Ahmet Aslan - Academia.edu (original) (raw)
Papers by Ahmet Aslan
Akademik Acil Tıp Dergisi, 2009
BACKGROUND: Acute mesenteric ischemia (AMI) is a life threatening vascular emergency which requir... more BACKGROUND: Acute mesenteric ischemia (AMI) is a life threatening vascular emergency which requires prompt diagnosis and treatment. The prevention of this cause of high mortality and morbidity depends on early clinical suspicion end timely intervention. In the present study we aimed to analyze the acute mesenteric ischemia cases treated in Mustafa Kemal University Department of General Surgery between January 2004 and December 2008. MATERIAL/ METHODS: The clinic records of all the patients who underwent surgical treatment for AMI between January 1, 2004, and December 2008, were retrospectively reviewed. The data from operative records, postoperative complications, mortality, and hospital stay were recorded. RESULTS: The study group included 18 patients. Mean age was 69. There was comorbidity in all patients and cardiac disease and hypertension were the most common ones. The most common laboratory abnormalities were leukocytes, hypoalbuminemia, hyperamylasemia. There was superiorly vascular necrosis in 16 patients; inferior vascular necrosis in one patient. One patient had non occlusive mesenteric ischemia. Segmentery resection was performed to 13 patients. Abdominoperineal resection was performed to the patient with inferior mesenter artery occlusion. We performed duodenotransversostomy on two patients and only laparotomy on two patients. Re-operation was required in 5 patients. Causes of death were multiorgan insufficiency in 7 cases, cardiac death in 2 cases. One patient died due to short intestine syndrome. CONCLUSION: Acute mesenteric ischemia is highly mortal emergency which should always be suspected in elderly patients with cardiac disease suffering from abdominal pain.
![Research paper thumbnail of [Fournier's gangrene caused by Candida albicans]](https://attachments.academia-assets.com/95170511/thumbnails/1.jpg)
](Mikrobiyoloji bülteni, 2008
Fournier's gangrene characterized by fulminant necrotizing fasciitis of the perineal, genital... more Fournier's gangrene characterized by fulminant necrotizing fasciitis of the perineal, genital or perianal regions, is generally caused by aerobic and anareobic bacteria. Although it is thought to be an idiopathic process, Fournier's gangrene has been shown to have a predilection for patients with diabetes, long term alcohol misuse and immunocompromised patients. The focus of infection is usually located in the urinary tract, lower gastrointestinal tract or skin. The development and progression of the gangrene is often fulminating and can rapidly lead to multiple organ failures and death. Here, we present a Fournier's gangrene case caused by Candida albicans. A 59-year-old woman was admitted to hospital with the complaint of swelling on the right thigh following a trauma occurred three weeks ago. Her history revealed that she had been hospitalized previously for four times due to diabetes mellitus, essential thrombocytopenia, chronic disease anemia and hypertension. Right...
Medical Journal of Bakirköy
Rectal prolapse is defined as the protrusion of the rectum from the mucosa of the anal canal. The... more Rectal prolapse is defined as the protrusion of the rectum from the mucosa of the anal canal. The etiology is not well known. There has been a wide spectrum of operations for treatment. Bleeding, perforation, incarceration, ischemia, necrosis and sepsis are rare fatal ...
TAF Preventive Medicine …, 2007
This research was performed in order to determine the knowledge, attitude and behaviours of nurse... more This research was performed in order to determine the knowledge, attitude and behaviours of nursery students about breast cancer. The study was performed between September 2006-November 2006. 100 nursery students of college out of 102 (98, 0% ...
Medical Journal of …
Colorectal cancer during pregnancy is very rare with the reported incidence of between 0.001-0.1%... more Colorectal cancer during pregnancy is very rare with the reported incidence of between 0.001-0.1%. The prognosis is poor due to delayed diagnosis and secondary advanced disease. Acute abdomen due to sigmoid colon tumor is extremely rare. We report two ...
![Research paper thumbnail of [Late-onset traumatic rupture of the diaphragm: two case reports]](https://attachments.academia-assets.com/90091739/thumbnails/1.jpg)
](Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, 2009
Ruptured diaphragm as a result of blunt thorax or abdominal trauma can present acutely or late in... more Ruptured diaphragm as a result of blunt thorax or abdominal trauma can present acutely or late in the disease. Symptoms may be nonspecific and diagnosis can easily be missed. Patients may present with dyspnea, chest pain or cough. Chest radiograph, CT scan, and MRI are the primary diagnostic tools. Clinicians must have a high index of suspicion for prompt diagnosis, especially in patients with a history of trauma to the abdomen or thorax. The only treatment in diaphragm rupture is surgery. We report two cases of traumatic diaphragm ruptures presenting years after the trauma.
Bakirkoy Tip Dergisi / Medical Journal of Bakirkoy, 2012
Multislice bilgisayarlı tomografi ile median arkuat ligament sendromu tanısı: Olgu sunumu Median ... more Multislice bilgisayarlı tomografi ile median arkuat ligament sendromu tanısı: Olgu sunumu Median arkuat ligament sendromu, median arkuat ligamentin çöliak arter köküne basısı sonucu oluşur ve kendini genellikle postprandial ağrı ile belli eder. Basıya bağlı, özelikle ekspiryumda daha belirgin darlık oluşur. Darlığa bağlı mezenterik iskemi ve gastro-intestinal sisteme yetersiz kan akımı olması nedeniyle sendroma ait karakteristik klinik bulgular görülür. Biz kliniğimize gelen ve multislice bilgisayarlı tomografi ile tanısı konan hastayı sunuyoruz.
Incarcerated rectal prolapsus causing rectal bleeding and laceration: Case report Rectal prolapse... more Incarcerated rectal prolapsus causing rectal bleeding and laceration: Case report Rectal prolapse is defined as the protrusion of the rectum from the mucosa of the anal canal. The etiology is not well known. There has been a wide spectrum of operations for treatment. Bleeding, perforation, incarceration, ischemia, necrosis and sepsis are rare fatal conditions which may require emergent surgery. In each case type of operation is decided on patients' base individually. We present an irreducible rectal prolapsus which caused perforation while trying to be reduced and thus taken under urgent surgery within the light of the literature. ektal prolapsus rektum duvar›n›n tam kat veya sa- dece mukozas›n›n anal kanaldan sarkmas›d›r. Her yaflta görülmekle birlikte, yetiflkinlerde belirli yafl grup- lar› (50 yafl üstü) ve cinsiyette daha fazla (kad›nlarda %80) görülen; hastal›¤›n derecesine ve kifliye özgü flart- lara göre tedavisi farkl›l›klar gösteren bir hastal›kt›r. Rek- tal prolapsus ...
Journal of International Medical Research, 2009
The objective of this study was to investigate the association between mortality and inflammation... more The objective of this study was to investigate the association between mortality and inflammation in patients who were admitted to the emergency room with gastrointestinal bleeding. Patients (n = 96) managed at two medical centres were included in the study. Initial levels of serum C-reactive protein (CRP), haemoglobin and albumin, and leucocyte and thrombocyte counts for 28 patients who died were compared with those for the 68 patients who survived and were successfully discharged. The data were analysed using the x 2-test. Serum levels of CRP and leucocyte counts were significantly higher, and albumin and haemoglobin were significantly lower in patients who died compared with patients who survived. The increased levels of serum CRP and leucocyte counts, and decreased levels of albumin and haemoglobin were found to be independent risk factors for mortality. It is concluded that increased serum CRP levels and leucocyte counts combined with decreased albumin and haemoglobin levels on admission to the emergency room may be used as predictive factors of mortality in patients with gastrointestinal bleeding.
International Journal of Surgery, 2008
Objective: We aimed to investigate the effect of mesalamine on healing of experimental colon anas... more Objective: We aimed to investigate the effect of mesalamine on healing of experimental colon anastomosis model. Material/Methods: Forty adult male Wistar albino rats were performed segmentary colonic resection and end-to-end anastomosis. Animals were randomly divided into four groups: group I, anastomosis group, received no treatment (GI, n ¼ 8); group II, anastomosis þ oral mesalamine group (100 mg/kg/day); group III, anastomosis þ rectal mesalamine (2 mL) group, (GIII, n ¼ 8); group IV, anastomosis þ oral mesalamine þ rectal mesalamine (GIV, n ¼ 8) group. A sham group (n ¼ 8) was constituted and was performed laparotomy. Bursting pressure, hydroxyproline levels and histopathological characteristics of the anastomosis were analyzed. Results: Although it was not statistically significant, there was an increase in the burst pressure of the mesalamine group. When hydroxyproline measurements were compared there were statistically significant difference between the non-treated colon and all groups. There were significant differences between GI and GIII-GIV, GII and GIV. The differences between group I and II and group II and III were not statistically significant. When we compared the median amount of the histopathological changes, we found significant difference between the anastomosis and the mesalamine groups (P < 0.05). But when mesalamine groups were compared with each other we did not observe a significant difference. Conclusion: Mesalamine had positive effects which were not statistically significant on bursting pressure and statistically different significant effects on hydroxyproline (HP) levels based on the way of administration and statistically significant positive effects on histopathologic anastomotic healing in experimental anastomosis model
Current Therapeutic Research, 2009
Background: Clinical effects, recovery characteristics, and costs of total intravenous anesthesia... more Background: Clinical effects, recovery characteristics, and costs of total intravenous anesthesia with different inhalational anesthetics have been investigated and compared; however, there are no reported clinical studies focusing on the effects of anesthesia with propofol and desflurane in patients undergoing laparoscopic cholecystectomy. Objective: The aim of this study was to determine the effects of total intravenous anesthesia with propofol and alfentanil compared with those of desflurane and alfentanil on recovery characteristics, postoperative nausea and vomiting (PONV), duration of hospitalization, and gastrointestinal motility. Methods: Patients classified as American Society of Anesthesiologists physical status I or II undergoing elective laparoscopic cholecystectomy due to benign gallbladder disease were enrolled in the study. Patients were randomly assigned at a 1:1 ratio to receive total intravenous anesthesia with propofol (2-2.5 mg/kg) and alfentanil (20 μg/kg) or desflurane (4%-6%) and alfentanil (20 μg/kg). Perioperative management during premedication, intraoperative analgesia, relaxation, ventilation, and postoperative analgesia were carried out identically in the 2 groups. Extubation time, recovery time, PONV, postoperative antiemetic requirement, time to gastrointestinal motility and flatus, duration of hospitalization, and adverse effects were recorded. Postoperative pain was assessed using a visual analogue scale. Conclusion: Total intravenous anesthesia with propofol and alfentanil was associated with a significantly reduced rate of PONV and analgesic consumption, shortened recovery time and duration of hospitalization, accelerated onset of bowel movements, and increased patient satisfaction compared with desflurane and alfentanil in these patients undergoing laparoscopic surgery who completed the study.
bakirkoytip.org
Gebelikte ileusa neden olan sigmoid kolon kanseri: ‹ki olgunun sunumu Gebelikte kolorektal kanser... more Gebelikte ileusa neden olan sigmoid kolon kanseri: ‹ki olgunun sunumu Gebelikte kolorektal kanser çok nadir olup bildirilen insidans %0.001-0.1'dir. Gecikmifl tan› ve hastal›¤›n ilerlemesi nedeni ile prognozu kötüdür. Sigmoid kolon tümörüne ba¤l› akut bat›n geliflmesi çok nadirdir. Gebelik esnas›nda ileus ile kendini gösteren iki sigmoid kolon kanseri olgusunu literatür eflli¤inde sunduk. Biri 35, di¤eri 32 yafl›nda ve s›ras› ile 32 ve 27 haftal›k gebe iki kad›n hasta kar›n a¤r›s› ve ileus tablosu ile baflvurdular. Her ikisinde de eksploratif laparotomide t›kay›c› sigmoid kolon kanseri tespit edildi. Uterus büyüklü¤ü izin vermedi¤i için vakalar›n birinde kolon mezo disseksiyonu genifl olarak yap›lamad›. Ayn› vakada kolon polipoid lezyonlarla dolu idi. Gebelerde sigmoid kolon tümörüne ba¤l› akut bat›n geliflmesi çok nadirdir ve cerrahi esnas›nda eksplorasyon tam olarak yap›lmazsa tümör kolayl›kla atlanabilir. Klinik flüphe tan›y› koymakta çok önemlidir.
Advances in Therapy, 2007
Eukaryotic cells normally differentiate from G 1 ; here we investigate the mechanism preventing e... more Eukaryotic cells normally differentiate from G 1 ; here we investigate the mechanism preventing expression of differentiation-specific genes outside G 1. In fission yeast, induction of the transcription factor Ste11 triggers sexual differentiation. We find that Ste11 is only active in G 1 when Cdk activity is low. In the remaining part of the cell cycle, Ste11 becomes Cdk-phosphorylated at Thr 82 (T82), which inhibits its DNA-binding activity. Since the ste11 gene is autoregulated and the Ste11 protein is highly unstable, this Cdk switch rapidly extinguishes Ste11 activity when cells enter S phase. When we mutated T82 to aspartic acid, mimicking constant phosphorylation, cells no longer underwent differentiation. Conversely, changing T82 to alanine rendered Ste11-controlled transcription constitutive through the cell cycle, and allowed mating from S phase with increased frequency. Thus, Cdk phosphorylation mediates periodic expression of Ste11 and its target genes, and we suggest this to be part of the mechanism restricting differentiation to G 1 .
Breast Care, 2008
Brustkrebs • Diagnose • Früherkennung • Epidemiologie Zusammenfassung Hintergrund: Ziel dieser St... more Brustkrebs • Diagnose • Früherkennung • Epidemiologie Zusammenfassung Hintergrund: Ziel dieser Studie war die Untersuchung des Wissens, der Einstellung und des Verhaltens von Lehrerinnen in der südlichen Türkei in Bezug auf Brustkrebs. Material und Methoden: Fast 5000 Lehrerinnen sind in Hatay, Türkei tätig. Unser Ziel war es, 10% dieser Population zu erreichen. Unser Fragebogen enthielt 14 personenbezogene Fragen, 14 Fragen zum Wissen um Brustkrebs und 14 Fragen zu Einstellung und Verhalten der Lehrerinnen. Ergebnisse: Insgesamt nahmen 490 Lehrerinnen an der Studie teil. Das Durchschnittsalter betrug 34,6 Jahre, und die Mehrzahl der Teilnehmerinnen war verheiratet (77,1%). 62,9% gaben an, über unzureichendes Wissen bezüglich Brustkrebs zu verfügen. Zu den Informationsquellen gehörten Zeitungen/ Fernsehen in 84,6% der Fälle, und das Gesundheitswesen in 22,8%. Obgleich alle Teilnehmerinnen der Meinung sind, dass Brustkrebsfrüherkennung von Bedeutung ist, glauben 19%, dass Körperpflege vor Brustkrebs schützt. 53,7% der Teilnehmerinnen haben noch nie eine Brustselbstuntersuchung durchgeführt. 80,6% derjenigen, die ihre Brust selbst untersuchen, tun dies wann immer sie daran denken, 12,5% untersuchen sich einmal im Monat. 38,4% haben die Selbstuntersuchung von einem Arzt gelernt, 38,0% aus dem Fernsehen. Gründe, keine Selbstuntersuchung durchzuführen, waren Unterschätzung in 46,7% der Fälle und Unwissen in 37,9%. 152 Teilnehmerinnen haben in der Vergangenheit eine klinische Brustuntersuchung durchführen lassen. 145 dieser Untersuchungen wurden von einem Spezialisten durchgeführt. Eine Mammographie war bei insgesamt 86 Teilnehmerinnen vorgenommen worden. 67 Frauen über 40 Jahren haben bisher an keiner Mammographie teilgenommen. Schlussfolgerung: 3/5 Lehrerinnen meinen, über unzureichendes Wissen bezüglich Brustkrebs zu verfügen. Mehr als die Hälfte führen keine Brustselbstuntersuchung durch, und nur 12,5% tun dies regelmäßig.
sagbilderg.mersin.edu.tr
Asian ve ark. Giriç ve Amaç Selenyum (Se) önemli bir antioksidan ve antikarsinojen efkinligi göst... more Asian ve ark. Giriç ve Amaç Selenyum (Se) önemli bir antioksidan ve antikarsinojen efkinligi gösterilmis esansiyel bir elementtir (1,2). Selenoprotein ailesinin bir bileseni olarak Se'un yapisal ve enzimatik görevleri vardir. Enzimatik görevlerinden en iyi bilineni aktif tiroid hormonu ...
Case reports in …, 2009
Cavernous hemangiomas are the most common benign tumors of the liver. They can reach enormous siz... more Cavernous hemangiomas are the most common benign tumors of the liver. They can reach enormous sizes and cause various complications. Kasabach-Merritt syndrome is a rare but serious complication characterized by consumptive coagulopathy caused by the hemangioma; mortality rate ...
bakirkoytip.org
Rectum perforation after anorectal trauma in children: Report of two cases Anorectal injury is a ... more Rectum perforation after anorectal trauma in children: Report of two cases Anorectal injury is a rare clinical condition in children. Since it may be an initial sign of concomitant rectal and other intrapelvic structural injuries, this clinical condition is ...
Advances in Therapy, 2008
Introduction: Propolis is the generic name for the resinous substance collected by honeybees, whi... more Introduction: Propolis is the generic name for the resinous substance collected by honeybees, which is known to have antioxidant, antiinflammatory, apoptosis-inducible effects. Anastomotic dehiscence after colorectal surgery is an important cause of morbidity and mortality. We aimed to assess the effect of propolis on healing in an experimental colon anastomosis in rats. Methods: Forty adult male Wistar albino rats were randomly assigned into 5 treatment groups with 8 rats in each: Group I, anastomosis+no treatment; Group II, anastomosis+oral propolis (600 mg/kg/d); Group III, anastomosis+oral ethyl alcohol (1 cc/d); Group IV, anastomosis+rectal propolis (600 mg/kg/d); Group V, anastomosis+rectal ethyl alcohol (1 cc/d). The bursting pressures, hydroxiproline levels and histopathological changes in each group were measured. Results: When bursting pressures were compared between groups, we observed that they were increased in the groups treated with propolis in contrast to all other groups. Hydroxiproline levels in the propolis groups were also significantly increased in contrast to the other groups. There was also a statistically significant difference in histopathological changes between the treatment types. When propolis administration methods were compared, we did not observe a statistically significant difference. Conclusion: Propolis has a significantly favourable effect on healing in experimental colon anastomosis, independent from the method of administration.
Akademik Acil Tıp Dergisi, 2009
BACKGROUND: Acute mesenteric ischemia (AMI) is a life threatening vascular emergency which requir... more BACKGROUND: Acute mesenteric ischemia (AMI) is a life threatening vascular emergency which requires prompt diagnosis and treatment. The prevention of this cause of high mortality and morbidity depends on early clinical suspicion end timely intervention. In the present study we aimed to analyze the acute mesenteric ischemia cases treated in Mustafa Kemal University Department of General Surgery between January 2004 and December 2008. MATERIAL/ METHODS: The clinic records of all the patients who underwent surgical treatment for AMI between January 1, 2004, and December 2008, were retrospectively reviewed. The data from operative records, postoperative complications, mortality, and hospital stay were recorded. RESULTS: The study group included 18 patients. Mean age was 69. There was comorbidity in all patients and cardiac disease and hypertension were the most common ones. The most common laboratory abnormalities were leukocytes, hypoalbuminemia, hyperamylasemia. There was superiorly vascular necrosis in 16 patients; inferior vascular necrosis in one patient. One patient had non occlusive mesenteric ischemia. Segmentery resection was performed to 13 patients. Abdominoperineal resection was performed to the patient with inferior mesenter artery occlusion. We performed duodenotransversostomy on two patients and only laparotomy on two patients. Re-operation was required in 5 patients. Causes of death were multiorgan insufficiency in 7 cases, cardiac death in 2 cases. One patient died due to short intestine syndrome. CONCLUSION: Acute mesenteric ischemia is highly mortal emergency which should always be suspected in elderly patients with cardiac disease suffering from abdominal pain.
Mikrobiyoloji bülteni, 2008
Fournier's gangrene characterized by fulminant necrotizing fasciitis of the perineal, genital... more Fournier's gangrene characterized by fulminant necrotizing fasciitis of the perineal, genital or perianal regions, is generally caused by aerobic and anareobic bacteria. Although it is thought to be an idiopathic process, Fournier's gangrene has been shown to have a predilection for patients with diabetes, long term alcohol misuse and immunocompromised patients. The focus of infection is usually located in the urinary tract, lower gastrointestinal tract or skin. The development and progression of the gangrene is often fulminating and can rapidly lead to multiple organ failures and death. Here, we present a Fournier's gangrene case caused by Candida albicans. A 59-year-old woman was admitted to hospital with the complaint of swelling on the right thigh following a trauma occurred three weeks ago. Her history revealed that she had been hospitalized previously for four times due to diabetes mellitus, essential thrombocytopenia, chronic disease anemia and hypertension. Right...
Medical Journal of Bakirköy
Rectal prolapse is defined as the protrusion of the rectum from the mucosa of the anal canal. The... more Rectal prolapse is defined as the protrusion of the rectum from the mucosa of the anal canal. The etiology is not well known. There has been a wide spectrum of operations for treatment. Bleeding, perforation, incarceration, ischemia, necrosis and sepsis are rare fatal ...
TAF Preventive Medicine …, 2007
This research was performed in order to determine the knowledge, attitude and behaviours of nurse... more This research was performed in order to determine the knowledge, attitude and behaviours of nursery students about breast cancer. The study was performed between September 2006-November 2006. 100 nursery students of college out of 102 (98, 0% ...
Medical Journal of …
Colorectal cancer during pregnancy is very rare with the reported incidence of between 0.001-0.1%... more Colorectal cancer during pregnancy is very rare with the reported incidence of between 0.001-0.1%. The prognosis is poor due to delayed diagnosis and secondary advanced disease. Acute abdomen due to sigmoid colon tumor is extremely rare. We report two ...
Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, 2009
Ruptured diaphragm as a result of blunt thorax or abdominal trauma can present acutely or late in... more Ruptured diaphragm as a result of blunt thorax or abdominal trauma can present acutely or late in the disease. Symptoms may be nonspecific and diagnosis can easily be missed. Patients may present with dyspnea, chest pain or cough. Chest radiograph, CT scan, and MRI are the primary diagnostic tools. Clinicians must have a high index of suspicion for prompt diagnosis, especially in patients with a history of trauma to the abdomen or thorax. The only treatment in diaphragm rupture is surgery. We report two cases of traumatic diaphragm ruptures presenting years after the trauma.
Bakirkoy Tip Dergisi / Medical Journal of Bakirkoy, 2012
Multislice bilgisayarlı tomografi ile median arkuat ligament sendromu tanısı: Olgu sunumu Median ... more Multislice bilgisayarlı tomografi ile median arkuat ligament sendromu tanısı: Olgu sunumu Median arkuat ligament sendromu, median arkuat ligamentin çöliak arter köküne basısı sonucu oluşur ve kendini genellikle postprandial ağrı ile belli eder. Basıya bağlı, özelikle ekspiryumda daha belirgin darlık oluşur. Darlığa bağlı mezenterik iskemi ve gastro-intestinal sisteme yetersiz kan akımı olması nedeniyle sendroma ait karakteristik klinik bulgular görülür. Biz kliniğimize gelen ve multislice bilgisayarlı tomografi ile tanısı konan hastayı sunuyoruz.
Incarcerated rectal prolapsus causing rectal bleeding and laceration: Case report Rectal prolapse... more Incarcerated rectal prolapsus causing rectal bleeding and laceration: Case report Rectal prolapse is defined as the protrusion of the rectum from the mucosa of the anal canal. The etiology is not well known. There has been a wide spectrum of operations for treatment. Bleeding, perforation, incarceration, ischemia, necrosis and sepsis are rare fatal conditions which may require emergent surgery. In each case type of operation is decided on patients' base individually. We present an irreducible rectal prolapsus which caused perforation while trying to be reduced and thus taken under urgent surgery within the light of the literature. ektal prolapsus rektum duvar›n›n tam kat veya sa- dece mukozas›n›n anal kanaldan sarkmas›d›r. Her yaflta görülmekle birlikte, yetiflkinlerde belirli yafl grup- lar› (50 yafl üstü) ve cinsiyette daha fazla (kad›nlarda %80) görülen; hastal›¤›n derecesine ve kifliye özgü flart- lara göre tedavisi farkl›l›klar gösteren bir hastal›kt›r. Rek- tal prolapsus ...
Journal of International Medical Research, 2009
The objective of this study was to investigate the association between mortality and inflammation... more The objective of this study was to investigate the association between mortality and inflammation in patients who were admitted to the emergency room with gastrointestinal bleeding. Patients (n = 96) managed at two medical centres were included in the study. Initial levels of serum C-reactive protein (CRP), haemoglobin and albumin, and leucocyte and thrombocyte counts for 28 patients who died were compared with those for the 68 patients who survived and were successfully discharged. The data were analysed using the x 2-test. Serum levels of CRP and leucocyte counts were significantly higher, and albumin and haemoglobin were significantly lower in patients who died compared with patients who survived. The increased levels of serum CRP and leucocyte counts, and decreased levels of albumin and haemoglobin were found to be independent risk factors for mortality. It is concluded that increased serum CRP levels and leucocyte counts combined with decreased albumin and haemoglobin levels on admission to the emergency room may be used as predictive factors of mortality in patients with gastrointestinal bleeding.
International Journal of Surgery, 2008
Objective: We aimed to investigate the effect of mesalamine on healing of experimental colon anas... more Objective: We aimed to investigate the effect of mesalamine on healing of experimental colon anastomosis model. Material/Methods: Forty adult male Wistar albino rats were performed segmentary colonic resection and end-to-end anastomosis. Animals were randomly divided into four groups: group I, anastomosis group, received no treatment (GI, n ¼ 8); group II, anastomosis þ oral mesalamine group (100 mg/kg/day); group III, anastomosis þ rectal mesalamine (2 mL) group, (GIII, n ¼ 8); group IV, anastomosis þ oral mesalamine þ rectal mesalamine (GIV, n ¼ 8) group. A sham group (n ¼ 8) was constituted and was performed laparotomy. Bursting pressure, hydroxyproline levels and histopathological characteristics of the anastomosis were analyzed. Results: Although it was not statistically significant, there was an increase in the burst pressure of the mesalamine group. When hydroxyproline measurements were compared there were statistically significant difference between the non-treated colon and all groups. There were significant differences between GI and GIII-GIV, GII and GIV. The differences between group I and II and group II and III were not statistically significant. When we compared the median amount of the histopathological changes, we found significant difference between the anastomosis and the mesalamine groups (P < 0.05). But when mesalamine groups were compared with each other we did not observe a significant difference. Conclusion: Mesalamine had positive effects which were not statistically significant on bursting pressure and statistically different significant effects on hydroxyproline (HP) levels based on the way of administration and statistically significant positive effects on histopathologic anastomotic healing in experimental anastomosis model
Current Therapeutic Research, 2009
Background: Clinical effects, recovery characteristics, and costs of total intravenous anesthesia... more Background: Clinical effects, recovery characteristics, and costs of total intravenous anesthesia with different inhalational anesthetics have been investigated and compared; however, there are no reported clinical studies focusing on the effects of anesthesia with propofol and desflurane in patients undergoing laparoscopic cholecystectomy. Objective: The aim of this study was to determine the effects of total intravenous anesthesia with propofol and alfentanil compared with those of desflurane and alfentanil on recovery characteristics, postoperative nausea and vomiting (PONV), duration of hospitalization, and gastrointestinal motility. Methods: Patients classified as American Society of Anesthesiologists physical status I or II undergoing elective laparoscopic cholecystectomy due to benign gallbladder disease were enrolled in the study. Patients were randomly assigned at a 1:1 ratio to receive total intravenous anesthesia with propofol (2-2.5 mg/kg) and alfentanil (20 μg/kg) or desflurane (4%-6%) and alfentanil (20 μg/kg). Perioperative management during premedication, intraoperative analgesia, relaxation, ventilation, and postoperative analgesia were carried out identically in the 2 groups. Extubation time, recovery time, PONV, postoperative antiemetic requirement, time to gastrointestinal motility and flatus, duration of hospitalization, and adverse effects were recorded. Postoperative pain was assessed using a visual analogue scale. Conclusion: Total intravenous anesthesia with propofol and alfentanil was associated with a significantly reduced rate of PONV and analgesic consumption, shortened recovery time and duration of hospitalization, accelerated onset of bowel movements, and increased patient satisfaction compared with desflurane and alfentanil in these patients undergoing laparoscopic surgery who completed the study.
bakirkoytip.org
Gebelikte ileusa neden olan sigmoid kolon kanseri: ‹ki olgunun sunumu Gebelikte kolorektal kanser... more Gebelikte ileusa neden olan sigmoid kolon kanseri: ‹ki olgunun sunumu Gebelikte kolorektal kanser çok nadir olup bildirilen insidans %0.001-0.1'dir. Gecikmifl tan› ve hastal›¤›n ilerlemesi nedeni ile prognozu kötüdür. Sigmoid kolon tümörüne ba¤l› akut bat›n geliflmesi çok nadirdir. Gebelik esnas›nda ileus ile kendini gösteren iki sigmoid kolon kanseri olgusunu literatür eflli¤inde sunduk. Biri 35, di¤eri 32 yafl›nda ve s›ras› ile 32 ve 27 haftal›k gebe iki kad›n hasta kar›n a¤r›s› ve ileus tablosu ile baflvurdular. Her ikisinde de eksploratif laparotomide t›kay›c› sigmoid kolon kanseri tespit edildi. Uterus büyüklü¤ü izin vermedi¤i için vakalar›n birinde kolon mezo disseksiyonu genifl olarak yap›lamad›. Ayn› vakada kolon polipoid lezyonlarla dolu idi. Gebelerde sigmoid kolon tümörüne ba¤l› akut bat›n geliflmesi çok nadirdir ve cerrahi esnas›nda eksplorasyon tam olarak yap›lmazsa tümör kolayl›kla atlanabilir. Klinik flüphe tan›y› koymakta çok önemlidir.
Advances in Therapy, 2007
Eukaryotic cells normally differentiate from G 1 ; here we investigate the mechanism preventing e... more Eukaryotic cells normally differentiate from G 1 ; here we investigate the mechanism preventing expression of differentiation-specific genes outside G 1. In fission yeast, induction of the transcription factor Ste11 triggers sexual differentiation. We find that Ste11 is only active in G 1 when Cdk activity is low. In the remaining part of the cell cycle, Ste11 becomes Cdk-phosphorylated at Thr 82 (T82), which inhibits its DNA-binding activity. Since the ste11 gene is autoregulated and the Ste11 protein is highly unstable, this Cdk switch rapidly extinguishes Ste11 activity when cells enter S phase. When we mutated T82 to aspartic acid, mimicking constant phosphorylation, cells no longer underwent differentiation. Conversely, changing T82 to alanine rendered Ste11-controlled transcription constitutive through the cell cycle, and allowed mating from S phase with increased frequency. Thus, Cdk phosphorylation mediates periodic expression of Ste11 and its target genes, and we suggest this to be part of the mechanism restricting differentiation to G 1 .
Breast Care, 2008
Brustkrebs • Diagnose • Früherkennung • Epidemiologie Zusammenfassung Hintergrund: Ziel dieser St... more Brustkrebs • Diagnose • Früherkennung • Epidemiologie Zusammenfassung Hintergrund: Ziel dieser Studie war die Untersuchung des Wissens, der Einstellung und des Verhaltens von Lehrerinnen in der südlichen Türkei in Bezug auf Brustkrebs. Material und Methoden: Fast 5000 Lehrerinnen sind in Hatay, Türkei tätig. Unser Ziel war es, 10% dieser Population zu erreichen. Unser Fragebogen enthielt 14 personenbezogene Fragen, 14 Fragen zum Wissen um Brustkrebs und 14 Fragen zu Einstellung und Verhalten der Lehrerinnen. Ergebnisse: Insgesamt nahmen 490 Lehrerinnen an der Studie teil. Das Durchschnittsalter betrug 34,6 Jahre, und die Mehrzahl der Teilnehmerinnen war verheiratet (77,1%). 62,9% gaben an, über unzureichendes Wissen bezüglich Brustkrebs zu verfügen. Zu den Informationsquellen gehörten Zeitungen/ Fernsehen in 84,6% der Fälle, und das Gesundheitswesen in 22,8%. Obgleich alle Teilnehmerinnen der Meinung sind, dass Brustkrebsfrüherkennung von Bedeutung ist, glauben 19%, dass Körperpflege vor Brustkrebs schützt. 53,7% der Teilnehmerinnen haben noch nie eine Brustselbstuntersuchung durchgeführt. 80,6% derjenigen, die ihre Brust selbst untersuchen, tun dies wann immer sie daran denken, 12,5% untersuchen sich einmal im Monat. 38,4% haben die Selbstuntersuchung von einem Arzt gelernt, 38,0% aus dem Fernsehen. Gründe, keine Selbstuntersuchung durchzuführen, waren Unterschätzung in 46,7% der Fälle und Unwissen in 37,9%. 152 Teilnehmerinnen haben in der Vergangenheit eine klinische Brustuntersuchung durchführen lassen. 145 dieser Untersuchungen wurden von einem Spezialisten durchgeführt. Eine Mammographie war bei insgesamt 86 Teilnehmerinnen vorgenommen worden. 67 Frauen über 40 Jahren haben bisher an keiner Mammographie teilgenommen. Schlussfolgerung: 3/5 Lehrerinnen meinen, über unzureichendes Wissen bezüglich Brustkrebs zu verfügen. Mehr als die Hälfte führen keine Brustselbstuntersuchung durch, und nur 12,5% tun dies regelmäßig.
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Asian ve ark. Giriç ve Amaç Selenyum (Se) önemli bir antioksidan ve antikarsinojen efkinligi göst... more Asian ve ark. Giriç ve Amaç Selenyum (Se) önemli bir antioksidan ve antikarsinojen efkinligi gösterilmis esansiyel bir elementtir (1,2). Selenoprotein ailesinin bir bileseni olarak Se'un yapisal ve enzimatik görevleri vardir. Enzimatik görevlerinden en iyi bilineni aktif tiroid hormonu ...
Case reports in …, 2009
Cavernous hemangiomas are the most common benign tumors of the liver. They can reach enormous siz... more Cavernous hemangiomas are the most common benign tumors of the liver. They can reach enormous sizes and cause various complications. Kasabach-Merritt syndrome is a rare but serious complication characterized by consumptive coagulopathy caused by the hemangioma; mortality rate ...
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Rectum perforation after anorectal trauma in children: Report of two cases Anorectal injury is a ... more Rectum perforation after anorectal trauma in children: Report of two cases Anorectal injury is a rare clinical condition in children. Since it may be an initial sign of concomitant rectal and other intrapelvic structural injuries, this clinical condition is ...
Advances in Therapy, 2008
Introduction: Propolis is the generic name for the resinous substance collected by honeybees, whi... more Introduction: Propolis is the generic name for the resinous substance collected by honeybees, which is known to have antioxidant, antiinflammatory, apoptosis-inducible effects. Anastomotic dehiscence after colorectal surgery is an important cause of morbidity and mortality. We aimed to assess the effect of propolis on healing in an experimental colon anastomosis in rats. Methods: Forty adult male Wistar albino rats were randomly assigned into 5 treatment groups with 8 rats in each: Group I, anastomosis+no treatment; Group II, anastomosis+oral propolis (600 mg/kg/d); Group III, anastomosis+oral ethyl alcohol (1 cc/d); Group IV, anastomosis+rectal propolis (600 mg/kg/d); Group V, anastomosis+rectal ethyl alcohol (1 cc/d). The bursting pressures, hydroxiproline levels and histopathological changes in each group were measured. Results: When bursting pressures were compared between groups, we observed that they were increased in the groups treated with propolis in contrast to all other groups. Hydroxiproline levels in the propolis groups were also significantly increased in contrast to the other groups. There was also a statistically significant difference in histopathological changes between the treatment types. When propolis administration methods were compared, we did not observe a statistically significant difference. Conclusion: Propolis has a significantly favourable effect on healing in experimental colon anastomosis, independent from the method of administration.