The diverse functions of histone lysine methylation (original) (raw)

• Kornberg, R. D. & Lorch, Y. Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome. Cell 98, 285–294 (1999).
  Article CAS PubMed Google Scholar
• van Holde, K. E. in Chromatin (ed. Rich, A.) 1–148 (Springer, New York, 1988).
  Google Scholar
• Bannister, A. J. & Kouzarides, T. Reversing histone methylation. Nature 436, 1103–1106 (2005).
  Article CAS PubMed Google Scholar
• Lachner, M., O'Sullivan, R. J. & Jenuwein, T. An epigenetic road map for histone lysine methylation. J. Cell Sci. 116, 2117–2124 (2003).
  Article CAS PubMed Google Scholar
• Margueron, R., Trojer, P. & Reinberg, D. The key to development: interpreting the histone code? Curr. Opin. Genet. Dev. 15, 163–176 (2005).
  Article CAS PubMed Google Scholar
• Zhang, Y. & Reinberg, D. Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails. Genes Dev. 15, 2343–2360 (2001).
  Article CAS PubMed Google Scholar
• Bedford, M. T. & Richard, S. Arginine methylation an emerging regulator of protein function. Mol. Cell 18, 263–272 (2005).
  Article CAS PubMed Google Scholar
• Stallcup, M. R. Role of protein methylation in chromatin remodeling and transcriptional regulation. Oncogene 20, 3014–3020 (2001).
  Article CAS PubMed Google Scholar
• Hansen, J. C. Conformational dynamics of the chromatin fiber in solution: determinants, mechanisms, and functions. Annu. Rev. Biophys. Biomol. Struct. 31, 361–392 (2002).
  Article CAS PubMed Google Scholar
• Carruthers, L. M. & Hansen, J. C. The core histone N termini function independently of linker histones during chromatin condensation. J. Biol. Chem. 275, 37285–37290 (2000).
  Article CAS PubMed Google Scholar
• Turner, B. M. Histone acetylation and an epigenetic code. Bioessays 22, 836–845 (2000).
  Article CAS PubMed Google Scholar
• Strahl, B. D. & Allis, C. D. The language of covalent histone modifications. Nature 403, 41–45 (2000).
  Article CAS PubMed Google Scholar
• Jenuwein, T. & Allis, C. D. Translating the histone code. Science 293, 1074–1080 (2001).
  Article CAS PubMed Google Scholar
• Dhalluin, C. et al. Structure and ligand of a histone acetyltransferase bromodomain. Nature 399, 491–496 (1999).
  Article CAS PubMed Google Scholar
• Jacobson, R. H., Ladurner, A. G., King, D. S. & Tjian, R. Structure and function of a human TAFII250 double bromodomain module. Science 288, 1422–1425 (2000).
  Article CAS PubMed Google Scholar
• Bannister, A. J. et al. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 410, 120–124 (2001).
  Article CAS PubMed Google Scholar
• Fischle, W. et al. Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains. Genes Dev. 17, 1870–1881 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Lachner, M., O'Carroll, D., Rea, S., Mechtler, K. & Jenuwein, T. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 410, 116–120 (2001).
  Article CAS PubMed Google Scholar
• Min, J., Zhang, Y. & Xu, R. M. Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27. Genes Dev. 17, 1823–1828 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Pray-Grant, M. G., Daniel, J. A., Schieltz, D., Yates, J. R., 3rd & Grant, P. A. Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation. Nature 433, 434–438 (2005). The first demonstration of a protein capable of binding directly to methyl-H3-K4.
  Article CAS PubMed Google Scholar
• Huyen, Y. et al. Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks. Nature 432, 406–411 (2004). Established the tudor domain as a methyl-lysine binding motif and a link between H3-K79 methylation and DNA repair processes.
  Article CAS PubMed Google Scholar
• Sanders, S. L. et al. Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage. Cell 119, 603–614 (2004).
  Article CAS PubMed Google Scholar
• Wysocka, J. et al. WDR5 associates with histone H3 methylated at K4 and is essential for H3-K4 methylation and vertebrate development. Cell 121, 859–872 (2005). Shows that the WD40-repeat domain within WDR5 binds specifically to dimethyl-H3-K4 and that this interaction is important for H3-K4 methylation.
  Article CAS PubMed Google Scholar
• Kurdistani, S. K. & Grunstein, M. Histone acetylation and deacetylation in yeast. Nature Rev. Mol.Cell Biol. 4, 276–284 (2003).
  Article CAS Google Scholar
• Henikoff, S. Histone modifications: combinatorial complexity or cumulative simplicity? Proc. Natl Acad. Sci. USA 102, 5308–5309 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Schubeler, D. et al. The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. Genes Dev. 18, 1263–1271 (2004).
  Article PubMed PubMed Central Google Scholar
• Bernstein, B. E. et al. Genomic maps and comparative analysis of histone modifications in human and mouse. Cell 120, 169–181 (2005).
  Article CAS PubMed Google Scholar
• Lindroth, A. M. et al. Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3. EMBO J. 23, 4286–4296 (2004).
  Article CAS PubMed Google Scholar
• Mateescu, B., England, P., Halgand, F., Yaniv, M. & Muchardt, C. Tethering of HP1 proteins to chromatin is relieved by phosphoacetylation of histone H3. EMBO Rep. 5, 490–496 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Sun, Z. W. & Allis, C. D. Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. Nature 418, 104–108 (2002).
  Article CAS PubMed Google Scholar
• Grunstein, M. Yeast heterochromatin: regulation of its assembly and inheritance by histones. Cell 93, 325–328 (1998).
  Article CAS PubMed Google Scholar
• Pidoux, A. L. & Allshire, R. C. The role of heterochromatin in centromere function. Philos. Trans. R. Soc. Lond. B Biol. Sci. 360, 569–579 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Jia, S., Yamada, T. & Grewal, S. I. Heterochromatin regulates cell type-specific long-range chromatin interactions essential for directed recombination. Cell 119, 469–480 (2004). Demonstrates the role of heterochromatin and H3-K9 methylation in cell-type-specific spreading of proteins involved in recombination.
  Article CAS PubMed Google Scholar
• Wakimoto, B. T. Beyond the nucleosome: epigenetic aspects of position-effect variegation in Drosophila. Cell 93, 321–324 (1998).
  Article CAS PubMed Google Scholar
• Tschiersch, B. et al. The protein encoded by the Drosophila position-effect variegation suppressor gene Su(var)3–9 combines domains of antagonistic regulators of homeotic gene complexes. EMBO J. 13, 3822–3831 (1994).
  Article CAS PubMed PubMed Central Google Scholar
• Rea, S. et al. Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature 406, 593–599 (2000).
  Article CAS PubMed Google Scholar
• Aagaard, L. et al. Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3–9 encode centromere-associated proteins which complex with the heterochromatin component M31. EMBO J. 18, 1923–1938 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Nakayama, J., Rice, J. C., Strahl, B. D., Allis, C. D. & Grewal, S. I. Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Science 292, 110–113 (2001).
  Article CAS PubMed Google Scholar
• Ekwall, K. et al. Mutations in the fission yeast silencing factors clr4+ and rik1+ disrupt the localisation of the chromo domain protein Swi6p and impair centromere function. J. Cell Sci. 109, 2637–2648 (1996).
  CAS PubMed Google Scholar
• Volpe, T. A. et al. Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science 297, 1833–1837 (2002).
  Article CAS PubMed Google Scholar
• Hall, I. M. et al. Establishment and maintenance of a heterochromatin domain. Science 297, 2232–2237 (2002).
  Article CAS PubMed Google Scholar
• Verdel, A. et al. RNAi-mediated targeting of heterochromatin by the RITS complex. Science 303, 672–676 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Motamedi, M. R. et al. Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs. Cell 119, 789–802 (2004).
  Article CAS PubMed Google Scholar
• Sugiyama, T., Cam, H., Verdel, A., Moazed, D. & Grewal, S. I. RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production. Proc. Natl Acad. Sci. USA 102, 152–157 (2005). This paper showed the interdependence between complexes that mediate heterochromatin formation.
  Article CAS PubMed Google Scholar
• Noma, K. et al. RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing. Nature Genet. 36, 1174–1180 (2004).
  Article CAS PubMed Google Scholar
• Partridge, J. F., Scott, K. S., Bannister, A. J., Kouzarides, T. & Allshire, R. C. _cis_-acting DNA from fission yeast centromeres mediates histone H3 methylation and recruitment of silencing factors and cohesin to an ectopic site. Curr. Biol. 12, 1652–1660 (2002).
  Article CAS PubMed Google Scholar
• Partridge, J. F., Borgstrom, B. & Allshire, R. C. Distinct protein interaction domains and protein spreading in a complex centromere. Genes Dev. 14, 783–791 (2000).
  CAS PubMed PubMed Central Google Scholar
• Peters, A. H. et al. Partitioning and plasticity of repressive histone methylation states in mammalian chromatin. Mol. Cell 12, 1577–1589 (2003).
  Article CAS PubMed Google Scholar
• Rice, J. C. et al. Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains. Mol.Cell 12, 1591–1598 (2003).
  Article CAS PubMed Google Scholar
• Schotta, G. et al. A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev. 18, 1251–1262 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Eissenberg, J. C. & Elgin, S. C. The HP1 protein family: getting a grip on chromatin. Curr. Opin. Genet. Dev. 10, 204–210 (2000).
  Article CAS PubMed Google Scholar
• Tachibana, M. et al. Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. Genes Dev. 19, 815–826 (2005). Shows that two methyltransferases cooperate to mediate the bulk of euchromatic H3-K9 methylation.
  Article CAS PubMed PubMed Central Google Scholar
• Tachibana, M. et al. G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Genes Dev. 16, 1779–1791 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Nielsen, S. J. et al. Rb targets histone H3 methylation and HP1 to promoters. Nature 412, 561–565 (2001).
  Article CAS PubMed Google Scholar
• Ait-Si-Ali, S. et al. A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cells. EMBO J. 23, 605–615 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Vakoc, C. R., Mandat, S. A., Olenchock, B. A. & Blobel, G. A. Histone H3 Lysine 9 methylation and HP1γ are associated with transcription elongation through mammalian chromatin. Mol. Cell 19, 381–391 (2005).
  Article CAS PubMed Google Scholar
• Weiler, K. S. & Wakimoto, B. T. Heterochromatin and gene expression in Drosophila. Annu. Rev. Genet. 29, 577–605 (1995).
  Article CAS PubMed Google Scholar
• Cao, R. & Zhang, Y. The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3. Curr. Opin. Genet. Dev. 14, 155–164 (2004).
  Article CAS PubMed Google Scholar
• Ringrose, L. & Paro, R. Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins. Annu. Rev. Genet. 38, 413–443 (2004).
  Article CAS PubMed Google Scholar
• Cao, R. et al. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 298, 1039–1043 (2002).
  Article CAS PubMed Google Scholar
• Czermin, B. et al. Drosophila Enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal polycomb sites. Cell 111, 185–196 (2002).
  Article CAS PubMed Google Scholar
• Muller, J. et al. Histone methyltransferase activity of a Drosophila polycomb group repressor complex. Cell 111, 197–208 (2002).
  Article CAS PubMed Google Scholar
• Kuzmichev, A., Nishioka, K., Erdjument-Bromage, H., Tempst, P. & Reinberg, D. Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev. 16, 2893–2905 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Wang, L. et al. Hierarchical recruitment of polycomb group silencing complexes. Mol. Cell 14, 637–646 (2004).
  Article CAS PubMed Google Scholar
• Shao, Z. et al. Stabilization of chromatin structure by PRC1, a Polycomb complex. Cell 98, 37–46 (1999).
  Article CAS PubMed Google Scholar
• Wang, H. et al. Role of histone H2A ubiquitination in Polycomb silencing. Nature 431, 873–878 (2004). Identifies the enzyme responsible for H2A ubiquitylation and shows that this modification is required for Polycomb gene silencing.
  Article CAS PubMed Google Scholar
• Heard, E. Recent advances in X-chromosome inactivation. Curr. Opin. Cell Biol. 16, 247–255 (2004).
  Article CAS PubMed Google Scholar
• Mak, W. et al. Reactivation of the paternal X chromosome in early mouse embryos. Science 303, 666–669 (2004). References 68 and 69 demonstrate that X-inactivation is dynamic in that imprinted X inactivation is reversed in the developing embryo followed by random X inactivation.
  Google Scholar
• Okamoto, I., Otte, A. P., Allis, C. D., Reinberg, D. & Heard, E. Epigenetic dynamics of imprinted X inactivation during early mouse development. Science 303, 644–649 (2004).
  Article CAS PubMed Google Scholar
• de Napoles, M. et al. Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation. Dev. Cell 7, 663–676 (2004).
  Article CAS PubMed Google Scholar
• Fang, J., Chen, T., Chadwick, B., Li, E. & Zhang, Y. Ring1b-mediated H2A ubiquitination associates with inactive X chromosomes and is involved in initiation of X inactivation. J. Biol. Chem. 279, 52812–52815 (2004).
  Article CAS PubMed Google Scholar
• Plath, K. et al. Role of histone H3 lysine 27 methylation in X inactivation. Science 300, 131–135 (2003).
  Article CAS PubMed Google Scholar
• Silva, J. et al. Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed–Enx1 polycomb group complexes. Dev. Cell 4, 481–495 (2003).
  Article CAS PubMed Google Scholar
• Wang, J. et al. Imprinted X inactivation maintained by a mouse Polycomb group gene. Nature Genet. 28, 371–375 (2001).
  Article CAS PubMed Google Scholar
• Mager, J., Montgomery, N. D., de Villena, F. P. & Magnuson, T. Genome imprinting regulated by the mouse Polycomb group protein Eed. Nature Genet. 33, 502–507 (2003). Establishes a connection between Polycomb proteins and imprinting.
  Article CAS PubMed Google Scholar
• Lewis, A. et al. Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation. Nature Genet. 36, 1291–1295 (2004).
  Article CAS PubMed Google Scholar
• Umlauf, D. et al. Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes. Nature Genet. 36, 1296–1300 (2004).
  Article CAS PubMed Google Scholar
• Schmitt, S., Prestel, M. & Paro, R. Intergenic transcription through a polycomb group response element counteracts silencing. Genes Dev. 19, 697–708 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Montgomery, N. D. et al. The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation. Curr. Biol. 15, 942–947 (2005).
  Article CAS PubMed Google Scholar
• Cao, R. & Zhang, Y. SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED–EZH2 complex. Mol. Cell 15, 57–67 (2004).
  Article CAS PubMed Google Scholar
• Pasini, D., Bracken, A. P., Jensen, M. R., Lazzerini Denchi, E. & Helin, K. Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J. 23, 4061–4071 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Kuzmichev, A., Jenuwein, T., Tempst, P. & Reinberg, D. Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3. Mol. Cell 14, 183–193 (2004).
  Article CAS PubMed Google Scholar
• Ng, H. H., Robert, F., Young, R. A. & Struhl, K. Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity. Mol. Cell 11, 709–719 (2003).
  Article CAS PubMed Google Scholar
• Xiao, T. et al. Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeast. Genes Dev. 17, 654–663 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Krogan, N. J. et al. Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II. Mol. Cell. Biol. 23, 4207–4218 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Li, B., Howe, L., Anderson, S., Yates, J. R., 3rd & Workman, J. L. The Set2 histone methyltransferase functions through the phosphorylated carboxyl-terminal domain of RNA polymerase II. J. Biol. Chem. 278, 8897–8903 (2003).
  Article CAS PubMed Google Scholar
• Xiao, T. et al. Histone H2B ubiquitylation is associated with elongating RNA polymerase II. Mol. Cell. Biol. 25, 637–651 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Briggs, S. D. et al. Gene silencing: trans-histone regulatory pathway in chromatin. Nature 418, 498 (2002).
  Article CAS PubMed Google Scholar
• Dover, J. et al. Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6. J. Biol Chem. 277, 28368–28371 (2002).
  Article CAS PubMed Google Scholar
• Ng, H. H., Xu, R. M., Zhang, Y. & Struhl, K. Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79. J. Biol. Chem. 277, 34655–34657 (2002).
  Article CAS PubMed Google Scholar
• Henry, K. W. et al. Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. Genes Dev. 17, 2648–2663 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Daniel, J. A. et al. Deubiquitination of histone H2B by a yeast acetyltransferase complex regulates transcription. J. Biol. Chem. 279, 1867–1871 (2004).
  Article CAS PubMed Google Scholar
• Kao, C. F. et al. Rad6 plays a role in transcriptional activation through ubiquitylation of histone H2B. Genes Dev. 18, 184–195 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Henry, K. W. & Berger, S. L. Trans-tail histone modifications: wedge or bridge? Nature Struct. Biol. 9, 565–566 (2002).
  Article CAS PubMed Google Scholar
• Ezhkova, E. & Tansey, W. P. Proteasomal ATPases link ubiquitylation of histone H2B to methylation of histone H3. Mol. Cell 13, 435–442 (2004).
  Article CAS PubMed Google Scholar
• Santos-Rosa, H. et al. Active genes are tri-methylated at K4 of histone H3. Nature 419, 407–411 (2002).
  Article CAS PubMed Google Scholar
• Bernstein, B. E. et al. Methylation of histone H3 Lys 4 in coding regions of active genes. Proc. Natl Acad. Sci. USA 99, 8695–8700 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Pokholok, D. K. et al. Genome-wide map of nucleosome acetylation and methylation in yeast. Cell 122, 517–527 (2005). Demonstrates the generality of previous work investigating the distribution of histone modifications at active and silent genes.
  Article CAS PubMed Google Scholar
• Briggs, S. D. et al. Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae. Genes Dev. 15, 3286–3295 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Nagy, P. L., Griesenbeck, J., Kornberg, R. D. & Cleary, M. L. A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3. Proc. Natl Acad. Sci. USA 99, 90–94 (2002).
  Article CAS PubMed Google Scholar
• Wang, H. et al. mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. Mol. Cell 12, 475–487 (2003).
  Article CAS PubMed Google Scholar
• Schlichter, A. & Cairns, B. R. Histone trimethylation by Set1 is coordinated by the RRM, autoinhibitory, and catalytic domains. EMBO J. 24, 1222–1231 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Laribee, R. N. et al. BUR kinase selectively regulates H3-K4 trimethylation and H2B ubiquitylation through recruitment of the PAF elongation complex. Curr. Biol. 15, 1487–1493 (2005). Identifies a regulatory pathway that regulates methylation status.
  Article CAS PubMed Google Scholar
• Santos-Rosa, H. et al. Methylation of histone H3-K4 mediates association of the Isw1p ATPase with chromatin. Mol. Cell 12, 1325–1332 (2003).
  Article CAS PubMed Google Scholar
• Timmers, H. T. & Tora, L. SAGA unveiled. Trends Biochem. Sci. 30, 7–10 (2005).
  Article CAS PubMed Google Scholar
• Dou, Y. et al. Physical association and coordinate function of the H3-K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell 121, 873–885 (2005).
  Article CAS PubMed Google Scholar
• Feng, Q. et al. Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain. Curr. Biol. 12, 1052–1058 (2002).
  Article CAS PubMed Google Scholar
• van Leeuwen, F., Gafken, P. R. & Gottschling, D. E. Dot1p modulates silencing in yeast by methylation of the nucleosome core. Cell 109, 745–756. (2002).
  Article CAS PubMed Google Scholar
• Ng, H. H. et al. Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association. Genes Dev. 16, 1518–1527 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Lacoste, N., Utley, R. T., Hunter, J. M., Poirier, G. G. & Cote, J. Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase. J. Biol. Chem. 277, 30421–30424 (2002).
  Article CAS PubMed Google Scholar
• Ng, H. H., Ciccone, D. N., Morshead, K. B., Oettinger, M. A. & Struhl, K. Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegation. Proc. Natl Acad. Sci. USA 100, 1820–1825 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Okada, Y. et al. hDOT1L links histone methylation to leukemogenesis. Cell 121, 167–178 (2005). This study provides evidence that MLL–AF10 fusion proteins induce leukaemia through the recruitment of DOT1L and H3-K79 methylation to target genes.
  Article CAS PubMed Google Scholar
• Bannister, A. J., Schneider, R. & Kouzarides, T. Histone methylation: dynamic or static? Cell 109, 801–806 (2002).
  Article CAS PubMed Google Scholar
• Cuthbert, G. L. et al. Histone deimination antagonizes arginine methylation. Cell 118, 545–553 (2004). References 114 and 115 are the first demonstrations of an enzyme capable of reversing histone methylation.
  Article CAS PubMed Google Scholar
• Wang, Y. et al. Human PAD4 regulates histone arginine methylation levels via demethylimination. Science 306, 279–283 (2004).
  Article CAS PubMed Google Scholar
• Shi, Y. et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 119, 941–953 (2004). Identifies the first histone lysine demethylase.
  Article CAS PubMed Google Scholar
• Lee, M. G., Wynder, C., Cooch, N. & Shiekhattar, R. An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation. Nature 437, 432–435 (2005).
  Article CAS PubMed Google Scholar
• Metzger, E. et al. LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature 437, 436–439 (2005).
  Article CAS PubMed Google Scholar
• Clissold, P. M. & Ponting, C. P. JmjC: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2β. Trends Biochem. Sci. 26, 7–9 (2001).
  Article CAS PubMed Google Scholar
• Trewick, S. C., McLaughlin, P. J. & Allshire, R. C. Methylation: lost in hydroxylation? EMBO Rep. 6, 315–320 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Varambally, S. et al. The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 419, 624–629 (2002).
  Article CAS PubMed Google Scholar
• Fang, J. et al. Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase. Curr. Biol. 12, 1086–1099 (2002).
  Article CAS PubMed Google Scholar
• Nishioka, K. et al. PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Mol. Cell 9, 1201–1213 (2002).
  Article CAS PubMed Google Scholar
• Xiao, B. et al. Specificity and mechanism of the histone methyltransferase Pr-Set7. Genes Dev. 19, 1444–1454 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Karachentsev, D., Sarma, K., Reinberg, D. & Steward, R. PR-Set7-dependent methylation of histone H4 Lys 20 functions in repression of gene expression and is essential for mitosis. Genes Dev. 19, 431–435 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Julien, E. & Herr, W. A switch in mitotic histone H4 lysine 20 methylation status is linked to M phase defects upon loss of HCF-1. Mol. Cell 14, 713–725 (2004).
  Article CAS PubMed Google Scholar
• Bird, A. DNA methylation patterns and epigenetic memory. Genes Dev. 16, 6–21 (2002).
  Article CAS PubMed Google Scholar
• Tamaru, H. & Selker, E. U. A histone H3 methyltransferase controls DNA methylation in Neurospora crassa. Nature 414, 277–283 (2001).
  Article CAS PubMed Google Scholar
• Jackson, J. P., Lindroth, A. M., Cao, X. & Jacobsen, S. E. Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase. Nature 416, 556–560 (2002).
  Article CAS PubMed Google Scholar
• Lehnertz, B. et al. Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr. Biol. 13, 1192–1200 (2003).
  Article CAS PubMed Google Scholar
• Freitag, M., Hickey, P. C., Khlafallah, T. K., Read, N. D. & Selker, E. U. HP1 is essential for DNA methylation in neurospora. Mol. Cell 13, 427–434 (2004).
  Article CAS PubMed Google Scholar
• Bachman, K. E. et al. Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene. Cancer Cell 3, 89–95 (2003).
  Article CAS PubMed Google Scholar
• Sarraf, S. A. & Stancheva, I. Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly. Mol.Cell 15, 595–605 (2004). Demonstrates that DNA methylation can direct histone methylation during DNA replication.
  Article CAS PubMed Google Scholar