Phosphorylation of the Stat1 Transactivation Domain Is Required for Full-Fledged IFN-γ-Dependent Innate Immunity (original) (raw)
Canonical and Non-Canonical Aspects of JAK-STAT Signaling: Lessons from Interferons for Cytokine Responses
Thomas Decker
Frontiers in immunology, 2017
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An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT
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Oncogene, 1997
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Cytokine receptor signal transduction through Jak tyrosine kinases and Stat transcription factors
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Sensitization of IFN-γ Jak-STAT signaling during macrophage activation
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Journal of Biological Chemistry, 2007
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Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway
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Cell, 1996
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JAKs, STATs and signal transduction in response to the interferons and other cytokines
Dmitry Y Guschin
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1996
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PKCε is a permissive link in integrin-dependent IFN-γ signalling that facilitates JAK phosphorylation of STAT1
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Dominant Negative Stat3 Mutant Inhibits Interleukin-6-induced Jak-STAT Signal Transduction
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Jak-STAT pathway is involved in the induction ofTNF-β gene during stimulation by IL-2
J. Theze
European Journal of Immunology, 1998
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Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-γ, but not IFN-α, signaling
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Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes
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STAT2 Binding to the Interferon-α Receptor 2 Subunit is Not Required for Interferon-α Signaling
Abu Saleh
Journal of Biological …, 2002
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Tuning' of type I interferon–induced Jak-STAT1 signaling by calcium-dependent kinases in macrophages
Roland Baron
Nature Immunology, 2008
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Jaks, Stats and the Immune System
Andreas L Meinke
Immunobiology, 1997
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Stat2 Binding to the Interferon-alpha Receptor 2 Subunit Is Not Required for Interferon-alpha Signaling
abu saleh
Journal of Biological Chemistry, 2002
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The Proximal Tyrosines of the Cytoplasmic Domain of the beta Chain of the Type I Interferon Receptor Are Essential for Signal Transducer and Activator of Transcription (Stat) 2 Activation. EVIDENCE THAT TWO Stat2 SITES ARE REQUIRED TO REACH A THRESHOLD OF INTERFERON alpha -INDUCED Stat2 TYROSINE ...
Regina Raz
Journal of Biological Chemistry, 1999
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Suppression of Pro-Inflammatory Cytokines via Targeting of STAT-Responsive Genes
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Triggering of Toll-like receptors modulates IFN-γ signaling: involvement of serine 727 STAT1 phosphorylation and suppressors of cytokine signaling
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Biologic consequences of Stat1-independent IFN signaling
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Proceedings of the National Academy of Sciences, 2001
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The WD Motif-containing Protein Receptor for Activated Protein Kinase C (RACK1) Is Required for Recruitment and Activation of Signal Transducer and Activator of Transcription 1 through the Type I Interferon Receptor
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Journal of Biological Chemistry, 2001
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A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6
B. Witthuhn
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Activation of STAT transcription factors in oncogenic tyrosine kinase signaling
Roy Garcia
Journal of Biomedical Science, 1998
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The Proximal Tyrosines of the Cytoplasmic Domain of the β Chain of the Type I Interferon Receptor Are Essential for Signal Transducer and Activator of Transcription (Stat) 2 Activation
Regina Raz
Journal of Biological Chemistry, 1999
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Antigen receptor signal transduction: activating and inhibitory antigen receptors regulate STAT1 serine phosphorylation
Thomas Decker
European Journal of Immunology, 2000
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New strategies for immunosuppression: interfering with cytokines by targeting the Jak/Stat pathway
Paul Changelian
Current Opinion in Rheumatology, 2005
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Stat1 combines signals derived from IFN-γ and LPS receptors during macrophage activation
Thomas Decker
The EMBO Journal, 1998
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Biological and clinical significance of the JAK-STAT pathway; lessons from knockout mice
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Inflammation Research, 2001
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