Variations in aggrecan structure modulate its susceptibility to aggrecanases (original) (raw)

The structure of aggrecan fragments in human synovial fluid. evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis

John Sandy

Arthritis & Rheumatism, 1993

Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro

Biochemical Journal, 1999

Aggrecanase" activity is implicated in tumour necrosis factor alpha mediated cartilage aggrecan breakdown but is not detected by an in vitro assay

David Buttle

Molecular Pathology, 1997

The cleavage of biglycan by aggrecanases

Osteoarthritis and Cartilage, 2006

Chemical and Immunological Assay of the Nonreducing Terminal Residues of Chondroitin Sulfate from Human Aggrecan

Anna Plaas, Peter Roughley, Ronald Midura

Journal of Biological Chemistry, 1997

Generation and novel distribution of matrix metalloproteinase-derived aggrecan fragments in porcine cartilage explants

2000

The mechanism of aggrecan release from cartilage differs with tissue origin and the agent used to stimulate catabolism

John Mort

Biochemical Journal, 2002

Coincubation of Bovine Synovial or Capsular Tissue with Cartilage Generates a Soluble “Aggrecanase” Activity

David Buttle

Biochemical and Biophysical Research Communications, 1999

Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments1

André Struglics

Osteoarthritis and Cartilage, 2006

The role of aggrecan in normal and osteoarthritic cartilage

John Mort

Journal of Experimental Orthopaedics, 2014

Demitrios Vynios

The Biochemical journal, 1996

Aggrecanase: A Target for the Design of Inhibitors of Cartilage Degradation

Robert Newton

Annals of the New York Academy of Sciences, 1999

Characterization of an ADAMTS-5-mediated cleavage site in aggrecan in OSM-stimulated bovine cartilage

Osteoarthritis and Cartilage, 2008

Aggrecan Turnover in Human Articular Cartilage: Use of Aspartic Acid Racemization as a Marker of Molecular Age

Nathali Kaushansky

A comparison of different purification methods of aggrecan fragments from human articular cartilage and synovial fluid

André Struglics

Matrix Biology, 2010

Cleavage of the Carboxyl Tail from the G3 Domain of Aggrecan but Not Versican and Identification of the Amino Acids Involved in the Degradation

Burton Yang

Journal of Biological Chemistry, 2002

The High Molecular Weight Cat-301 Chondroitin Sulfate Proteoglycan from Brain Is Related to the Large Aggregating Proteoglycan from Cartilage, Aggrecan

Larry Molinaro

Degradation of cartilage aggrecan by collagenase-3 (MMP-13)

FEBS Letters, 1996

Effects of transforming growth factor-β on aggrecanase production and proteoglycan degradation by human chondrocytes in vitro

Philippe Pastoureau

Osteoarthritis and Cartilage, 2004

Recombinant Human Aggrecan G1-G2 Exhibits Native Binding Properties and Substrate Specificity for Matrix Metalloproteinases and Aggrecanase

Journal of Biological Chemistry, 1999

Molecular cloning and analysis of the protein modules of aggrecans

William Upholt

Experientia, 1993

Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain

Biochemical Journal, 1993

Soluble Recombinant Neprilysin Induces Aggrecanase-Mediated Cleavage of Aggrecan in Cartilage Explant Cultures

Caroline Hoemann

Archives of Biochemistry and Biophysics, 2001

Structure determination for octasaccharides derived from the carbohydrate-protein linkage region of chondroitin sulphate chains in the proteoglycan aggrecan from bovine articular cartilage

Thomas N Huckerby, Robert Lauder

European journal of biochemistry / FEBS, 1998

Metalloproteinase digestion of cartilage proteoglycan. Pattern of cleavage by stromelysin and susceptibility to collagenase

Tim Hardingham

1991

Proteoglycan aggregates in adult human costal cartilage

jeffrey Pearson

Biochimica et Biophysica Acta (BBA) - General Subjects, 1979

A radioassay for proteolytic cleavage of isolated cartilage proteoglycan

Ross Stephens

Analytical Biochemistry, 1978

Influence of aging on the synthesis and morphology of the aggrecans synthesized by differentiated human articular chondrocytes

G. Verbruggen

Osteoarthritis and Cartilage, 2000

Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage

European cells & materials

ELISA for the core protein of the cartilage large aggregating proteoglycan, aggrecan: Comparison with the concentrations of immunogenic keratan sulphate in synovial fluid, serum and urine

Jens-christian Poulsen

Clinica Chimica Acta, 1994

Collagenases and aggrecanases: understanding the role of non-catalytic domains in cartilage matrix breakdown

Corinne Gendron

Arthritis Research Therapy, 2005

Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan

Tim Hardingham

The Biochemical journal, 1994

The Glycosaminoglycan Attachment Regions of Human Aggrecan

Elida Rodriguez

Journal of Biological Chemistry, 2006

Coculture of bovine cartilage with synovium and fibrous joint capsule increases aggrecanase and matrix metalloproteinase activity

André Struglics

Arthritis research & therapy, 2017