Antifertility Research Papers - Academia.edu (original) (raw)

Evaluation of herbs has been in progress worldwide for several decades to identify effective and safe substances for fertility regulation. This approach proved to be a good alternative to synthetic drugs as the chemicals of plant origin have limited side effects. Various medicinal plants extracts were investigated for their antifertility activity both in male and female animal models. This review presents update information gathered on scientifically screened medicinal plants used for anti-fertility activity in females. This review provides the information on botanical name along with their common name, ethnic use, parts used, solvents used and their chemical constituents present in plants and their antifertility activity on target organ like ovary, uterus and on pregnancy.

- by
- •
- Antifertility

Azadirachta indica is a fast growing, evergreen tree
found commonly in India, Africa and America. Neem is one of
the most useful traditional medicinal plant in India. It is a highly
esteemed tree with several beneficial properties and applications,
especially known for its incredible therapeutic and
ethnomedicinal values for mankind. It has been used in different
medicinal systems: Ayurveda, unani, homeopathic medicine,
therefore considered as cynosure of modern medicine. Neem has
been used as the traditional medicine since a long time. The main
focus of research on Neem has been on the insecticidal properties
but in recent years investigations have expanded to the medicinal
utilizations as well. A large number of studies have been
published on the medicinal properties of Neem and Neem
extracts, covering a wide range of indications and ailments. The
present paper reviews the medicinal and therapeutical aspects of
Neem.

- by IJSRP Journal
- •
- Insect Repellent, Antifertility, Anti-bacterial activity, Isoprenoids

The ethanol extract of stem barks of Crataeva nurvala Buch-Ham was administered orally at the dose levels of 300 and 600 mg/kg body weight to adult female albino rats and resulted in an irregular estrous cycle with shortened estrus and metestrus, and with lengthened proestrus in dose increasing dependent manner. Significant decreases in number of graffian follicles and corpora lutea and significant increases in number of atretic follicles in treated rats during experimental period indicated the antiovulatory effect of the extract. Increases in the weight of the uterus, its thickness and diameter indicated the uterotrophic effect of the extract. The significant increase in the level of cholesterol in the tissues of treated rats indicated the inhibition of steroidogenesis of cholesterol by ovarian endocrine tissues of female albino rats. Restoration of normal estrous cycles after 14-21 days of withdrawal of treatment indicates the reversible effect of ethanol extract in rats.

- by Prafulla Adkar
- •
- Antifertility

Presently there is an increasing interest worldwide in herbal plants pharmacological properties primerly due to advancement in scientific methods. The bioactive ingredients and their potential to treat various diseases of many Indian medical plants are now well established. Ficus religiosa is one of religious and medical plant of India, various parts of which like stem, fruit, leaves and roots are widely used in indigenous system of medicine. In recent studies F. religiosa has been investigated for presence of a wide range of phytoconstituents which impart a wide spectrum of pharmacological activities. The present review is an attempt to provide a detailed survey of the literature on medical properties of the plants based on scientific experimentation.

- by Atul Kumar Goyal
- •
- Antifertility

To study the effects of Citrullus colocynthis on testicular function and fertility, 70% methanolic extract of C. colocynthis was fed orally to male albino rats at the dose levels of 75 and 150 mg/kg body wt/day for 60 days. Oral administration of C. colocynthis caused a significant decrease in testicular weight and sperm concentration. The level of serum testosterone, LH and FSH also declined and spermatogenesis was impaired. The histoarchitecture of the testes in the rats receiving C. colocynthis methanolic extract showed degenerative changes and disruption of spermatogenesis and the number of spermatogonia remained significantly decreased. Thus the antifertility effects of C. colocynthis seemed to be mediated by disturbances in structure and testicular function including leydig and Sertoli cells resulting in an alteration in physio-morphological events of spermatogenesis.

- by Am Jour of Phytomed & Clinical Therapeut
- •
- Sperm Competition, Sperm Whales, Spermatogenesis, Sperm

The main of objectives of this studies aim to develop an effective strategy for implementation of rodent management programs in ecosystems by used the new alternative to control rodent without rodenticides such as chemostralisation, antifertility, vitamins with wheat in different ratios, protozoa, anti feeding and natural plant materials and other methods. Because. The main options available for non chemical control and non lethal chemical control methods may be cost effective, but they rarely achieve the rapid knockdown of a pest population that is possible with properly used chemical rodenticides. However, they can be integrated with chemical control, except perhaps vertebrate predators which may be vulnerable to secondary poisoning from some persistent chemical rodenticides. (Keshta 2003).

- by abdelalem saad soliman desoky
- •
- Management, Pharmacology, Zoology, Pharmacy

Use of herbal methods for fertility regulation is widely accepted alternative for the synthetic drugs containing chemical having side effects. Ficus religiosa is the plant having several medical properties but no report is available on the antifertility activity. Effects of 1% methanol extract of fruits extract was studied on the goat uterus in vitro in exposure duration dependent manner (1 hour, 4 hours and 8 hours). Effects on dimensions of uterine glands, surface epithelium, gland cell and myometrium were observed. The treatment induces a decline in uterine glands diameter which are crucial for implantation. Present observations suggest that the extract has antifertility activity and should be experimented for antifertility programme.

- by Atul Kumar Goyal
- •
- Antifertility
- by Chee Beng Jin
- •
- Medicinal plants and natural products, Antifertility

Present study was conducted to know the antifertility potential of Achyranthus aspera leaves in female mice and has shown promising results of antiovulatory activity, estrogenic and constant teratogenic activities. Administrations of A. aspera leaves methanolic extract at the dosage 25 mg/kg and 50 mg/kg body weight were subjected for testing their antiovulatory, estrogenic and teratogenic activity in female mice by applying statistical analysis in gravimetric, biochemical and histopathological parameters of ovary and uterus. At autopsy on day 31 st , both the dose treated mice revealed increase in ovarian weight, histological changes like increasing number of atretic follicle and decreases in healthy developing follicles, Graafian follicles and corpora lutea. Total cholesterol content and alkaline phosphatase of the ovary were increased and protein, glycogen, acid phosphatase content were decreased. Teratogenic activity did not alter any changes in the morphological and physiological behavior of experimental period. Results suggested that, methanolic extract of A. aspera leaves are more active at low dose compared to high dose and might be used as an herbal contraceptive in females.

- by Dr. Sharangouda J. Patil and +1
- •
- Medicinal Plants, Antifertility, Teratogenicity, Estrogenic Compounds

Population explosion in certain parts of the world, especially in the developing countries like India, has led to a continuous effort towards development. The therapeutic properties of medicinal plants are conditioned by the presence in their organs of active substances, such as alkaloids, glycosides, vitamins, tanins and coumarin compounds which physiologically affects the bodies of humans and animals or which are biologically active in relation to causative agents of various diseases. The tribal people and ethnic races throughout the world have developed their own medical practices. The root extract of Abutilon indicum (L.) (Beng-Potari) was selected for the present experimental study of antifertility activity in the male albino mice. Treatment after seven days (dosage of 1 g/kg.bw./day), the gradual decease in the seminiferous tubular area. Nuclear diameter of epithelial cells and tubular area of the epididymis, Sertoli cells and sperm populations were also decreased significantly.

The study involves a standard pharmacological model to test antifertility activity of seeds of Madhuca latifolia (Roxb.) Macbride. When the aqueous powdered drug (2gm/body weight) was administered to male albino rats has proved to be an effective antifertility drug. The activity was confirmed by significant decrease in sperm count, biochemical assays so also through histopathological investigations. Hence seeds of Madhuca latifolia can be a reliable herbal option after the necessary clinical trials.

- by Bindu Gopalkrishnan
- •
- Pharmacology, Medicine, Key words, Antifertility

This study was designed to evaluate the reproductive toxicity of Cassia absus seeds, which have been used in Persian folk medicine. Female rats in treatment groups (N = 5) received C. absus n-hexane fraction (CAF) at oral doses of 100, 200, and 500 mg/kg b.wt./day, once per day on days one to five post-coitum (pc). The control group received 0.2 mL of olive oil (vehicle). Fertility, maternal index, hormone level, and teratogenicity were evaluated. Phytoconstituents of the seeds were detected by HPTLC and GC-MS. The presence of phytoprogesterones was evaluated by docking software. The fertility index and number of fetuses in treated groups decreased significantly. Missed abortion was 50% after administration of 500 mg/kg/day of CAF. The maternal body weight, uterine weight, and levels of FSH, LH, and estradiol exhibited insignificance changes. The serum concentration of progesterone also changed significantly in a dose-dependent manner. No teratogenic effect was found. Oleic acid (35.89%) and linoleic acid (24.22%) were the major constituents of the seed oil. In addition, chaksine and b-sitosterol showed potential phytoprogesteronic properties in docking studies. The reproductive toxicity of C. absus seeds may be related to a hormonal imbalance, a decline in the fertility index, and an increase in the rate of missed abortions of fetuses.

- by azadeh h and +1
- •
- Sexual and Reproductive Health, Natural Products, Medicinal Plants, Abortion