Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells (original) (raw)

• Chong, J. A. et al. REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell 80, 949–957 (1995).
  Article CAS PubMed Google Scholar
• Schoenherr, C. J. & Anderson, D. J. The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes. Science 267, 1360–1363 (1995).
  Article CAS PubMed Google Scholar
• Ballas, N., Grunseich, C., Lu, D. D., Speh, J. C. & Mandel, G. REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. Cell 121, 645–657 (2005).
  Article CAS PubMed Google Scholar
• Abrajano, J. J. et al. Differential deployment of REST and CoREST promotes glial subtypes specification and oligodendrocyte lineage maturation. PLoS One 4, e7665 (2010).
  Article Google Scholar
• Westbrook, T. F. et al. SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature 452, 370–374 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Guardavaccaro, D. et al. Control of chromosome stability by the β-TrCP-REST-Mad2 axis. Nature 452, 365–369 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Ballas, N. & Mandel, G. The many faces of REST oversee epigenetic programming of neuronal genes. Curr. Opin. Neurobiol. 15, 500–506 (2005).
  Article CAS PubMed Google Scholar
• Johnson, R. et al. REST regulates distinct transcriptional networks in embryonic and neural stem cells. PLoS Biol. 6, 2205–2219 (2008).
  CAS Google Scholar
• Zuccato, C. et al. Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes. Nat. Genet. 35, 76–83 (2003).
  Article CAS PubMed Google Scholar
• Lepagnol-Bestel, A. M. et al. Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes. Hum. Mol. Genet. 18, 1405–1414 (2009).
  Article CAS PubMed Google Scholar
• Tahiliani, M. et al. The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation. Nature 447, 601–605 (2007).
  Article CAS PubMed Google Scholar
• Canzonetta, C. et al. DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome. Am. J. Hum. Genet. 83, 388–400 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Lawinger, P. et al. The neuronal repressor REST/NRSF is an essential regulator in medulloblastoma cells. Nat. Med. 6, 826–831 (2000).
  Article CAS PubMed Google Scholar
• Su, X. et al. Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation. Mol. Cell Biol. 26, 1666–1678 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Fuller, G. N. et al. Many human medulloblastoma tumors overexpress repressor element-1 silencing transcription (REST)/neuron-restrictive silencer factor, which can be functionally countered by REST-VP16. Mol. Cancer Ther. 4, 343–349 (2005).
  CAS PubMed Google Scholar
• Westbrook, T. et al. A genetic screen for candidate tumor suppressors identifies REST. Cell 121, 837–848 (2005).
  Article CAS PubMed Google Scholar
• Holowaty, M. N. et al. Protein profiling with Epstein-Barr nuclear antigen-1 reveals an interaction with the herpesvirus-associated ubiquitin-specific protease HAUSP/USP7. J. Biol. Chem. 278, 29987–29994 (2003).
  Article CAS PubMed Google Scholar
• Boutell, C., Canning, M., Orr, A. & Everett, R. D. Reciprocal activities between herpes simplex virus type 1 regulatory protein ICP0, a ubiquitin E3 ligase, and ubiquitin-specific protease USP7. J. Virol. 79, 12342–12354 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Andres, M. E. et al. CoREST: a functional corepressor required for regulation of neural-specific gene expression. Proc. Natl Acad. Sci. USA 96, 9873–9878 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Van der Horst, A. et al. FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP. Nat. Cell Biol. 8, 1064–1073 (2006).
  Article CAS PubMed Google Scholar
• Sheng, Y. et al. Molecular recognition of p53 and MDM2 by USP7/HAUSP. Nat. Struct. Mol. Biol. 13, 285–291 (2006).
  Article CAS PubMed Google Scholar
• Saridakis, V. et al. Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization. Mol. Cell 18, 25–36 (2005).
  Article CAS PubMed Google Scholar
• Li, M., Brooks, C. L., Kon, N. & Gu, W. A dynamic role of HAUSP in the p53-Mdm2 pathway. Mol. Cell 13, 879–886 (2004).
  Article CAS PubMed Google Scholar
• Cummins, J. M. et al. Tumour suppression: disruption of HAUSP gene stabilizes p53. Nature 428, 6982 (2004).
  Article Google Scholar
• Song, M. S. et al. The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network. Nature 455, 813–817 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Jorgensen, H. F. et al. REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells. Development 136, 715–721 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Chen, Z. F., Paquette, A. J. & Anderson, D. J. NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis. Nat. Genet. 20, 136–142 (1998).
  Article CAS PubMed Google Scholar
• Singh, S. K., Kagalwala, M. N., Parker-Thornburg, J., Adams, H. & Majumder, S. REST maintains self-renewal and pluripotency of embryonic stem cells. Nature 453, 223–227 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Buckley, N. J., Johnson, R., Sun, Y. M. & Stanton, L. W. Is REST a regulator of pluripotency? Nature 457, E5–E6 (2009).
  Article CAS PubMed Google Scholar
• Yamada, Y., Aoki, H., Kunisada, T. & Hara, A. Rest promotes the early differentiation of mouse ESCs but is not required for their maintenance. Cell Stem Cell 6, 10–15 (2010).
  Article CAS PubMed Google Scholar
• Zhang, P. et al. Nontelomeric TRF2-REST interaction modulates neuronal gene silencing and fate of tumor and stem cells. Curr. Biol. 18, 1489–1494 (2008).
  Article PubMed PubMed Central Google Scholar
• Bao, S. et al. Cancer stem cells promote radioresistance of malignant glioma through preferential activation of DNA damage checkpoint and repair. Nature 444, 756–760 (2006).
  Article CAS PubMed Google Scholar
• Bao, S. et al. Targeting cancer stem cells through L1CAM suppresses glioma growth. Cancer Res. 68, 6043–6048 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Li, Z. et al. Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell 15, 501–513 (2009).
  Article CAS PubMed PubMed Central Google Scholar