Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer (original) (raw)

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Acknowledgements

The authors thank all the individuals who took part in these studies and all the researchers, clinicians, technicians and administrative staff who have enabled this work to be carried out.

BCAC is funded by Cancer Research UK (C1287/A10118, C1287/A12014) and by the European Community's Seventh Framework Programme under grant agreement 223175 (HEALTH-F2-2009-223175) (COGS). Meetings of the BCAC have been funded by the European Union COST programme (BM0606). Genotyping on the iCOGS array was funded by the European Union (HEALTH-F2-2009-223175), Cancer Research UK (C1287/A10710, C8197/A16565), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer program and the Ministry of Economic Development, Innovation and Export Trade of Quebec, grant PSR-SIIRI-701. Combination of the GWAS data was supported in part by the US National Institutes of Health (NIH) Cancer Post-Cancer GWAS initiative, grant 1 U19 CA148065-01 (DRIVE, part of the GAME-ON initiative). For a full description of funding and acknowledgments, see the Supplementary Note.

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Authors and Affiliations

1. Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK
   Kyriaki Michailidou, Joe Dennis, Michael J Lush, Manjeet K Bolla, Qin Wang, Paul P D P Pharoah & Douglas F Easton
2. Department of Genetics, QIMR (Queensland Institute for Medical Research) Berghofer Medical Research Institute, Brisbane, Queensland, Australia
   Jonathan Beesley & Georgia Chenevix-Trench
3. Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts, USA
   Sara Lindstrom, David J Hunter & Peter Kraft
4. Division of Molecular Carcinogenesis, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands
   Sander Canisius
5. Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK
   Mel J Maranian, Mitul Shah, Barbara J Perkins, Craig Luccarini, Caroline Baynes, Shahana Ahmed, Catherine S Healey, Paul P D P Pharoah, Alison M Dunning & Douglas F Easton
6. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
   Kamila Czene, Mikael Eriksson, Hatef Darabi, Judith S Brand, Jingmei Li, Keith Humphreys & Per Hall
7. Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
   Stig E Bojesen, Børge G Nordestgaard & Sune F Nielsen
8. Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
   Stig E Bojesen, Børge G Nordestgaard & Sune F Nielsen
9. Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
   Stig E Bojesen & Børge G Nordestgaard
10. Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    Henrik Flyger
11. Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK
    Nazneen Rahman, Clare Turnbull, Minouk J Schoemaker, Anthony J Swerdlow & Montserrat Garcia-Closas
12. Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
    Olivia Fletcher, Alan Ashworth, Nick Orr & Montserrat Garcia-Closas
13. Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK
    Julian Peto, Lorna Gibson & Isabel dos-Santos-Silva
14. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
    Jenny Chang-Claude, Anja Rudolph, Ursula Eilber & Sabine Behrens
15. Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Hamburg, Germany
    Dieter Flesch-Janys
16. Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany
    Dieter Flesch-Janys
17. Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Heli Nevanlinna, Taru A Muranen, Sofia Khan & Kirsimari Aaltonen
18. Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland
    Kristiina Aittomäki
19. Department of Oncology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Carl Blomqvist
20. Center for Cancer Epidemiology and Prevention, University of Chicago, Chicago, Illinois, USA
    Habibul Ahsan & Muhammad G Kibriya
21. Department of Health Studies, University of Chicago, Chicago, Illinois, USA
    Habibul Ahsan & Muhammad G Kibriya
22. Department of Medicine, University of Chicago, Chicago, Illinois, USA
    Habibul Ahsan
23. Department of Human Genetics, University of Chicago, Chicago, Illinois, USA
    Habibul Ahsan
24. Comprehensive Cancer Center, University of Chicago, Chicago, Illinois, USA
    Habibul Ahsan
25. Department of Health Research and Policy–Epidemiology, Stanford University School of Medicine, Stanford, California, USA
    Alice S Whittemore & Esther M John
26. Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California, USA
    Alice S Whittemore & Esther M John
27. Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California, USA
    Esther M John
28. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Kathleen E Malone
29. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Marilie D Gammon
30. Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York, USA
    Regina M Santella
31. Cancer Registry of Norway, Oslo, Norway
    Giske Ursin
32. Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health, Melbourne, Victoria, Australia
    Enes Makalic & Daniel F Schmidt
33. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Graham Casey, Christopher A Haiman, Fredrick Schumacher, Brian E Henderson, Anna H Wu, Chiu-chen Tseng, David Van Den Berg & Daniel O Stram
34. Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA
    Susan M Gapstur, Mia M Gaudet & W Ryan Diver
35. Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA
    Loic Le Marchand
36. Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Medicine, Baltimore, Maryland, USA
    Christine D Berg
37. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
    Stephen J Chanock, Jonine Figueroa, Robert N Hoover & Louise Brinton
38. Vesalius Research Center, VIB, Leuven, Belgium
    Diether Lambrechts
39. Department of Oncology, Laboratory for Translational Genetics, University of Leuven, Leuven, Belgium
    Diether Lambrechts
40. Multidisciplinary Breast Center, University Hospitals Leuven, Leuven, Belgium
    Patrick Neven, Hans Wildiers & Erik van Limbergen
41. Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands
    Marjanka K Schmidt, Annegien Broeks, Senno Verhoef & Sten Cornelissen
42. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA
    Fergus J Couch
43. Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA
    Janet E Olson, Emily Hallberg, Celine Vachon & Susan Slager
44. Department of Clinical Genetics, Section Oncogenetics, VU University Medical Center, Amsterdam, the Netherlands
    Quinten Waisfisz, Hanne Meijers-Heijboer & Muriel A Adank
45. Division of Biomedical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands
    Rob B van der Luijt
46. Human Genetics Division, Genome Institute of Singapore, Singapore
    Jianjun Liu
47. Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
    Daehee Kang & Sue K Park
48. Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea
    Daehee Kang, Ji-Yeob Choi & Sue K Park
49. Cancer Research Institute, Seoul National University, Seoul, Korea
    Daehee Kang, Ji-Yeob Choi & Sue K Park
50. Seoul National University College of Medicine, Seoul, Korea
    Keun-Young Yoo
51. Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan
    Keitaro Matsuo
52. Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Hidemi Ito
53. Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan
    Hiroji Iwata
54. Epidemiology Center for Disease Control and Prevention, Mie University Hospital, Tsu, Japan
    Kazuo Tajima
55. INSERM), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France
    Pascal Guénel, Thérèse Truong & Marie Sanchez
56. University Paris–Sud, UMRS 1018, Villejuif, France
    Pascal Guénel, Thérèse Truong & Marie Sanchez
57. Université Paris Sorbonne Cité, UMRS 775, INSERM, Paris, France
    Claire Mulot
58. Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany
    Barbara Burwinkel, Frederik Marme, Harald Surowy, Christof Sohn & Rongxi Yang
59. Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany
    Barbara Burwinkel, Harald Surowy & Rongxi Yang
60. National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany
    Frederik Marme
61. Human Genotyping (CEGEN) Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain
    Anna González-Neira, Javier Benitez, Guillermo Pita, M Rosario Alonso, Nuria Álvarez & Daniel Herrero
62. Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia, Spain
    Javier Benitez
63. Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid, Spain
    M Pilar Zamora
64. Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain
    Jose Ignacio Arias Perez
65. Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Xiao-Ou Shu, Hui Cai, William Blot, Qiuyin Cai, Wei Zheng, Sandra L Halverson, Martha Shrubsole & Jirong Long
66. Shanghai Center for Disease Control and Prevention, Changning, China
    Wei Lu
67. Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China
    Yu-Tang Gao
68. Sheffield Cancer Research Centre, University of Sheffield, Sheffield, UK
    Angela Cox & Malcolm W R Reed
69. Department of Oncology, University of Sheffield, Sheffield, UK
    Angela Cox & Malcolm W R Reed
70. Department of Neuroscience, Academic Unit of Pathology, University of Sheffield, Sheffield, UK
    Simon S Cross
71. Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada
    Irene L Andrulis & Gord Glendon
72. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Irene L Andrulis
73. Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada
    Julia A Knight
74. Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
    Julia A Knight
75. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Anna Marie Mulligan
76. Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada
    Anna Marie Mulligan
77. Division of Cancer Studies, Research Oncology, King's College London, Guy's Hospital, London, UK
    Elinor J Sawyer
78. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Ian Tomlinson
79. Oxford Biomedical Research Centre, University of Oxford, Oxford, UK
    Ian Tomlinson
80. Department of Surgery, School of Medicine, National University of Ireland, Galway, Ireland
    Michael J Kerin & Nicola Miller
81. Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Annika Lindblom
82. Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
    Sara Margolin
83. Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia
    Soo Hwang Teo
84. Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia
    Soo Hwang Teo, Cheng Har Yip, Nur Aishah Mohd Taib & Gie-Hooi Tan
85. Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands
    Maartje J Hooning, Antoinette Hollestelle & John W M Martens
86. Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands
    J Margriet Collée
87. International Epidemiology Institute, Rockville, Maryland, USA
    William Blot
88. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Lisa B Signorello & Dimitrios Trichopoulos
89. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia
    John L Hopper, Carmel Apicella, Graham G Giles & Roger L Milne
90. Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia
    Melissa C Southey & Helen Tsimiklis
91. Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Chen-Yang Shen & Pei-Ei Wu
92. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Chen-Yang Shen, Chia-Ni Hsiung & Pei-Ei Wu
93. School of Public Health, China Medical University, Taichung, Taiwan
    Chen-Yang Shen
94. Cancer Center, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan
    Ming-Feng Hou
95. Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan
    Ming-Feng Hou
96. Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway
    Vessela N Kristensen, Silje Nord & Grethe I Grenaker Alnaes
97. Institute of Clinical Medicine, University of Oslo, Oslo, Norway
    Vessela N Kristensen
98. Department of Clinical Molecular Biology (EpiGen), University of Oslo, Oslo, Norway
    Vessela N Kristensen
99. Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia
    Graham G Giles & Roger L Milne
100. Department of Anatomical Pathology, Alfred Hospital, Melbourne, Victoria, Australia
     Catriona McLean
101. Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany
     Federico Canzian
102. Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece
     Dimitrios Trichopoulos
103. Hellenic Health Foundation, Athens, Greece
     Dimitrios Trichopoulos
104. Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands
     Petra Peeters
105. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
     Petra Peeters & Marc J Gunter
106. Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Arctic University of Norway, Tromsø, Norway
     Eiliv Lund
107. Department of Surgical and Perioperative Sciences, Umea University, Umea, Sweden
     Malin Sund
108. School of Clinical Medicine, Cambridge Institute of Public Health, University of Cambridge, Cambridge, UK
     Kay-Tee Khaw
109. Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute, Istituto per lo Studio e la Prevenzione Oncologica (ISPO), Florence, Italy
     Domenico Palli
110. Section for Epidemiology, Aarhus University, Aarhus, Denmark
     Lotte Maxild Mortensen
111. INSERM Centre for Research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women's Health Team, Villejuif, France
     Laure Dossus
112. Université Paris–Sud, Villejuif, France
     Laure Dossus
113. Department of Epidemiology, Consejería de Sanidad y Política Social, CIBER de Epidemiología y Salud Pública, Murcia, Spain
     Jose-Maria Huerta
114. Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany
     Alfons Meindl
115. Center for Hereditary Breast and Ovarian Cancer, University Hospital Cologne, Cologne, Germany
     Rita K Schmutzler
116. Center for Integrated Oncology (CIO), University Hospital Cologne, Cologne, Germany
     Rita K Schmutzler
117. Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine, University of Cologne, Cologne, Germany
     Rita K Schmutzler
118. Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany
     Christian Sutter
119. Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK
     Kenneth Muir, Artitaya Lophatananon & Sarah Stewart-Brown
120. Institute of Population Health, University of Manchester, Manchester, UK
     Kenneth Muir
121. Ministry of Public Health, Nonthaburi, Thailand
     Pornthep Siriwanarangsan
122. Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore
     Mikael Hartman
123. Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore
     Mikael Hartman, Hui Miao & Kee Seng Chia
124. Division of General Surgery, National University Health System, Singapore
     Ching Wan Chan
125. Department of Gynecology and Obstetrics, University Breast Center Franconia, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center of the Erlangen-Nuremberg Metropolitan Region, Erlangen, Germany
     Peter A Fasching, Alexander Hein, Matthias W Beckmann & Lothar Haeberle
126. Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
     Peter A Fasching
127. Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
     Hermann Brenner, Aida Karina Dieffenbach & Volker Arndt
128. German Cancer Consortium (DKTK), Heidelberg, Germany
     Hermann Brenner, Aida Karina Dieffenbach & Hiltrud Brauch
129. Saarland Cancer Registry, Saarbrücken, Germany
     Christa Stegmaier
130. Division of Breast Cancer Research, Institute of Cancer Research, London, UK
     Anthony J Swerdlow
131. Department of Medicine, McGill University, Montreal, Quebec, Canada
     Mark S Goldberg
132. Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, Montreal, Quebec, Canada
     Mark S Goldberg
133. Département de Santé Environnementale et Santé au Travail, Ecole de Santé Publique, Université de Montréal, Montreal, Quebec, Canada
     France Labrèche
134. Département de Médecine Sociale et Préventive, Ecole de Santé Publique, Université de Montréal, Montreal, Quebec, Canada
     France Labrèche
135. Centre Hospitalier Universitaire de Québec Research Center, Quebec City, Quebec, Canada
     Martine Dumont & Jacques Simard
136. Department of Molecular Medicine, Laval University, Quebec City, Quebec, Canada
     Martine Dumont & Jacques Simard
137. Department of Clinical Chemistry and Biocenter Oulu, Laboratory of Cancer Genetics and Tumor Biology, University of Oulu, NordLab Oulu/Oulu University Hospital, Oulu, Finland
     Robert Winqvist & Katri Pylkäs
138. Department of Oncology, Oulu University Hospital, University of Oulu, Oulu, Finland
     Arja Jukkola-Vuorinen
139. Department of Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland
     Mervi Grip
140. Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
     Hiltrud Brauch
141. University of Tübingen, Tübingen, Germany
     Hiltrud Brauch
142. German Cancer Research Center (DKFZ), Heidelberg, Germany
     Hiltrud Brauch
143. Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany
     Ute Hamann, Maria Kabisch & Diana Torres
144. Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany
     Thomas Brüning
145. Department of Preventive and Predictive Medicine, Unit of Molecular Bases of Genetic Risk and Genetic Testing, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Milan, Italy
     Paolo Radice
146. Fondazione Istituto FIRC (Italian Foundation for Cancer Research) di Oncologia Molecolare (IFOM), Milan, Italy
     Paolo Peterlongo
147. Department of Preventive and Predictive Medicine, Unit of Medical Genetics, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Milan, Italy
     Siranoush Manoukian
148. Department of Experimental Oncology, Istituto Europeo di Oncologia, Milan, Italy
     Loris Bernard
149. Cogentech Cancer Genetic Test Laboratory, Milan, Italy
     Loris Bernard
150. Department of Radiation Oncology, Hannover Medical School, Hannover, Germany
     Natalia V Bogdanova
151. Gynaecology Research Unit, Hannover Medical School, Hannover, Germany
     Thilo Dörk
152. School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland
     Arto Mannermaa, Veli-Matti Kosma & Jaana M Hartikainen
153. Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland
     Arto Mannermaa, Veli-Matti Kosma & Jaana M Hartikainen
154. Department of Clinical Pathology, Imaging Center, Kuopio University Hospital, Kuopio, Finland
     Arto Mannermaa, Veli-Matti Kosma & Jaana M Hartikainen
155. Cancer Center, Kuopio University Hospital, Kuopio, Finland
     Vesa Kataja
156. Central Finland Hospital District, Jyväskylä Central Hospital, Jyväskylä, Finland
     Vesa Kataja
157. Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands
     Peter Devilee
158. Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands
     Peter Devilee
159. Department of Surgical Oncology, Leiden University Medical Center, Leiden, the Netherlands
     Robert A E M Tollenaar
160. Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands
     Caroline Seynaeve
161. Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands
     Christi J Van Asperen
162. Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
     Anna Jakubowska, Jan Lubinski, Katarzyna Jaworska & Tomasz Huzarski
163. National Cancer Institute of Thailand, Bangkok, Thailand
     Suleeporn Sangrajrang
164. International Agency for Research on Cancer, Lyon, France
     Valerie Gaborieau, Paul Brennan & James McKay
165. Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, Ohio, USA
     Amanda E Toland
166. Roswell Park Cancer Institute, Buffalo, New York, USA
     Christine B Ambrosone
167. Molecular Diagnostics Laboratory, Institute of Radioisotopes and Radiodiagnostic Products (IRRP), National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis, Athens, Greece
     Drakoulis Yannoukakos
168. Institute of Human Genetics, Pontificia Universidad Javeriana, Bogotá, Colombia
     Diana Torres
169. Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, USA
     Susan L Neuhausen
170. Department of Epidemiology, University of California–Irvine, Irvine, California, USA
     Hoda Anton-Culver
171. McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada
     Daniel C Tessier, Daniel Vincent & Francois Bacot

Authors

1. Kyriaki Michailidou
2. Jonathan Beesley
3. Sara Lindstrom
4. Sander Canisius
5. Joe Dennis
6. Michael J Lush
7. Mel J Maranian
8. Manjeet K Bolla
9. Qin Wang
10. Mitul Shah
11. Barbara J Perkins
12. Kamila Czene
13. Mikael Eriksson
14. Hatef Darabi
15. Judith S Brand
16. Stig E Bojesen
17. Børge G Nordestgaard
18. Henrik Flyger
19. Sune F Nielsen
20. Nazneen Rahman
21. Clare Turnbull
22. Olivia Fletcher
23. Julian Peto
24. Lorna Gibson
25. Isabel dos-Santos-Silva
26. Jenny Chang-Claude
27. Dieter Flesch-Janys
28. Anja Rudolph
29. Ursula Eilber
30. Sabine Behrens
31. Heli Nevanlinna
32. Taru A Muranen
33. Kristiina Aittomäki
34. Carl Blomqvist
35. Sofia Khan
36. Kirsimari Aaltonen
37. Habibul Ahsan
38. Muhammad G Kibriya
39. Alice S Whittemore
40. Esther M John
41. Kathleen E Malone
42. Marilie D Gammon
43. Regina M Santella
44. Giske Ursin
45. Enes Makalic
46. Daniel F Schmidt
47. Graham Casey
48. David J Hunter
49. Susan M Gapstur
50. Mia M Gaudet
51. W Ryan Diver
52. Christopher A Haiman
53. Fredrick Schumacher
54. Brian E Henderson
55. Loic Le Marchand
56. Christine D Berg
57. Stephen J Chanock
58. Jonine Figueroa
59. Robert N Hoover
60. Diether Lambrechts
61. Patrick Neven
62. Hans Wildiers
63. Erik van Limbergen
64. Marjanka K Schmidt
65. Annegien Broeks
66. Senno Verhoef
67. Sten Cornelissen
68. Fergus J Couch
69. Janet E Olson
70. Emily Hallberg
71. Celine Vachon
72. Quinten Waisfisz
73. Hanne Meijers-Heijboer
74. Muriel A Adank
75. Rob B van der Luijt
76. Jingmei Li
77. Jianjun Liu
78. Keith Humphreys
79. Daehee Kang
80. Ji-Yeob Choi
81. Sue K Park
82. Keun-Young Yoo
83. Keitaro Matsuo
84. Hidemi Ito
85. Hiroji Iwata
86. Kazuo Tajima
87. Pascal Guénel
88. Thérèse Truong
89. Claire Mulot
90. Marie Sanchez
91. Barbara Burwinkel
92. Frederik Marme
93. Harald Surowy
94. Christof Sohn
95. Anna H Wu
96. Chiu-chen Tseng
97. David Van Den Berg
98. Daniel O Stram
99. Anna González-Neira
100. Javier Benitez
101. M Pilar Zamora
102. Jose Ignacio Arias Perez
103. Xiao-Ou Shu
104. Wei Lu
105. Yu-Tang Gao
106. Hui Cai
107. Angela Cox
108. Simon S Cross
109. Malcolm W R Reed
110. Irene L Andrulis
111. Julia A Knight
112. Gord Glendon
113. Anna Marie Mulligan
114. Elinor J Sawyer
115. Ian Tomlinson
116. Michael J Kerin
117. Nicola Miller
118. Annika Lindblom
119. Sara Margolin
120. Soo Hwang Teo
121. Cheng Har Yip
122. Nur Aishah Mohd Taib
123. Gie-Hooi Tan
124. Maartje J Hooning
125. Antoinette Hollestelle
126. John W M Martens
127. J Margriet Collée
128. William Blot
129. Lisa B Signorello
130. Qiuyin Cai
131. John L Hopper
132. Melissa C Southey
133. Helen Tsimiklis
134. Carmel Apicella
135. Chen-Yang Shen
136. Chia-Ni Hsiung
137. Pei-Ei Wu
138. Ming-Feng Hou
139. Vessela N Kristensen
140. Silje Nord
141. Grethe I Grenaker Alnaes
142. Graham G Giles
143. Roger L Milne
144. Catriona McLean
145. Federico Canzian
146. Dimitrios Trichopoulos
147. Petra Peeters
148. Eiliv Lund
149. Malin Sund
150. Kay-Tee Khaw
151. Marc J Gunter
152. Domenico Palli
153. Lotte Maxild Mortensen
154. Laure Dossus
155. Jose-Maria Huerta
156. Alfons Meindl
157. Rita K Schmutzler
158. Christian Sutter
159. Rongxi Yang
160. Kenneth Muir
161. Artitaya Lophatananon
162. Sarah Stewart-Brown
163. Pornthep Siriwanarangsan
164. Mikael Hartman
165. Hui Miao
166. Kee Seng Chia
167. Ching Wan Chan
168. Peter A Fasching
169. Alexander Hein
170. Matthias W Beckmann
171. Lothar Haeberle
172. Hermann Brenner
173. Aida Karina Dieffenbach
174. Volker Arndt
175. Christa Stegmaier
176. Alan Ashworth
177. Nick Orr
178. Minouk J Schoemaker
179. Anthony J Swerdlow
180. Louise Brinton
181. Montserrat Garcia-Closas
182. Wei Zheng
183. Sandra L Halverson
184. Martha Shrubsole
185. Jirong Long
186. Mark S Goldberg
187. France Labrèche
188. Martine Dumont
189. Robert Winqvist
190. Katri Pylkäs
191. Arja Jukkola-Vuorinen
192. Mervi Grip
193. Hiltrud Brauch
194. Ute Hamann
195. Thomas Brüning
196. Paolo Radice
197. Paolo Peterlongo
198. Siranoush Manoukian
199. Loris Bernard
200. Natalia V Bogdanova
201. Thilo Dörk
202. Arto Mannermaa
203. Vesa Kataja
204. Veli-Matti Kosma
205. Jaana M Hartikainen
206. Peter Devilee
207. Robert A E M Tollenaar
208. Caroline Seynaeve
209. Christi J Van Asperen
210. Anna Jakubowska
211. Jan Lubinski
212. Katarzyna Jaworska
213. Tomasz Huzarski
214. Suleeporn Sangrajrang
215. Valerie Gaborieau
216. Paul Brennan
217. James McKay
218. Susan Slager
219. Amanda E Toland
220. Christine B Ambrosone
221. Drakoulis Yannoukakos
222. Maria Kabisch
223. Diana Torres
224. Susan L Neuhausen
225. Hoda Anton-Culver
226. Craig Luccarini
227. Caroline Baynes
228. Shahana Ahmed
229. Catherine S Healey
230. Daniel C Tessier
231. Daniel Vincent
232. Francois Bacot
233. Guillermo Pita
234. M Rosario Alonso
235. Nuria Álvarez
236. Daniel Herrero
237. Jacques Simard
238. Paul P D P Pharoah
239. Peter Kraft
240. Alison M Dunning
241. Georgia Chenevix-Trench
242. Per Hall
243. Douglas F Easton

Consortia

BOCS

kConFab Investigators

AOCS Group

NBCS

GENICA Network

Contributions

K. Michailidou and D.F.E. performed the statistical analysis and drafted the manuscript. D.F.E. conceived and coordinated the synthesis of the iCOGS array and led the BCAC. P.H. coordinated COGS. J. Benitez led the iCOGS genotyping working group. A.G.-N., G.P., M.R.A., N.Á., D.H., J. Benitez, D.V., F.B., D.C.T., J.S., A.M.D., C.L., C. Baynes, S.A., C.S.H. and M.J.M. coordinated genotyping of the iCOGS array. M.G.-C., P.P.D.P.P. and M.K.S. led the BCAC pathology and survival working group. J.C.-C. led the BCAC risk factor working group. A.M.D. and G.C.-T. led the iCOGS quality control working group. J. Beesley, J.D. and M.J.L. provided bioinformatics support. M.K.B. and Q. Wang provided data management support for BCAC. S. Canisius provided analysis of the TCGA expression data. J.L.H., M.C.S., H.T. and C.A. coordinated ABCFS. M.K.S., A.B., S.V. and S. Cornelissen coordinated ABCS. K. Muir, A. Lophatananon, S.S.-B. and P.S. coordinated ACP. P.A.F., A. Hein, M.W.B. and L.H. coordinated BBCC. J.P., I.d.-S.-S., O.F. and L.G. coordinated BBCS. E.J.S., I.T., M.J.K. and N.M. coordinated BIGGS. P.K., D.J.H., S.L., S.M.G., M.M.G., W.R.D., C.A.H., F.S., B.E.H., L.L.M., C.D.B., S.J.C., J.F. and R.N.H. coordinated BPC3. B.B., F.M., H.S. and C. Sohn coordinated BSUCH. N.R. and C. Turnbull coordinated BOCS. P.G., T.T., C. Mulot and M. Sanchez coordinated CECILE. S.E.B., B.G.N., H.F. and S.F.N. coordinated CGPS. A.G.-N., J. Benitez, M.P.Z. and J.I.A.P. coordinated CNIO-BCS. H.A.-C. and S.L.N. coordinated CTS. H. Brenner, A.K.D., V.A. and C. Stegmaier coordinated ESTHER. A. Meindl, R.K.S., C. Sutter and R.Y. coordinated GC-HBOC. H. Brauch, U.H. and T.B. coordinated GENICA. H.N., T.A.M., K. Aittomäki, C. Blomqvist, K. Aaltonen and S.K. coordinated HEBCS. K. Matsuo, H. Ito, H. Iwata and K.T. coordinated HERPACC. T.D. and N.V.B. coordinated HMBCS. A. Lindblom and S. Margolin coordinated KARBAC. A. Mannermaa, V.K., V.-M.K. and J.M.H. coordinated KBCP. G.C.-T. and J. Beesley coordinated kConFab/AOCS. A.H.W., C. Tseng, D.V.D.B. and D.O.S. coordinated LAABC. D.L., P.N., H.W. and E.v.L. coordinated LMBC. J.C.-C., D.F.-J., U.E., S.B. and A.R. coordinated MARIE. P.R., P. Peterlongo, S. Manoukian and L. Bernard coordinated MBCSG. F.J.C., J.E.O., E.H. and C.V. coordinated MCBCS. G.G.G., R.L.M. and C. McLean coordinated MCCS. C.A.H., B.E.H., F.S. and L.L.M. coordinated MEC. J.S., M.S.G., F.L. and M.D. coordinated MTLGEBCS. S.H.T., C.H.Y., N.A.M.T. and G.-H.T. coordinated MYBRCA. V.N.K., G.I.G.A. and S.N. coordinated NBCS. W.Z., S.L.H., M. Shrubsole and J. Long coordinated NBHS. R.W., K.P., A.J.-V. and M.G. coordinated OBCS. I.L.A., J.A.K., G.G. and A.M.M. coordinated OFBCR. P.D., R.A.E.M.T., C. Seynaeve and C.J.V.A. coordinated ORIGO. M.G.-C., J.F., S.J.C. and L. Brinton coordinated PBCS. K.C., H.D., M.E. and J.S.B. coordinated pKARMA. M.J.H., A. Hollestelle, J.W.M.M. and J.M.C. coordinated RBCS. P.H., J. Li, J. Liu and K.H. coordinated SASBAC. X.-O.S., W.L., Y.-T.G. and H.C. coordinated SBCGS. A.C., S.S.C. and M.W.R.R. coordinated SBCS. W.B., L.B.S. and Q.C. coordinated SCCS. M. Shah and B.J.P. coordinated SEARCH. D.K., J.-Y.C., S.K.P. and K.-Y.Y. coordinated SEBCS. M.H., H.M., K.S.C. and C.W.C. coordinated SGBCC. U.H., M.K. and D. Torres coordinated SKKDKFZS. A.J., J. Lubinski, K.J. and T.H. coordinated SZBCS. S. Sangrajrang, V.G., P.B. and J.M. coordinated TBCS. F.J.C., S. Slager, A.E.T., C.B.A. and D.Y. coordinated the TNBCC. C.-Y.S., C.-N.H., P.-E.W. and M.-F.H. coordinated TWBCS. A.J.S.,A.A., N.O. and M.J.S. coordinated UKBGS. H.A., M.G.K., A.S.W., E.M.J., K.E.M., M.D.G., R.M.S., G.U., E.M., D.F.S. and G.C. coordinated EBCG GWAS. Q. Waisfisz, H.M.-H., M.A.A. and R.B.v.d.L. coordinated DFBBCS GWAS. D.F.E., N.R. and C. Turnbull coordinated UK2 GWAS. F.C., D. Trichopoulos, P. Peeters, E.L., M. Sund, K.-T.K., M.J.G., D.P., L.D., J.-M.H. and L.M.M. coordinated EPIC. All authors provided critical review of the manuscript.

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Correspondence toDouglas F Easton.

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The authors declare no competing financial interests.

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A full list of members and affiliations appears in the Supplementary Note.

A full list of members and affiliations appears in the Supplementary Note.

A full list of members and affiliations appears in the Supplementary Note.

A full list of members and affiliations appears in the Supplementary Note.

A full list of members and affiliations appears in the Supplementary Note.

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Michailidou, K., Beesley, J., Lindstrom, S. et al. Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.Nat Genet 47, 373–380 (2015). https://doi.org/10.1038/ng.3242

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• Received: 05 September 2014
• Accepted: 11 February 2015
• Published: 09 March 2015
• Issue date: April 2015
• DOI: https://doi.org/10.1038/ng.3242