RETRACTED ARTICLE: APP binds DR6 to trigger axon pruning and neuron death via distinct caspases (original) (raw)

• Raff, M. C., Whitmore, A. V. & Finn, J. T. Axonal self-destruction and neurodegeneration. Science 296, 868–871 (2002)
  Article ADS CAS PubMed Google Scholar
• Luo, L. & O’Leary, D. D. Axon retraction and degeneration in development and disease. Annu. Rev. Neurosci. 28, 127–156 (2005)
  Article CAS PubMed Google Scholar
• Buss, R. R., Sun, W. & Oppenheim, R. W. Adaptive roles of programmed cell death during nervous system development. Annu. Rev. Neurosci. 29, 1–35 (2006)
  Article CAS PubMed Google Scholar
• Saxena, S. & Caroni, P. Mechanisms of axon degeneration: from development to disease. Prog. Neurobiol. 83, 174–191 (2007)
  Article CAS PubMed Google Scholar
• Haase, G., Pettmann, B., Raoul, C. & Henderson, C. E. Signaling by death receptors in the nervous system. Curr. Opin. Neurobiol. 18, 284–291 (2008)
  Article CAS PubMed PubMed Central Google Scholar
• Kuida, K. et al. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384, 368–372 (1996)
  Article ADS CAS PubMed Google Scholar
• White, F. A., Keller-Peck, C. R., Knudson, C. M., Korsmeyer, S. J. & Snider, W. D. Widespread elimination of naturally occurring neuronal death in _Bax_-deficient mice. J. Neurosci. 18, 1428–1439 (1998)
  Article CAS PubMed PubMed Central Google Scholar
• Finn, J. T. et al. Evidence that Wallerian degeneration and localized axon degeneration induced by local neurotrophin deprivation do not involve caspases. J. Neurosci. 20, 1333–1341 (2000)
  Article CAS PubMed PubMed Central Google Scholar
• Kuo, C. T., Zhu, S., Younger, S., Jan, L. Y. & Jan, Y. N. Identification of E2/E3 ubiquitinating enzymes and caspase activity regulating Drosophila sensory neuron dendrite pruning. Neuron 51, 283–290 (2006)
  Article CAS PubMed Google Scholar
• Williams, D. W., Kondo, S., Krzyzanowska, A., Hiromi, Y. & Truman, J. W. Local caspase activity directs engulfment of dendrites during pruning. Nature Neurosci. 9, 1234–1236 (2006)
  Article CAS PubMed Google Scholar
• Plachta, N. et al. Identification of a lectin causing the degeneration of neuronal processes using engineered embryonic stem cells. Nature Neurosci. 10, 712–719 (2007)
  Article CAS PubMed Google Scholar
• Sagot, Y. et al. Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease. J. Neurosci. 15, 7727–7733 (1995)
  Article CAS PubMed PubMed Central Google Scholar
• Watts, R. J., Hoopfer, E. D. & Luo, L. Axon pruning during Drosophila metamorphosis: evidence for local degeneration and requirement of the ubiquitin-proteasome system. Neuron 38, 871–885 (2003)
  Article CAS PubMed Google Scholar
• Bodmer, J. L., Schneider, P. & Tschopp, J. The molecular architecture of the TNF superfamily. Trends Biochem. Sci. 27, 19–26 (2002)
  Article CAS PubMed Google Scholar
• Bossen, C. et al. Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human. J. Biol. Chem. 281, 13964–13971 (2006)
  Article CAS PubMed Google Scholar
• Pan, G. et al. Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett. 431, 351–356 (1998)
  Article CAS PubMed Google Scholar
• Zhao, H. et al. Impaired c-Jun amino terminal kinase activity and T cell differentiation in death receptor 6-deficient mice. J. Exp. Med. 194, 1441–1448 (2001)
  Article CAS PubMed PubMed Central Google Scholar
• Schmidt, C. S. et al. Enhanced B cell expansion, survival, and humoral responses by targeting death receptor 6. J. Exp. Med. 197, 51–62 (2003)
  Article CAS PubMed PubMed Central Google Scholar
• Walsh, D. M. et al. The APP family of proteins: similarities and differences. Biochem. Soc. Trans. 35, 416–420 (2007)
  Article CAS PubMed Google Scholar
• Reinhard, C., Hebert, S. S. & De Strooper, B. The amyloid-β precursor protein: integrating structure with biological function. EMBO J. 24, 3996–4006 (2005)
  Article CAS PubMed PubMed Central Google Scholar
• Hardy, J. & Selkoe, D. J. The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics. Science 297, 353–356 (2002)
  Article ADS CAS PubMed Google Scholar
• Haass, C. & Selkoe, D. J. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer’s amyloid β-peptide. Nature Rev. Mol. Cell Biol. 8, 101–112 (2007)
  Article CAS Google Scholar
• Wang, H. & Tessier-Lavigne, M. En passant neurotrophic action of an intermediate axonal target in the developing mammalian CNS. Nature 401, 765–769 (1999)
  Article ADS CAS PubMed Google Scholar
• Campenot, R. B., Walji, A. H. & Draker, D. D. Effects of sphingosine, staurosporine, and phorbol ester on neurites of rat sympathetic neurons growing in compartmented cultures. J. Neurosci. 11, 1126–1139 (1991)
  Article CAS PubMed PubMed Central Google Scholar
• Cole, S. L. & Vassar, R. BACE1 structure and function in health and Alzheimer’s disease. Curr. Alzheimer Res. 5, 100–120 (2008)
  Article CAS PubMed Google Scholar
• Edwards, P. D. et al. Application of fragment-based lead generation to the discovery of novel, cyclic amidine β-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiency. J. Med. Chem. 50, 5912–5925 (2007)
  Article CAS PubMed Google Scholar
• Slunt, H. H. et al. Expression of a ubiquitous, cross-reactive homologue of the mouse β-amyloid precursor protein (APP). J. Biol. Chem. 269, 2637–2644 (1994)
  Article CAS PubMed Google Scholar
• Hilbich, C., Monning, U., Grund, C., Masters, C. L. & Beyreuther, K. Amyloid-like properties of peptides flanking the epitope of amyloid precursor protein-specific monoclonal antibody 22C11. J. Biol. Chem. 268, 26571–26577 (1993)
  Article CAS PubMed Google Scholar
• Wang, P. et al. Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-like protein 2. J. Neurosci. 25, 1219–1225 (2005)
  Article CAS PubMed PubMed Central Google Scholar
• Singh, K. K. et al. Developmental axon pruning mediated by BDNF-p75NTR-dependent axon degeneration. Nature Neurosci. 11, 649–658 (2008)
  Article CAS PubMed Google Scholar
• Deppmann, C. D. et al. A model for neuronal competition during development. Science 320, 369–373 (2008)
  Article ADS CAS PubMed PubMed Central Google Scholar
• LeBlanc, A., Liu, H., Goodyer, C., Bergeron, C. & Hammond, J. Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer’s disease. J. Biol. Chem. 274, 23426–23436 (1999)
  Article CAS PubMed Google Scholar
• Horowitz, P. M. et al. Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer’s disease. J. Neurosci. 24, 7895–7902 (2004)
  Article CAS PubMed PubMed Central Google Scholar
• Guo, H. et al. Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer’s disease. Am. J. Pathol. 165, 523–531 (2004)
  Article CAS PubMed PubMed Central Google Scholar
• Klaiman, G., Petzke, T. L., Hammond, J. & Leblanc, A. C. Targets of caspase-6 activity in human neurons and Alzheimer disease. Mol. Cell. Proteomics 7, 1541–1555 (2008)
  Article CAS PubMed PubMed Central Google Scholar
• Young-Pearse, T. L., Chen, A. C., Chang, R., Marquez, C. & Selkoe, D. J. Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin β1. Neural Develop. 3, 15 (2008)
  Article PubMed Central Google Scholar
• Heber, S. et al. Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. J. Neurosci. 20, 7951–7963 (2000)
  Article CAS PubMed PubMed Central Google Scholar
• Perez, R. G., Zheng, H., Van der Ploeg, L. H. & Koo, E. H. The β-amyloid precursor protein of Alzheimer’s disease enhances neuron viability and modulates neuronal polarity. J. Neurosci. 17, 9407–9414 (1997)
  Article CAS PubMed PubMed Central Google Scholar
• Han, P. et al. Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of Tau phosphorylation. J. Neurosci. 25, 11542–11552 (2005)
  Article CAS PubMed PubMed Central Google Scholar
• Matrone, C. et al. Activation of the amyloidogenic route by NGF deprivation induces apoptotic death in PC12 cells. J. Alzheimers Dis. 13, 81–96 (2008)
  Article CAS PubMed Google Scholar
• Matrone, C., Ciotti, M. T., Mercanti, D., Marolda, R. & Calissano, P. NGF and BDNF signaling control amyloidogenic route and Aβ production in hippocampal neurons. Proc. Natl Acad. Sci. USA 105, 13139–13144 (2008)
  Article ADS CAS PubMed PubMed Central Google Scholar
• Medana, I. M. & Esiri, M. M. Axonal damage: a key predictor of outcome in human CNS diseases. Brain 126, 515–530 (2003)
  Article CAS PubMed Google Scholar
• Chiang, L. W. et al. An orchestrated gene expression component of neuronal programmed cell death revealed by cDNA array analysis. Proc. Natl Acad. Sci. USA 98, 2814–2819 (2001)
  Article ADS CAS PubMed PubMed Central Google Scholar
• Muller, T., Meyer, H. E., Egensperger, R. & Marcus, K. The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer’s disease. Prog. Neurobiol. 85, 393–406 (2008)
  Article PubMed Google Scholar
• Van Gool, D., De Strooper, B., Van Leuven, F. & Dom, R. Amyloid precursor protein accumulation in Lewy body dementia and Alzheimer’s disease. Dementia 6, 63–68 (1995)
  CAS PubMed Google Scholar
• Palmert, M. R. et al. Antisera to an amino-terminal peptide detect the amyloid protein precursor of Alzheimer’s disease and recognize senile plaques. Biochem. Biophys. Res. Commun. 156, 432–437 (1988)
  Article CAS PubMed Google Scholar
• Bertram, L. & Tanzi, R. E. Alzheimer’s disease: one disorder, too many genes? Hum. Mol. Genet. 13, R135–R141 (2004)
  Article CAS PubMed Google Scholar
• Doyle, J. P. et al. Application of a translational profiling approach for the comparative analysis of CNS cell types. Cell 135, 749–762 (2008)
  Article CAS PubMed PubMed Central Google Scholar
• Albrecht, S. et al. Activation of caspase-6 in aging and mild cognitive impairment. Am. J. Pathol. 170, 1200–1209 (2007)
  Article CAS PubMed PubMed Central Google Scholar
• Graham, R. K. et al. Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin. Cell 125, 1179–1191 (2006)
  Article CAS PubMed Google Scholar
• Sabatier, C. et al. The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons. Cell 117, 157–169 (2004)
  Article CAS PubMed Google Scholar
• Atwal, J. K. et al. PirB is a functional receptor for myelin inhibitors of axonal regeneration. Science 322, 967–970 (2008)
  Article ADS CAS PubMed Google Scholar
• Chen, Z. et al. Alternative splicing of the Robo3 axon guidance Receptor governs the midline switch. Neuron 58, 325–332 (2008)
  Article CAS PubMed Google Scholar
• Higuchi, H., Yamashita, T., Yoshikawa, H. & Tohyama, M. Functional inhibition of the p75 receptor using a small interfering RNA. Biochem. Biophys. Res. Commun. 301, 804–809 (2003)
  Article CAS PubMed Google Scholar
• McLaughlin, T., Torborg, C. L., Feller, M. B. & O’Leary, D. D. Retinotopic map refinement requires spontaneous retinal waves during a brief critical period of development. Neuron 40, 1147–1160 (2003)
  Article CAS PubMed Google Scholar
• Pettmann, B. et al. Biological activities of nerve growth factor bound to nitrocellulose paper by western blotting. J. Neurosci. 8, 3624–3632 (1988)
  Article CAS PubMed PubMed Central Google Scholar
• Okada, A. et al. Boc is a receptor for sonic hedgehog in the guidance of commissural axons. Nature 444, 369–373 (2006)
  Article ADS CAS PubMed Google Scholar
• Knudson, C. M. et al. Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270, 96–99 (1995)
  Article ADS CAS PubMed Google Scholar
• Lee, K. F. et al. Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell 69, 737–749 (1992)
  Article CAS PubMed Google Scholar