Comparative biology of mouse versus human cells: modelling human cancer in mice (original) (raw)

• Van Dyke, T. & Jacks, T. Cancer modeling in the modern era: progress and challenges. Cell 108, 135–144 (2002).
  Article CAS PubMed Google Scholar
• Herzig, M. & Christofori, G. Recent advances in cancer research: mouse models of tumorigenesis. Biochim. Biophys. Acta 1602, 97–113 (2002).
  CAS PubMed Google Scholar
• Jonkers, J. & Berns, A. Conditional mouse models of sporadic cancer. Nature Rev. Cancer 2, 251–265 (2002).
  Article CAS Google Scholar
• Ames, B. N., Saul, R. L., Schwiers, E., Adelman, R. & Cathcart, R. in Molecular Biology of Ageing (eds Sohal, R. S., Birnbam, L. S. & Cutler, R. G.) 137–144 (Raven Press, New York, 1985).
  Google Scholar
• Holliday, R. Neoplastic transformation: the contrasting stability of human and mouse cells. Cancer Surv. 28, 103–115 (1996).
  CAS PubMed Google Scholar
• Hanahan, D. & Weinberg, R. A. The hallmarks of cancer. Cell 100, 57–70 (2000).
  Article CAS PubMed Google Scholar
• Ames, B. N., Shigenaga, M. K. & Hagen, T. M. Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl Acad. Sci. USA 90, 7915–7922 (1993).
  Article CAS PubMed PubMed Central Google Scholar
• Adelman, R., Saul, R. L. & Ames, B. N. Oxidative damage to DNA: relation to species metabolic rate and life span. Proc. Natl Acad. Sci. USA 85, 2706–2708 (1988).
  Article CAS PubMed PubMed Central Google Scholar
• Schwartz, A. G. & Moore, C. J. Inverse correlation between species life span and capacity of cultured fibroblasts to bind 7,12-dimethylbenz(a)anthracene to DNA. Exp. Cell Res. 109, 448–450 (1977).
  Article CAS PubMed Google Scholar
• DePinho, R. A. The age of cancer. Nature 408, 248–254 (2000).
  Article CAS PubMed Google Scholar
• Blasco, M. A. et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91, 25–34 (1997).
  Article CAS PubMed Google Scholar
• Lee, H. W. et al. Essential role of mouse telomerase in highly proliferative organs. Nature 392, 569–574 (1998).
  Article CAS PubMed Google Scholar
• Artandi, S. E. et al. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 406, 641–645 (2000).
  Article CAS PubMed Google Scholar
• Atkin, N. B. Lack of reciprocal translocations in carcinomas. Cancer Genet. Cytogenet. 21, 275–278 (1986).
  Article CAS PubMed Google Scholar
• Heyer, J., Yang, K., Lipkin, M., Edelmann, W. & Kucherlapati, R. Mouse models for colorectal cancer. Oncogene 18, 5325–5333 (1999).
  Article CAS PubMed Google Scholar
• Newbold, R. F., Overell, R. W. & Connell, J. R. Induction of immortality is an early event in malignant transformation of mammalian cells by carcinogens. Nature 299, 633–635 (1982).
  Article CAS PubMed Google Scholar
• Hayflick, L. & Moorhead, P. S. The serial cultivation of human diploid cell strains. Exp. Cell Res. 25, 585–621 (1961).
  Article CAS PubMed Google Scholar
• Shay, J. W., Wright, W. E. & Werbin, H. Defining the molecular mechanisms of human cell immortalization. Biochim. Biophys. Acta 1072, 1–7 (1991).
  CAS PubMed Google Scholar
• Harley, C. B. et al. Telomerase, cell immortality, and cancer. Cold Spring Harb. Symp. Quant. Biol. 59, 307–315 (1994).
  Article CAS PubMed Google Scholar
• Prowse, K. R. & Greider, C. W. Developmental and tissue-specific regulation of mouse telomerase and telomere length. Proc. Natl Acad. Sci. USA 92, 4818–4822 (1995).
  Article CAS PubMed PubMed Central Google Scholar
• Kim, N. W. et al. Specific association of human telomerase activity with immortal cells and cancer. Science 266, 2011–2015 (1994).
  Article CAS PubMed Google Scholar
• Vaziri, H. & Benchimol, S. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr. Biol. 8, 279–282 (1998).
  Article CAS PubMed Google Scholar
• Sherr, C. J. The INK4a/ARF network in tumour suppression. Nature Rev. Mol. Cell Biol. 2, 731–737 (2001).
  Article CAS Google Scholar
• Parrinello, S. et al. Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nature Cell Biol. 5, 741–747 (2003).
  Article CAS PubMed Google Scholar
• Sherr, C. J. & DePinho, R. A. Cellular senescence: mitotic clock or culture shock? Cell 102, 407–410 (2000).
  Article CAS PubMed Google Scholar
• Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D. & Lowe, S. W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593–602 (1997).
  Article CAS PubMed Google Scholar
• Zindy, F. et al. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev. 12, 2424–2433 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Kamijo, T. et al. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 91, 649–659 (1997).
  Article CAS PubMed Google Scholar
• Harvey, M. et al. In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. Oncogene 8, 2457–2467 (1993).
  CAS PubMed Google Scholar
• Pantoja, C. & Serrano, M. Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras. Oncogene 18, 4974–4982 (1999).
  Article CAS PubMed Google Scholar
• Sharpless, N. E. et al. Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Nature 413, 86–91 (2001).
  Article CAS PubMed Google Scholar
• Sage, J. et al. Targeted disruption of the three _Rb_-related genes leads to loss of G(1) control and immortalization. Genes Dev. 14, 3037–3050 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Krimpenfort, P., Quon, K. C., Mooi, W. J., Loonstra, A. & Berns, A. Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice. Nature 413, 83–86 (2001).
  Article CAS PubMed Google Scholar
• Dannenberg, J. H., van Rossum, A., Schuijff, L. & te Riele, H. Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions. Genes Dev. 14, 3051–3064 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Peeper, D. S., Dannenberg, J. H., Douma, S., te Riele, H. & Bernards, R. Escape from premature senescence is not sufficient for oncogenic transformation by Ras. Nature Cell Biol. 3, 198–203 (2001).
  Article CAS PubMed Google Scholar
• Wei, W., Hemmer, R. M. & Sedivy, J. M. Role of p14ARF in replicative and induced senescence of human fibroblasts. Mol. Cell Biol. 21, 6748–6757 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Dickson, M. A. et al. Human keratinocytes that express hTERT and also bypass a p16INK4a-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics. Mol. Cell Biol. 20, 1436–1447 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Stampfer, M. R. et al. Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor β growth inhibition in p16 INK4A(-) human mammary epithelial cells. Proc. Natl Acad. Sci. USA 98, 4498–4503 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Huot, T. J. et al. Biallelic mutations in p16 INK4a confer resistance to Ras- and Ets-induced senescence in human diploid fibroblasts. Mol Cell Biol 22, 8135–43 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Rogan, E. M. et al. Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts. Mol. Cell Biol. 15, 4745–4753 (1995).
  Article CAS PubMed PubMed Central Google Scholar
• Brown, J. P., Wei, W. & Sedivy, J. M. Bypass of senescence after disruption of p21 CIP1 /WAF1 gene in normal diploid human fibroblasts. Science 277, 831–834 (1997).
  Article CAS PubMed Google Scholar
• Rodriguez-Viciana, P. et al. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell 89, 457–467 (1997).
  Article CAS PubMed Google Scholar
• Campbell, S. L., Khosravi-Far, R., Rossman, K. L., Clark, G. J. & Der, C. J. Increasing complexity of Ras signaling. Oncogene 17, 1395–1413 (1998).
  Article CAS PubMed Google Scholar
• Morales, C. P. et al. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nature Genet. 21, 115–118 (1999).
  Article CAS PubMed Google Scholar
• Hahn, W. C. et al. Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol. Cell Biol. 22, 2111–2123 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Hahn, W. C. et al. Creation of human tumour cells with defined genetic elements. Nature 400, 464–468 (1999).
  Article CAS PubMed Google Scholar
• Janssens, V. & Goris, J. Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem. J. 353, 417–439 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Zhao, J. J. et al. Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase. Cancer Cell 3, 483–495 (2003).
  Article CAS PubMed Google Scholar
• Lazarov, M. et al. CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis. Nature Med. 8, 1105–1114 (2002).
  Article CAS PubMed Google Scholar
• Seger, Y. R. et al. Transformation of normal human cells in the absence of telomerase activation. Cancer Cell 2, 401–413 (2002).
  Article CAS PubMed Google Scholar
• Oldham, S. M., Clark, G. J., Gangarosa, L. M., Coffey, R. J. Jr. & Der, C. J. Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells. Proc. Natl Acad. Sci. USA 93, 6924–6928 (1996).
  Article CAS PubMed PubMed Central Google Scholar
• Hamad, N. M. et al. Distinct requirements for Ras oncogenesis in human versus mouse cells. Genes Dev. 16, 2045–2057 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Robanus-Maandag, E. et al. p107 is a suppressor of retinoblastoma development in pRb-deficient mice. Genes Dev. 12, 1599–1609 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Giovannini, M. et al. Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2. Genes Dev. 14, 1617–1630 (2000).
  CAS PubMed PubMed Central Google Scholar
• Dimri, G. P. et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl Acad. Sci. USA 92, 9363–9367 (1995).
  Article CAS PubMed PubMed Central Google Scholar
• Chin, L. et al. Essential role for oncogenic Ras in tumour maintenance. Nature 400, 468–472 (1999).
  Article CAS PubMed Google Scholar
• Zhu, Y., Ghosh, P., Charnay, P., Burns, D. K. & Parada, L. F. Neurofibromas in NF1: Schwann cell origin and role of tumor environment. Science 296, 920–922 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Lyden, D. et al. Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth Nature Med. 7, 1194–1201 (2001).
  Article CAS PubMed Google Scholar
• Coussens, L. M. et al. Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. Genes Dev. 13, 1382–1397 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Rabbany, S. Y., Heissig, B., Hattori, K. & Rafii, S. Molecular pathways regulating mobilization of marrow-derived stem cells for tissue revascularization. Trends Mol. Med. 9, 109–117 (2003).
  Article CAS PubMed Google Scholar
• Pompei, F., Polkanov, M. & Wilson, R. Age distribution of cancer in mice: the incidence turnover at old age. Toxicol. Ind. Health 17, 7–16 (2001).
  Article CAS PubMed Google Scholar
• Bayani, J. et al. Parallel analysis of sporadic primary ovarian carcinomas by spectral karyotyping, comparative genomic hybridization, and expression microarrays. Cancer Res. 62, 3466–3476 (2002).
  CAS PubMed Google Scholar
• Shibata, H. et al. Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science 278, 120–123 (1997).
  Article CAS PubMed Google Scholar
• Xu, X. et al. Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation. Nature Genet. 22, 37–43 (1999).
  Article CAS PubMed Google Scholar
• Jonkers, J. et al. Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nature Genet. 29, 418–425 (2001).
  Article CAS PubMed Google Scholar
• Reilly, K. M., Loisel, D. A., Bronson, R. T., McLaughlin, M. E. & Jacks, T. Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Nature Genet. 26, 109–113 (2000).
  Article CAS PubMed Google Scholar