Inflammation and cancer (original) (raw)

• Balkwill, F. & Mantovani, A. Inflammation and cancer: back to Virchow? Lancet 357, 539–545 (2001).
  Article CAS PubMed Google Scholar
• Dvorak, H. F. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N. Engl. J. Med. 315, 1650–1659 (1986).
  Article CAS PubMed Google Scholar
• Dranoff, G. Tumour immunology: immune recognition and tumor protection. Curr. Opin. Immunol. 14, 161–164 (2002).
  Article CAS Google Scholar
• Pardoll, D. M. Spinning molecular immunology into successful immunotherapy. Nature Rev. Immunol. 2, 227–238 (2002).
  Article CAS Google Scholar
• Chettibi, S. & Ferguson, M. W. J. in Inflammation: Basic Principles and Clinical Correlates (eds Gallin, J. I. & Snyderman, R.) 865–881 (Lipincott, Williams and Wilkinson, Philadelphia, 1999).
  Google Scholar
• Rossi, D. & Zlotnik, A. The biology of chemokines and their receptors. Annu. Rev. Immunol. 18, 217–242 (2000).
  Article CAS PubMed Google Scholar
• Homey, B., Muller, A. & Zlotnik, A. Chemokines: agents for the immunotherapy of cancer? Nature Rev. Immunol. 2, 175–184 (2002).
  Article CAS Google Scholar
• Moustakas, A., Pardali, K., Gaal, A. & Heldin, C. H. Mechanisms of TGF-β signaling in regulation of cell growth and differentiation. Immunol. Lett. 82, 85–91 (2002).
  Article CAS PubMed Google Scholar
• Rous, P. & Kidd, J. Conditional neoplasms and subthreshold neoplastic states: a study of the tar tumors of rabbits. J. Exp. Med. 73, 365–389 (1941).
  Article CAS PubMed PubMed Central Google Scholar
• Mackenzie, I. C. & Rous, P. The experimental disclosure of latent neoplastic changes in tarred skin. J. Exp. Med. 73, 391–415 (1941).
  Article CAS PubMed PubMed Central Google Scholar
• Kuper, H., Adami, H. O. & Trichopoulos, D. Infections as a major preventable cause of human cancer. J. Intern. Med. 248, 171–183 (2000).
  Article CAS PubMed Google Scholar
• Wahl, L. M. & Kleinman, H. K. Tumor-associated macrophages as targets for cancer therapy. J. Natl Cancer Inst. 90, 1583–1584 (1998).
  Article CAS PubMed Google Scholar
• Talmor, M. et al. Generation of large numbers of immature and mature dendritic cells from rat bone marrow cultures. Eur. J. Immunol. 28, 811–817 (1998).
  Article CAS PubMed Google Scholar
• Allavena, P. et al. The chemokine receptor switch paradigm and dendritic cell migration: its significance in tumor tissues. Immunol. Rev. 177, 141–149 (2000).
  Article CAS PubMed Google Scholar
• Brigati, C., Noonan, D. M., Albini, A. & Benelli, R. Tumors and inflammatory infiltrates: friends or foes? Clin. Exp. Metastasis 19, 247–258 (2002).
  Article CAS PubMed Google Scholar
• Tsung, K., Dolan, J. P., Tsung, Y. L. & Norton, J. A. Macrophages as effector cells in interleukin 12-induced T cell-dependent tumor rejection. Cancer Res. 62, 5069–5075 (2002).
  CAS PubMed Google Scholar
• Schoppmann, S. et al. Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis. Am. J. Pathol. 161, 947–956 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Torisu, H. et al. Macrophage infiltration correlates with tumor stage and angiogenesis in human malignant melanoma: possible involvement of TNFα and IL-1α. Int. J. Cancer 85, 182–188 (2000).
  Article CAS PubMed Google Scholar
• Ono, M., Torisu, H., Fukushi, J., Nishie, A. & Kuwano, M. Biological implications of macrophage infiltration in human tumor angiogenesis. Cancer Chemother. Pharmacol. 43, S69–S71 (1999).
  Article CAS PubMed Google Scholar
• Jonjic, N. et al. Expression of adhesion molecules and chemotactic cytokines in cultured human mesothelial cells. J. Exp. Med. 176, 1165–1174 (1992).
  Article CAS PubMed Google Scholar
• Lin, E. Y., Nguyen, A. V., Russell, R. G. & Pollard, J. W. Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J. Exp. Med. 193, 727–740 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Nowicki, A. et al. Impaired tumor growth in colony-stimulating factor 1 (CSF-1)-deficient, macrophage-deficient op/op mouse: evidence for a role of CSF-1-dependent macrophages in formation of tumor stroma. Int. J. Cancer 65, 112–119 (1996).
  Article CAS PubMed Google Scholar
• DiCarlo, E. et al. The intriguing role of polymorphonuclear neutrophils in antitumor reactions. Blood 97, 339–345 (2001).
  Article CAS Google Scholar
• Coussens, L. M. et al. Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. Genes Dev. 13, 1382–1397 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Coussens, L. M., Tinkle, C. L., Hanahan, D. & Werb, Z. MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell 103, 481–490 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Bergers, G. et al. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nature Cell Biol. 2, 737–744 (2000).
  Article CAS PubMed Google Scholar
• Blaser, M. J., Chyou, P. H. & Nomura, A. Age at establishment of Helicobacter pylori infection and gastric carcinoma, gastric ulcer, and duodenal ulcer risk. Cancer Res. 55, 562–565 (1995).
  CAS PubMed Google Scholar
• Scholl, S. M. et al. Anti-colony-stimulating factor-1 antibody staining in primary breast adenocarcinomas correlates with marked inflammatory cell infiltrates and prognosis. J. Natl Cancer Inst. 86, 120–126 (1994).
  Article CAS PubMed Google Scholar
• Shacter, E. & Weitzman, S. A. Chronic inflammation and cancer. Oncology 16, 217–226 (2002).
  PubMed Google Scholar
• Maeda, H. & Akaike, T. Nitric oxide and oxygen radicals in infection, inflammation, and cancer. Biochemistry 63, 854–865 (1998).
  CAS PubMed Google Scholar
• Yamanishi, Y. et al. Regional analysis of p53 mutations in rheumatoid arthritis synovium. Proc. Natl Acad. Sci. USA 99, 10025–10030 (2002).
  Article ADS CAS PubMed PubMed Central Google Scholar
• Ernst, P. B. & Gold, B. D. The disease spectrum of Helicobacter pylori: the immunopathogenesis of gastroduodenal ulcer and gastric cancer. Annu. Rev. Microbiol. 54, 615–640 (2000).
  Article CAS PubMed Google Scholar
• Hudson, J. D. et al. A proinflammatory cytokine inhibits p53 tumor suppressor activity. J. Exp. Med. 190, 1375–1382 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Jensen, U. B., Lowell, S. & Watt, F. M. The spatial relationship between stem cells and their progeny in the basal layer of human epidermis: a new view based on whole-mount labeling and lineage analysis. Development 126, 2409–2418 (1999).
  CAS PubMed Google Scholar
• Martins-Green, M., Boudreau, N. & Bissell, M. J. Inflammation is responsible for the development of wound-induced tumors in chickens infected with Rous sarcoma virus. Cancer Res. 54, 4334–4341 (1994).
  CAS PubMed Google Scholar
• Yoshida, T. et al. Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation. J. Exp. Med. 196, 641–653 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Bromberg, J. & Darnell, J. E. The role of STATs in transcriptional control and their impact on cellular function. Oncogene 19, 2468–2473 (2000).
  Article CAS PubMed Google Scholar
• Tebbutt, N. C. et al. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nature Med. 8, 1089–1097 (2002).
  Article CAS PubMed Google Scholar
• Mantovani, A., Muzio, M., Garlanda, C., Sozzani, S. & Allavena, P. Macrophage control of inflammation: negative pathways of regulation of inflammatory cytokines. Novartis Found. Symp. 234, 120–131 (2001).
  CAS PubMed Google Scholar
• Richmond, A. & Thomas, H. Purification of melanoma growth stimulatory activity. J. Cell. Physiol. 129, 375–384 (1986).
  Article CAS PubMed Google Scholar
• Norgauer, J., Metzner, B. & Schraufstatter, I. Expression and growth-promoting function of the IL-8 receptor β in human melanoma cells. J. Immunol. 156, 1132–1137 (1996).
  CAS PubMed Google Scholar
• Balentien, E., Mufson, B. E., Shattuck, R. L., Derynck, R. & Richmond, A. Effects of MGSA/GRO alpha on melanocyte transformation. Oncogene 6, 1115–1124 (1991).
  CAS PubMed Google Scholar
• Owen, J. D. et al. Enhanced tumor-forming capacity for immortalized melanocytes expressing melanoma growth stimulatory activity/growth-regulated cytokine beta and gamma proteins. Int. J. Cancer 73, 94–103 (1997).
  Article CAS PubMed Google Scholar
• Vicari, A. P. & Caux, C. Chemokines in cancer. Cytokine Growth Factor Rev. 13, 143–154 (2002).
  Article CAS PubMed Google Scholar
• Farrow, B. & Evers, B. M. Inflammation and the development of pancreatic cancer. Surg. Oncol. 10, 153–169 (2002).
  Article PubMed Google Scholar
• Arenberg, D. A. et al. Epithelial-neutrophil activating peptide (ENA-78) is an important angiogenic factor in non-small cell lung cancer. J. Clin. Invest. 102, 465–472 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Kleeff, J. et al. Detection and localization of Mip-3α/LARC/Exodus, a macrophage proinflammatory chemokine, and its CCR6 receptor in human pancreatic cancer. Int. J. Cancer 81, 650–657 (1999).
  Article CAS PubMed Google Scholar
• Hanahan, D. & Weinberg, R. A. The hallmarks of cancer. Cell 100, 57–70 (2000).
  Article CAS PubMed Google Scholar
• Strieter, R. M. et al. The functional role of the ELR motif in CXC chemokine-mediated angiogenesis. J. Biol. Chem. 270, 27348–27357 (1995).
  Article CAS PubMed Google Scholar
• Muller, A. et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 410, 50–56 (2001).
  Article ADS CAS PubMed Google Scholar
• Moore, M. A. The role of chemoattraction in cancer metastases. BioEssays 23, 674–676 (2001).
  Article CAS PubMed Google Scholar
• Kim, Y. J., Borsig, L., Varki, N. M. & Varki, A. P-selectin deficiency attenuates tumor growth and metastasis. Proc. Natl Acad. Sci. USA 95, 9325–9330 (1998).
  Article ADS CAS PubMed PubMed Central Google Scholar
• Zhang, J et al. Sialyl Lewis X-dependent lung colonization of B16 melanoma cells through a selectin-like endothelial receptor distinct from E- or P-selectin. Cancer Res. 62, 4194–4198 (2002).
  CAS PubMed Google Scholar
• Borsig, L. et al. Heparin and cancer revisited: mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis. Proc. Natl Acad. Sci. USA 98, 3352–3357 (2001).
  Article ADS CAS PubMed PubMed Central Google Scholar
• Borsig, L., Wong, R., Hynes, R. O., Varki, N. M. & Varki, A. Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis. Proc. Natl Acad. Sci. USA 99, 2193–2198 (2002).
  Article ADS CAS PubMed PubMed Central Google Scholar
• Qian, F., Hanahan, D. & Weissman, I. L. L-selectin can facilitate metastasis to lymph nodes in a transgenic mouse model of carcinogenesis. Proc. Natl Acad. Sci. USA 98, 3976–3981 (2001).
  Article ADS CAS PubMed PubMed Central Google Scholar
• Baron, J. A. & Sandler, R. S. Nonsteroidal anti-inflammatory drugs and cancer prevention. Annu. Rev. Med. 51, 511–523 (2000).
  Article CAS PubMed Google Scholar
• Garcia-Rodriguez, L. A. & Huerta-Alvarez, C. Reduced risk of colorectal cancer among long-term users of aspirin and nonaspirin nonsteroidal antiinflammatory drugs. Epidemiology 12, 88–93 (2001).
  Article CAS PubMed Google Scholar
• Williams, C. S., Mann, M. & DuBois, R. N. The role of cyclooxygenases in inflammation, cancer, and development. Oncogene 18, 7908–7916 (1999).
  Article CAS PubMed Google Scholar
• Mamytbekova, A., Rezabek, K., Kacerovska, H., Grimova, J. & Svobodova, J. Antimetastatic effect of flurbiprofen and other platelet aggregation inhibitors. Neoplasma 33, 417–421 (1986).
  CAS PubMed Google Scholar
• Elder, D. J., Halton, D. E., Hague, A. & Paraskeva, C. Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug: independence from COX-2 protein expression. Clin. Cancer Res. 3, 1679–1683 (1997).
  CAS PubMed Google Scholar
• Balkwill, F. Tumor necrosis factor or tumor promoting factor? Cytokine Growth Factor Rev. 13, 135–141 (2002).
  Article CAS PubMed Google Scholar
• Shanahan, J. C. & St. Clair, E. W. Tumor necrosis factor-alpha blockade: a novel therapy for rheumatic disease. Clin. Immunol. 103, 231–242 (2002).
  Article CAS PubMed Google Scholar
• Egeblad, M. & Werb, Z. New functions for the matrix metalloproteinases in cancer progression. Nature Rev. Cancer 2, 161–174 (2002).
  Article CAS Google Scholar
• Overall, C. M. & Lopez-Otin, C. Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nature Rev. Cancer 2, 657–672 (2002).
  Article CAS Google Scholar
• Coussens, L. M., Fingleton, B. & Matrisian, L. M. Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science 295, 2387–2392 (2002).
  Article ADS CAS PubMed Google Scholar
• Dalgleish, A. G. & O'Byrne, K. J. Chronic immune activation and inflammation in the pathogenesis of AIDS and cancer. Adv. Cancer Res. 84, 231–276 (2002).
  Article CAS PubMed Google Scholar
• Feiken, E., Romer, J., Eriksen, J. & Lund, L. R. Neutrophils express tumor necrosis factor-alpha during mouse skin wound healing. J. Invest. Dermatol. 105, 120–123 (1995).
  Article CAS PubMed Google Scholar
• Hubner, G. et al. Differential regulation of pro-inflammatory cytokines during wound healing in normal and glucocorticoid-treated mice. Cytokine 8, 548–556 (1996).
  Article CAS PubMed Google Scholar
• Chedid, M., Rubin, J. S., Csaky, K. G. & Aaronson, S. A. Regulation of keratinocyte growth factor gene expression by interleukin 1. J. Biol. Chem. 269, 10753–10757 (1994).
  CAS PubMed Google Scholar
• Osusky, R., Malik, P. & Ryan, S. J. Retinal pigment epithelium cells promote the maturation of monocytes to macrophages in vitro. Ophthalmic Res. 29, 31–36 (1997).
  Article CAS PubMed Google Scholar
• DiPietro, L. Wound healing: the role of the macrophage and other immune cells. Shock 4, 233–240 (1995).
  Article CAS PubMed Google Scholar
• Fritsch, C., Simon-Assmann, P., Kedinger, M. & Evans, G. S. Cytokines modulate fibroblast phenotype and epithelial-stroma interactions in rat intestine. Gastroenterology 112, 826–838 (1997).
  Article CAS PubMed Google Scholar
• Grutzkau, A. et al. Synthesis, storage, and release of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) by human mast cells: implications for the biological significance of VEGF206. Mol. Biol. Cell 9, 875–884 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Chensue, S. W., Ruth, J. H., Warmington, K., Lincoln, P. & Kunkel, S. L. In vivo regulation of macrophage IL-12 production during type 1 and type 2 cytokine-mediated granuloma formation. J. Immunol. 155, 3546–3551 (1995).
  CAS PubMed Google Scholar
• Romer, J. et al. Impaired wound healing in mice with a disrupted plasminogen gene. Nature Med. 2, 287–292 (1996).
  Article CAS PubMed Google Scholar