The Signaling Adapter FRS-2 Competes with Shc for Binding to the Nerve Growth Factor Receptor TrkA (original) (raw)
Overexpression of the signaling adapter FRS2 reconstitutes the cell cycle deficit of a nerve growth factor non-responsive TrkA receptor mutant
Susan Meakin
Journal of Neurochemistry, 2002
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Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase.
David Loeb
Oncogene, 1998
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Trk receptor binding and neurotrophin/fibroblast growth factor (FGF)-dependent activation of the FGF receptor substrate (FRS)-3
Susan Meakin
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2006
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The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3
Shuqian Jing
Cell, 1991
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Nerve Growth Factor Stimulates Multisite Tyrosine Phosphorylation and Activation of the Atypical Protein Kinase C's via a src Kinase Pathway
Thangiah Geetha
Molecular and Cellular Biology, 2001
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FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors
Siew Hwa Ong
Molecular and cellular biology, 2000
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Brain-derived Neurotrophic Factor Induces Phosphorylation of Fibroblast Growth Factor Receptor Substrate 2
David Middlemas
Journal of Biological Chemistry, 1999
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Direct interaction of nerve growth factor receptor, TrkA, with non‐receptor tyrosine kinase, c‐Abl, through the activation loop
Monica Ștefan
FEBS Letters, 2000
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Direct Binding of the Signaling Adapter Protein Grb2 to the Activation Loop Tyrosines on the Nerve Growth Factor Receptor Tyrosine Kinase, TrkA
Susan Meakin, Ela Gryz
Journal of Biological Chemistry, 2000
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TrkA Tyrosine Residues Involved in NGF-induced Neurite Outgrowth of PC12 Cells
Dan Lindholm
European Journal of Neuroscience, 1995
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The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3
Shuqian Jing
Cell, 1991
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A Kinase Insert Isoform of Rat TrkA Supports Nerve Growth Factor-Dependent Cell Survival but Not Neurite Outgrowth
Ela Gryz
Journal of Neurochemistry, 2002
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Neurotrophin-dependent tyrosine phosphorylation of RasGrf1 and associated neurite outgrowth is dependent on the HIKE domain of TrkA
Rachel Buchsbaum
Journal of Biological Chemistry, 2004
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Autocrine regulation of nerve growth factor expression by Trk receptors
Alessandra Mallei
Journal of Neurochemistry, 2004
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A branched signaling pathway for nerve growth factor is revealed by Src-, Ras-, and Raf-mediated gene inductions
G. D'Arcangelo
Molecular and cellular biology, 1993
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P2Y2 and TrkA receptors interact with Src family kinase for neuronal differentiation
Katerina Akassoglou
Biochemical and Biophysical Research Communications, 2006
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Molecular dissection of TrkA signal transduction pathways mediating differentiation in human neuroblastoma cells
Garrett Brodeur
Oncogene, 2000
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Fibroblast Growth Factor Receptors Participate in the Control of Mitogen-activated Protein Kinase Activity during Nerve Growth Factor-induced Neuronal Differentiation of PC12 Cells
Andreas Bikfalvi
Journal of Biological Chemistry, 1999
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Nucleocytoplasmic Shuttling of the Adapter Protein SH2B1β (SH2-Bβ) Is Required for Nerve Growth Factor (NGF)-Dependent Neurite Outgrowth and Enhancement of Expression of a Subset of NGF-Responsive Genes
Lingyun Chen
Molecular Endocrinology, 2009
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Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling
Louis Reichardt
The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996
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ShcB and ShcC Activation by the Trk Family of Receptor Tyrosine Kinases
Susan Meakin
Journal of Biological Chemistry, 2002
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Neurotrophin-dependent Tyrosine Phosphorylation of Ras Guanine-releasing Factor 1 and Associated Neurite Outgrowth Is Dependent on the HIKE Domain of TrkA
Susan Meakin
Journal of Biological Chemistry, 2004
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High Resolution Mapping of the Binding Site of TrkA for Nerve Growth Factor and TrkC for Neurotrophin-3 on the Second Immunoglobulin-like Domain of the Trk Receptors
Pantelis Tsoulfas
Journal of Biological Chemistry, 1998
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Identification of a Switch in Neurotrophin Signaling by Selective Tyrosine Phosphorylation
Daniela - Pereira
Journal of Biological Chemistry, 2006
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A novel inducible tyrosine kinase receptor to regulate signal transduction and neurite outgrowth
Armin Blesch
Journal of Neuroscience Research, 2009
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Acidic substitution of the activation loop tyrosines in TrkA supports nerve growth factor-independent cell survival and neuronal differentiation
Susan Meakin, Ela Gryz
Oncogene, 2000
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SH2-B, a Membrane-associated Adapter, Is Phosphorylated on Multiple Serines/Threonines in Response to Nerve Growth Factor by Kinases within the MEK/ERK Cascade
Christin Carter-su
Journal of Biological Chemistry, 1999
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Phosphorylation of Serine 779 in Fibroblast Growth Factor Receptor 1 and 2 by Protein Kinase C Regulates Ras/Mitogen-activated Protein Kinase Signaling and Neuronal Differentiation
ah yang kong
Journal of Biological Chemistry, 2013
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TrkC Isoforms with Inserts in the Kinase Domain Show Impaired Signaling Responses
Pantelis Tsoulfas
Journal of Biological Chemistry, 1996
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δ-Protein Kinase C Phosphorylation Parallels Inhibition of Nerve Growth Factor– Induced Differentiation Independent of Changes in Trk A and MAP Kinase Signalling in PC12 Cells
jari heikkila
Cellular Signalling, 1998
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Mapping of Atypical Protein Kinase C within the Nerve Growth Factor Signaling Cascade: Relationship to Differentiation and Survival of PC12 Cells
Lamar Seibenhener
Molecular and Cellular Biology, 2000
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Two Restricted Sites on the Surface of the Nerve Growth Factor Molecule Independently Determine Specific TrkA Receptor Binding and Activation
Ted Ebendal
Journal of Biological Chemistry, 1997
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Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of src and ras actions
G. D'Arcangelo
The Journal of Cell Biology, 1991
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