T-cell-receptor gene therapy (original) (raw)

• Taylor, P. C., Williams, R. O. & Maini, R. N. Immunotherapy for rheumatoid arthritis. Curr. Opin. Immunol. 13, 611–616 (2001).
  Article CAS PubMed Google Scholar
• Weiner, L. M. Monoclonal antibody therapy of cancer. Semin. Oncol. 26, 43–51 (1999).
  CAS PubMed Google Scholar
• Kisielow, P., Bluthmann, H., Staerz, U. D., Steinmetz, M. & von Boehmer, H. Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+CD8+ thymocytes. Nature 333, 742–746 (1988).
  Article CAS PubMed Google Scholar
• Romieu, R. et al. Passive but not active CD8+ T-cell-based immunotherapy interferes with liver tumor progression in a transgenic mouse model. J. Immunol. 161, 5133–5137 (1998).A mouse model system that graphically illustrates the consequences of self-tolerance on tumour immunity and the effectiveness of adoptive therapies.
  CAS PubMed Google Scholar
• Granziero, L. et al. Adoptive immunotherapy prevents prostate cancer in a transgenic animal model. Eur. J. Immunol. 29, 1127–1138 (1999).
  Article CAS PubMed Google Scholar
• Schell, T. D. et al. Cytotoxic T-lymphocyte epitope immunodominance in the control of choroid plexus tumors in simian virus 40 large T antigen transgenic mice. J. Virol. 73, 5981–5993 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Maraninchi, D. et al. Impact of T-cell depletion on outcome of allogeneic bone-marrow transplantation for standard-risk leukaemias. Lancet 2, 175–178 (1987).
  Article CAS PubMed Google Scholar
• Kolb, H. J. et al. Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients. Blood 76, 2462–2465 (1990).
  Article CAS PubMed Google Scholar
• Gale, R. P. et al. Identical-twin bone marrow transplants for leukemia. Ann. Intern. Med. 120, 646–652 (1994).
  Article CAS PubMed Google Scholar
• Horowitz, M. M. et al. Graft-versus-leukemia reactions after bone marrow transplantation. Blood 75, 555–562 (1990).
  Article CAS PubMed Google Scholar
• Walter, E. A. et al. Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N. Engl. J. Med. 333, 1038–1044 (1995).A human trial that shows that infusion of in vitro -expanded CMV-specific T-cell lines is sufficient to restore CMV-specific T-cell immunity in immunodeficient individuals.
  Article CAS PubMed Google Scholar
• Rooney, C. M. et al. Use of gene-modified virus-specific T lymphocytes to control Epstein–Barr-virus-related lymphoproliferation. Lancet 345, 9–13 (1995).A human trial that shows that infusion of in vitro -expanded EBV-specific T-cell lines is sufficient to protect immunodeficient individuals from EBV+ B-cell lymphomas and can also be used as treatment for patients with established disease.
  Article CAS PubMed Google Scholar
• Dembic, Z. et al. Transfer of specificity by murine α and β T-cell receptor genes. Nature 320, 232–238 (1986).A classic paper that establishes that the TCR α- and β-chains are the TCR components that determine the antigen specificity of T cells.
  Article CAS PubMed Google Scholar
• Calogero, A. et al. Retargeting of a T-cell line by anti-MAGE-3/HLA-A2 αβ TCR gene transfer. Anticancer Res. 20, 1793–1799 (2000).
  CAS PubMed Google Scholar
• Clay, T. M. et al. Efficient transfer of a tumor-antigen-reactive TCR to human peripheral-blood lymphocytes confers anti-tumor reactivity. J. Immunol. 163, 507–513 (1999).
  CAS PubMed Google Scholar
• Cooper, L. J., Kalos, M., Lewinsohn, D. A., Riddell, S. R. & Greenberg, P. D. Transfer of specificity for human immunodeficiency virus type 1 into primary human T lymphocytes by introduction of T-cell receptor genes. J. Virol. 74, 8207–8212 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Fujio, K. et al. Functional reconstitution of class II MHC-restricted T-cell immunity mediated by retroviral transfer of the αβ TCR complex. J. Immunol. 165, 528–532 (2000).
  Article CAS PubMed Google Scholar
• Heemskerk, M. H. et al. Dual HLA class-I- and class-II-restricted recognition of alloreactive T lymphocytes mediated by a single T-cell receptor complex. Proc. Natl Acad. Sci. USA 98, 6806–6811 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Orentas, R. J., Roskopf, S. J., Nolan, G. P. & Nishimura, M. I. Retroviral transduction of a T-cell receptor specific for an Epstein–Barr-virus-encoded peptide. Clin. Immunol. 98, 220–228 (2001).
  Article CAS PubMed Google Scholar
• Stanislawski, T. et al. Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer. Nature Immunol. 2, 962–970 (2001).This study describes the combination of sophisticated selection technologies that are available for the identification of desirable TCRs and the use of such TCRs by gene transfer into peripheral T cells.
  Article CAS Google Scholar
• Kessels, H. W., Wolkers, M. C., van den Boom, M. D., van der Valk, M. A. & Schumacher, T. N. Immunotherapy through TCR gene transfer. Nature Immunol. 2, 957–961 (2001).The first description of the in vivo behaviour and function of peripheral T cells that have been redirected by TCR gene transfer.
  Article CAS Google Scholar
• Jahner, D. et al. De novo methylation and expression of retroviral genomes during mouse embryogenesis. Nature 298, 623–628 (1982).
  Article CAS PubMed Google Scholar
• Challita, P. M. & Kohn, D. B. Lack of expression from a retroviral vector after transduction of murine hematopoietic stem cells is associated with methylation in vivo. Proc. Natl Acad. Sci. USA 91, 2567–2571 (1994).
  Article CAS PubMed PubMed Central Google Scholar
• Hawley, R. G., Lieu, F. H., Fong, A. Z. & Hawley, T. S. Versatile retroviral vectors for potential use in gene therapy. Gene Ther. 1, 136–138 (1994).
  CAS PubMed Google Scholar
• Dang, Q., Auten, J. & Plavec, I. Human β-interferon scaffold attachment region inhibits de novo methylation and confers long-term, copy-number-dependent expression to a retroviral vector. J. Virol. 74, 2671–2678 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Rivella, S., Callegari, J. A., May, C., Tan, C. W. & Sadelain, M. The cHS4 insulator increases the probability of retroviral expression at random chromosomal integration sites. J. Virol. 74, 4679–4687 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Agarwal, M. et al. Scaffold attachment region-mediated enhancement of retroviral vector expression in primary T cells. J. Virol. 72, 3720–3728 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Emery, D. W., Yannaki, E., Tubb, J. & Stamatoyannopoulos, G. A chromatin insulator protects retrovirus vectors from chromosomal position effects. Proc. Natl Acad. Sci. USA 97, 9150–9155 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Unutmaz, D., Kewal Ramani, V. N., Marmon, S. & Littman, D. R. Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes. J. Exp. Med. 189, 1735–1746 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Cavazzana-Calvo, M. et al. Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. Science 288, 669–672 (2000).A description of the most successful human gene-therapy trial so far, which exemplifies the optimal conditions for gene therapy.
  Article CAS PubMed Google Scholar
• Viola, A. & Lanzavecchia, A. T-cell activation determined by T-cell receptor number and tunable thresholds. Science 273, 104–106 (1996).
  Article CAS PubMed Google Scholar
• Labrecque, N. et al. How much TCR does a T-cell need? Immunity 15, 71–82 (2001).
  Article CAS PubMed Google Scholar
• Holler, P. D. et al. In vitro evolution of a T-cell receptor with high affinity for peptide–MHC. Proc. Natl Acad. Sci. USA 97, 5387–5392 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Kessels, H. W., van Den Boom, M. D., Spits, H., Hooijberg, E. & Schumacher, T. N. Changing T-cell specificity by retroviral T-cell receptor display. Proc. Natl Acad. Sci. USA 97, 14578–14583 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Kalergis, A. M. et al. Efficient T-cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex. Nature Immunol. 2, 229–234 (2001).
  Article CAS Google Scholar
• Holler, P. D., Lim, A. R., Cho, B. K., Rund, L. A. & Kranz, D. M. CD8-transfectants that express a high-affinity T-cell receptor exhibit enhanced peptide-dependent activation. J. Exp. Med. 194, 1043–1052 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Savage, P. A. & Davis, M. M. A kinetic window constricts the T-cell receptor repertoire in the thymus. Immunity 14, 243–252 (2001).
  Article CAS PubMed Google Scholar
• Padovan, E. et al. Expression of two T-cell receptor α-chains: dual receptor T cells. Science 262, 422–424 (1993).
  Article CAS PubMed Google Scholar
• Elliott, J. I. & Altmann, D. M. Non-obese diabetic mice hemizygous at the T-cell receptor α-locus are susceptible to diabetes and sialitis. Eur. J. Immunol. 26, 953–956 (1996).
  Article CAS PubMed Google Scholar
• Argaet, V. P. et al. Dominant selection of an invariant T-cell antigen receptor in response to persistent infection by Epstein–Barr virus. J. Exp. Med. 180, 2335–2340 (1994).
  Article CAS PubMed Google Scholar
• Burrows, S. R. et al. T-cell receptor repertoire for a viral epitope in humans is diversified by tolerance to a background major histocompatibility complex antigen. J. Exp. Med. 182, 1703–1715 (1995).
  Article CAS PubMed Google Scholar
• Riddell, S. R. et al. T-cell-mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients. Nature Med. 2, 216–223 (1996).
  Article CAS PubMed Google Scholar
• Bonini, C. et al. HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia. Science 276, 1719–1724 (1997).
  Article CAS PubMed Google Scholar
• Lutzko, C. et al. Genetically corrected autologous stem cells engraft, but host immune responses limit their utility in canine α-l-iduronidase deficiency. Blood 93, 1895–1905 (1999).
  CAS PubMed Google Scholar
• Berger, C. et al. Nonmyeloablative immunosuppressive regimen prolongs in vivo persistence of gene-modified autologous T cells in a nonhuman primate model. J. Virol. 75, 799–808 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Altman, J. D. et al. Phenotypic analysis of antigen-specific T lymphocytes. Science 274, 94–96 (1996).A landmark paper that describes how fluorescently labelled multivalent MHC molecules can be used to visualize antigen-specific T cells.
  Article CAS PubMed Google Scholar
• Thomis, D. C. et al. A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease. Blood 97, 1249–1257 (2001).
  Article CAS PubMed Google Scholar
• White, J., Haskins, K. M., Marrack, P. & Kappler, J. Use of I-region-restricted, antigen-specific T-cell hybridomas to produce idiotypically specific anti-receptor antibodies. J. Immunol. 130, 1033–1037 (1983).
  CAS PubMed Google Scholar
• Infante, A. J., Infante, P. D., Gillis, S. & Fathman, C. G. Definition of T-cell idiotypes using anti-idiotypic antisera produced by immunization with T-cell clones. J. Exp. Med. 155, 1100–1107 (1982).
  Article CAS PubMed Google Scholar
• Kaech, S. M. & Ahmed, R. Memory CD8+ T-cell differentiation: initial antigen encounter triggers a developmental program in naive cells. Nature Immunol. 2, 415–422 (2001).
  Article CAS Google Scholar
• van Stipdonk, M. J., Lemmens, E. E. & Schoenberger, S. P. Naive CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation. Nature Immunol. 2, 423–429 (2001).
  Article CAS Google Scholar
• Ossendorp, F., Mengede, E., Camps, M., Filius, R. & Melief, C. J. Specific T-helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class-II-negative tumors. J. Exp. Med. 187, 693–702 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Hung, K. et al. The central role of CD4+ T cells in the antitumor immune response. J. Exp. Med. 188, 2357–2368 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Zajac, A. J. et al. Viral immune evasion due to persistence of activated T cells without effector function. J. Exp. Med. 188, 2205–2213 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Moritani, M. et al. Prevention of adoptively transferred diabetes in nonobese diabetic mice with IL-10-transduced islet-specific Th1 lymphocytes. A gene therapy model for autoimmune diabetes. J. Clin. Invest. 98, 1851–1859 (1996).
  Article CAS PubMed PubMed Central Google Scholar
• Shaw, M. K. et al. Local delivery of interleukin-4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis. J. Exp. Med. 185, 1711–1714 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Costa, G. L. et al. Adoptive immunotherapy of experimental autoimmune encephalomyelitis via T-cell delivery of the IL-12 p40 subunit. J. Immunol. 167, 2379–2387 (2001).
  Article CAS PubMed Google Scholar
• Nakajima, A. et al. Antigen-specific T-cell-mediated gene therapy in collagen-induced arthritis. J. Clin. Invest. 107, 1293–1301 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Yamamoto, A. M. et al. The activity of immunoregulatory T cells mediating active tolerance is potentiated in nonobese diabetic mice by an IL-4-based retroviral gene therapy. J. Immunol. 166, 4973–4980 (2001).
  Article CAS PubMed Google Scholar
• Mageed, R. A., Adams, G., Woodrow, D., Podhajcer, O. L. & Chernajovsky, Y. Prevention of collagen-induced arthritis by gene delivery of soluble p75 tumour necrosis factor receptor. Gene Ther. 5, 1584–1592 (1998).
  Article CAS PubMed Google Scholar
• Gorelik, L. & Flavell, R. A. Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells. Nature Med. 7, 1118–1122 (2001).
  Article CAS PubMed Google Scholar
• Randolph, D. A., Huang, G., Carruthers, C. J., Bromley, L. E. & Chaplin, D. D. The role of CCR7 in TH1 and TH2 cell localization and delivery of B-cell help in vivo. Science 286, 2159–2162 (1999).
  Article CAS PubMed Google Scholar
• Szabo, S. J. et al. A novel transcription factor, T-bet, directs TH1 lineage commitment. Cell 100, 655–669 (2000).
  Article CAS PubMed Google Scholar
• Eshhar, Z. Tumor-specific T-bodies: towards clinical application. Cancer Immunol. Immunother. 45, 131–136 (1997).
  Article CAS PubMed Google Scholar
• Altenschmidt, U., Klundt, E. & Groner, B. Adoptive transfer of _in-vitro_-targeted, activated T lymphocytes results in total tumor regression. J. Immunol. 159, 5509–5515 (1997).
  CAS PubMed Google Scholar
• Haynes, N. M. et al. Redirecting mouse CTL against colon carcinoma: superior signaling efficacy of single-chain variable-domain chimeras containing TCR-ζ vs FcɛRI-γ. J. Immunol. 166, 182–187 (2001).
  Article CAS PubMed Google Scholar
• Hekele, A. et al. Growth retardation of tumors by adoptive transfer of cytotoxic T lymphocytes reprogrammed by CD44v6-specific scFv:ζ-chimera. Int. J. Cancer 68, 232–238 (1996).
  Article CAS PubMed Google Scholar
• Brocker, T. Chimeric Fv-ζ or Fv-ɛ receptors are not sufficient to induce activation or cytokine production in peripheral T cells. Blood 96, 1999–2001 (2000).
  Article CAS PubMed Google Scholar
• Geiger, T. L., Leitenberg, D. & Flavell, R. A. The TCR ζ-chain immunoreceptor tyrosine-based activation motifs are sufficient for the activation and differentiation of primary T lymphocytes. J. Immunol. 162, 5931–5939 (1999).
  CAS PubMed Google Scholar
• Osman, N., Turner, H., Lucas, S., Reif, K. & Cantrell, D. A. The protein interactions of the immunoglobulin receptor family tyrosine-based activation motifs present in the T-cell receptor ζ-subunits and the CD3 γ-, δ- and ɛ-chains. Eur. J. Immunol. 26, 1063–1068 (1996).
  Article CAS PubMed Google Scholar
• Dustin, M. L. Membrane domains and the immunological synapse: keeping T cells resting and ready. J. Clin. Invest. 109, 155–160 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Krummel, M. F. & Davis, M. M. Dynamics of the immunological synapse: finding, establishing and solidifying a connection. Curr. Opin. Immunol. 14, 66–74 (2002).
  Article CAS PubMed Google Scholar
• Garcia, K. C., Teyton, L. & Wilson, I. A. Structural basis of T-cell recognition. Annu. Rev. Immunol. 17, 369–397 (1999).
  Article CAS PubMed Google Scholar
• Reich, Z. et al. Ligand-specific oligomerization of T-cell receptor molecules. Nature 387, 617–620 (1997).
  Article CAS PubMed Google Scholar
• Baker, B. M. & Wiley, D. C. αβ T-cell receptor ligand-specific oligomerization revisited. Immunity 14, 681–692 (2001).
  Article CAS PubMed Google Scholar
• Cochran, J. R., Cameron, T. O., Stone, J. D., Lubetsky, J. B. & Stern, L. J. Receptor proximity, not intermolecular orientation, is critical for triggering T-cell activation. J. Biol. Chem. 276, 28068–28074 (2001).
  Article CAS PubMed Google Scholar
• Lanzavecchia, A., Lezzi, G. & Viola, A. From TCR engagement to T-cell activation: a kinetic view of T-cell behavior. Cell 96, 1–4 (1999).
  Article CAS PubMed Google Scholar
• van der Merwe, P. A., Davis, S. J., Shaw, A. S. & Dustin, M. L. Cytoskeletal polarization and redistribution of cell-surface molecules during T-cell antigen recognition. Semin. Immunol. 12, 5–21 (2000).
  Article CAS Google Scholar
• Davis, M. M. et al. Ligand recognition by αβ T-cell receptors. Annu. Rev. Immunol. 16, 523–544 (1998).
  Article CAS PubMed Google Scholar
• McMichael, A. J. & Phillips, R. E. Escape of human immunodeficiency virus from immune control. Annu. Rev. Immunol. 15, 271–296 (1997).
  Article CAS PubMed Google Scholar
• Medema, J. P. et al. Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors. Proc. Natl Acad. Sci. USA 98, 11515–11520 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Medema, J. P., de Jong, J., van Hall, T., Melief, C. J. & Offringa, R. Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein. J. Exp. Med. 190, 1033–1038 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Gilboa, E. How tumors escape immune destruction and what we can do about it. Cancer Immunol. Immunother. 48, 382–385 (1999).
  Article CAS PubMed Google Scholar
• Gray, D. A. Insertional mutagenesis: neoplasia arising from retroviral integration. Cancer Invest. 9, 295–304 (1991).
  Article CAS PubMed Google Scholar
• Somia, N. & Verma, I. M. Gene therapy: trials and tribulations. Nature Rev. Genet. 1, 91–99 (2000).
  Article CAS PubMed Google Scholar
• Plasterk, R. H., Izsvak, Z. & Ivics, Z. Resident aliens: the Tc1/mariner superfamily of transposable elements. Trends Genet. 15, 326–332 (1999).
  Article CAS PubMed Google Scholar
• Van Craenenbroeck, K., Vanhoenacker, P. & Haegeman, G. Episomal vectors for gene expression in mammalian cells. Eur. J. Biochem. 267, 5665–5678 (2000).
  Article CAS PubMed Google Scholar