Autocrine IL-2 is required for secondary population expansion of CD8+ memory T cells (original) (raw)

• Ahmed, R. & Gray, D. Immunological memory and protective immunity: understanding their relation. Science 272, 54–60 (1996).
  Article CAS Google Scholar
• van Stipdonk, M.J. et al. Dynamic programming of CD8+ T lymphocyte responses. Nat. Immunol. 4, 361–365 (2003).
  Article CAS Google Scholar
• van Stipdonk, M.J., Lemmens, E.E. & Schoenberger, S.P. Naive CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation. Nat. Immunol. 2, 423–429 (2001).
  Article CAS Google Scholar
• Kaech, S.M. & Ahmed, R. Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naive cells. Nat. Immunol. 2, 415–422 (2001).
  Article CAS Google Scholar
• Badovinac, V.P., Porter, B.B. & Harty, J.T. Programmed contraction of CD8+ T cells after infection. Nat. Immunol. 3, 619–626 (2002).
  Article CAS Google Scholar
• Masopust, D., Kaech, S.M., Wherry, E.J. & Ahmed, R. The role of programming in memory T-cell development. Curr. Opin. Immunol. 16, 217–225 (2004).
  Article CAS Google Scholar
• Sun, J.C. & Bevan, M.J. Defective CD8 T cell memory following acute infection without CD4 T cell help. Science 300, 339–342 (2003).
  Article CAS Google Scholar
• Shedlock, D.J. & Shen, H. Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 300, 337–339 (2003).
  Article CAS Google Scholar
• Bourgeois, C., Rocha, B. & Tanchot, C. A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory. Science 297, 2060–2063 (2002).
  Article CAS Google Scholar
• Janssen, E.M. et al. CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes. Nature 421, 852–856 (2003).
  Article CAS Google Scholar
• Janssen, E.M. et al. CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death. Nature 434, 88–93 (2005).
  Article CAS Google Scholar
• Badovinac, V.P., Messingham, K.A., Griffith, T.S. & Harty, J.T. TRAIL deficiency delays, but does not prevent, erosion in the quality of “helpless” memory CD8 T cells. J. Immunol. 177, 999–1006 (2006).
  Article CAS Google Scholar
• Bennett, S.R. et al. Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature 393, 478–480 (1998).
  Article CAS Google Scholar
• Lanzavecchia, A. Immunology. Licence to kill. Nature 393, 413–414 (1998).
  Article CAS Google Scholar
• Ridge, J.P., Di Rosa, F. & Matzinger, P. A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature 393, 474–478 (1998).
  Article CAS Google Scholar
• Schoenberger, S.P., Toes, R.E., van der Voort, E.I., Offringa, R. & Melief, C.J. T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions. Nature 393, 480–483 (1998).
  Article CAS Google Scholar
• Horak, I., Lohler, J., Ma, A. & Smith, K.A. Interleukin-2 deficient mice: a new model to study autoimmunity and self-tolerance. Immunol. Rev. 148, 35–44 (1995).
  Article CAS Google Scholar
• Keene, J.A. & Forman, J. Helper activity is required for the in vivo generation of cytotoxic T lymphocytes. J. Exp. Med. 155, 768–782 (1982).
  Article CAS Google Scholar
• Mitchison, N.A. & O'Malley, C. Three-cell-type clusters of T cells with antigen-presenting cells best explain the epitope linkage and noncognate requirements of the in vivo cytolytic response. Eur. J. Immunol. 17, 1579–1583 (1987).
  CAS Google Scholar
• Williams, M.A., Tyznik, A.J. & Bevan, M.J. Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells. Nature 441, 890–893 (2006).
  Article CAS Google Scholar
• Kalia, V. et al. Prolonged interleukin-2Rα expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo. Immunity 32, 91–103 (2010).
  Article CAS Google Scholar
• Pipkin, M.E. et al. Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells. Immunity 32, 79–90 (2010).
  Article CAS Google Scholar
• Malek, T.R. & Bayer, A.L. Tolerance, not immunity, crucially depends on IL-2. Nat. Rev. Immunol. 4, 665–674 (2004).
  Article CAS Google Scholar
• Sadlack, B. et al. Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells. Eur. J. Immunol. 25, 3053–3059 (1995).
  Article CAS Google Scholar
• Kurts, C. et al. Constitutive class I-restricted exogenous presentation of self antigens in vivo. J. Exp. Med. 184, 923–930 (1996).
  Article CAS Google Scholar
• Ehst, B.D., Ingulli, E. & Jenkins, M.K. Development of a novel transgenic mouse for the study of interactions between CD4 and CD8 T cells during graft rejection. Am. J. Transplant. 3, 1355–1362 (2003).
  Article CAS Google Scholar
• Nikolić-Zugić, J. & Bevan, M.J. Role of self-peptides in positively selecting the T-cell repertoire. Nature 344, 65–67 (1990).
  Article Google Scholar
• Granucci, F., Feau, S., Angeli, V., Trottein, F. & Ricciardi-Castagnoli, P. Early IL-2 production by mouse dendritic cells is the result of microbial-induced priming. J. Immunol. 170, 5075–5081 (2003).
  Article CAS Google Scholar
• Badovinac, V.P., Haring, J.S. & Harty, J.T. Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8+ T cell response to infection. Immunity 26, 827–841 (2007).
  Article CAS Google Scholar
• D'Souza, W.N. & Lefrancois, L. IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion. J. Immunol. 171, 5727–5735 (2003).
  Article CAS Google Scholar
• Kurts, C. et al. CD4+ T cell help impairs CD8+ T cell deletion induced by cross-presentation of self-antigens and favors autoimmunity. J. Exp. Med. 186, 2057–2062 (1997).
  Article CAS Google Scholar
• Wilson, E.B. & Livingstone, A.M. Cutting edge: CD4+ T cell-derived IL-2 is essential for help-dependent primary CD8+ T cell responses. J. Immunol. 181, 7445–7448 (2008).
  Article CAS Google Scholar
• Granucci, F. et al. A contribution of mouse dendritic cell-derived IL-2 for NK cell activation. J. Exp. Med. 200, 287–295 (2004).
  Article CAS Google Scholar
• Clarke, S.R. et al. Characterization of the ovalbumin-specific TCR transgenic line OT-I: MHC elements for positive and negative selection. Immunol. Cell Biol. 78, 110–117 (2000).
  CAS Google Scholar
• Castellino, F. et al. Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction. Nature 440, 890–895 (2006).
  Article CAS Google Scholar
• Kündig, T.M. et al. Immune responses in interleukin-2-deficient mice. Science 262, 1059–1061 (1993).
  Article Google Scholar
• Macintyre, A.N. et al. Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism. Immunity 34, 224–236 (2011).
  Article CAS Google Scholar
• Schorle, H., Holtschke, T., Hunig, T., Schimpl, A. & Horak, I. Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352, 621–624 (1991).
  Article CAS Google Scholar
• Mach, N. et al. Differences in dendritic cells stimulated in vivo by tumors engineered to secrete granulocyte-macrophage colony-stimulating factor or Flt3-ligand. Cancer Res. 60, 3239–3246 (2000).
  CAS Google Scholar
• Henri, S. et al. The dendritic cell populations of mouse lymph nodes. J. Immunol. 167, 741–748 (2001).
  Article CAS Google Scholar