IRF7: activation, regulation, modification and function (original) (raw)

• Nehyba J, Hrdlickova R, Burnside J, Bose Jr HR . A novel interferon regulatory factor (IRF), IRF10, has a unique role in immune defense and is induced by the v-Rel oncoprotein. Mol Cell Biol 2002; 22: 3942–3957.
  CAS PubMed PubMed Central Google Scholar
• Miyamoto M, Fujita T, Kimura Y, Maruyama M, Harada H, Sudo Y et al. Regulated expression of a gene encoding a nuclear factor, IRF1, that specifically binds to IFN-β gene regulatory elements. Cell 1988; 54: 903–913.
  CAS PubMed Google Scholar
• Nehyba J, Hrdlickova R, Bose Jr HR . Dynamic evolution of immune system regulators: the history of the interferon regulatory factor (IRF) family. Mol Biol Evol 2009; 26: 2539–2550.
  CAS PubMed PubMed Central Google Scholar
• Lee HR, Kim MH, Lee JS, Liang C, Jung JU . Viral interferon regulatory factors. J Interferon Cytokine Res 2009; 29: 621–628.
  CAS PubMed PubMed Central Google Scholar
• Takaoka A, Tamura T, Taniguchi T . Interferon regulatory factor family of transcription factors and regulation of oncogenesis. Cancer Sci 2008; 99: 467–478.
  CAS PubMed Google Scholar
• Ghosh S, May MJ, Kopp EB . NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 1998; 16: 225–260.
  CAS PubMed Google Scholar
• Ghosh S, Hayden MS . New regulators of NF-κB in inflammation. Nat Rev Immunol 2008; 8: 837–848.
  CAS PubMed Google Scholar
• Hiscott J . Convergence of the NF-κB and IRF pathways in the regulation of the innate antiviral response. Cytokine Growth Factor Rev 2007; 18: 483–490.
  CAS PubMed Google Scholar
• Chen W, Royer W . Structural insights into interferon regulatory factor activation. Cell Signal 2010; 22: 883–887.
  CAS PubMed Google Scholar
• Chen W, Lam SS, Srinath H, Jiang Z, Correia JJ, Schiffer CA et al. Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Nat Struct Mol Biol 2008; 15: 1213–1220.
  CAS PubMed PubMed Central Google Scholar
• Takahasi K, Suzuki NN, Horiuchi M, Mori M, Suhara W, Okabe Y et al. X-ray crystal structure of IRF3 and its functional implications. Nat Struct Mol Biol 2003; 10: 922–927.
  CAS Google Scholar
• Qin BY, Liu C, Lam SS, Srinath H, Delston R, Correia JJ et al. Crystal structure of IRF3 reveals mechanism of autoinhibition and virus-induced phosphoactivation. Nat Struct Mol Biol 2003; 10: 913–921.
  CAS Google Scholar
• Fujii Y, Shimizu T, Kusumoto M, Kyogoku Y, Taniguchi T, Hakoshima T . Crystal structure of an IRF-DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences. EMBO J 1999; 18: 5028–5041.
  CAS PubMed PubMed Central Google Scholar
• Kusumoto M, Fujii Y, Tsukuda Y, Ohira T, Kyougoku Y, Taniguchi T et al. Crystallographic characterization of the DNA-binding domain of interferon regulatory factor-2 complexed with DNA. J Stract Biol 1998; 121: 363–366.
  CAS Google Scholar
• Escalante CR, Nistal-Villβn E, Shen L, Garcia-Sastre A, Aggarwal AK . Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-β enhancer. Mol Cell 2007; 26: 703–716.
  CAS PubMed Google Scholar
• Panne D, Maniatis T, Harrison SC . An atomic model of the interferon-β enhanceosome. Cell 2007; 129: 1111–1123.
  CAS PubMed PubMed Central Google Scholar
• Hiscott J . Triggering the innate antiviral response through IRF3 activation. J Biol Chem 2007; 282: 15325–15329.
  CAS PubMed Google Scholar
• Honda K, Taniguchi T . IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat Rev Immunol 2006; 6: 644–658.
  CAS PubMed Google Scholar
• Savitsky D, Tamura T, Yanai H, Taniguchi T . Regulation of immunity and oncogenesis by the IRF transcription factor family. Cancer Immunol Immunother 2010; 59: 489–510.
  CAS PubMed Google Scholar
• Gabriele L, Ozato K . The role of the interferon regulatory factor (IRF) family in dendritic cell development and function. Cytokine Growth Factor Rev 2010; 18: 503–510.
  Google Scholar
• Zhang L, Pagano JS . IRF7, a new interferon regulatory factor associated with Epstein-Barr virus latency. Mol Cell Biol 1997; 17: 5748–5757.
  CAS PubMed PubMed Central Google Scholar
• Zhang L, Pagano JS . Structure and function of IRF7. J Interferon Cytokine Res 2002; 22: 95–102.
  PubMed Google Scholar
• Wathelet MG, Lin CH, Parekh BS, Ronco LV, Howley PM, Maniatis T . Virus infection induces the assembly of coordinately activated transcription factors on the IFN-β enhancer in vivo. Mol Cell 1998; 1: 507–518.
  CAS PubMed Google Scholar
• Yang H, Lin CH, Ma G, Baffi MO, Wathelet MG . Interferon regulatory factor (IRF)-7 synergizes with other transcription factors through multiple interactions with p300/CBP coactivators. J Biol Chem 2003; 278: 15495–15504.
  CAS PubMed Google Scholar
• Qin BY, Liu C, Srinath H, Lam SS, Correia JJ, Derynck R et al. Crystal structure of IRF-3 in complex with CBP. Structure 2005; 13: 1269–1277.
  CAS PubMed Google Scholar
• Lin R, Mamane Y, Hiscott J . Multiple regulatory domains control IRF7 activity in response to virus infection. J Biol Chem 2000; 275: 34320–34327.
  CAS PubMed Google Scholar
• Balachandran S, Roberts PC, Brown LE, Truong H, Pattnaik AK, Archer DR et al. Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection. Immunity 2000; 13: 129–141.
  CAS PubMed Google Scholar
• Takaoka A, Wang Z, Choi MK, Yanai H, Negishi H, Ban T et al. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 2007; 448: 501–505.
  CAS PubMed Google Scholar
• Burckstummer T, Baumann C, Bluml S, Dixit E, Durnberger G, Jahn H et al. An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol 2009; 10: 266–272.
  PubMed Google Scholar
• Fernandes-Alnemri T, Yu JW, Datta P, Wu J, Alnemri ES . AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 2009; 458: 509–513.
  CAS PubMed PubMed Central Google Scholar
• Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, Horvath G, Caffrey D et al. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 2009; 458: 514–518.
  CAS PubMed PubMed Central Google Scholar
• Roberts TL, Idris A, Dunn JA, Kelly GM, Burnton CM, Hodgson S et al. HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science 2009; 323: 1057–1060.
  CAS PubMed Google Scholar
• Kim T, Pazhoor S, Bao M, Zhang Z, Hanabuchi S, Facchinetti V et al. Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells. Proc Natl Acad Sci USA 2010; 107: 15181–15186.
  CAS PubMed PubMed Central Google Scholar
• Unterholzner L, Keating SE, Baran M, Horan KA, Jensen SB, Sharma S et al. IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol 2010; 11: 997–1004.
  CAS PubMed PubMed Central Google Scholar
• Ablasser A, Bauernfeind F, Hartmann G, Latz E, Fitzgerald KA, Hornung V . RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Nat Immunol 2009; 10: 1065–1072.
  CAS PubMed Google Scholar
• Chiu YH, MacMillan JB, Chen ZJ . RNA polymerase III detects cytosolic DNA and induces Type I interferons through the RIG-I pathway. Cell 2009; 138: 576–591.
  CAS PubMed PubMed Central Google Scholar
• Choi MK, Wang Z, Ban T, Yanai H, Lu Y, Koshiba R et al. A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA. Proc Natl Acad Sci USA 2009; 106: 17870–17875.
  CAS PubMed PubMed Central Google Scholar
• Barton GM, Kagan JC . A cell biological view of Toll-like receptor function: regulation through compartmentalization. Nat Rev Immunol 2009; 9: 535–542.
  CAS PubMed PubMed Central Google Scholar
• Nakhaei P, Genin P, Civas A, Hiscott J . RIG-I-like receptors: sensing and responding to RNA virus infection. Semin Immunol 2009; 21: 215–222.
  CAS PubMed Google Scholar
• Sabbah A, Chang TH, Harnack R, Frohlich V, Tominaga K, Dube PH et al. Activation of innate immune antiviral responses by Nod2. Nat Immunol 2009; 10: 1073–1080.
  CAS PubMed PubMed Central Google Scholar
• Barbalat R, Lau L, Locksley RM, Barton GM . Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands. Nat Immunol 2009; 10: 1200–1207.
  CAS PubMed PubMed Central Google Scholar
• Martinez J, Huang X, Yang Y . Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNA. Proc Natl Acad Sci USA 2010; 107: 6442–6447.
  CAS PubMed PubMed Central Google Scholar
• Dietrich N, Lienenklaus S, Weiss S, Gekara NO . Murine toll-like receptor 2 activation induces type I interferon responses from endolysosomal compartments. PLoS ONE 2010; 5: e10250.
  PubMed PubMed Central Google Scholar
• Kim TW, Staschke K, Bulek K, Yao J, Peters K, Oh KH et al. A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity. J Exp Med 2007; 204: 1025–1036.
  CAS PubMed PubMed Central Google Scholar
• Koziczak-Holbro M, Joyce C, Gluck A, Kinzel B, Muller M, Tschopp C et al. IRAK-4 kinase activity is required for Interleukin-1 (IL-1) receptor- and Toll-like Receptor 7-mediated signaling and gene expression. J Biol Chem 2007; 282: 13552–13560.
  CAS PubMed Google Scholar
• Konno H, Yamamoto T, Yamazaki K, Gohda J, Akiyama T, Semba K et al. TRAF6 establishes innate immune responses by activating NF-κB and IRF7 upon sensing cytosolic viral RNA and DNA. PLoS ONE 2009; 4: e5674.
  PubMed PubMed Central Google Scholar
• Kawai T, Sato S, Ishii KJ, Coban C, Hemmi H, Yamamoto M et al. Interferon α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol 2004; 5: 1061–1068.
  CAS PubMed Google Scholar
• Saha SK, Pietras EM, He JQ, Kang JR, Liu SY, Oganesyan G et al. Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif. EMBO J 2006; 25: 3257–3263.
  CAS PubMed PubMed Central Google Scholar
• Oganesyan G, Saha SK, Guo B, He JQ, Shahangian A, Zarnegar B et al. Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature 2006; 439: 208–211.
  CAS PubMed Google Scholar
• Hacker H, Redecke V, Blagoev B, Kratchmarova I, Hsu LC, Wang GG et al. Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature 2006; 439: 204–207.
  PubMed Google Scholar
• Kawai T, Takahashi K, Sato S, Coban C, Kumar H, Kato H et al. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol 2005; 6: 981–988.
  CAS PubMed Google Scholar
• Kumar H, Kawai T, Kato H, Sato S, Takahashi K, Coban C et al. Essential role of IPS-1 in innate immune responses against RNA viruses. J Exp Med 2006; 203: 1795–1803.
  CAS PubMed PubMed Central Google Scholar
• Xu LG, Wang YY, Han KJ, Li LY, Zhai ZH, Shu HB . VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol Cell 2005; 19: 727–740.
  CAS PubMed Google Scholar
• Ishikawa H, Barber GN . STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 2008; 455: 674–678.
  CAS PubMed PubMed Central Google Scholar
• Jin L, Waterman PM, Jonscher KR, Short CM, Reisdorph NA, Cambier JC . MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals. Mol Cell Biol 2008; 28: 5014–5026.
  CAS PubMed PubMed Central Google Scholar
• Zhong B, Yang Y, Li S, Wang YY, Li Y, Diao F et al. The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity 2008; 29: 538–550.
  CAS PubMed Google Scholar
• Sun W, Li Y, Chen L, Chen H, You F, Zhou X et al. ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. Proc Natl Acad Sci USA 2009; 106: 8653–8658.
  CAS PubMed PubMed Central Google Scholar
• Balachandran S, Thomas E, Barber GN . A FADD-dependent innate immune mechanism in mammalian cells. Nature 2004; 432: 401–405.
  CAS PubMed Google Scholar
• Ishikawa H, Ma Z, Barber GN . STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 2009; 461: 788–792.
  CAS PubMed PubMed Central Google Scholar
• Richez C, Yasuda K, Watkins AA, Akira S, Lafyatis R, van Seventer JM et al. TLR4 ligands induce IFN-α production by mouse conventional dendritic cells and human monocytes after IFN-β priming. J Immunol 2009; 182: 820–828.
  CAS PubMed Google Scholar
• Sakaguchi S, Negishi H, Asagiri M, Nakajima C, Mizutani T, Takaoka A et al. Essential role of IRF-3 in lipopolysaccharide-induced interferon-[beta] gene expression and endotoxin shock. Biochem Biophys Res Commun 2003; 306: 860–866.
  CAS PubMed Google Scholar
• Hiscott J . Another detour on the Toll road to the interferon antiviral response. Nat Struct Mol Biol 2004; 11: 1028–1030.
  CAS PubMed Google Scholar
• Fukao T, Koyasu S . PI3K and negative regulation of TLR signaling. Trends Immunol 2003; 24: 358–363.
  CAS PubMed Google Scholar
• Schmitz F, Heit A, Dreher S, Eisenacher K, Mages J, Haas T et al. Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells. Eur J Immunol 2008; 38: 2981–2992.
  CAS PubMed Google Scholar
• Cao W, Manicassamy S, Tang H, Kasturi SP, Pirani A, Murthy N et al. Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI3K-mTOR-p70S6K pathway. Nat Immunol 2008; 9: 1157–1164.
  CAS PubMed PubMed Central Google Scholar
• Guiducci C, Ghirelli C, Marloie-Provost MA, Matray T, Coffman RL, Liu YJ et al. PI3K is critical for the nuclear translocation of IRF7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation. J Exp Med 2008; 205: 315–322.
  CAS PubMed PubMed Central Google Scholar
• Di Domizio J, Blum A, Gallagher-Gambarelli M, Molens JP, Chaperot L, Plumas J . TLR7 stimulation in human plasmacytoid dendritic cells leads to the induction of early IFN-inducible genes in the absence of type I IFN. Blood 2009; 114: 1794–1802.
  CAS PubMed Google Scholar
• Zhang L, Pagano JS . Interferon regulatory factor 7 mediates activation of Tap-2 by Epstein-Barr virus latent membrane protein 1. J Virol 2001; 75: 341–350.
  CAS PubMed PubMed Central Google Scholar
• Zhang L, Pagano JS . Interferon regulatory factor 7 is induced by Epstein-Barr virus latent membrane protein 1. J Virol 2000; 74: 1061–1068.
  CAS PubMed PubMed Central Google Scholar
• Ning S, Campos AD, Darnay B, Bentz G, Pagano JS . TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the tumor necrosis factor receptor family member latent membrane protein 1. Mol Cell Biol 2008; 28: 6536–6546.
  CAS PubMed PubMed Central Google Scholar
• Huye LE, Ning S, Kelliher M, Pagano JS . IRF7 is activated by a viral oncoprotein through RIP-dependent ubiquitination. Mol Cell Biol 2007; 27: 2910–2918.
  CAS PubMed PubMed Central Google Scholar
• Dempsey PW, Doyle SE, He JQ, Cheng G . The signaling adaptors and pathways activated by TNF superfamily. Cytokine Growth Factor Rev 2003; 14: 193–209.
  CAS PubMed Google Scholar
• Eliopoulos AG, Young LS . LMP1 structure and signal transduction. Semin Cancer Biol 2001; 11: 435–444.
  CAS PubMed Google Scholar
• Hayden MS, Ghosh S . Signaling to NF-κB. Genes Dev 2004; 18: 2195–2224.
  CAS PubMed Google Scholar
• Li HP, Chang YS . Epstein-Barr virus latent membrane protein 1: structure and functions. J Biomed Sci 2003; 10: 490–504.
  CAS PubMed Google Scholar
• Song YJ, Izumi KM, Shinners NP, Gewurz BE, Kieff E . IRF7 activation by Epstein-Barr virus latent membrane protein 1 requires localization at activation sites and TRAF6, but not TRAF2 or TRAF3. Proc Natl Acad Sci USA 2008; 105: 18448–18453.
  CAS PubMed PubMed Central Google Scholar
• Au W-C, Moore PA, LaFleur DW, Tombal B, Pitha PM . Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes. J Biol Chem 1998; 273: 29210–29217.
  CAS PubMed Google Scholar
• Marie I, Durbin JE, Levy DE . Differential viral induction of distinct interferon-α genes by positive feedback through interferon regulatory factor-7. EMBO J 1998; 17: 6660–6669.
  CAS PubMed PubMed Central Google Scholar
• Sato M, Hata N, Asagiri M, Nakaya T, Taniguchi T, Tanaka N . Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF7. FEBS Lett 1998; 441: 106–110.
  CAS PubMed Google Scholar
• Honda K, Takaoka A, Taniguchi T . Type I interferon gene induction by the interferon regulatory factor family of transcription factors. Immunity 2006; 25: 349–360.
  CAS PubMed Google Scholar
• Zhang L, Wu L, Hong K, Pagano JS . Intracellular signaling molecules activated by Epstein-Barr virus for induction of interferon regulatory factor 7. J Virol 2001; 75: 12393–12401.
  CAS PubMed PubMed Central Google Scholar
• Lu R, Au W-C, Yeow W-S, Hageman N, Pitha PM . Regulation of the promoter activity of interferon regulatory factor-7 gene-activation by interferon and silencing by hypermethylation. J Biol Chem 2000; 275: 31805–31812.
  CAS PubMed Google Scholar
• Xu D, Zhao L, Del Valle L, Miklossy J, Zhang L . Interferon regulatory factors 4 is involved in Epstein-Barr virus-mediated transformation of human B lymphocytes. J Virol 2008; 82: 6251–6258.
  CAS PubMed PubMed Central Google Scholar
• Zhang L, Pagano JS . Interferon regulatory factor 2 represses the Epstein-Barr virus BamH I Q latency promoter in type III latency. Mol Cell Biol 1999; 19: 3216–3223.
  CAS PubMed PubMed Central Google Scholar
• Lu R, Moore PA, Pitha PM . Stimulation of IRF7 gene expression by tumor necrosis factor α: requirement for NF-κB transcription factor and gene accessibility. J Biol Chem 2002; 277: 16592–16598.
  CAS PubMed Google Scholar
• Ning S, Huye LE, Pagano JS . Regulation of the transcriptional activity of the IRF7 promoter by a pathway independent of interferon signaling. J Biol Chem 2005; 285: 12262–12270.
  Google Scholar
• Colina R, Costa-Mattioli M, Dowling RJO, Jaramillo M, Tai LH, Breitbach CJ et al. Translational control of the innate immune response through IRF7. Nature 2008; 452: 323–328.
  CAS PubMed Google Scholar
• Sato M, Suemori H, Hata N, Asagiri M, Ogasawara K, Nakao K et al. Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-α/β gene induction. Immunity 2000; 13: 539–548.
  CAS PubMed Google Scholar
• Prakash A, Levy DE . Regulation of IRF7 through cell type-specific protein stability. Biochem Biophys Res Commun 2006; 342: 50–56.
  CAS PubMed PubMed Central Google Scholar
• Agalioti T, Lomvardas S, Parekh B, Yie J, Maniatis T, Thanos D . Ordered recruitment of chromatin modifying and general transcription factors to the IFN-β promoter. Cell 2000; 103: 667–678.
  CAS PubMed Google Scholar
• Barnes BJ, Field AE, Pitha PM . Virus-induced heterodimer formation between IRF-5 and IRF-7 modulates assembly of the IFNA enhanceosome in vivo and transcriptional activity of IFNA genes. J Biol Chem 2003; 278: 16630–16641.
  CAS PubMed Google Scholar
• Ning S, Huye LE, Pagano JS . Interferon regulatory factor 5 represses expression of the Epstein-Barr virus oncoprotein LMP1: braking of the IRF7/LMP1 regulatory circuit. J Virol 2005; 79: 11671–11676.
  CAS PubMed PubMed Central Google Scholar
• Qing J, Liu C, Choy L, Wu RY, Pagano JS, Derynck R . Transforming growth factor β/Smad3 signaling regulates IRF7 function and transcriptional activation of the beta interferon promoter. Mol Cell Biol 2004; 24: 1411–1425.
  CAS PubMed PubMed Central Google Scholar
• Eroshkin A, Mushegian A . Conserved transactivation domain shared by interferon regulatory factors and Smad morphogens. J Mol Med 1999; 77: 403–405.
  CAS PubMed Google Scholar
• Kim H, Seed B . The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3. Nat Immunol 2010; 11: 743–750.
  CAS PubMed PubMed Central Google Scholar
• Haller O, Kochs G, Weber F . The interferon response circuit: induction and suppression by pathogenic viruses. Virology 2006; 344: 119–130.
  CAS PubMed Google Scholar
• Tsuchida T, Kawai T, Akira S . Inhibition of IRF3-dependent antiviral responses by cellular and viral proteins. Cell Res 2009; 19: 3–4.
  CAS PubMed Google Scholar
• Buettner N, Vogt C, Martinez-Sobrido L, Weber F, Waibler Z, Kochs G . Thogoto virus ML protein is a potent inhibitor of the IRF7 transcription factor. J Gen Virol 2010; 91: 220–227.
  CAS PubMed Google Scholar
• Jennings S, MartØnez-Sobrido L, GarcØa-Sastre A, Weber F, Kochs G . Thogoto virus ML protein suppresses IRF3 function. Virology 2005; 331: 63–72.
  CAS PubMed Google Scholar
• Barro M, Patton JT . Rotavirus NSP1 inhibits expression of type I interferon by antagonizing the function of interferon regulatory factors IRF3, IRF5, and IRF7. J Virol 2007; 81: 4473–4481.
  CAS PubMed PubMed Central Google Scholar
• Ronco LV, Karpova AY, Vidal M, Howley PM . Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity. Genes Dev 1998; 12: 2061–2072.
  CAS PubMed PubMed Central Google Scholar
• Chang TH, Kubota T, Matsuoka M, Jones S, Bradfute SB, Bray M et al. Ebola Zaire virus blocks type I interferon production by exploiting the host SUMO modification machinery. PLoS Pathog 2009; 5: e1000493.
  PubMed PubMed Central Google Scholar
• Li K, Foy E, Ferreon JC, Nakamura M, Ferreon ACM, Ikeda M et al. Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc Natl Acad Sci USA 2005; 102: 2992–2997.
  CAS PubMed PubMed Central Google Scholar
• Yu Y, Wang SE, Hayward GS . The KSHV immediate-early transcription factor RTA encodes ubiquitin E3 ligase activity that targets IRF7 for proteosome-mediated degradation. Immunity 2005; 22: 59–70.
  CAS PubMed Google Scholar
• Zhu FX, King SM, Smith EJ, Levy DE, Yuan Y . A Kaposi's sarcoma-associated herpesviral protein inhibits virus-mediated induction of type I interferon by blocking IRF7 phosphorylation and nuclear accumulation. Proc Natl Acad Sci USA 2002; 99: 5573–5578.
  CAS PubMed PubMed Central Google Scholar
• Zhu FX, Sathish N, Yuan Y . Antagonism of host antiviral responses by Kaposi's sarcoma-associated herpesvirus tegument protein ORF45. PLoS ONE 2010; 5: e10573.
  PubMed PubMed Central Google Scholar
• Wies E, Hahn AS, Schmidt K, Viebahn C, Rohland N, Lux A et al. The Kaposi's sarcoma-associated herpesvirus encoded vIRF-3 inhibits cellular IRF-5. J Biol Chem 2009; 284: 8525–8538.
  CAS PubMed PubMed Central Google Scholar
• Liang C, Lee JS, Jung JU . Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis. Semin Cancer Biol 2008; 18: 423–436.
  CAS PubMed PubMed Central Google Scholar
• Joo CH, Shin YC, Gack M, Wu L, Levy D, Jung JU . Inhibition of IRF7-mediated interferon signal transduction by Kaposi′s sarcoma-associated herpesvirus vIRF3. J Virol 2007; 81: 8282–8292.
  CAS PubMed PubMed Central Google Scholar
• Lubyova B, Pitha PM . Characterization of a novel human herpesvirus 8-encoded protein, vIRF3, that shows homology to viral and cellular interferon regulatory factors. J Virol 2000; 74: 8194–8201.
  CAS PubMed PubMed Central Google Scholar
• Karpova AY, Trost M, Murray JM, Cantley LC, Howley PM . Interferon regulatory factor-3 is an in vivo target of DNA-PK. Proc Natl Acad Sci USA 2002; 99: 2818–2823.
  CAS PubMed PubMed Central Google Scholar
• Lin R, Noyce RS, Collins SE, Everett RD, Mossman KL . The herpes simplex virus ICP0 RING finger domain inhibits IRF3- and IRF7-mediated activation of interferon-stimulated genes. J Virol 2004; 78: 1675–1684.
  CAS PubMed PubMed Central Google Scholar
• Eidson KM, Hobbs WE, Manning BJ, Carlson P, DeLuca NA . Expression of herpes simplex virus ICP0 inhibits the induction of interferon-stimulated genes by viral infection. J Virol 2002; 76: 2180–2191.
  CAS PubMed PubMed Central Google Scholar
• Daubeuf S, Singh D, Tan Y, Liu H, Federoff HJ, Bowers WJ et al. HSV ICP0 recruits USP7 to modulate TLR-mediated innate response. Blood 2009; 113: 3264–3275.
  CAS PubMed PubMed Central Google Scholar
• Hahn AM, Huye LE, Ning S, Webster-Cyriaque J, Pagano JS . Interferon regulatory factor 7 is negatively regulated by the Epstein-Barr virus immediate-early gene, BZLF1. J Virol 2005; 79: 10040–10052.
  CAS PubMed PubMed Central Google Scholar
• Wu L, Fossum E, Joo CH, Lee K, Shin YC, Johannsen E et al. Epstein-Barr virus LF2: an antagonist to type I interferon. J Virol 2009; 83: 1140–1146.
  CAS PubMed Google Scholar
• Bentz G, Liu R, Hahn A, Shackelford J, Pagano JS . Epstein-Barr virus immediate-early protein RTA negatively regulates interferon regulatory factors. Virology 2010; 402: 121–128.
  CAS PubMed Google Scholar
• Gershburg E, Pagano JS . Conserved herpesvirus protein kinases. Biochimica et Biophysica Acta (BBA)—Proteins Proteomics 2008; 1784: 203–212.
  CAS Google Scholar
• Wang JT, Doong SL, Teng SC, Lee CP, Tsai CH, Chen MR . Epstein-Barr virus BGLF4 kinase suppresses the interferon regulatory factor 3 signaling pathway. J Virol 2009; 83: 1856–1869.
  CAS PubMed Google Scholar
• Ning S, Hahn AM, Huye LE, Joseph PS . Interferon regulatory factor 7 regulates expression of Epstein-Barr virus latent membrane protein 1: a regulatory circuit. J Virol 2003; 77: 9359–9368.
  CAS PubMed PubMed Central Google Scholar
• Martin HJ, Lee JM, Walls D, Hayward SD . Manipulation of the TLR7 signaling pathway by Epstein-Barr virus. J Virol 2007; 81: 9748–9758.
  CAS PubMed PubMed Central Google Scholar
• Cahir-McFarland ED, Carter K, Rosenwald A, Giltnane JM, Henrickson SE, Staudt LM et al. Role of NF-κB in cell survival and transcription of latent membrane protein 1-expressing or Epstein-Barr virus latency III-infected cells. J Virol 2004; 78: 4108–4119.
  CAS PubMed PubMed Central Google Scholar
• Yang L, Zhao T, Shi X, Nakhaei P, Wang Y, Sun Q et al. Functional analysis of a dominant negative mutation of interferon regulatory factor 5. PLoS ONE 2009; 4: e5500.
  PubMed PubMed Central Google Scholar
• Dirmeier U, Hoffmann R, Kilger E, Schultheiss U, Briseno C, Gires O et al. Latent membrane protein 1 of Epstein-Barr virus coordinately regulates proliferation with control of apoptosis. Oncogene 2005; 24: 1711–1717.
  CAS PubMed Google Scholar
• Laherty CD, Hu HM, Opipari AW, Wang F, Dixit VM . The Epstein-Barr virus LMP1 gene product induces A20 zinc finger protein expression by activating nuclear factor kappa B. J Biol Chem 1992; 267: 24157–24160.
  CAS PubMed Google Scholar
• Fries KL, Miller WE, Raab-Traub N . Epstein-Barr virus latent membrane protein 1 blocks p53-mediated apoptosis through the induction of the A20 gene. J Virol 1996; 70: 8653–8659.
  CAS PubMed PubMed Central Google Scholar
• Ning S, Pagano J . The A20 deubiquitinase activity negatively regulates LMP1 activation of IRF7. J Virol 2010; 84: 6130–6138.
  CAS PubMed PubMed Central Google Scholar
• Zhao T, Yang L, Sun Q, Arguello M, Ballard DW, Hiscott J et al. The NEMO adaptor bridges the nuclear factor-κB and interferon regulatory factor signaling pathways. Nat Immunol 2007; 8: 592–600.
  CAS PubMed Google Scholar
• Marie I, Smith E, Prakash A, Levy DE . Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain. Mol Cell Biol 2000; 20: 8803–8814.
  CAS PubMed PubMed Central Google Scholar
• Au W-C, Yeow W-S, Pitha PM . Analysis of functional domains of interferon regulatory factor 7 and its association with IRF3. Virology 2001; 280: 273–282.
  CAS PubMed Google Scholar
• tenOever BR, Sharma S, Zou W, Sun Q, Grandvaux N, Julkunen I et al. Activation of TBK1 and IKKɛ kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity. J Virol 2004; 78: 10636–10649.
  CAS PubMed PubMed Central Google Scholar
• Sharma S, tenOever BR, Grandvaux N, Zhou GP, Lin R, Hiscott J . Triggering the interferon antiviral response through an IKK-related pathway. Science 2003; 300: 1148–1151.
  CAS PubMed Google Scholar
• Iwamura T, Yoneyama M, Yamaguchi K, Suhara W, Mori W, Shiota K et al. Induction of IRF-3/-7 kinase and NF-kappaB in response to double-stranded RNA and virus infection: common and unique pathways. Genes Cells 2001; 6: 375–388.
  CAS PubMed Google Scholar
• Hemmi H, Takeuchi O, Sato S, Yamamoto M, Kaisho T, Sanjo H et al. The roles of two IκB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. J Exp Med 2004; 199: 1641–1650.
  CAS PubMed PubMed Central Google Scholar
• Fitzgerald KA, McWhirter SM, Faia KL, Rowe DC, Latz E, Golenbock DT et al. IKKɛ and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol 2003; 4: 491–496.
  CAS PubMed Google Scholar
• Uematsu S, Sato S, Yamamoto M, Hirotani T, Kato H, Takeshita F et al. Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction. J Exp Med 2005; 201: 915–923.
  CAS PubMed PubMed Central Google Scholar
• Hoshino K, Sugiyama T, Matsumoto M, Tanaka T, Saito M, Hemmi H et al. IκB kinase-α is critical for interferon-α production induced by Toll-like receptors 7 and 9. Nature 2006; 440: 949–953.
  CAS PubMed Google Scholar
• An H, Hou J, Zhou J, Zhao W, Xu H, Zheng Y et al. Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1. Nat Immunol 2008; 9: 542–550.
  CAS PubMed Google Scholar
• Wang RP, Zhang M, Li Y, Diao FC, Chen D, Zhai Z et al. Differential regulation of IKKα-mediated activation of IRF3/7 by NIK. Mol Immunol 2008; 45: 1926–1934.
  CAS PubMed Google Scholar
• Bhoj VG, Chen ZJ . Ubiquitylation in innate and adaptive immunity. Nature 2009; 458: 430–437.
  CAS PubMed Google Scholar
• Chen ZJ, Sun LJ . Nonproteolytic functions of ubiquitin in cell signaling. Mol Cell 2009; 33: 275–286.
  CAS PubMed Google Scholar
• Mukhopadhyay D, Riezman H . Proteasome-independent functions of ubiquitin in endocytosis and signaling. Science 2007; 315: 201–205.
  CAS PubMed Google Scholar
• Welchman RL, Gordon C, Mayer RJ . Ubiquitin and ubiquitin-like proteins as multifunctional signals. Nat Rev Mol Cell Biol 2005; 6: 599–609.
  CAS PubMed Google Scholar
• Higgs R, Jefferies CA . Targeting IRFs by ubiquitination: regulating antiviral responses. Biochem Soc Trans 2008; 36: 453–458.
  CAS PubMed Google Scholar
• Yu Y, Hayward GS . The ubiquitin E3 ligase RAUL negatively regulates type I interferon through ubiquitination of the transcription factors IRF7 and IRF3. Immunity 2010; 33: 863–877.
  CAS PubMed PubMed Central Google Scholar
• Zhang M, Tian Y, Wang RP, Gao D, Zhang Y, Diao FC et al. Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3. Cell Res 2008; 18: 1096–1104.
  CAS PubMed Google Scholar
• Higgs R, Gabhann JN, Larbi NB, Breen EP, Fitzgerald KA, Jefferies CA . The E3 ubiquitin ligase Ro52 negatively regulates IFN-β production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. J Immunol 2008; 181: 1780–1786.
  CAS PubMed Google Scholar
• Higgs R, Lazzari E, Wynne C, NÃ-Gabhann J, Espinosa A, Wahren-Herlenius M et al. Self protection from anti-viral responses—Ro52 promotes degradation of the transcription factor IRF7 downstream of the viral toll-like receptors. PLoS ONE 2010; 5: e11776.
  PubMed PubMed Central Google Scholar
• Bailey CM, Abbott DE, Margaryan NV, Khalkhali-Ellis Z, Hendrix MJC . IRF6 promotes cell cycle arrest and is regulated by the proteasome in a cell cycle-dependent manner. Mol Cell Biol 2008; 28: 2235–2243.
  CAS PubMed PubMed Central Google Scholar
• Xiong H, Li H, Kong HJ, Chen Y, Zhao J, Xiong S et al. Ubiquitin-dependent degradation of interferon regulatory factor-8 mediated by Cbl down-regulates interleukin-12 expression. J Biol Chem 2005; 280: 23531–23539.
  CAS PubMed Google Scholar
• Nakagawa K, Yokosawa H . Degradation of transcription factor IRF1 by the ubiquitin-proteasome pathway. The C-terminal region governs the protein stability. Eur J Biochem 2000; 267: 1680–1686.
  CAS PubMed Google Scholar
• Zheng D, Chen G, Guo B, Cheng G, Tang H . PLP2, a potent deubiquitinase from murine hepatitis virus, strongly inhibits cellular type I interferon production. Cell Res 2008; 18: 1105–1113.
  CAS PubMed Google Scholar
• Zeng W, Xu M, Liu S, Sun L, Chen ZJ . Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3. Mol Cell 2009; 36: 315–325.
  PubMed PubMed Central Google Scholar
• Balkhi MY, Fitzgerald KA, Pitha PM . Functional regulation of MyD88-activated interferon regulatory factor 5 by K63-linked polyubiquitination. Mol Cell Biol 2008; 28: 7296–7308.
  CAS PubMed PubMed Central Google Scholar
• Pettersson S, Kelleher M, Pion E, Wallace M, Ball KL . Role of MDM2 acid domain interactions in recognition and ubiquitination of the transcription factor IRF2. Biochem J 2009; 418: 575–585.
  CAS PubMed Google Scholar
• Kong HJ, Anderson DE, Lee CH, Jang MK, Tamura T, Tailor P et al. Cutting edge: autoantigen Ro52 is an interferon inducible E3 ligase that ubiquitinates IRF8 and enhances cytokine expression in macrophages. J Immunol 2007; 179: 26–30.
  CAS PubMed Google Scholar
• Yang K, Shi HX, Liu XY, Shan YF, Wei B, Chen S et al. TRIM21 is essential to sustain IFN regulatory factor 3 activation during antiviral response. J Immunol 2009; 182: 3782–3792.
  CAS PubMed Google Scholar
• Meulmeester E, Melchior F . Cell biology: SUMO. Nature 2008; 452: 709–711.
  CAS PubMed Google Scholar
• Bergink S, Jentsch S . Principles of ubiquitin and SUMO modifications in DNA repair. Nature 2009; 458: 461–467.
  CAS PubMed Google Scholar
• Kubota T, Matsuoka M, Chang TH, Tailor P, Sasaki T, Tashiro M et al. Virus infection triggers SUMOylation of IRF3 and IRF7, leading to the negative regulation of type I interferon gene expression. J Biol Chem 2008; 283: 25660–25670.
  CAS PubMed PubMed Central Google Scholar
• Zhang T, Wang Y, Zhang L, Liu B, Xie J, Wood C et al. Lysine residues of interferon regulatory factor 7 affect the replication and transcription activator-mediated lytic replication of Kaposi′s sarcoma-associated herpesvirus/human herpesvirus 8. J Gen Virol 2011; 92: 181–187.
  CAS PubMed PubMed Central Google Scholar
• Nakagawa K, Yokosawa H . PIAS3 induces SUMO-1 modification and transcriptional repression of IRF1. FEBS Lett 2002; 530: 204–208.
  CAS PubMed Google Scholar
• Park SM, Chae M, Kim BK, Seo T, Jang IS, Choi JS et al. SUMOylated IRF-1 shows oncogenic potential by mimicking IRF-2. Biochem Biophys Res Commun 2010; 391: 926–930.
  CAS PubMed Google Scholar
• Park J, Kim K, Lee EJ, Seo YJ, Lim SN, Park K et al. Elevated level of SUMOylated IRF1 in tumor cells interferes with IRF1-mediated apoptosis. Proc Natl Acad Sci USA 2007; 104: 17028–17033.
  CAS PubMed PubMed Central Google Scholar
• Han KJ, Jiang L, Shu HB . Regulation of IRF2 transcriptional activity by its sumoylation. Biochem Biophys Res Commun 2008; 372: 772–778.
  CAS PubMed Google Scholar
• Caillaud A, Prakash A, Smith E, Masumi A, Hovanessian AG, Levy DE et al. Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding. J Biol Chem 2002; 277: 49417–49421.
  CAS PubMed Google Scholar
• Masumi A, Yamakawa Y, Fukazawa H, Ozato K, Komuro K . Interferon regulatory factor-2 regulates cell growth through its acetylation. J Biol Chem 2003; 278: 25401–25407.
  CAS PubMed Google Scholar
• Masumi A, Ozato K . Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment. J Biol Chem 2001; 276: 20973–20980.
  CAS PubMed Google Scholar
• Tang X, Gao JS, Guan Yj, McLane KE, Yuan ZL, Ramratnam B et al. Acetylation-dependent signal transduction for type I interferon receptor. Cell 2007; 131: 93–105.
  CAS PubMed Google Scholar
• Suhara W, Yoneyama M, Iwamura T, Yoshimura S, Tamura K, Namiki H et al. Analyses of virus-induced homomeric and heteromeric protein associations between IRF3 and coactivator CBP/p300. J Biochem (Tokyo) 2000; 128: 301–307.
  CAS Google Scholar
• Li Q, Tang L, Roberts PC, Kraniak JM, Fridman AL, Kulaeva OI et al. Interferon regulatory factors IRF5 and IRF7 inhibit growth and induce senescence in immortal li-fraumeni fibroblasts. Mol Cancer Res 2008; 6: 770–784.
  CAS PubMed Google Scholar
• Fukasawa M, Kimura M, Morita S, Matsubara K, Yamanaka S, Endo C et al. Microarray analysis of promoter methylation in lung cancers. J Hum Genet 2006; 51: 368–374.
  CAS PubMed Google Scholar
• Ozato K, Tailor P, Kubota T . The interferon regulatory factor family in host defense: mechanism of action. J Biol Chem 2007; 282: 20065–20069.
  CAS PubMed Google Scholar
• Honda K, Yanai H, Negishi H, Asagiri M, Sato M, Mizutani T et al. IRF7 is the master regulator of type-I interferon-dependent immune responses. Nature 2005; 434: 772–777.
  CAS PubMed Google Scholar
• Bonjardim CA, Ferreira PCP, Kroon EG . Interferons: signaling, antiviral and viral evasion. Immunol Lett 2009; 122: 1–11.
  CAS PubMed Google Scholar
• Borden EC, Sen GC, Uze G, Silverman RH, Ransohoff RM, Foster GR et al. Interferons at age 50: past, current and future impact on biomedicine. Nat Rev Drug Discov 2007; 6: 975–990.
  CAS PubMed PubMed Central Google Scholar
• Marshak-Rothstein A . Toll-like receptors in systemic autoimmune disease. Nat Rev Immunol 2006; 6: 823–835.
  CAS PubMed PubMed Central Google Scholar
• Randall RE, Goodbourn S . Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. J Gen Virol 2008; 89: 1–47.
  CAS PubMed Google Scholar
• Stetson DB, Medzhitov R . Type I interferons in host defense. Immunity 2006; 25: 373–381.
  CAS PubMed Google Scholar
• Sadler AJ, Williams BRG . Interferon-inducible antiviral effectors. Nat Rev Immunol 2008; 8: 559–568.
  CAS PubMed PubMed Central Google Scholar
• Tailor P, Tamura T, Kong HJ, Kubota T, Kubota M, Borghi P et al. The feedback phase of type I interferon induction in dendritic cells requires Interferon Regulatory Factor 8. Immunity 2007; 27: 228–239.
  CAS PubMed PubMed Central Google Scholar
• Tamura T, Yanai H, Savitsky D, Taniguchi T . The IRF family transcription factors in immunity and oncogenesis. Annu Rev Immunol 2008; 26: 535–584.
  CAS PubMed Google Scholar
• Genin P, Lin R, Hiscott J, Civas A . Differential regulation of human interferon-A genes expression by Interferon Regulatory Factor 3 and 7. Mol Cell Biol 2009; 29: 3435–3450.
  CAS PubMed PubMed Central Google Scholar
• Meier A, Alter G, Frahm N, Sidhu H, Li B, Bagchi A et al. MyD88-dependent immune activation mediated by human immunodeficiency virus type 1-encoded Toll-like receptor ligands. J Virol 2007; 81: 8180–8191.
  CAS PubMed PubMed Central Google Scholar
• Takahashi K, Asabe S, Wieland S, Garaigorta U, Gastaminza P, Isogawa M et al. Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection. Proc Natl Acad Sci USA 2011; 107: 7431–7436.
  Google Scholar
• Kawai T, Akira S . The roles of TLRs, RLRs and NLRs in pathogen recognition. Int Immunol 2009; 21: 317–337.
  CAS PubMed PubMed Central Google Scholar
• Tanaka N, Taniguchi T . The interferon regulatory factors and oncogenesis. Semin Cancer Biol 2000; 10: 73–81.
  CAS PubMed Google Scholar
• Liebermann DA, Hoffman B . Good and bad IRF-1: role in tumor suppression versus autoimmune disease. Leukemia Res 2009; 33: 1301–1302.
  Google Scholar
• Shaffer AL, Emre NCT, Lamy L, Ngo VN, Wright G, Xiao W et al. IRF4 addiction in multiple myeloma. Nature 2008; 454: 226–231.
  CAS PubMed PubMed Central Google Scholar
• Shaffer AL, Emre NC, Romesser PB, Staudt LM . IRF4: immunity. Malignancy! Therapy? Clin Cancer Res 2009; 15: 2954–2961.
  CAS PubMed PubMed Central Google Scholar
• Heylbroeck C, Balachandran S, Servant MJ, Deluca C, Barber GN, Lin R et al. The IRF3 transcription factor mediates sendai virus-induced apoptosis. J Virol 2000; 74: 3781–3792.
  CAS PubMed PubMed Central Google Scholar
• Romieu-Mourez R, Solis M, Nardin A, Goubau D, Baron-Bodo V, Lin R et al. Distinct roles for IFN regulatory factor (IRF)-3 and IRF7 in the activation of antitumor properties of human macrophages. Cancer Res 2006; 66: 10576–10585.
  CAS PubMed Google Scholar
• Holm GH, Zurney J, Tumilasci V, Leveille S, Danthi P, Hiscott J et al. Retinoic acid-inducible gene-I and interferon-beta promoter stimulator-1 augment proapoptotic responses following mammalian reovirus infection via interferon regulatory factor-3. J Biol Chem 2007; 282: 21953–21961.
  CAS PubMed Google Scholar
• Chattopadhyay S, Marques JT, Yamashita M, Peters KL, Smith K, Desai A et al. Viral apoptosis is induced by IRF-3-mediated activation of Bax. EMBO J 2010; 29: 1762–1773.
  CAS PubMed PubMed Central Google Scholar
• Tokunaga T, Naruke Y, Shigematsu S, Kohno T, Yasui K, Ma Y et al. Aberrant expression of interferon regulatory factor 3 in human lung cancer. Biochem Biophys Res Commun 2010; 397: 202–207.
  CAS PubMed Google Scholar
• Couzinet A, Tamura K, Chen Hm, Nishimura K, Wang Z, Morishita Y et al. A cell-type-specific requirement for IFN regulatory factor 5 (IRF5) in Fas-induced apoptosis. Proc Natl Acad Sci USA 2008; 105: 2556–2561.
  CAS PubMed PubMed Central Google Scholar
• Yanai H, Chen Hm, Inuzuka T, Kondo S, Mak TW, Takaoka A et al. Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression. Proc Natl Acad Sci USA 2007; 104: 3402–3407.
  CAS PubMed PubMed Central Google Scholar
• Hu G, Barnes BJ . IRF5 is a mediator of the death receptor-induced apoptotic signaling pathway. J Biol Chem 2009; 284: 2767–2777.
  CAS PubMed Google Scholar
• Mori T, Anazawa Y, Iiizumi M, Fukuda S, Nakamura Y, Arakawa H . Identification of the interferon regulatory factor 5 gene (IRF5) as a direct target for p53. Oncogene 2002; 21: 2914–2918.
  CAS PubMed Google Scholar
• Hrdlickova R, Nehyba J, Bose Jr HR . Regulation of telomerase activity by Interferon regulatory factors 4 and 8 in immune cells. Mol Cell Biol 2009; 29: 929–941.
  CAS PubMed Google Scholar
• Burchert A, Cai D, Hofbauer L, Samuelsson MKR, Slater EP, Duyster J et al. Interferon consensus sequence binding protein (ICSBP, IRF8) antagonizes BCR/ABL and down-regulates bcl-2. Blood 2003; 103: 3480–3489.
  PubMed Google Scholar
• Taniguchi T, Ogasawara K, Takaoka A, Tanaka N . IRF family of transcription factors as regulators of host defense. Annu Rev Immunol 2001; 19: 623–655.
  CAS PubMed Google Scholar
• Pagano JS . Viruses and lymphomas. N Engl J Med 2002; 347: 78–79.
  PubMed Google Scholar
• Zhang L, Zhang J, Lambert Q, Der CJ, Del Valle L, Miklossy J et al. Interferon regulatory factor 7 is associated with Epstein-Barr virus-transformed central nervous system lymphoma and has oncogenic properties. J Virol 2004; 78: 12987–12995.
  CAS PubMed PubMed Central Google Scholar
• Alizadeh AA, Bohen SP, Lossos C, Martinez-Climent JA, Ramos JC, Cubedo-Gil E et al. Expression profiles of adult T-cell leukemia-lymphoma and associations with clinical responses to zidovudine and interferon α. Leukemia Lymphoma 2010; 51: 1200–1216.
  CAS PubMed PubMed Central Google Scholar
• Barnes BJ, Kellum MJ, Pinder KE, Frisancho JA, Pitha PM . Interferon regulatory factor 5, a novel mediator of cell cycle arrest and cell death. Cancer Res 2003; 63: 6424–6431.
  CAS PubMed Google Scholar
• Xiao C, Rajewsky K . MicroRNA control in the immune system: basic principles. Cell 2009; 136: 26–36.
  CAS PubMed Google Scholar
• O′Connell RM, Rao DS, Chaudhuri AA, Baltimore D . Physiological and pathological roles for microRNAs in the immune system. Nat Rev Immunol 2010; 10: 111–122.
  PubMed Google Scholar
• Eis PS, Tam W, Sun L, Chadburn A, Li Z, Gomez MF et al. Accumulation of miR-155 and BIC RNA in human B cell lymphomas. Proc Natl Acad Sci USA 2005; 102: 3627–3632.
  CAS PubMed PubMed Central Google Scholar
• Garzon R, Croce CM . MicroRNAs in normal and malignant hematopoiesis. Curr Opin Hematol 2008; 15: 352–358.
  CAS PubMed Google Scholar
• Cho WC . OncomiRs: the discovery and progress of microRNAs in cancers. Mol Cancer 2007; 6: 60.
  PubMed PubMed Central Google Scholar
• Gatto G, Rossi A, Rossi D, Kroening S, Bonatti S, Mallardo M . Epstein-Barr virus latent membrane protein 1 transactivates miR-155 transcription through the NF-κB pathway. Nucleic Acids Res 2008; 36: 6608–6619.
  CAS PubMed PubMed Central Google Scholar
• Yin Q, McBride J, Fewell C, Lacey M, Wang X, Lin Z et al. MicroRNA-155 is an Epstein-Barr virus-induced gene that modulates Epstein-Barr virus-regulated gene expression pathways. J Virol 2008; 82: 5295–5306.
  CAS PubMed PubMed Central Google Scholar
• Rahadiani N, Takakuwa T, Tresnasari K, Morii E, Aozasa K . Latent membrane protein-1 of Epstein-Barr virus induces the expression of B-cell integration cluster, a precursor form of microRNA-155, in B lymphoma cell lines. Biochem Biophys Res Commun 2008; 377: 579–583.
  CAS PubMed Google Scholar
• Huang Y, Walstrom A, Zhang L, Zhao Y, Cui M, Ye L et al. Type I interferons and interferon regulatory factors regulate TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected macrophages. PLoS ONE 2009; 4: e5397.
  PubMed PubMed Central Google Scholar
• Andrews HN, Mullan PB, McWilliams S, Sebelova S, Quinn JE, Gilmore PM et al. BRCA1 regulates the interferon gamma-mediated apoptotic response. J Biol Chem 2002; 277: 26225–26232.
  CAS PubMed Google Scholar
• Kim TK, Kim T, Kim TY, Lee WG, Yim J . Chemotherapeutic DNA-damaging drugs activate interferon regulatory factor-7 by the mitogen-activated protein kinase kinase-4-c-Jun NH2-terminal kinase pathway. Cancer Res 2000; 60: 1153–1156.
  CAS PubMed Google Scholar
• Nonkwelo C, Ruf IK, Sample J . Interferon-independent and -induced regulation of Epstein-Barr virus EBNA-1 gene transcription in Burkitt lymphoma. J Virol 1997; 71: 6887–6897.
  CAS PubMed PubMed Central Google Scholar
• Schaefer BC, Paulson E, Strominger JL, Speck SH . Constitutive activation of Epstein-Barr virus (EBV) nuclear antigen 1 gene transcription by IRF1 and IRF2 during restricted EBV latency. Mol Cell Biol 1997; 17: 873–886.
  CAS PubMed PubMed Central Google Scholar
• Negishi H, Ohba Y, Yanai H, Takaoka A, Honma K, Yui K et al. Negative regulation of Toll-like-receptor signaling by IRF4. Proc Natl Acad Sci USA 2005; 102: 15989–15994.
  CAS PubMed PubMed Central Google Scholar
• Chen H, Huang J, Wu FY, Liao G, Hutt-Fletcher L, Hayward SD . Regulation of expression of the Epstein-Barr virus BamHI-A rightward transcripts. J Virol 2005; 79: 1724–1733.
  CAS PubMed PubMed Central Google Scholar
• Lo AKF, To KF, Lo KW, Lung RWM, Hui JWY, Liao G et al. Modulation of LMP1 protein expression by EBV-encoded microRNAs. Proc Natl Acad Sci USA 2007; 104: 16164–16169.
  CAS PubMed PubMed Central Google Scholar
• Xu D, Brumm K, Zhang L . The latent membrane protein 1 of Epstein-Barr virus (EBV) primes EBV latency cells for type I interferon production. J Biol Chem 2006; 281: 9163–9169.
  CAS PubMed Google Scholar
• Zhang J, Das SC, Kotalik C, Pattnaik AK, Zhang L . The latent membrane protein 1 of Epstein-Barr virus establishes an antiviral state via induction of interferon-stimulated genes. J Biol Chem 2004; 279: 46335–46342.
  CAS PubMed Google Scholar
• Kim WU, Sreih A, Bucala R . Toll-like receptors in systemic lupus erythematosus: prospects for therapeutic intervention. Autoimmun Rev 2009; 8: 204–208.
  CAS PubMed Google Scholar
• Baccala R, Hoebe K, Kono DH, Beutler B, Theofilopoulos AN . TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity. Nat Med 2007; 13: 543–551.
  CAS PubMed Google Scholar
• Graham RR, Kozyrev SV, Baechler EC, Reddy MVP, Plenge RM, Bauer JW, et al. Collaborative Groupsthe Argentine and Spanish. A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus. Nat Genet 2006; 38: 550–555.
  CAS PubMed Google Scholar
• Pinheiro RF, Metze K, Silva MRR, de Lourdes Lopes Ferrari Chauffaille M . The ambiguous role of interferon regulatory factor-1 (IRF-1) immunoexpression in myelodysplastic syndrome. Leukemia Res 2009; 33: 1308–1312.
  CAS Google Scholar
• Honda K, Yanai H, Takaoka A, Taniguchi T . Regulation of the type I IFN induction: a current view. Int Immunol 2005; 17: 1367–1378.
  CAS PubMed Google Scholar
• Okabe Y, Kawane K, Nagata S . IFN regulatory factor (IRF) 3/7-dependent and -independent gene induction by mammalian DNA that escapes degradation. Eur J Immunol 2008; 38: 3150–3158.
  CAS PubMed Google Scholar
• Harley JB, Alarcon-Riquelme ME, Criswell LA, Jacob CO, Kimberly RP, Moser KL et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet 2008; 40: 204–210.
  CAS PubMed PubMed Central Google Scholar
• Salloum R, Franek BS, Kariuki SN, Rhee L, Mikolaitis RA, Jolly M et al. Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-alpha activity in lupus patients. Arthritis Rheum 2010; 62: 553–561.
  CAS PubMed PubMed Central Google Scholar
• Fu Q, Zhao J, Qian X, Wong JL, Kaufman KM, Yu CY, et al., Hwee Siew Howe the TTSH Lupus Study Group. Association of a functional IRF7 variant with systemic lupus erythematosus. Arthritis Rheumatism 2011; 63: 749–754.
  CAS PubMed Google Scholar
• Heinig M, Petretto E, Wallace C, Bottolo L, Rotival M, Lu H, et al. A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. Nature 2010; 467: 460–464.
  CAS PubMed PubMed Central Google Scholar
• Battistini A . Interferon regulatory factors in hematopoietic cell differentiation and immune regulation. J Interferon Cytokine Res 2009; 29: 765–780.
  CAS PubMed Google Scholar
• Lien C, Fang CM, Huso D, Livak F, Lu R, Pitha PM . Critical role of IRF-5 in regulation of B-cell differentiation. Proc Natl Acad Sci USA 2010; 107: 4664–4668.
  CAS PubMed PubMed Central Google Scholar
• Lu R, Pitha PM . Monocyte differentiation to macrophage requires interferon regulatory factor 7. J Biol Chem 2001; 276: 45491–45496.
  CAS PubMed Google Scholar
• Pietila TE, Veckman V, Lehtonen A, Lin R, Hiscott J, Julkunen I . Multiple NF-kappaB and IFN regulatory factor family transcription factors regulate CCL19 gene expression in human monocyte-derived dendritic cells. J Immunol 2007; 178: 253–261.
  CAS PubMed Google Scholar
• Lin R, Genin P, Mamane Y, Hiscott J . Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of α/β interferon genes by interferon regulatory factors 3 and 7. Mol Cell Biol 2000; 20: 6342–6353.
  CAS PubMed PubMed Central Google Scholar
• Sgarbanti M, Marsili G, Remoli AL, Orsatti R, Battistini A . IRF7: new role in the regulation of genes involved in adaptive immunity. Ann N Y Acad Sci 2007; 1095: 325–333.
  CAS PubMed Google Scholar
• Barnes BJ, Richards J, Mancl ME, Hanash S, Beretta L, Pitha PM . Global and specific targets of IRF5 and IRF7 during innate response to viral infection. J Biol Chem 2004; 279: 45194–45207.
  CAS PubMed Google Scholar
• Zhao Y, Xu D, Jiang Y, Zhang L . Dual functions of interferon regulatory factors 7C in Epstein-Barr virus-mediated transformation of human B lymphocytes. PLoS ONE 2010; 5: e9459.
  PubMed PubMed Central Google Scholar
• Green DR, Kroemer G . Cytoplasmic functions of the tumour suppressor p53. Nature 2009; 458: 1127–1130.
  CAS PubMed PubMed Central Google Scholar