Ferula Research Papers - Academia.edu (original) (raw)

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- Chemistry, Medicine, Essential Oil, Humans

The extinction of some of medical plants is not only due to the overuse of them and the grazing pressure but also their incorrect exploitation methods. Ferula assafoetida is one of the most important medical plants in Iranian rangelands, which is gradually disappeared from its habitats due to destructive traditional exploitations. Therefore, in order to determine how different incision techniques (exploitation methods) affect F. assafoetida properties, a study was carried out in the research field of Agricultural and Natural Resources Research Center in Mashad, Iran from 2009 to 2010. F. assafoetida plants were five years olds. The plants were cultivated in four densities in the field (25×50, 40×50, 55×50, and 70×50 cm) and four incision treatments as horizontal cutting (traditional), 45-degree cutting, concave cutting and non-incision (control) using a split plot design based on the completely randomized block design with three replications. In each plot, three plants were selected...

- by Mohsen Sharafatmandrad
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- Mathematics, Randomized Block design, Rangeland Science, Rangeland
- by Maged Abdel-Kader
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- Pharmacology, Traditional Medicine, Diabetes, Biology

Ferula turcica and Ferula latialata are two novel endemic species discovered in the Konya and Kırşehir provinces of the central Anatolian region of Türkiye. These two new species are described by morphological, ecological, carpological, and phytochemical characteristics and phylogenetic analysis. F. turcica and F. latialata are morphologically distinct from F. szowitsiana by their habit, the stalk of the terminal umbella, and the mericarp size, as well as by the profile of their secondary metabolite markers and phylogenetic placement. The phylogenetic analyses of sequences of the internal transcribed spacer in ribosomal DNA belonging to both new taxa were conducted to reveal the evolutionary relationships of the new species. Their relationships with the other related species and proposed conservation status were reviewed. The morphological, molecular, and phytochemical evidence supported the hypothesis that Ferula turcica and Ferula latialata are two new distinct species.

- by Memnune Erucar (Maiden name: Yildirim)
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- Biology, Apiaceae, Ferula, Phylogenetic Tree

The divergence time of the largely Asian element, the genus Ferula L. (subtribe Ferulinae, tribe Scandiceae, Apiaceae)
was initially analyzed using nrDNA, internal transcribed spacer (ITS) sequence data followed with three regions of
cpDNA (rps16 and rpoC1 introns and rpoB-trnC intergenic spacers) from 141 representatives of subtribe Ferulinae
(Ferula, Dorema, Leutea) and relatives. Further analyses of the biogeographical history of the Ferula group were
carried out using BEAST, S-DIVA and BBM in RASP on all datasets. The results suggested that the initial split within
Ferulinae occurred during Early Pliocene about 4.8 Ma and earlier ancestor of Ferula group has been originated mostly
in Armeno-Iranian province. One descendent giving rises to the Ferula clade and another descendent subsequently
underwent further divergence to account for Leutea lineages about 1.8-2 Ma. The rapid diversification within
Ferulinae clade has occurred since the Middle Pliocene. Subsequent diversification of the Ferula clade intensified in
the Irano-Turanian region during the late Pliocene in the Central Asian zone and toward west in Mediterranean zone
during early Pleistocene. The ancestor of Chinese group of Ferula spread from Central Asia to eastern Asia in the
Pliocene (2.2-4 Ma). The ancestor of the Mediterranean group of Ferula occurred in the West Mediterranean with
high marginal probability. These diversifications likely corresponded with the Himalayas-Tibetan plateau upliftdriven climatic changes and aridification of Central Asia and also after refilling the Mediterranean basin and Zanclean
flood during the Pliocene respectively.

- by Mehrnoush Panahi
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- Phylogenetics, Biology, Biogeography, Molecular phylogeny
- by hasan yusufoglu
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- Pharmacology, Traditional Medicine, Diabetes, Biology

In the present study, preliminary phytochemical investigations were performed on the fruit essential oil and antioxidant-rich methanolic extracts of the fruits and roots of Ferula drudeana, the putative Anatolian ecotype of the Silphion plant, to corroborate its medicinal plant potential and identify its unique characteristics amongst other Ferula species. The essential oil from the fruits of the endemic species Ferula drudeana collected from Aksaray was analyzed by GC and GC/MS. The main components of the oil were determined as shyobunone (44.2%) and 6-epishyobunone (12.6%). The essential oil of the fruits and various solvent extracts of the fruits and roots of F. drudeana were evaluated for their antibacterial and anticandidal activity using microbroth dilution methods. The essential oil of the fruits, methanol, and methylene chloride extracts of the fruits and roots showed weak to moderate inhibitory activity against all tested microorganisms with MIC values of 78–2000 µg/mL. How...

- by Mine Kürkçüoğlu
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- Chemistry, Traditional Medicine, Pliny the Elder, Essential Oil
- by soad ali
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- Physiology, Fertility, Medicine, Erectile dysfunction

Ferula assa-foetida L. (Asafoetida) a medicinal plant with antimicrobial and antioxidant properties, is crucial in the food and pharmaceutical industries. Ferula essential oils (EOs), rich in ferulic acid, flavonoids, alkaloids, and glycosides compositions, may offer a potential solution to antibiotic resistance. The aim of this work is to investigate the components of Ferula chemical essential oil (EO) and its antioxidant and antimicrobial properties in different habitats of Iran (Tabas, Yazd, Neishabur, and Kerman). Gas Chromatography-Mass Spectrometry (GC-MS) analysis was performed to determine the composition of the essential oils from the four different sources. The antimicrobial activity, the minimum inhibitory concentration (MIC), and the minimum bactericidal concentration (MBC) of the essential oils against both Gram-positive and Gram-negative pathogenic bacteria were evaluated using the broth microdilution method and the well diffusion test. Likewise, the antioxidant properties of the essential oils were examined using the DPPH radical scavenging method. GC-MS analysis identified the major components of the essential oils, with the Nishabur EO having the highest percentage of components. The Kerman EO had the lowest inhibitory concentration against Escherichia coli, at 6.25 mg/mL, while the Yazd EO demonstrated the highest inhibitory concentration against Staphylococcus aureus, at a minimum inhibitory concentration of 50mg/mL. Yazd EO showed the strongest antimicrobial activity, particularly against Gram-positive bacteria, with a halo diameter of 22.5 mm. In contrast, the Kerman EO showed the least amount of antimicrobial activity against Escherichia coli, with a halo diameter of 11.5 mm. Kerman EO had the highest antioxidant activity, with 93.9393%. The Ferula EO has the ability to inhibit DPPH radicals and demonstrated activity against both Gram-positive and Gram-negative bacteria, making it a strong antioxidant and natural preservative in the pharmaceutical industry.

- by Sobhan Aboulhassanzadeh
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- Antioxidants, GC-MS, Ferula, antimicrobial tests
- by Mohan Sharma
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- Surgery, Rehabilitation, Tendon, Medicine
- by ghadir taheri
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- Chemistry, Antioxidant, Catalase, Lipid peroxidation

Objective: Free radicals are generated during different reactions in cells and are potentially threats to macromolecules such as DNA and protein. Cells have established defense systems to remove these radicals. In some diseases, the systems are defective because of different damages and cells cannot remove the radicals. Plants have been used for a long time as sources of antioxidants for treatment of different diseases. Ferula species have also been used and investigated as a source of antioxidants in Iranian herbal medicine. Methods: Here, we have studied the antioxidants activity of catalase, superoxide dismutase and lipid peroxidation from aqueous and ethanolic extracts of Ferula flabelliloba and Ferula diversivitata plants. Results: Our results have shown that they have significant antioxidant activity in different parts at different stages. Conclusion: We can conclude that these plants extracts can be used for more studies as antioxidant sources.

- by ghadir taheri
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- Chemistry, Antioxidant, Catalase, Lipid peroxidation
- by Ahmed Ahmed
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- Chemistry, Macrophages, Medicine, Lipopolysaccharide

Ferula assa-foetida L. (Asafoetida) a medicinal plant with antimicrobial and antioxidant properties, is crucial in the food and pharmaceutical industries. Ferula essential oils (EOs), rich in ferulic acid, flavonoids, alkaloids, and glycosides compositions, may offer a potential solution to antibiotic resistance. The aim of this work is to investigate the components of Ferula chemical essential oil (EO) and its antioxidant and antimicrobial properties in different habitats of Iran (Tabas, Yazd, Neishabur, and Kerman). Gas Chromatography-Mass Spectrometry (GC-MS) analysis was performed to determine the composition of the essential oils from the four different sources. The antimicrobial activity, the minimum inhibitory concentration (MIC), and the minimum bactericidal concentration (MBC) of the essential oils against both Gram-positive and Gram-negative pathogenic bacteria were evaluated using the broth microdilution method and the well diffusion test. Likewise, the antioxidant properties of the essential oils were examined using the DPPH radical scavenging method. GC-MS analysis identified the major components of the essential oils, with the Nishabur EO having the highest percentage of components. The Kerman EO had the lowest inhibitory concentration against Escherichia coli, at 6.25 mg/ml, while the Yazd EO demonstrated the highest inhibitory concentration against Staphylococcus aureus, at a minimum inhibitory concentration of 50 mg/ml. Yazd EO showed the strongest antimicrobial activity, particularly against Gram-positive bacteria, with a halo diameter of 22.5 mm. In contrast, the Kerman EO showed the least amount of antimicrobial activity against Escherichia coli, with a halo diameter of 11.5 mm. Kerman EO had the highest antioxidant activity, with 93.9393%. The Ferula EO has the ability to inhibit DPPH radicals and demonstrated activity against both Gram-positive and Gram-negative bacteria, making it a strong antioxidant and natural preservative in the pharmaceutical industry.

- by Sobhan Aboulhassanzadeh and +1
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- GC-MS, Antioxidant, Antimicrobial, Well Testing
- by Mehmet Sağıroğlu
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- Botany

Lo scritto qui presentato si ricollega all’articolo di Simonetta Coppa contenuto in questo stesso volume, nel quale si parla del ritratto dell’arciprete di Montagna Giovanni Battista Castellani, dipinto con la ferula da Antonio Caimi nel... more

- by Rita Pellegrini
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- Valtellina, Ferula, Suppellettili Liturgiche, Arredi Sacri
- by William Setzer
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- Chemistry, Apiaceae, Ferula, Chemical Composition
- by Prabodh Satyal
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- Chemistry, Apiaceae, Ferula, Chemical Composition
- by Prabodh Satyal
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- Chemistry, Organic Chemistry, Essential Oil, Ferula
- by Hossein Azarnivand
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- Botany, Horticulture, Biology, seed Science and Technology
- by Erjon Mamoci
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- Botany, Organic Chemistry, Biology, Fungi
- by Manuel B. Crespo Villalba
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- Apiaceae, Ferula

A solvent extract of the soft coral Sarcophyton ehrenbergi afforded cembrene diterpenoids, sarcoehrenbergilid D–F (1–3).

- by Khishgee Khishgee
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- Chemistry, Chemical, Ferula, Pharmacology and pharmaceutical sciences
- by Merza Hamza Homady
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- Medicine, Production economics, Preputial Gland, Endocrine System
- by Michelangelo Parrilli
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- Chemistry, Organic Chemistry, Biology, Medicinal Plants
- by Jesús Manuel González Díaz
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- Computer Science, Natural Products, Biology, Social Media

Summary. Asafoetida resin has been reported for various biological activities but its use has been widely restricted owing to its pungent smell and pool water solubility. Aim: In vitro study of the anticancer potential of microwave-extracted essential oil (EO) of Ferula asafoetida. Materials and Methods: The phytochemical investigation and in vitro cytotoxicity assessment was carried out in two human liver cancer cell lines. The expression of NFKB1, TGFB1, TNF, CASP3 was analyzed by reverse transcription polymerase chain reaction. Results: Ferula asafoetida EO contains high concentrations of dithiolane, which possess antiproliferative activity in human liver carcinoma cell lines (HepG2 and SK-Hep1) in a dose-dependent manner. The bioactive compounds in F. asafoetida are capable of induction of apoptosis and altered NF-kB and TGF-β signalling with increase in caspase-3 and TNF-α expression. Conclusion: Further elucidation of bioactive molecules and underlying mechanisms could lead to...

- by Sriram Seshadri
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- Chemistry, Cytotoxicity, Apoptosis, Medicine

Crude methanolic extract of roots, aerial parts and its subsequent fractions of Ferula narthex Boiss were tested for antibacterial, anti-fungal and phytotoxic activities. Crude methanolic extract of roots and its fractions showed significant antibacterial effect against P.aeruginosa (86.95%, 73.91, 69.59, 78.26 & 73.91%) represented by percent inhibition except ethyl acetate (EtoAc) fraction. The EtoAc fraction of roots and aerial parts showed significant activity against E. coli (80%), S. typhi (81.2 & 81.25%) and S. pneumoniae (80%). The n-hexane, chloroform and aqueous fractions of aerial parts showed significant activity against P. aeruginosa (78.26, 69.56 & 73.91%). Following fungal strains (T. longifusus, C. albicans, A. flavus, M. canis, F. solani, C. glabrata) were also used for anti-fungal activity. Among tested samples only crude methanol extract of roots, n-hexane and chloroform fraction showed moderate anti-fungal activity against M. canis (40, 35 & 30%) represented by p...

- by Mehboob Alam
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- Pharmacology, Biochemistry, Microbiology, Chemistry
- by Farshid Saadat
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- Pharmacology, Chemistry, Complementary and Alternative Medicine, Plant Biology
- by vahid karimian
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- Chemistry, Traditional Medicine, Medicine, Multidisciplinary
- by hasan yusufoglu
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- Pharmacology, Traditional Medicine, Diabetes, Biology

Two new poly-hydroxy steroids, zahramycins A (1) and B (2), have been isolated from the polar fraction of the extract of the coral Sarcophyton trocheliophorum. Compound 1 was confirmed to bear an oxirane ring at C-5 and C-6, while 2 has a keto-hydroxy sterol structure. The known DNA primary metabolites uracil, thymine, adenine, uridine, 2´-deoxyuridine, and thymidine were also isolated and identified. Structures of the new sterols 1 and 2 were confirmed by NMR ( 1H, 13C, 1H-1H COSY, HMQC, HMBC, and NOESY) spectroscopy, mass spectrometry (EI, ESI, and HRMS), and by comparison with related structures. The antimicrobial and cytotoxic activities of compounds 1 and 2 along with that of the coral extract were also determined. Zahramycin B (2) showed high (15 mm) and moderate (12 mm) antibacterial activity against Staphylococcus aureus and Bacillus subtilis, and fungus Pythium ultimum (12 mm), while zahramycin A (1) and the crude extract of Sarcophyton trocheliophorum were inactive. Both s...

- by Khaled Shaaban
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- Chemistry, Inorganic Chemistry, Organic Chemistry, Cytotoxicity
- by Kartick Pramanik
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- Biology, Apoptosis, Medicine, Reactive Oxygen Species

Background: Smooth muscle contraction and enlargement of the prostate are important targets for the treatment of lower urinary tract symptoms in patients with benign prostatic hyperplasia. The effect of Ferula elaeochytris (FE) root extract on tissues that play a role on fertility such as the prostate has not been demonstrated yet. The aim of this study is to investigate the effects of FE extract on isolated rat prostate tissue induced by electrical field stimulation (EFS) in vitro. Methods: In this experimental study, 48 male rats were randomly divided into 6 groups (n = 8). Groups were consisting FE (20 µl), FE + Adenosine triphosphate (ATP; 50 μM), FE + prazosin (0.3 μM), FE + Calcium (Ca2+; 3 mM and 6 mM), FE + suramin (100 μM), FE + phenylephrine and FE + carbachol. Result: In our study, FE extract inhibited the neurogenic contractions induced by EFS on isolated rat anterior prostate tissue. The presence of suramin and prazosin were not significantly increase the inhibition cau...

- by Cemil Göçmen
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- Endocrinology, Chemistry, Prostate, Hyperplasia
- by Alexandru Badarau
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- Botany, Biology, Genus, Apiaceae

A solvent extract of the soft coral Sarcophyton ehrenbergi afforded cembrene diterpenoids, sarcoehrenbergilid D–F (1–3).

- by hasan yusufoglu
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- Pharmacology, Traditional Medicine, Diabetes, Biology
- by RASHMI NAGESH
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- Chemistry, Prostate Cancer, Cancer Research, Medicine

- by Fadıl Kaan Kuran
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- Chemistry, Traditional Medicine, Pliny the Elder, Essential Oil
- by Prof Lutfun Nahar
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- Ethnobotany, Phytochemistry, Traditional Medicine, Biology

Ferula orientalis (Apiaceae) is a well-known perennial herb growing wild in Iran used in traditional medicine. To perform phytochemical studies, dried ground roots of F. orientalis were sequentially Soxhlet-extracted using n-hexane, dichloromethane and methanol. A combination of vacuum liquid chromatography and preparative thin-layer chromatographic analyses were performed to isolate coumarin esters. The structures of the isolated compounds were elucidated by spectroscopic means, and in vitro free-radical-scavenging property was determined by the DPPH assay. Two new coumarin esters, 7-O-(4,8,12,16-tetrahydroxy-4,8,12,16-tetramethyl-heptadecanoyl)-coumarinand 7-O-(4-hydroxy-4,8,12-trimethyl-trideca-7,11-dienoyl)-coumarin, named ferulone A and ferulone B, respectively, were isolated from the n-hexane extract of the roots of F. orientalis. Both compounds showed a low level of free-radical-scavenging property with the RC50 values of 0.252 and 0.556 mg/mL for compounds 1 and 2, respectiv...

- by Prof Satyajit D Sarker
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- Chemistry, Medicinal Plants, Magnetic Resonance Spectroscopy, Medicine
- by Farukh Sharopov
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- Chemistry, Organic Chemistry, Essential Oil, Ferula

- by Bashir Ahmad
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- Pharmacology, Biochemistry, Microbiology, Chemistry

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

- by Paul Paré
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- Chemistry, Stereochemistry, RSC, Enzyme

SUMMARY - The circum-Mediterranean perennial Ferula communis (giant fennel) contains anticoagulant constituents. The value of conditioned feed aversion (CFA) - building up temporal contiguity between ingestion of the plant and post-ingestive malaise in order to elicit rejection at later encounters - as a means to minimize intake of F. communis was investigated. Because most casualties are ewe-lambs, within 30 days of being turned out, the first objective was to achieve CFA for 30 days. In experiment 1, six weaned lambs (15 kg BW), which had been accustomed to F. communis for 1 week, were averted to F. communis by administrating orally two doses of 266 mg LiCl/kg BW at 5-day intervals at the time of F. communis meals. Six lambs served as unaverted controls. The aversion persisted for 31 days. The lambs were then turned out to pasture on a F. communis-infested artificially-constructed paddock divided into two plots differing in standing biomass of Italian ryegrass. Averted and unavert...

- by Yan Landau
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- Biology, Ferula, Poisonous Plants
- by Gulab Said
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- Chemistry, Organic Chemistry, Isocoumarins, Isocoumarin
- by Ali Qasim
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- Epididymis, Monosodium glutamate
- by Narges Marefati
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- Morphine, Naloxone, Datura Stramonium, Medical Biology