Genome-wide association analysis identifies three new breast cancer susceptibility loci (original) (raw)

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Acknowledgements

We thank the following individuals for their contribution to this project (study names given in parentheses): S. Cornelissen, R. van Hien, L. Braaf, L. Van't Veer, B. Bueno-de-Mesquita and S. Canisius (ABCS); N. McInerney, G. Colleran, A. Rowan and N. Miller (BIGGS); A. Langheinz (BSUCH); J.I. Arias Pérez, P. Zamora, P. Menendez, T. Moreno and G. Pita (CNIO-BCS); M. Adank, M. Ausems and S. Verhoef (DFBBCS); U. Hamann, Y.-D. Ko, C. Baisch, H.-P. Fischer, B. Pesch, S. Rabstein and V. Harth (GENICA); K. Aaltonen, P. Heikkilä, T. Heikkinen, D. Greco, R.N.H. Jäntti and I. Erkkilä (HEBCS); H. Kemiläinen, E. Myöhänen and A. Parkkinen (KBCP); T. Slanger, E. Mutschelknauss, S. Behrens, R. Birr, M. Celik, U. Eilber, B. Kaspereit, N. Knese and K. Smit (MARIE); P. Radice, B. Peissel, M. Barile and M.A. Pierotti (MBCSG); T. Selander, M. Gill, L. Collins and N. Weerasooriya (OFBCR); M. Grip, K. Mononen and M. Otsukka (OBCS); E. Krol-Warmerdam and J. Blom (ORIGO); and P. Boonyawongviroj and P. Siriwanarungsan (ACP). For full acknowledgments, including funding sources, see the Supplementary Note.

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Authors and Affiliations

1. Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK
   Maya Ghoussaini, Ed Dicks, Craig Luccarini, Caroline Baynes, Don Conroy, Melanie Maranian, Shahana Ahmed, Kristy Driver, Mitul Shah, Paul D P Pharoah, Alison M Dunning & Douglas F Easton
2. Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
   Olivia Fletcher, Nichola Johnson, Nicholas Orr & Alan Ashworth
3. Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK
   Kyriaki Michailidou, Joe Dennis, Qin Wang, Manjeet K Humphreys, Paul D P Pharoah & Douglas F Easton
4. Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK
   Clare Turnbull, Montserrat Garcia-Closas & Nazneen Rahman
5. Department of Experimental Therapy, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
   Marjanka K Schmidt & Annegien Broeks
6. Department of Epidemiology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
   Marjanka K Schmidt
7. Non-Communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK
   Isabel dos Santos Silva & Julian Peto
8. Department of Clinical Genetics, Section Oncogenetics, VU University Medical Center, Amsterdam, The Netherlands
   Quinten Waisfisz & Hanne Meijers-Heijboer
9. Department of Internal Medicine and Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
   Andre G Uitterlinden & Fernando Rivadeneira
10. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Per Hall & Kamila Czene
11. Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Astrid Irwanto & Heli Nevanlinna
12. Human Genetics Division, Genome Institute of Singapore, Singapore
    Jianjun Liu
13. Department of Clinical Genetics, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Kristiina Aittomäki
14. Department of Oncology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Carl Blomqvist
15. Division for Gynaecological Tumor Genetics, Clinic of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany
    Alfons Meindl
16. Department of Obstetrics and Gynaecology, Division of Molecular Gynaeco-Oncology, University of Cologne, Cologne, Germany
    Rita K Schmutzler
17. Max Planck Institute of Psychiatry, Munich, Germany
    Bertram Müller-Myhsok
18. Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
    Peter Lichtner
19. Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Jenny Chang-Claude, Rebecca Hein, Stefan Nickels & Ursula Eilber
20. Primär Medizinische Versorgung (PMV) Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
    Rebecca Hein
21. Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Hamburg, Germany
    Dieter Flesch-Janys
22. Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany
    Dieter Flesch-Janys
23. Department of Pathology, Genetic Epidemiology Laboratory, The University of Melbourne, Melbourne, Victoria, Australia
    Helen Tsimiklis, Daniel J Park & Melissa Southey
24. Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, Melbourne, Victoria, Australia
    Enes Makalic, Daniel Schmidt, Minh Bui, John L Hopper, Carmel Apicella, Graham G Giles, Laura Baglietto & Gianluca Severi
25. Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    David J Hunter
26. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
    Stephen J Chanock, Jonine D Figueroa & Louise Brinton
27. Department of Clinical Genetics, Family Cancer Clinic, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Senno Verhoef
28. Department of Molecular Pathology, Family Cancer Clinic, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Frans B L Hogervorst
29. Department of Gynecology and Obstetrics, University Breast Center, University Hospital Erlangen, Erlangen, Germany
    Peter A Fasching, Michael P Lux & Matthias W Beckmann
30. Institute of Human Genetics, Friedrich-Alexander University Erlangen Nuremberg, Erlangen, Germany
    Arif B Ekici
31. Division of Cancer Studies, National Institute for Health Research (NIHR) Comprehensive Biomedical Research Centre, Guy's & St. Thomas' National Health Service (NHS) Foundation Trust, London, UK
    Elinor Sawyer
32. Division of Cancer Studies, King's College London, London, UK
    Elinor Sawyer
33. Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford, UK
    Ian Tomlinson
34. Clinical Science Institute, University Hospital Galway, Galway, Ireland
    Michael Kerin
35. Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany
    Frederik Marme, Andreas Schneeweiss, Christof Sohn & Barbara Burwinkel
36. National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany
    Frederik Marme & Andreas Schneeweiss
37. Molecular Epidemiology Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany
    Barbara Burwinkel
38. Institut National de la Santé et la Recherche Médicale (Inserm), Centre for Research in Epidemiology and Population Health (CESP), U1018, Environmental Epidemiology of Cancer, Villejuif, France
    Pascal Guénel, Thérèse Truong, Emilie Cordina-Duverger & Florence Menegaux
39. Université Paris-Sud, Unité Mixte de Recherche en Santé (UMRS) 1018, Villejuif, France
    Pascal Guénel, Thérèse Truong, Emilie Cordina-Duverger & Florence Menegaux
40. Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark
    Stig E Bojesen, Børge G Nordestgaard & Sune F Nielsen
41. Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark
    Stig E Bojesen, Børge G Nordestgaard & Sune F Nielsen
42. Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark
    Henrik Flyger
43. Genetic & Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain
    Roger L Milne
44. Human Genotyping Unit, Human Cancer Genetics Programme, CNIO, Madrid, Spain
    M Rosario Alonso & Anna González-Neira
45. Human Genetics Group, Human Cancer Genetics Programme, CNIO, Madrid, Spain
    Javier Benítez
46. Department of Epidemiology, University of California–Irvine, Irvine, California, USA
    Hoda Anton-Culver & Argyrios Ziogas
47. City of Hope Cancer Centre, Duarte, California, USA
    Leslie Bernstein
48. Cancer Prevention Institute of California, Fremont, California, USA
    Christina Clarke Dur & Esther M John
49. Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
    Hermann Brenner, Heiko Müller & Volker Arndt
50. Saarland Cancer Registry, Saarbrücken, Germany
    Christa Stegmaier
51. Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany
    Christina Justenhoven & Hiltrud Brauch
52. University of Tübingen, Tübingen, Germany
    Christina Justenhoven & Hiltrud Brauch
53. Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum, Germany
    Thomas Brüning
54. Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany
    Shan Wang-Gohrke
55. Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany
    Thilo Dörk, Peter Schürmann, Michael Bremer & Peter Hillemanns
56. Department of Radiation Oncology, Hannover Medical School, Hannover, Germany
    Natalia V Bogdanova & Johann H Karstens
57. N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus
    Natalia N Antonenkova & Yuri I Rogov
58. Institute of Biochemistry and Genetics, Ufa Scientific Center of the Russian Academy of Sciences, Ufa, Russia
    Marina Bermisheva, Darya Prokofieva & Elza Khusnutdinova
59. Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Annika Lindblom
60. Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
    Sara Margolin
61. Department of Pathology and Forensic Medicine, School of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    Arto Mannermaa, Veli-Matti Kosma & Jaana M Hartikainen
62. Biocenter Kuopio, University of Eastern Finland, Kuopio, Finland
    Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma & Jaana M Hartikainen
63. Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland
    Arto Mannermaa, Veli-Matti Kosma & Jaana M Hartikainen
64. Department of Oncology, School of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    Vesa Kataja
65. Department of Oncology, Kuopio University Hospital, Kuopio, Finland
    Vesa Kataja
66. Vesalius Research Center (VRC), Vlaams Instituut voor Biotechnologie (VIB), Leuven, Belgium
    Diether Lambrechts & Betul T Yesilyurt
67. Multidisciplinary Breast Center, University Hospital Gasthuisberg, Leuven, Belgium
    Giuseppe Floris & Karin Leunen
68. Department of Preventive and Predictive Medicine, Unit of Medical Genetics, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale Tumori (INT), Milan, Italy
    Siranoush Manoukian
69. Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy
    Bernardo Bonanni
70. Istituto FIRC (Fondazione Italiana per la Ricerca sul Cancero) di Oncologia Molecolare (IFOM), Milan, Italy
    Stefano Fortuzzi & Paolo Peterlongo
71. Department of Preventive and Predictive Medicine, Unit of Molecular Bases of Genetic Risk and Genetic Testing, Fondazione IRCCS INT, Milan, Italy
    Paolo Peterlongo
72. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA
    Fergus J Couch & Xianshu Wang
73. Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA
    Fergus J Couch & Kristen Stevens
74. Department of Pharmacology, Mayo Clinic, Rochester, Minnesota, USA
    Adam Lee
75. Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria, Australia
    Graham G Giles, Laura Baglietto & Gianluca Severi
76. Department of Anatomical Pathology, Alfred Hospital, Melbourne, Victoria, Australia
    Catriona McLean
77. Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway
    Grethe Grenaker Alnæs, Vessela Kristensen & Anne-Lise Børrensen-Dale
78. Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
    Vessela Kristensen & Anne-Lise Børrensen-Dale
79. Department of Health Research Policy, Division of Epidemiology, Stanford University School of Medicine, Stanford, California, USA
    Esther M John
80. Dana Farber Cancer Center, Boston, Massachusetts, USA
    Alexander Miron
81. Department of Clinical Genetics and Biocenter Oulu, Laboratory of Cancer Genetics, University of Oulu, Oulu University Hospital, Oulu, Finland
    Robert Winqvist & Katri Pylkäs
82. Department of Oncology, University of Oulu, Oulu University Hospital, Oulu, Finland
    Arja Jukkola-Vuorinen
83. Department of Pathology, University of Oulu, Oulu University Hospital, Oulu, Finland
    Saila Kauppila
84. Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Irene L Andrulis
85. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Irene L Andrulis
86. Ontario Cancer Genetics Network, Cancer Care Ontario, Toronto, Ontario, Canada
    Gord Glendon
87. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Anna Marie Mulligan
88. Department of Laboratory Medicine and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada
    Anna Marie Mulligan
89. Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands
    Peter Devilee
90. Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands
    Peter Devilee
91. Department of Clinical Genetics, Leiden University Medical Centre, Leiden, The Netherlands
    Christie J van Asperen
92. Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands
    Rob A E M Tollenaar
93. Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus MC–Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Caroline Seynaeve
94. Section of Epidemiology, Institute of Cancer Research, Sutton, UK
    Montserrat Garcia-Closas, Michael Jones, Minouk Schoemaker & Anthony Swerdlow
95. Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
    Jolanta Lissowska
96. Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands
    Maartje J Hooning
97. Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, The Netherlands
    Antoinette Hollestelle
98. Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands
    Rogier A Oldenburg & Ans M W van den Ouweland
99. Department of Oncology, Institute for Cancer Studies, University of Sheffield, Sheffield, UK
    Angela Cox
100. Department of Oncology, Academic Unit of Surgical Oncology, University of Sheffield, Sheffield, UK
     Malcolm W R Reed
101. Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland
     Ania Jakubowska, Jan Lubinski, Katarzyna Jaworska & Katarzyna Durda
102. Queensland Institute of Medical Research, Brisbane, Queensland, Australia
     Jonathan Beesley, Xiaoqing Chen & Georgia Chenevix-Trench
103. Warwick Medical School, Warwick University, Coventry, UK
     Kenneth R Muir & Artitaya Lophatananon
104. Department of Preventive Medicine, Srinakharainwirot University, Ongkharak, Thailand
     Suthee Rattanamongkongul
105. Department of Academic Support, The National Cancer Institute of Thailand, Ministry of Public Health, Bangkok, Thailand
     Arkom Chaiwerawattana
106. Department of Preventitive Medicine, Seoul National University College of Medicine, Seoul, Korea
     Daehee Kang, Keun-Young Yoo & Dong-Young Noh
107. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
     Chen-Yang Shen, Pei-Ei Wu & Chia-Ni Hsiung
108. Department of Surgery, Tri-Service General Hospital, Taipei, Taiwan
     Jyh-Cherng Yu
109. Department of Molecular and Applied Biosciences, Against Breast Cancer Research Group, University of Westminster, London, UK
     Annie Perkins, Ruth Swann & Louiza Velentzis
110. Faculty of Medicine, University of Southampton, Southampton, UK
     Diana M Eccles, Will J Tapper, Susan M Gerty & Nikki J Graham
111. Department of Oncology, University of Cambridge, Cambridge, UK
     Bruce A J Ponder
112. Cancer Research UK (CRUK) Cambridge Research Institute, Cambridge, UK
     Bruce A J Ponder
113. Centre National de Genotypage, Evry, France
     Mark Lathrop
114. Fondation Jean Dausset–Centre d'Etude de Polymorphisme Humaine (CEPH), Paris, France
     Mark Lathrop

Authors

1. Maya Ghoussaini
2. Olivia Fletcher
3. Kyriaki Michailidou
4. Clare Turnbull
5. Marjanka K Schmidt
6. Ed Dicks
7. Joe Dennis
8. Qin Wang
9. Manjeet K Humphreys
10. Craig Luccarini
11. Caroline Baynes
12. Don Conroy
13. Melanie Maranian
14. Shahana Ahmed
15. Kristy Driver
16. Nichola Johnson
17. Nicholas Orr
18. Isabel dos Santos Silva
19. Quinten Waisfisz
20. Hanne Meijers-Heijboer
21. Andre G Uitterlinden
22. Fernando Rivadeneira
23. Per Hall
24. Kamila Czene
25. Astrid Irwanto
26. Jianjun Liu
27. Heli Nevanlinna
28. Kristiina Aittomäki
29. Carl Blomqvist
30. Alfons Meindl
31. Rita K Schmutzler
32. Bertram Müller-Myhsok
33. Peter Lichtner
34. Jenny Chang-Claude
35. Rebecca Hein
36. Stefan Nickels
37. Dieter Flesch-Janys
38. Helen Tsimiklis
39. Enes Makalic
40. Daniel Schmidt
41. Minh Bui
42. John L Hopper
43. Carmel Apicella
44. Daniel J Park
45. Melissa Southey
46. David J Hunter
47. Stephen J Chanock
48. Annegien Broeks
49. Senno Verhoef
50. Frans B L Hogervorst
51. Peter A Fasching
52. Michael P Lux
53. Matthias W Beckmann
54. Arif B Ekici
55. Elinor Sawyer
56. Ian Tomlinson
57. Michael Kerin
58. Frederik Marme
59. Andreas Schneeweiss
60. Christof Sohn
61. Barbara Burwinkel
62. Pascal Guénel
63. Thérèse Truong
64. Emilie Cordina-Duverger
65. Florence Menegaux
66. Stig E Bojesen
67. Børge G Nordestgaard
68. Sune F Nielsen
69. Henrik Flyger
70. Roger L Milne
71. M Rosario Alonso
72. Anna González-Neira
73. Javier Benítez
74. Hoda Anton-Culver
75. Argyrios Ziogas
76. Leslie Bernstein
77. Christina Clarke Dur
78. Hermann Brenner
79. Heiko Müller
80. Volker Arndt
81. Christa Stegmaier
82. Christina Justenhoven
83. Hiltrud Brauch
84. Thomas Brüning
85. Shan Wang-Gohrke
86. Ursula Eilber
87. Thilo Dörk
88. Peter Schürmann
89. Michael Bremer
90. Peter Hillemanns
91. Natalia V Bogdanova
92. Natalia N Antonenkova
93. Yuri I Rogov
94. Johann H Karstens
95. Marina Bermisheva
96. Darya Prokofieva
97. Elza Khusnutdinova
98. Annika Lindblom
99. Sara Margolin
100. Arto Mannermaa
101. Vesa Kataja
102. Veli-Matti Kosma
103. Jaana M Hartikainen
104. Diether Lambrechts
105. Betul T Yesilyurt
106. Giuseppe Floris
107. Karin Leunen
108. Siranoush Manoukian
109. Bernardo Bonanni
110. Stefano Fortuzzi
111. Paolo Peterlongo
112. Fergus J Couch
113. Xianshu Wang
114. Kristen Stevens
115. Adam Lee
116. Graham G Giles
117. Laura Baglietto
118. Gianluca Severi
119. Catriona McLean
120. Grethe Grenaker Alnæs
121. Vessela Kristensen
122. Anne-Lise Børrensen-Dale
123. Esther M John
124. Alexander Miron
125. Robert Winqvist
126. Katri Pylkäs
127. Arja Jukkola-Vuorinen
128. Saila Kauppila
129. Irene L Andrulis
130. Gord Glendon
131. Anna Marie Mulligan
132. Peter Devilee
133. Christie J van Asperen
134. Rob A E M Tollenaar
135. Caroline Seynaeve
136. Jonine D Figueroa
137. Montserrat Garcia-Closas
138. Louise Brinton
139. Jolanta Lissowska
140. Maartje J Hooning
141. Antoinette Hollestelle
142. Rogier A Oldenburg
143. Ans M W van den Ouweland
144. Angela Cox
145. Malcolm W R Reed
146. Mitul Shah
147. Ania Jakubowska
148. Jan Lubinski
149. Katarzyna Jaworska
150. Katarzyna Durda
151. Michael Jones
152. Minouk Schoemaker
153. Alan Ashworth
154. Anthony Swerdlow
155. Jonathan Beesley
156. Xiaoqing Chen
157. Kenneth R Muir
158. Artitaya Lophatananon
159. Suthee Rattanamongkongul
160. Arkom Chaiwerawattana
161. Daehee Kang
162. Keun-Young Yoo
163. Dong-Young Noh
164. Chen-Yang Shen
165. Jyh-Cherng Yu
166. Pei-Ei Wu
167. Chia-Ni Hsiung
168. Annie Perkins
169. Ruth Swann
170. Louiza Velentzis
171. Diana M Eccles
172. Will J Tapper
173. Susan M Gerty
174. Nikki J Graham
175. Bruce A J Ponder
176. Georgia Chenevix-Trench
177. Paul D P Pharoah
178. Mark Lathrop
179. Alison M Dunning
180. Nazneen Rahman
181. Julian Peto
182. Douglas F Easton

Consortia

Netherlands Collaborative Group on Hereditary Breast and Ovarian Cancer (HEBON)

Familial Breast Cancer Study (FBCS)

The Gene Environment Interaction of Breast Cancer in Germany (GENICA) Network

kConFab Investigators

Australian Ovarian Cancer Study Group

Contributions

M.G. and D.F.E. wrote the manuscript. K.M., M.G. and D.F.E. performed the statistical analysis. O.F., N.J., N.O., I.d.S.S., M.L. and J.P. led the BBCS GWAS. D.F.E., P.D.P.P., A.M.D., C.T. and N.R. led the UK2 GWAS. Q. Waisfisz and H.M.-H. led the DFBBCS GWAS, with support from A.G.U. and F.R., P. Hall, K.C., A.I. and J. Liu led the SASBAC GWAS. H.N., K.A. and C. Blomqvist led the HEBCS GWAS. A. Meindl, R.K.S., B.M.-M. and P.L. led the GC-HBOC GWAS. J.C.-C., R.H., S.N. and D.F.-J. led the MARIE GWAS. J.L.H., M. Southey, H.T., E.M., D.S. and M. Bui led the ABCFS/kConFab GWAS. D.J.H. and S.J.C. led the CGEMS GWAS. E.D. and J.D. provided bioinformatics support. Q. Wang, M.K.H. and K.D. provided data management support for BCAC. C.L., C. Baynes, D.C., M.M. and S.A. managed centralized genotyping for BCAC samples. M.K.S. provided gene expression analysis. J.L.H., M. Southey, C.A. and D.J.P. coordinated the ABCFR study. M.K.S., A.B., S.V. and F.B.L.H. coordinated ABCS. P.A.F., M.P.L., M.W.B. and A.B.E. coordinated the BBCC study. E.S., I.T. and M.K. coordinated BIGGS. F. Marme, A. Schneeweiss, C. Sohn and B. Burwinkel coordinated the BSUCH study. P.G., T.T., E.C.-D. and F. Menegaux coordinated the CECILE study. S.E.B., B.G.N. and S.F.N. coordinated CGPS. R.L.M., M.R.A., A.G.-N. and J. Benítez coordinated CNIO-BCS. H.A.-C., A.Z., L. Bernstein and C.C.D. coordinated CTS. H. Brenner, H.M., V.A. and C. Stegmaier coordinated the ESTHER study. C.J., H. Brauch and T.B. coordinated the GENICA study. J.C.-C., S.W.-G. and U.E. coordinated the GESBC study. T.D., P.S., M. Bremer and P. Hillemanns coordinated HABCS. N.V.B., N.N.A., Y.I.R., J.H.K. and T.D. coordinated HMBCS. M. Bermisheva, D.P., N.V.B., T.D. and E.K. coordinated HUBCS. A. Lindblom and S. Margolin coordinated the KARBAC study. A. Mannermaa, V. Kataja, V.-M.K. and J.M.H. coordinated the KBCP study. D.L., B.T.Y., G.F. and K.L. coordinated the LMBC study. S. Manoukian, B. Bonanni, S.F. and P.P. coordinated the MBCSG study. F.J.C., X.W., K.S. and A. Lee coordinated the MCBCS study. M. Southey, G.G.G., L. Baglietto, G.S. and C.M. coordinated MCCS. G.G.A., V. Kristensen and A.-L.B.-D. coordinated NBCS. E.M.J. and A. Miron coordinated the NC-BCFR study. R.W., K.P., A.J.-V. and S.K. coordinated OBCS. I.L.A., G.G. and A.M.M. coordinated the OFBCR study. P.D. C.J.v.A., R.A.E.M.T. and C. Seynaeve coordinated the ORIGO study. J.D.F., M.G.-C., L. Brinton and J. Lissowska coordinated PBCS. M.J.H., A.H., R.A.O. and A.M.W.v.d.O. coordinated RBCS. A. Cox and M.W.R.R. coordinated SBCS. B.A.J.P. initiated SEARCH with P.D.P.P. and D.F.E., M. Shah coordinated SEARCH. A.J., J. Lubinski, K.J. and K. Durda coordinated SZBCS. M.J., M. Schoemaker, A.A. and A. Swerdlow coordinated UKBGS. G.C.-T. led the contribution of kConFab cases and AOCS controls to BCAC, and J. Beesley and X.C. performed iPLEX genotyping for several of the BCAC sites. K.R.M., A. Lophatananon, S.R. and A. Chaiwerawattana coordinated the ACP study. D.K., K.-Y.Y. and D.-Y.N. coordinated SEBCS. C.-Y.S. J.-C.Y., P.-E.W. and C.-N.H. coordinated TWBCS. A.P., R.S. and L.V. coordinated DBCSS. D.M.E., W.J.T., S.M.G. and N.J.G. coordinated the POSH study. HEBON organized the patient recruitment and data and sample collection for the DFBBCS GWAS. FBCS organized patient recruitment and data and sample collection for the UK2 GWAS. The GENICA Network organized patient recruitment and data and sample collection for the GENICA study. kConFab investigators and the Australian Ovarian Cancer Study organized recruitment and data and sample collection for kConFab and AOCS, respectively.

Corresponding author

Correspondence toDouglas F Easton.

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The authors declare no competing financial interests.

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A full list of contributing authors is provided in the Supplementary Note.

A full list of contributing authors is provided in the Supplementary Note.

A full list of contributing authors is provided in the Supplementary Note.

A full list of contributing authors is provided in the Supplementary Note.

A full list of contributing authors is provided in the Supplementary Note.

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Ghoussaini, M., Fletcher, O., Michailidou, K. et al. Genome-wide association analysis identifies three new breast cancer susceptibility loci.Nat Genet 44, 312–318 (2012). https://doi.org/10.1038/ng.1049

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• Received: 16 August 2011
• Accepted: 01 December 2011
• Published: 22 January 2012
• Issue date: March 2012
• DOI: https://doi.org/10.1038/ng.1049