Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2 (original) (raw)

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Acknowledgements

This study makes use of data generated by the Wellcome Trust Case Control Consortium. A full list of the investigators who contributed to the generation of the data is available from www.wtccc.org.uk. Funding for the project was provided by the Wellcome Trust under award 076113. The UK research was supported by grants from the MRC, the Wellcome Trust and by a NIMH (USA) CONTE: 2 P50 MH066392-05A1. In Dublin, the research was supported by Science Foundation Ireland, the Health Research Board (Ireland), and the Wellcome Trust. We are grateful to Professor John Waddington for sample recruitment. Irish controls were supplied by Dr Joe McPartlin and the Trinity College Biobank. In Bonn and Mannheim, the work was supported by the National Genomic Network of the ‘Bundesministerium für Bildung und Forschung’ (BMBF), the Alfried Krupp von Bohlen und Halbach-Stiftung and in Bethesda the work was supported in part by the Intramural Program of the NIMH. We also thank the Department of Psychiatry, LMU Munich for clinical characterization of the Munich subjects and the processing of the samples. Recruitment in Munich was partially supported by GlaxoSmithKline. The Ashkenazi samples are part of the Hebrew University Genetic Resource, HUGR (www.hugr.org). In Sweden support was obtained from the Swedish Research Council (K2007-62X-15078-04-3, K2008-62P-20597-01-3), the Wallenberg Foundation and the HUBIN project. The following authors are included under the Molecular Genetics of Schizophrenia Collaboration: PV Gejman, AR Sanders, J Duan (Evanston Healthcare and Northwestern University, IL, USA), DF Levinson (Stanford University, CA, USA), NG Buccola (Louisiana State University, LA, USA), BJ Mowry (University of Queensland, Brisbane, Australia), R Freedman (University of Colorado Health Science Centre, Denver, USA), F Amin (Emory University, Atlanta, USA), DW Black (University of Iowa College of Medicine, IA, USA), JM Silverman (Mount Sinai School of Medicine, New York, USA), WJ Byerley (University of California, San Francisco, USA), CR Cloninger (Washington University).

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Author notes

1. M C O'Donovan, N Norton, H Williams, T Peirce, V Moskvina, I Nikolov, M Hamshere, L Carroll, L Georgieva, S Dwyer, P Holmans, J L Marchini, C C A Spencer, B Howie, H-T Leung, I Giegling, A M Hartmann, H-J Möller, D W Morris, Y Shi, G Feng, P Hoffmann, P Propping, C Vasilescu, W Maier, M Rietschel, S Zammit, J Schumacher, E M Quinn, T G Schulze, N Iwata, M Ikeda, A Darvasi, S Shifman, L He, J Duan, A R Sanders, D F Levinson, R Adolfsson, U Ösby, L Terenius, E G Jönsson, S Cichon, M M Nöthen, M Gill, A P Corvin, D Rujescu, P V Gejman, G Kirov, N Craddock, N M Williams and M J Owen: Individual authors listed in acknowledgements.

Authors and Affiliations

1. Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
   M C O'Donovan, N Norton, H Williams, T Peirce, V Moskvina, I Nikolov, M Hamshere, L Carroll, L Georgieva, S Dwyer, P Holmans, S Zammit, G Kirov, N Craddock, N M Williams & M J Owen
2. Department of Statistics, University of Oxford, Oxford, UK
   J L Marchini, C C A Spencer & B Howie
3. Department of Medical Genetics, Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, University of Cambridge, Cambridge, UK
   H-T Leung
4. Division of Molecular and Clinical Neurobiology; Ludwig-Maximilians-University,
   I Giegling, A M Hartmann & D Rujescu
5. Ludwig-Maximilians-University, Munich, Germany
   I Giegling, A M Hartmann & D Rujescu
6. Department of Psychiatry, Ludwig-Maximilians-University, Munich, Germany
   H-J Möller
7. Neuropsychiatric Genetics Research Group, School of Medicine, Trinity College Dublin, Dublin, Ireland
   D W Morris, E M Quinn, M Gill & A P Corvin
8. Bio-X Center, Shanghai Jiao Tong University, Shanghai, PR China
   Y Shi & L He
9. Shanghai Institute of Mental Health, Shanghai, PR China
   G Feng
10. Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    P Hoffmann, C Vasilescu, S Cichon & M M Nöthen
11. Institute of Human Genetics, University of Bonn, Bonn, Germany
    P Propping, S Cichon & M M Nöthen
12. Department of Psychiatry, University of Bonn, Bonn, Germany
    W Maier
13. Division of Genetic Epidemiology in Psychiatry, Central Institute for Mental Health, Mannheim, Germany
    M Rietschel
14. Genetic Basis of Mood and Anxiety Disorders, NIMH/NIH, Bethesda, MD, USA
    J Schumacher & T G Schulze
15. Department of Psychiatry, School of Medicine, Fujita Health University, Aichi, Japan
    N Iwata & M Ikeda
16. CREST, Japan Science and Technology Agency, Saitama, Japan
    N Iwata & M Ikeda
17. Department of Genetics, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, Israel
    A Darvasi & S Shifman
18. Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, PR China
    L He
19. Center for Psychiatric Genetics, Evanston Northwestern Healthcare, The Northwestern University, Evanston, IL, USA
    J Duan, A R Sanders & P V Gejman
20. Feinberg School of Medicine, The Northwestern University, Evanston, IL, USA
    J Duan, A R Sanders & P V Gejman
21. Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA
    D F Levinson
22. Division of Psychiatry, Department of Clinical Sciences, Umeå University, Umeå, Sweden
    R Adolfsson
23. Department of Clinical Neuroscience, HUBIN Project, Karolinska Institutet, Stockholm, Sweden
    U Ösby, L Terenius & E G Jönsson

Authors

1. M C O'Donovan
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2. N Norton
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3. H Williams
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4. T Peirce
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5. V Moskvina
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6. I Nikolov
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7. M Hamshere
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8. L Carroll
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9. L Georgieva
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10. S Dwyer
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11. P Holmans
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12. J L Marchini
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13. C C A Spencer
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14. B Howie
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15. H-T Leung
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16. I Giegling
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17. A M Hartmann
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18. H-J Möller
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19. D W Morris
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20. Y Shi
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21. G Feng
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22. P Hoffmann
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23. P Propping
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24. C Vasilescu
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25. W Maier
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26. M Rietschel
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27. S Zammit
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28. J Schumacher
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29. E M Quinn
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30. T G Schulze
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31. N Iwata
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32. M Ikeda
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33. A Darvasi
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34. S Shifman
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35. L He
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36. J Duan
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37. A R Sanders
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38. D F Levinson
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39. R Adolfsson
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40. U Ösby
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41. L Terenius
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42. E G Jönsson
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43. S Cichon
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44. M M Nöthen
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45. M Gill
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46. A P Corvin
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47. D Rujescu
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48. P V Gejman
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49. G Kirov
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50. N Craddock
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51. N M Williams
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52. M J Owen
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Molecular Genetics of Schizophrenia Collaboration

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Correspondence toM C O'Donovan.

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Supplementary Information accompanies the paper on the Molecular Psychiatry website (http://www.nature.com/mp)

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O'Donovan, M., Norton, N., Williams, H. et al. Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2.Mol Psychiatry 14, 30–36 (2009). https://doi.org/10.1038/mp.2008.108

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• Received: 11 August 2008
• Accepted: 12 August 2008
• Published: 23 September 2008
• Issue Date: January 2009
• DOI: https://doi.org/10.1038/mp.2008.108

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