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Papers by harun iskandar

Research paper thumbnail of Increased Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) value is not related to glomerular filtration rate in healthy non-diabetic young adults

Gazzetta medica italiana. Archivio per le scienze mediche, Jun 1, 2024

Research paper thumbnail of Correlation between HOMA-IR value and urinary albumin excretion rate in nondiabetic young adult subjects

Gazzetta medica italiana. Archivio per le scienze mediche, Jun 1, 2024

Research paper thumbnail of Relationship between fibroblast growth factor 23 level and vitamin D status in chronic kidney disease: A cross-sectional study

Ukraïnsʹkij žurnal nefrologìï ta dìalìzu, Apr 14, 2024

Research paper thumbnail of Praziquantel as the preferred treatment for schistosomiasis

PubMed, 2024

Schistosomiasis, caused by Schistosoma trematode worms, represents a significant global health ch... more Schistosomiasis, caused by Schistosoma trematode worms, represents a significant global health challenge. This review offers a thorough examination of the disease's epidemiology, transmission dynamics, diagnostic modalities, and treatment options. Diagnostic techniques encompass direct parasitological methods, immunological assays, DNA/RNA detection, and biomarker utilization, each with distinct advantages and limitations. There is an urgent need for improved diagnostic tools with enhanced sensitivity and specificity. Praziquantel remains the cornerstone of treatment, exhibiting efficacy against all Schistosoma species, while the potential of artemisin derivatives in combination therapy is also explored. In this review, we focus on the importance of praziquantel administration as the central aspect of schistosomiasis treatment, highlighting ongoing efforts to optimize its utilization for improved patient outcomes.

Research paper thumbnail of The Impact of Diagnosing and Treating Schistosomiasis

Archives of the Balkan Medical Union, Mar 20, 2024

Research paper thumbnail of Karakteristik serta Profil Koagulasi Pasien Covid-19

Umi medical journal/UMI Medical Journal, Dec 29, 2023

Latar belakang: Derajat keparahan Covid-19 dikaitkan dengan koagulasi dan kerusakan endotel yang ... more Latar belakang: Derajat keparahan Covid-19 dikaitkan dengan koagulasi dan kerusakan endotel yang dipicu oleh reaksi inflamasi akibat dari pelepasan sitokin proinflamasi yang berlebihan oleh karena infeksi SARS CoV-2. Metode: Penelitian deskriptif analitik yang dilakukan dengan pendekatan kohor retrospektif dilakukan di Rumah Sakit Umum Pemerintah Wahidin Sudirohusodo Makassar dengan mengumpulkan data rekam medis pasien Covid-19 pada bulan Juni 2020 -Juni 2021 dengan menggunakan total sampling yang memenuhi kriteria inklusi dan eksklusi. Hasil: Pada penelitian ini didapatkan rerata trombosit lebih rendah (265.442) pada kasus berat, sedangkan rerata fibrinogen (405,54) dan D-dimer (9,84) lebih tinggi pada derajat keparahan lebih berat, serta Prothrombin time (PT) lebih panjang (10,92) pada derajat keparahan lebih berat. Kesimpulan: Profil koagulasi penderita Covid-19 didatakan rerata rombosit lebih rendah pada derajat keparahan lebih berat, sedangkan fibrinogen dan D-dimer lebih tinggi serta Prothrombin time (PT) lebih panjang pada derajat keparahan lebih berat.

Research paper thumbnail of Association between Random Glucose Level, HbA1c and COVID-19 Mortality: A Single Center, Cross-Sectional Study

Clinical Diabetology, Oct 21, 2023

This article is available in open access under Creative Common Attribution-Non-Commercial-No Deri... more This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.

Research paper thumbnail of Osimertinib as a Potential Targeted Therapy for Non-Small Cell Lung Carcinoma (NSCLC) Patients with EGFR Exon 20 T790M

The Indonesian Biomedical Journal, Oct 17, 2023

Research paper thumbnail of Concurrent pleural and pericardial effusions in advanced lung adenocarcinoma: a case report

Palliative Medicine in Practice, Apr 30, 2024

This article is available in open access under Creative Common Attribution-Non-Commercial-No Deri... more This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.

Research paper thumbnail of 住宅密集地下における大断面交差部の設計・施工 阪神高速道路高取山工区(北行)トンネル工事 (その2)

Research paper thumbnail of Syndrome of inappropriate antidiuretic hormone secretion approach in lung tuberculosis patient

Gazzetta Medica Italiana Archivio per le Scienze Mediche

Research paper thumbnail of Coagulation factors as potential predictors of COVID-19 patient outcomes

Medical Journal of Indonesia

BACKGROUND Causes of death and length of hospitalization in patients with COVID-19 have been asso... more BACKGROUND Causes of death and length of hospitalization in patients with COVID-19 have been associated with coagulopathy. The coagulopathy mechanism involves the process of coagulation and endothelial damage triggered by an inflammatory response of the SARS-CoV-2 infection due to excessive release of proinflammatory cytokines. This study aimed to determine the association of coagulation factors as potential predictors of COVID-19 patient outcomes. METHODS This retrospective study was performed on 595 patients at Wahidin Sudirohusodo Hospital, Makassar, from June 2020 to June 2021. Participants were recruited using total sampling and assessed for COVID-19 severity using the World Health Organization classification and coagulation factors (D-dimer, fibrinogen, thrombocyte, and prothrombin time [PT]). Patient outcome assessments were survival and length of hospitalization. RESULTS We found a significant sex-based disparity, with a higher COVID-19 incidence in males. Severe cases were ...

Research paper thumbnail of Surfactant Protein A Serum Level in Cement Worker

Jurnal respirologi Indonesia, Sep 29, 2022

Background: Pneumoconiosis occurs almost in entire worldwide. Pneumoconiosis had threatened cemen... more Background: Pneumoconiosis occurs almost in entire worldwide. Pneumoconiosis had threatened cement workers. Serologic abnormalities had found in pneumoconiosis. Surfactant Protein A (SP-A) levels increased in silica-exposed workers. Surfactant Protein A (SP-A) may be a helpful biomarker for the early diagnosis of pneumoconiosis, but it has not yet been studied in Indonesia. Methods: The design of this study was observational with cross-sectional. A sampling of cementexposed workers was done by consecutive sampling. The subjects were 88, approach population of 67 cement exposed workers from September 2017-March 2018 and 17 healthy people as control. The serum level of SPA was measured by the ELISA method. Cement exposed workers is a worker in the production area and workers in the quarry area. Results: The total number of research subjects met the criteria was 67, and the control subjects were 21. The mean serum SPA level in the study subject group or the exposed group was 6.02 ng/ml, and the mean SPA level in the control group was 4.50 ng/ml. The difference in SPA levels between the exposed and control groups was different but not significant, with value of P=0.084. Conclusion: SPA levels in the exposed and control groups were different but not statistically significant.

Research paper thumbnail of Possitivity Rate of Sputum Cytology Compared to Bronchoscopy and Transthoracic Needle Aspiration in Lung Cancer Patients at Wahidin Sudirohusodo Hospital, Indonesia

Journal of Cancer and Tumor International

Introduction: Sputum cytology is the only non-invasive method which can detect early lung maligna... more Introduction: Sputum cytology is the only non-invasive method which can detect early lung malignancies. The principle of it is a finding of cells shed from the lesion, either spontaneously or artificially. Aim: This study purposed to evaluate the positivity rate of sputum cytology compared to bronchoscopy or transthoracic needle aspiration (TTNA) in lung cancer patients. Place and Duration of Study: A prospective cross-sectional study used medical record data using SIRS from 2022 until completed or reached the desired number of samples at Wahidin Sudirohusodo General Hospital, Makassar. Methodology: Patients diagnosed with lung cancers, done a sputum cytology, and bronchoscopy/ TTNA were included. The patients had consented to be included in the study and the study had passed the ethical clearance from Hasanuddin Medical University Ethical Research Committee. Results: Of111 patients with lung cancer, which 46 patients (41,4%) were adenocarcinoma and the other 65 patients (58,6%) wer...

Research paper thumbnail of Fatal Case of Possible Thyroid Crisis Induced by SARS-CoV-2 Infection: A Case Report

Journal of the ASEAN Federation of Endocrine Societies

Thyroid crisis is an emergency due to impaired thyroid function caused by various conditions, par... more Thyroid crisis is an emergency due to impaired thyroid function caused by various conditions, particularly infections such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that result in the dysfunction of various vital organs. We report a case of a 31-year-old Indonesian female with a 2-year history of hyperthyroidism with elevated thyroid-stimulating hormone (TSH) receptor antibodies. (TRAb) who developed thyroid crisis possibly in association with SARS-CoV-2 pneumonia, sepsis, and disseminated intravascular coagulation (DIC). Prior to admission, she was treated for her hyperthyroidism with propylthiouracil and had been in stable remission for a year. She was admitted to the Emergency Room with complaints of watery stools, icteric sclerae, jaundice, coughing, and shortness of breath. The physical examination showed a World Health Organization (WHO) performance score of 4, delirium, blood pressure within normal limits, tachycardia, tachypnea, axillary temperature of 36.7°C, icteric sclerae, jaundice, and exophthalmos. There was a 3 cm palpable nodule on the right side of the neck. Auscultation of the lungs revealed bilateral pulmonary rales. Abdominal examination noted a palpable liver and enlarged spleen. Laboratory tests showed thrombocytopenia, electrolyte imbalance, hypoalbuminemia and elevated transaminases. The thyroid function tests showed a suppressed TSH level with an elevated free thyroxine (FT4) level. The SARS-CoV-2 polymerase chain reaction (PCR) swab test was positive. Initial patient management was with supportive therapy that included favipiravir and anti-hyperthyroidism medication; however, despite these interventions, her condition continued to deteriorate and she died after a few hours. This case demonstrates no difference in therapy between patients with thyroid crises and COVID-19 or other infections. Proper and timely treatment is important for reducing mortality rates.

Research paper thumbnail of Surfactant Protein A Serum Level in Cement Worker

Jurnal Respirologi Indonesia

Background: Pneumoconiosis occurs almost in entire worldwide. Pneumoconiosis had threatened cemen... more Background: Pneumoconiosis occurs almost in entire worldwide. Pneumoconiosis had threatened cement workers. Serologic abnormalities had found in pneumoconiosis. Surfactant Protein A (SP-A) levels increased in silica-exposed workers. Surfactant Protein A (SP-A) may be a helpful biomarker for the early diagnosis of pneumoconiosis, but it has not yet been studied in Indonesia.Methods: The design of this study was observational with cross-sectional. A sampling of cement-exposed workers was done by consecutive sampling. The subjects were 88, approach population of 67 cement exposed workers from September 2017 – March 2018 and 17 healthy people as control. The serum level of SP-A was measured by the ELISA method. Cement exposed workers is a worker in the production area and workers in the quarry area.Results: The total number of research subjects met the criteria was 67, and the control subjects were 21. The mean serum SP-A level in the study subject group or the exposed group was 6.02 ng...

Research paper thumbnail of Effect of age and gender on high - Sensitivity C - Reactive protein levels serum on health worker with latent tuberculosis and healthy control

Indian Journal of Tuberculosis

Research paper thumbnail of Analysis Of Risk Factors For Pulmonary Tuberculosis Incidence In Type-2 Diabetes Mellitus Patients

European Journal of Molecular & Clinical Medicine, Dec 3, 2020

Background:Incidence of pulmonary TB in type-2 diabetes mellitus patients is still high. Gender, ... more Background:Incidence of pulmonary TB in type-2 diabetes mellitus patients is still high. Gender, age, nutritional status, duration of diabetes, blood glucose control, smoking habit, and HbA1c, are among risk factors that influence its occurrence. This study aims to analyze the risk factors that contribute to the incidence of pulmonary TB in type-2 DM patients in Makassar. Methods:A survey analysis study at Wahidin Sudirohusodo Hospital. Hasanuddin University Hospital. and educational network hospital.on December 2019 until the desired sample reached. Sample collection using consecutive sampling. Data analysis using SPSS verse 22. Statistical analysis using pearson's correlation. chi square test. and multiple logistic regression (backward method). Significant result if p value <0.05. Results:Study included 225 type-2 DM patients. From study shows distribution of pulmonary TB in type-2 DM patients is 13.3%. Incidence of pulmonary TB was high in patient with underweight (OR=6.7 and p<0.05), duration of DM>5 years (OR=3.8 and p<0.05), and uncontrolled blood glucose (OR=2.7 and p<0.05). There was no significant correlation between gender (female 19 from 135, male 11 from 90 with p>0.05), age (age >60yo 15 from 92, age ≤60yo 15 from 133 with p>0.05), smoking habit (yes 10 from 84, no 20 from 141 with p>0.05) and HbA1c (A1c <7 was 0 from 7 and A1c ≥7 was 30 from 165 with p>0.05) with pulmonary TB incidence. Discussions:Incidence pulmonary TB in type-2 DM patients according to BMI was significant (p<0.05) because condition of malnutrition can lowering the immune status by decreased the limphocytes production and immune proliferation also decreased of IFNgamma and IL-2 level, and increased of TGF-beta. Incidence according to duration of DM was significant (p<0.05). Incidence according to blood glucose control was significant (p<0.05), DM and uncontrolled blood glucose can lead to an immune compromise condition, some of risk factors that also can contribute to infection disease. Conclusion:There was significant correlation between underweight, duration of DM >5 years, and uncontrolled blood glucose with pulmonary TB incidence.

Research paper thumbnail of Correlation of glomerular filtration rate and fibroblast growth factor-23 levels in chronic kidney disease; sub analysis chronic kidney disease–mineral and bone disorder study

Journal of Nephropharmacology

Introduction: One of the chronic kidney disease (CKD) manifestations is mineral disorder, such as... more Introduction: One of the chronic kidney disease (CKD) manifestations is mineral disorder, such as phosphate and calcium. Phosphatonin levels are regulated by the hormone phosphatonin, which the most commonly associated with CKD is fibroblast growth factor-23 (FGF-23), mainly synthesized by bone cells. The increase in FGF-23 in CKD subjects is a physiological response to stabilize phosphate levels. Several conditions can increase FGF-23 levels including age, body mass index (BMI), diabetes mellitus (DM), and hypertension. Objectives: This study aims to test the correlation between FGF-23 levels at various stages of glomerular filtration rate (GFR) in CKD. Patients and Methods: This study is observational with a cross-sectional approach conducted at Wahidin Sudirohusodo and Unhas hospitals of Makassar. Subjects are CKD patients which meet inclusion criteria. Intact serum FGF-23 levels were measured using an ELISA (enzyme-linked immunosorbent assay) kit (Immutopics). Statistical analys...

Research paper thumbnail of Survival Rate Comparison of Non Small Cell Lung Carcinoma Patients Who Are Given by Epidermal Growth Factor Receptor-Tyrosin Kinase Inhibitor and Those Given by First-Line Chemotherapy Treatment

Nusantara Medical Science Journal, 2022

Introduction. Lung cancer is the type of non-small cell carcinoma (NSCLC) consists of non-squamou... more Introduction. Lung cancer is the type of non-small cell carcinoma (NSCLC) consists of non-squamous and squamous. Non-small cell lung cancer of non squamous types consist of adenocarcinoma and large cell carcinoma. Currently, lung cancer therapy is highly developed of chemotherapeutic agents to targeted therapy especially EGFR-TKI. This study aims to assess the survival rate of NSCLC patients who receive first line chemotherapy and those who recieve EGFR-TKI therapy at Wahidin Sudirohusodo hospital. Methods. This study is a retrospective study between 2017 to 2019 from the medical records of NSCLC patients who receive first-line chemotherapy and thise who recieve EGFR-TKI. Patients with platinum-based chemotherapy and EGFR-TKI with gefitinib therapy 1x250 mg/day or erlotinib 1x150mg/day and or afatinib 1x40 mg/day. Survival rate assessed from start to erect the diagnosis until the patient dies or when the study is discontinued. Result. From 239 subject of NSCLC patients consiste...

Research paper thumbnail of Increased Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) value is not related to glomerular filtration rate in healthy non-diabetic young adults

Gazzetta medica italiana. Archivio per le scienze mediche, Jun 1, 2024

Research paper thumbnail of Correlation between HOMA-IR value and urinary albumin excretion rate in nondiabetic young adult subjects

Gazzetta medica italiana. Archivio per le scienze mediche, Jun 1, 2024

Research paper thumbnail of Relationship between fibroblast growth factor 23 level and vitamin D status in chronic kidney disease: A cross-sectional study

Ukraïnsʹkij žurnal nefrologìï ta dìalìzu, Apr 14, 2024

Research paper thumbnail of Praziquantel as the preferred treatment for schistosomiasis

PubMed, 2024

Schistosomiasis, caused by Schistosoma trematode worms, represents a significant global health ch... more Schistosomiasis, caused by Schistosoma trematode worms, represents a significant global health challenge. This review offers a thorough examination of the disease's epidemiology, transmission dynamics, diagnostic modalities, and treatment options. Diagnostic techniques encompass direct parasitological methods, immunological assays, DNA/RNA detection, and biomarker utilization, each with distinct advantages and limitations. There is an urgent need for improved diagnostic tools with enhanced sensitivity and specificity. Praziquantel remains the cornerstone of treatment, exhibiting efficacy against all Schistosoma species, while the potential of artemisin derivatives in combination therapy is also explored. In this review, we focus on the importance of praziquantel administration as the central aspect of schistosomiasis treatment, highlighting ongoing efforts to optimize its utilization for improved patient outcomes.

Research paper thumbnail of The Impact of Diagnosing and Treating Schistosomiasis

Archives of the Balkan Medical Union, Mar 20, 2024

Research paper thumbnail of Karakteristik serta Profil Koagulasi Pasien Covid-19

Umi medical journal/UMI Medical Journal, Dec 29, 2023

Latar belakang: Derajat keparahan Covid-19 dikaitkan dengan koagulasi dan kerusakan endotel yang ... more Latar belakang: Derajat keparahan Covid-19 dikaitkan dengan koagulasi dan kerusakan endotel yang dipicu oleh reaksi inflamasi akibat dari pelepasan sitokin proinflamasi yang berlebihan oleh karena infeksi SARS CoV-2. Metode: Penelitian deskriptif analitik yang dilakukan dengan pendekatan kohor retrospektif dilakukan di Rumah Sakit Umum Pemerintah Wahidin Sudirohusodo Makassar dengan mengumpulkan data rekam medis pasien Covid-19 pada bulan Juni 2020 -Juni 2021 dengan menggunakan total sampling yang memenuhi kriteria inklusi dan eksklusi. Hasil: Pada penelitian ini didapatkan rerata trombosit lebih rendah (265.442) pada kasus berat, sedangkan rerata fibrinogen (405,54) dan D-dimer (9,84) lebih tinggi pada derajat keparahan lebih berat, serta Prothrombin time (PT) lebih panjang (10,92) pada derajat keparahan lebih berat. Kesimpulan: Profil koagulasi penderita Covid-19 didatakan rerata rombosit lebih rendah pada derajat keparahan lebih berat, sedangkan fibrinogen dan D-dimer lebih tinggi serta Prothrombin time (PT) lebih panjang pada derajat keparahan lebih berat.

Research paper thumbnail of Association between Random Glucose Level, HbA1c and COVID-19 Mortality: A Single Center, Cross-Sectional Study

Clinical Diabetology, Oct 21, 2023

This article is available in open access under Creative Common Attribution-Non-Commercial-No Deri... more This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.

Research paper thumbnail of Osimertinib as a Potential Targeted Therapy for Non-Small Cell Lung Carcinoma (NSCLC) Patients with EGFR Exon 20 T790M

The Indonesian Biomedical Journal, Oct 17, 2023

Research paper thumbnail of Concurrent pleural and pericardial effusions in advanced lung adenocarcinoma: a case report

Palliative Medicine in Practice, Apr 30, 2024

This article is available in open access under Creative Common Attribution-Non-Commercial-No Deri... more This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.

Research paper thumbnail of 住宅密集地下における大断面交差部の設計・施工 阪神高速道路高取山工区(北行)トンネル工事 (その2)

Research paper thumbnail of Syndrome of inappropriate antidiuretic hormone secretion approach in lung tuberculosis patient

Gazzetta Medica Italiana Archivio per le Scienze Mediche

Research paper thumbnail of Coagulation factors as potential predictors of COVID-19 patient outcomes

Medical Journal of Indonesia

BACKGROUND Causes of death and length of hospitalization in patients with COVID-19 have been asso... more BACKGROUND Causes of death and length of hospitalization in patients with COVID-19 have been associated with coagulopathy. The coagulopathy mechanism involves the process of coagulation and endothelial damage triggered by an inflammatory response of the SARS-CoV-2 infection due to excessive release of proinflammatory cytokines. This study aimed to determine the association of coagulation factors as potential predictors of COVID-19 patient outcomes. METHODS This retrospective study was performed on 595 patients at Wahidin Sudirohusodo Hospital, Makassar, from June 2020 to June 2021. Participants were recruited using total sampling and assessed for COVID-19 severity using the World Health Organization classification and coagulation factors (D-dimer, fibrinogen, thrombocyte, and prothrombin time [PT]). Patient outcome assessments were survival and length of hospitalization. RESULTS We found a significant sex-based disparity, with a higher COVID-19 incidence in males. Severe cases were ...

Research paper thumbnail of Surfactant Protein A Serum Level in Cement Worker

Jurnal respirologi Indonesia, Sep 29, 2022

Background: Pneumoconiosis occurs almost in entire worldwide. Pneumoconiosis had threatened cemen... more Background: Pneumoconiosis occurs almost in entire worldwide. Pneumoconiosis had threatened cement workers. Serologic abnormalities had found in pneumoconiosis. Surfactant Protein A (SP-A) levels increased in silica-exposed workers. Surfactant Protein A (SP-A) may be a helpful biomarker for the early diagnosis of pneumoconiosis, but it has not yet been studied in Indonesia. Methods: The design of this study was observational with cross-sectional. A sampling of cementexposed workers was done by consecutive sampling. The subjects were 88, approach population of 67 cement exposed workers from September 2017-March 2018 and 17 healthy people as control. The serum level of SPA was measured by the ELISA method. Cement exposed workers is a worker in the production area and workers in the quarry area. Results: The total number of research subjects met the criteria was 67, and the control subjects were 21. The mean serum SPA level in the study subject group or the exposed group was 6.02 ng/ml, and the mean SPA level in the control group was 4.50 ng/ml. The difference in SPA levels between the exposed and control groups was different but not significant, with value of P=0.084. Conclusion: SPA levels in the exposed and control groups were different but not statistically significant.

Research paper thumbnail of Possitivity Rate of Sputum Cytology Compared to Bronchoscopy and Transthoracic Needle Aspiration in Lung Cancer Patients at Wahidin Sudirohusodo Hospital, Indonesia

Journal of Cancer and Tumor International

Introduction: Sputum cytology is the only non-invasive method which can detect early lung maligna... more Introduction: Sputum cytology is the only non-invasive method which can detect early lung malignancies. The principle of it is a finding of cells shed from the lesion, either spontaneously or artificially. Aim: This study purposed to evaluate the positivity rate of sputum cytology compared to bronchoscopy or transthoracic needle aspiration (TTNA) in lung cancer patients. Place and Duration of Study: A prospective cross-sectional study used medical record data using SIRS from 2022 until completed or reached the desired number of samples at Wahidin Sudirohusodo General Hospital, Makassar. Methodology: Patients diagnosed with lung cancers, done a sputum cytology, and bronchoscopy/ TTNA were included. The patients had consented to be included in the study and the study had passed the ethical clearance from Hasanuddin Medical University Ethical Research Committee. Results: Of111 patients with lung cancer, which 46 patients (41,4%) were adenocarcinoma and the other 65 patients (58,6%) wer...

Research paper thumbnail of Fatal Case of Possible Thyroid Crisis Induced by SARS-CoV-2 Infection: A Case Report

Journal of the ASEAN Federation of Endocrine Societies

Thyroid crisis is an emergency due to impaired thyroid function caused by various conditions, par... more Thyroid crisis is an emergency due to impaired thyroid function caused by various conditions, particularly infections such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that result in the dysfunction of various vital organs. We report a case of a 31-year-old Indonesian female with a 2-year history of hyperthyroidism with elevated thyroid-stimulating hormone (TSH) receptor antibodies. (TRAb) who developed thyroid crisis possibly in association with SARS-CoV-2 pneumonia, sepsis, and disseminated intravascular coagulation (DIC). Prior to admission, she was treated for her hyperthyroidism with propylthiouracil and had been in stable remission for a year. She was admitted to the Emergency Room with complaints of watery stools, icteric sclerae, jaundice, coughing, and shortness of breath. The physical examination showed a World Health Organization (WHO) performance score of 4, delirium, blood pressure within normal limits, tachycardia, tachypnea, axillary temperature of 36.7°C, icteric sclerae, jaundice, and exophthalmos. There was a 3 cm palpable nodule on the right side of the neck. Auscultation of the lungs revealed bilateral pulmonary rales. Abdominal examination noted a palpable liver and enlarged spleen. Laboratory tests showed thrombocytopenia, electrolyte imbalance, hypoalbuminemia and elevated transaminases. The thyroid function tests showed a suppressed TSH level with an elevated free thyroxine (FT4) level. The SARS-CoV-2 polymerase chain reaction (PCR) swab test was positive. Initial patient management was with supportive therapy that included favipiravir and anti-hyperthyroidism medication; however, despite these interventions, her condition continued to deteriorate and she died after a few hours. This case demonstrates no difference in therapy between patients with thyroid crises and COVID-19 or other infections. Proper and timely treatment is important for reducing mortality rates.

Research paper thumbnail of Surfactant Protein A Serum Level in Cement Worker

Jurnal Respirologi Indonesia

Background: Pneumoconiosis occurs almost in entire worldwide. Pneumoconiosis had threatened cemen... more Background: Pneumoconiosis occurs almost in entire worldwide. Pneumoconiosis had threatened cement workers. Serologic abnormalities had found in pneumoconiosis. Surfactant Protein A (SP-A) levels increased in silica-exposed workers. Surfactant Protein A (SP-A) may be a helpful biomarker for the early diagnosis of pneumoconiosis, but it has not yet been studied in Indonesia.Methods: The design of this study was observational with cross-sectional. A sampling of cement-exposed workers was done by consecutive sampling. The subjects were 88, approach population of 67 cement exposed workers from September 2017 – March 2018 and 17 healthy people as control. The serum level of SP-A was measured by the ELISA method. Cement exposed workers is a worker in the production area and workers in the quarry area.Results: The total number of research subjects met the criteria was 67, and the control subjects were 21. The mean serum SP-A level in the study subject group or the exposed group was 6.02 ng...

Research paper thumbnail of Effect of age and gender on high - Sensitivity C - Reactive protein levels serum on health worker with latent tuberculosis and healthy control

Indian Journal of Tuberculosis

Research paper thumbnail of Analysis Of Risk Factors For Pulmonary Tuberculosis Incidence In Type-2 Diabetes Mellitus Patients

European Journal of Molecular & Clinical Medicine, Dec 3, 2020

Background:Incidence of pulmonary TB in type-2 diabetes mellitus patients is still high. Gender, ... more Background:Incidence of pulmonary TB in type-2 diabetes mellitus patients is still high. Gender, age, nutritional status, duration of diabetes, blood glucose control, smoking habit, and HbA1c, are among risk factors that influence its occurrence. This study aims to analyze the risk factors that contribute to the incidence of pulmonary TB in type-2 DM patients in Makassar. Methods:A survey analysis study at Wahidin Sudirohusodo Hospital. Hasanuddin University Hospital. and educational network hospital.on December 2019 until the desired sample reached. Sample collection using consecutive sampling. Data analysis using SPSS verse 22. Statistical analysis using pearson's correlation. chi square test. and multiple logistic regression (backward method). Significant result if p value <0.05. Results:Study included 225 type-2 DM patients. From study shows distribution of pulmonary TB in type-2 DM patients is 13.3%. Incidence of pulmonary TB was high in patient with underweight (OR=6.7 and p<0.05), duration of DM>5 years (OR=3.8 and p<0.05), and uncontrolled blood glucose (OR=2.7 and p<0.05). There was no significant correlation between gender (female 19 from 135, male 11 from 90 with p>0.05), age (age >60yo 15 from 92, age ≤60yo 15 from 133 with p>0.05), smoking habit (yes 10 from 84, no 20 from 141 with p>0.05) and HbA1c (A1c <7 was 0 from 7 and A1c ≥7 was 30 from 165 with p>0.05) with pulmonary TB incidence. Discussions:Incidence pulmonary TB in type-2 DM patients according to BMI was significant (p<0.05) because condition of malnutrition can lowering the immune status by decreased the limphocytes production and immune proliferation also decreased of IFNgamma and IL-2 level, and increased of TGF-beta. Incidence according to duration of DM was significant (p<0.05). Incidence according to blood glucose control was significant (p<0.05), DM and uncontrolled blood glucose can lead to an immune compromise condition, some of risk factors that also can contribute to infection disease. Conclusion:There was significant correlation between underweight, duration of DM >5 years, and uncontrolled blood glucose with pulmonary TB incidence.

Research paper thumbnail of Correlation of glomerular filtration rate and fibroblast growth factor-23 levels in chronic kidney disease; sub analysis chronic kidney disease–mineral and bone disorder study

Journal of Nephropharmacology

Introduction: One of the chronic kidney disease (CKD) manifestations is mineral disorder, such as... more Introduction: One of the chronic kidney disease (CKD) manifestations is mineral disorder, such as phosphate and calcium. Phosphatonin levels are regulated by the hormone phosphatonin, which the most commonly associated with CKD is fibroblast growth factor-23 (FGF-23), mainly synthesized by bone cells. The increase in FGF-23 in CKD subjects is a physiological response to stabilize phosphate levels. Several conditions can increase FGF-23 levels including age, body mass index (BMI), diabetes mellitus (DM), and hypertension. Objectives: This study aims to test the correlation between FGF-23 levels at various stages of glomerular filtration rate (GFR) in CKD. Patients and Methods: This study is observational with a cross-sectional approach conducted at Wahidin Sudirohusodo and Unhas hospitals of Makassar. Subjects are CKD patients which meet inclusion criteria. Intact serum FGF-23 levels were measured using an ELISA (enzyme-linked immunosorbent assay) kit (Immutopics). Statistical analys...

Research paper thumbnail of Survival Rate Comparison of Non Small Cell Lung Carcinoma Patients Who Are Given by Epidermal Growth Factor Receptor-Tyrosin Kinase Inhibitor and Those Given by First-Line Chemotherapy Treatment

Nusantara Medical Science Journal, 2022

Introduction. Lung cancer is the type of non-small cell carcinoma (NSCLC) consists of non-squamou... more Introduction. Lung cancer is the type of non-small cell carcinoma (NSCLC) consists of non-squamous and squamous. Non-small cell lung cancer of non squamous types consist of adenocarcinoma and large cell carcinoma. Currently, lung cancer therapy is highly developed of chemotherapeutic agents to targeted therapy especially EGFR-TKI. This study aims to assess the survival rate of NSCLC patients who receive first line chemotherapy and those who recieve EGFR-TKI therapy at Wahidin Sudirohusodo hospital. Methods. This study is a retrospective study between 2017 to 2019 from the medical records of NSCLC patients who receive first-line chemotherapy and thise who recieve EGFR-TKI. Patients with platinum-based chemotherapy and EGFR-TKI with gefitinib therapy 1x250 mg/day or erlotinib 1x150mg/day and or afatinib 1x40 mg/day. Survival rate assessed from start to erect the diagnosis until the patient dies or when the study is discontinued. Result. From 239 subject of NSCLC patients consiste...