The Proximal Tyrosines of the Cytoplasmic Domain of the beta Chain of the Type I Interferon Receptor Are Essential for Signal Transducer and Activator of Transcription (Stat) 2 Activation. EVIDENCE THAT TWO Stat2 SITES ARE REQUIRED TO REACH A THRESHOLD OF INTERFERON alpha -INDUCED Stat2 TYROSINE ... (original) (raw)

The Proximal Tyrosines of the Cytoplasmic Domain of the β Chain of the Type I Interferon Receptor Are Essential for Signal Transducer and Activator of Transcription (Stat) 2 Activation

Regina Raz

Journal of Biological Chemistry, 1999

View PDFchevron_right

STAT2 Binding to the Interferon-α Receptor 2 Subunit is Not Required for Interferon-α Signaling

Abu Saleh

Journal of Biological …, 2002

View PDFchevron_right

Stat2 Binding to the Interferon-alpha Receptor 2 Subunit Is Not Required for Interferon-alpha Signaling

abu saleh

Journal of Biological Chemistry, 2002

View PDFchevron_right

The Stat1 Binding Motif of the Interferon-gamma Receptor Is Sufficient to Mediate Stat5 Activation and Its Repression by SOCS3

Thomas Decker

Journal of Biological Chemistry, 2001

View PDFchevron_right

Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes

B. Witthuhn

The EMBO journal, 1994

View PDFchevron_right

Activation of STAT transcription factors in oncogenic tyrosine kinase signaling

Roy Garcia

Journal of Biomedical Science, 1998

View PDFchevron_right

Affinity of Stat2 for the Subunits of the Interferon Alpha Receptor

Abu Saleh

Biochemistry, 2002

View PDFchevron_right

Identification of STAT2 Serine 287 as a Novel Regulatory Phosphorylation Site in Type I Interferon-induced Cellular Responses

Ana Gamero, C. Barrero

Journal of Biological Chemistry, 2013

View PDFchevron_right

Cytokine receptor signal transduction through Jak tyrosine kinases and Stat transcription factors

Olli Silvennoinen

APMIS, 1997

View PDFchevron_right

Interferons up-regulate STAT1, STAT2, and IRF family transcription factor gene expression in human peripheral blood mononuclear cells and macrophages

Ilkka Julkunen

Journal of Immunology, 1997

View PDFchevron_right

Interferon-α activates signal transducers and activators of transcription 5 and 6 in Daudi cells

Elizaveta Fasler-kan

1998

View PDFchevron_right

Interferon-alpha activates signal transducers and activators of transcription 5 and 6 in Daudi cells

Elizaveta Fasler-kan

European Journal of Biochemistry, 1998

View PDFchevron_right

An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT

Masahiko Hibi

Oncogene, 1997

View PDFchevron_right

The WD Motif-containing Protein Receptor for Activated Protein Kinase C (RACK1) Is Required for Recruitment and Activation of Signal Transducer and Activator of Transcription 1 through the Type I Interferon Receptor

Gleb Baida

Journal of Biological Chemistry, 2001

View PDFchevron_right

JAK-STAT Signaling: From Interferons to Cytokines

David Levy

Journal of Biological Chemistry, 2007

View PDFchevron_right

Jak-STAT pathway is involved in the induction ofTNF-β gene during stimulation by IL-2

J. Theze

European Journal of Immunology, 1998

View PDFchevron_right

JAKs, STATs and signal transduction in response to the interferons and other cytokines

Dmitry Y Guschin

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1996

View PDFchevron_right

Canonical and Non-Canonical Aspects of JAK-STAT Signaling: Lessons from Interferons for Cytokine Responses

Thomas Decker

Frontiers in immunology, 2017

View PDFchevron_right

Phosphorylation of the Stat1 transactivating domain is required for the response to type I interferons

Thomas Decker

EMBO reports, 2003

View PDFchevron_right

Dominant Negative Stat3 Mutant Inhibits Interleukin-6-induced Jak-STAT Signal Transduction

Allard Kaptein

Journal of Biological Chemistry, 1996

View PDFchevron_right

Definition of the Interferon-α Receptor-binding Domain on the TYK2 Kinase

Flavia Piazza

Journal of Biological Chemistry, 1998

View PDFchevron_right

Specific Contribution of Tyk2 JH Regions to the Binding and the Expression of the Interferon alpha /beta Receptor Component IFNAR1

Marc Richter

Journal of Biological Chemistry, 1998

View PDFchevron_right

Activation of the Jak-Stat Pathway in Cells That Exhibit Selective Sensitivity to the Antiviral Effects of IFN-beta Compared with IFN-alpha

I. Grumbach

Journal of Interferon & Cytokine Research, 1999

View PDFchevron_right

Palmitoylation of Interferon-(IFN-) Receptor Subunit IFNAR1 Is Required for the Activation of Stat1 and Stat2 by IFN

Pierre Eid

View PDFchevron_right

Protein Kinase C-delta (PKC-delta ) Is Activated by Type I Interferons and Mediates Phosphorylation of Stat1 on Serine 727

Arshad Rahman

Journal of Biological Chemistry, 2002

View PDFchevron_right

Cutting Edge: Selective Tyrosine Dephosphorylation of Interferon-Activated Nuclear STAT5 by the VHR Phosphatase

T. Mustelin

The Journal of Immunology, 2007

View PDFchevron_right

Phosphorylation of the Stat1 Transactivation Domain Is Required for Full-Fledged IFN-γ-Dependent Innate Immunity

Thomas Decker

Immunity, 2003

View PDFchevron_right

Differential tyrosine phosphorylation of the IFNAR chain of the type I interferon receptor and of an associated surface protein in response to IFN-alpha and IFN-beta

Lester Shulman

The EMBO Journal

View PDFchevron_right

Activation of a CrkL-Stat5 Signaling Complex by Type I Interferons

Shahab Uddin

Journal of Biological Chemistry, 1999

View PDFchevron_right

I B kinase (IKK ) regulates the balance between type I and type II interferon responses

Sonja Schmid

Proceedings of the National Academy of Sciences, 2011

View PDFchevron_right

Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-γ, but not IFN-α, signaling

Mitsuharu Sato

Embo Journal, 1999

View PDFchevron_right

Palmitoylation of Interferon-α (IFN-α) Receptor Subunit IFNAR1 Is Required for the Activation of Stat1 and Stat2 by IFN-α

Pierre Eid

Journal of Biological Chemistry, 2009

View PDFchevron_right