györke, S. Regulation of calcium release by calcium inside the sarcoplasmic reticulum in ventricular myocytes. Pflügers Arch.432, 1047–1054 (1996). CASPubMed Google Scholar
Brittsan, A. G. & Kranias, E. G. Phospholamban and cardiac contractile function. J. Mol. Cell. Cardiol.32, 2131–2139 (2000). CASPubMed Google Scholar
Fruen, B. R., Bardy, J. M., Byrem, T. M., Strasburg, G. M. & Louis, C. F. Differential Ca2+ sensitivity of skeletal and cardiac muscle ryanodine receptors in the presence of calmodulin. Am. J. Physiol.279, C724–C733 (2000). CAS Google Scholar
Marx, S. O. et al. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell101, 365–376 (2000). CASPubMed Google Scholar
Marx, S. O. et al. Phosphorylation-dependent regulation of ryanodine receptors: a novel role for leucine/isoleucine zippers. J. Cell Biol.153, 699–708 (2001). CASPubMedPubMed Central Google Scholar
Meyers, M. B. et al. Sorcin associates with the pore-forming subunit of voltage-dependent L-type Ca2+ channels. J. Biol. Chem.273, 18930–18935 (1998). CASPubMed Google Scholar
Zhang, L., Kelley, J., Schmeisser, G., Kobayashi, Y. M. & Jones, L. R. Complex formation between junctin, triadin, calsequestrin, and the ryanodine receptor. Proteins of the cardiac junctional sarcoplasmic reticulum membrane. J. Biol. Chem.272, 23389–23397 (1997). CASPubMed Google Scholar
Franzini-Armstrong, C., Protasi, F. & Ramesh, V. Shape, size, and distribution of Ca2+ release units and couplons in skeletal and cardiac muscles. Biophys. J.77, 1528–1539 (1999). CASPubMedPubMed Central Google Scholar
Cheng, H., Lederer, W. J. & Cannell, M. B. Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle. Science262, 740–744 (1993). ADSCASPubMed Google Scholar
Wier, W. G. & Balke, C. W. Ca2+ release mechanisms, Ca2+ sparks, and local control of excitation-contraction coupling in normal heart muscle. Circ. Res.85, 770–776 (1999). CASPubMed Google Scholar
Bridge, J. H. B., Ershler, P. R. & Cannell, M. B. Properties of Ca2+ sparks evoked by action potentials in mouse ventricular myocytes. J. Physiol.518, 469–478 (1999). ADSCASPubMedPubMed Central Google Scholar
Lukyanenko, V. et al. Inhibition of Ca2+ sparks by ruthenium red in permeabilized rat ventricular myocytes. Biophys. J.79, 1273–1284 (2000). ADSCASPubMedPubMed Central Google Scholar
Cannell, M. B., Cheng, H. & Lederer, W. J. The control of calcium release in heart muscle. Science268, 1045–1049 (1995). ADSCASPubMed Google Scholar
López-López, J. R., Shacklock, P. S., Balke, C. W. & Wier, W. G. Local calcium transients triggered by single L-type calcium channel currents in cardiac cells. Science268, 1042–1045 (1995). ADSPubMed Google Scholar
Sham, J. S. K. et al. Termination of Ca2+ release by a local inactivation of ryanodine receptors in cardiac myocytes. Proc. Natl Acad. Sci. USA95, 15096–15101 (1998). ADSCASPubMedPubMed Central Google Scholar
Sipido, K. R., Carmeliet, E. & van de Werf, F. T-type Ca2+ current as a trigger for Ca2+ release from the sarcoplasmic reticulum in guinea-pig ventricular myocytes. J. Physiol.508, 439–451 (1998). CASPubMedPubMed Central Google Scholar
Zhou, Z. F. & January, C. T. Both T- and L-type Ca2+ channels can contribute to excitation-contraction coupling in cardiac Purkinje cells. Biophys. J.74, 1830–1839 (1998). ADSCASPubMedPubMed Central Google Scholar
Levesque, P. C., Leblanc, N. & Hume, J. R. Release of calcium from guinea pig cardiac sarcoplasmic reticulum induced by sodium-calcium exchange. Cardiovasc. Res.28, 370–378 (1994). CASPubMed Google Scholar
Lipp, P. & Niggli, E. Sodium current-induced calcium signals in isolated guinea-pig ventricular myocytes. J. Physiol.474, 439–446 (1994). CASPubMedPubMed Central Google Scholar
Sham, J. S. K., Cleemann, L. & Morad, M. Gating of the cardiac Ca2+ release channel: the role of Na+ current and Na+-Ca2+ exchange. Science255, 850–853 (1992). ADSCASPubMed Google Scholar
Bouchard, R. A., Clark, R. B. & Giles, W. R. Role of sodium-calcium exchange in activation of contraction in rat ventricle. J. Physiol.472, 391–413 (1993). CASPubMedPubMed Central Google Scholar
Sipido, K. R., Carmeliet, E., & Pappano, A. Na+ current and Ca2+ release from the sarcoplasmic reticulum during action potentials in guinea-pig ventricular myocytes. J. Physiol.489, 1–17 (1995). CASPubMedPubMed Central Google Scholar
Levi, A. J., Spitzer, K. W., Kohmoto, O. & Bridge, J. H. B. Depolarization-induced Ca entry via Na-Ca exchange triggers SR release in guinea pig cardiac myocytes. Am. J. Physiol.266, H1422–H1433 (1994). CASPubMed Google Scholar
Litwin, S. E., Li, J. & Bridge, J. H. B. Na-Ca exchange and the trigger for sarcoplasmic reticulum Ca release: studies in adult rabbit ventricular myocytes. Biophys. J.75, 359–371 (1998). ADSCASPubMedPubMed Central Google Scholar
Sipido, K. R., Maes, M. & van de Werf, F. Low efficiency of Ca2+ entry through the Na+-Ca2+ exchanger as trigger for Ca2+ release from the sarcoplasmic reticulum—a comparison between L-type Ca2+ current and reverse-mode Na+-Ca2+ exchange. Circ. Res.81, 1034–1044 (1997). CASPubMed Google Scholar
Lemaire, S., Piot, C., Seguin, J., Nargeot, J. & Richard, S. Tetrodotoxin-sensitive Ca2+ and Ba2+ currents in human atrial cells. Recept. Channels3, 71–81 (1995). CASPubMed Google Scholar
Aggarwal, R., Shorofsky, S. R., Goldman, L. & Balke, C. W. Tetrodotoxin-blockable calcium currents in rat ventricular myocytes; a third type of cardiac cell sodium current. J. Physiol.505, 353–369 (1997). CASPubMedPubMed Central Google Scholar
Santana, L. F., Gómez, A. M. & Lederer, W. J. Ca2+ flux through promiscuous cardiac Na+ channels: slip-mode conductance. Science279, 1027–1033 (1998). ADSCASPubMed Google Scholar
Cruz, J. D. S. et al. Whether “slip-mode conductance” occurs. Science284, 711a (1999). ADS Google Scholar
Nuss, H. B. & Marbán, E. Whether “slip-mode conductance” occurs. Science284, 711a (1999). ADS Google Scholar
Chandra, R., Chauhan, V. S., Starmer, C. F. & Grant, A. O. β-Adrenergic action on wild-type and KPQ mutant human cardiac Na+ channels: shift in gating but no change in Ca2+:Na+ selectivity. Cardiovasc. Res.42, 490–502 (1999). CASPubMed Google Scholar
DelPrincipe, F., Egger, M., Niggli, E. L-type Ca2+ current as the predominant pathway of Ca2+ entry during _I_Na activation in β-stimulated cardiac myocytes. J. Physiol.527, 455–466 (2000). CASPubMedPubMed Central Google Scholar
Ferrier, G. R. & Howlett, S. E. Cardiac excitation–contraction coupling: role of membrane potential in regulation of contraction. Am. J. Physiol. (Heart Circ. Physiol.)280, H1928–H1944 (2001). CAS Google Scholar
Piacentino, V. III., Dipla, K., Gaughan, J. P. & Houser, S. R. Voltage-dependent Ca2+ release from the SR of feline ventricular myocytes is explained by Ca2+-induced Ca2+ release. J. Physiol.523, 533–548 (2000). CASPubMedPubMed Central Google Scholar
Perez, P. J., Ramos-Franco, J., Fill, M. & Mignery, G. A. Identification and functional reconstitution of the type 2 inositol 1,4,5-trisphosphate receptor from ventricular cardiac myocytes. J. Biol. Chem.272, 23961–23969 (1997). CASPubMed Google Scholar
Lipp, P. et al. Functional InsP3 receptors that may modulate excitation-contraction coupling in the heart. Curr. Biol.10, 939–942 (2000). CASPubMed Google Scholar
Kentish, J. C. et al. Calcium release from cardiac sarcoplasmic reticulum induced by photorelease of calcium or Ins(1,4,5)P3 . Am. J. Physiol.258, H610–H615 (1990). CASPubMed Google Scholar
Brown, J. H. & Jones, L. G. in Phosphoinositides and Receptor Mechanisms (ed. Putney, J. W. Jr) 245–270 (Alan R. Liss, New York, 1986). Google Scholar
Poggioli, J., Sulpice, J. C. & Vassort, G. Inositol phosphate production following α1-adrenergic, muscarinic, or electrical stimulation in isolated rat heart. FEBS Lett.206, 292–298 (1986). CASPubMed Google Scholar
Endoh, M. Cardiac α1-adrenoceptors that regulate contractile function: subtypes and subcellular signal transduction mechanisms. Neurochem. Res.21, 217–229 (1996). CASPubMed Google Scholar
Gambassi, G., Spurgeon, H. A., Ziman, B. D., Lakatta, E. G. & Capogrossi, M. C. Opposing effects of α1-adrenergic receptor subtypes on Ca2+ and pH homeostasis in rat cardiac myocytes. Am. J. Physiol.274, H1152–H1162 (1998). CASPubMed Google Scholar
Ramirez, M. T., Zhao, X. L., Schulman, H. & Brown, J. H. The nuclear δB isoform of Ca2+/calmodulin-dependent protein kinase II regulates atrial natriuretic factor gene expression in ventricular myocytes. J. Biol. Chem.272, 31203–31208 (1997). CASPubMed Google Scholar
Lukyanenko, V., Wiesner, T. F. & Györke, S. Termination of Ca2+ release during Ca2+ sparks in rat ventricular myocytes. J. Physiol.507, 667–677 (1998). CASPubMedPubMed Central Google Scholar
Marx, S. O. et al. Coupled gating between cardiac calcium release channels (ryanodine receptors). Circ. Res.88, 1151–1158 (2001). CASPubMed Google Scholar
Satoh, H., Blatter, L. A. & Bers, D. M. Effects of [Ca2+]i, SR Ca2+ load, and rest on Ca2+ spark frequency in ventricular myocytes. Am. J. Physiol.272, H657–H668 (1997). CASPubMed Google Scholar
Fabiato, A. Rapid ionic modifications during the aequorin-detected calcium transient in a skinned canine cardiac Purkinje cell. J. Gen. Physiol.85, 189–246 (1985). CASPubMed Google Scholar
Schiefer, A., Meissner, G. & Isenberg, G. Ca2+ activation and Ca2+ inactivation of canine reconstituted cardiac sarcoplasmic reticulum Ca2+-release channels. J. Physiol.489, 337–348 (1995). CASPubMedPubMed Central Google Scholar
Sitsapesan, R., Montgomery, R. A. P. & Williams, A. J. New insights into the gating mechanisms of cardiac ryanodine receptors revealed by rapid changes in ligand concentration. Circ. Res.77, 765–772 (1995). CASPubMed Google Scholar
Györke, S. & Fill, M. Ryanodine receptor adaptation: control mechanism of Ca2+-induced Ca2+ release in heart. Science260, 807–809 (1993). ADSPubMed Google Scholar
Valdivia, H. H., Kaplan, J. H., Ellis-Davies, G. C. R. & Lederer, W. J. Rapid adaptation of cardiac ryanodine receptors: modulation by Mg2+ and phosphorylation. Science267, 1997–2000 (1995). ADSCASPubMedPubMed Central Google Scholar
Li, L., DeSantiago, J., Chu, G., Kranias, E. G. & Bers, D. M. Phosphorylation of phospholamban and troponin I in β-adrenergic-induced acceleration of cardiac relaxation. Am. J. Physiol.278, H769–H779 (2000). CAS Google Scholar
Kentish, J. C. et al. Phosphorylation of troponin I by protein kinase A accelerates relaxation and crossbridge cycle kinetics in mouse ventricular muscle. Circ. Res.88, 1059–1065 (2001). CASPubMed Google Scholar
Li, Y. & Bers, D. M. Protein kinase A phosphorylation of the ryanodine receptor does not alter Ca sparks in permeabilized mouse ventricular myocyte. Circulation104, II-131 (2001). Google Scholar
Viatchenko-Karpinski, S. & Gyorke, S. Modulation of the Ca2+-induced Ca2+ release cascade by β-adrenergic stimulation in rat ventricular myocytes. J. Physiol.533, 837–848 (2001). CASPubMedPubMed Central Google Scholar
Song, L. S. et al. β-Adrenergic stimulation synchronizes intracellular Ca2+ release during excitation-contraction coupling in cardiac myocytes. Circ. Res.88, 794–801 (2001). CASPubMed Google Scholar
Ginsburg, K. S. & Bers, D. M. Isoproterenol does not increase the intrinsic gain of cardiac excitation–contraction coupling (ECC). Biophys. J.80, 590a (2001).
Eisner, D. A., Choi, H. S., Díaz, M. E., O'Neill, S. C. & Trafford, A. W. Integrative analysis of calcium cycling in cardiac muscle. Circ. Res.87, 1087–1094 (2000). CASPubMed Google Scholar
Davare, M. A. et al. A β2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav 1.2. Science293, 298–101 (2001). Google Scholar
Bers, D. M. & Ziolo, M. T. When is cAMP not cAMP? Effects of compartmentalization. Circ. Res.89, 373–375 (2001). CASPubMed Google Scholar
Kuschel, M. et al. β2-adrenergic cAMP signaling is uncoupled from phosphorylation of cytoplasmic proteins in canine heart. Circulation99, 2458–2465 (1999). CASPubMed Google Scholar
Rybin, V. O., Xu, X. & Steinberg, S. F. Activated protein kinase C isoforms target to cardiomyocyte caveolae: stimulation of local protein phosphorylation. Circ. Res.84, 980–988 (1999). CASPubMed Google Scholar
Vila Petroff, M. G., Egan, J. M., Wang, X. & Sollott, S. J. Glucagon-like peptide-1 increases cAMP but fails to augment contraction in adult rat cardiac myocytes. Circ. Res.89, 445–452 (2001). CASPubMed Google Scholar
Aprigliano, O., Rybin, V. O., Pak, E., Robinson, R. B. & Steinberg, S. F. β1- and β2-adrenergic receptors exhibit differing susceptibility to muscarinic accentuated antagonism. Am. J. Physiol.272, H2726–H2735 (1997). CASPubMed Google Scholar