Renal failure Research Papers - Academia.edu (original) (raw)

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- Acute kidney injury, Humans, Hemodialysis, Renal failure

Objective: To measure the frequency of depression and its risk factors in patients under going hemodialysis. Methodology: It is a cross-sectional prospective study conducted at Hemodialysis unit of Shalamar Hospital and Shaikh Zayed Hospital, Lahore from 1 st January 2006 to 30 th April 2006. All patients getting regular hemodialysis for more than three months were included. Beck’s Depression Inventory- II (BDI-II; adapted in Urdu) was administered on all the patients who were able to read or understand it. Blood sample were drawn at the same time for routine hematological, biochemical parameters and viral markers (Anti HCV and HbsAg). Diagnosis was made as per Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM IV) for correlation of psychological variables with clinical, hematological and biochemical parameters. Results: Eighty nine patients were enrolled which included fifty two (58.4%) were male and seventy seven (86.5%) were married. Major causes of renal...

- by Mahrukh Masood
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- Medicine, Hepatitis C, Hemodialysis, Renal failure
- by Rakhshanda Bilal
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- Nutrition and Dietetics, Obesity, Spinal Cord Injury, Medicine
- by Iman M Bastawecy
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- Hemostasis and Thrombosis, Cancer, Cystic Fibrosis, Inflammation

Objective: While treating anaemia in end stage renal disease (ESRD) patients, recombinant human erythropoietin (EpO) is the therapy of choice. However, it is rarely used in developing countries because of the financial constrains to the healthcare as well as the patient. Keeping the point of view in mind, the objective of this research was to identify the use of Epo, its frequency, and dosage in the patients of ESRD receiving continuous haemodialysis in Quetta city, Pakistan. Methods: This was a retrospective, single cantered study. The selected population was subject with ESRD and on dialysis with prolonged anaemia. All recipients of dialysis in the past one year were targeted for the study. Data of the patients regarding anaemia and the use of erythropoietin was collected through a data collection sheet. Evaluation of the biochemical parameters of ESRD patients on haemodialysis was also be taken into consideration. Demographics of the selected patients were recorded carefully for the evaluation and analysis. SPSS 20.0 was used for data analysis and based on the objectives; both descriptive and inferential statistics were used for data elaboration. Results: A total of 97 ESRD patients that fulfilled the inclusion criteria were enrolled. Out of the 97, (52.6%) had age of more than 47 years and the cohort was dominated by males (63, 64.9%). Seventy two patients were on EPo use with majority on dose of 10000 IU with once a week frequency. The Man Whitney U test was used to compare erythropoietin use / non use and biochemical parameters. Haemoglobin percentage was significantly associated with erythropoietin use (p<0.05). The mean rank interpretation revealed erythropoietin users significantly associated with improved haemoglobin percentage. The Kruskal Wallis test was used to compare erythropoietin usage frequency and biochemical parameters. Haemoglobin percentage was again significantly associated with erythropoietin use frequency. The Bonferroni correction revealed erythropoietin frequency of twice a week was significantly associated with improved haemoglobin percentage. Conclusion: Although the use of EPO among ESRD was reasonable, few patients were not prescribed EPo for anaemia associated with ESRD. We do understand that availability and affordability can be a major reason here; policy makers should make sure about the use of EPo because of its evidence-based advantages over other procedures.

- by Luis Yu
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- Acute kidney injury, Survival Analysis, Multivariate Analysis, Acute renal failure
- by Russell Lewis
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- Treatment Outcome, Multivariate Analysis, Transplantation, Humans

The aim of the present study was to evaluate the effect of hemodialysis and renal failure on serum bone markers. Serum total alkaline phosphatase (TAP), procollagen type I aminoterminal propeptide (PINP), and Β-carboxyterminal telopeptide of type I collagen (Β-CTX), as well as intact parathyroid hormone (iPTH), creatinine, and total protein were measured in 14 patients with endstage renal disease (ESRD) before and at 1, 2, and 4 h during a hemodialysis session, and at the same sampling interval in 6 renal transplant recipients. The results were compared to those obtained in 20 healthy adults. All patients showed increased baseline mean values of PINP, Β-CTX, and iPTH. Β-CTX differed significantly between hemodialysis patients and renal transplant recipients. TAP and Β-CTX were the only markers which correlated with iPTH (P ≪ 0.05) and creatinine values (P ≪ 0.001), respectively. Renal transplant recipients did not show significant variations in the evolution of mean values of bone markers throughout the study, whereas, during the dialysis period, all the bone markers analyzed in the study showed a significant change. The change differed depending on the marker considered: Β-CTX showed a significant decrease at the end of the session, TAP increased at this time and, although PINP showed an initial increase during hemodialysis, no significant changes were observed at the end of the session. We conclude that bone markers are significantly influenced by hemodialysis, especially serum TAP and Β-CTX. ESRD is associated with an increase in these bone markers, in some cases related to iPTH values and in others to glomerular function. These findings should be taken into account when evaluating bone markers in these patients.

- by Luisa Rico
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- Kidney transplantation, Prospective studies, Humans, Bone
- by Jonas Ramos
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- Mass Spectrometry, Proteomics, Lepidoptera, Acute renal failure
- by Vicente Vega
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- Monitoring And Evaluation, Magnetic Resonance Imaging, Liver diseases, Humans
- by ratan jha
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- Immunology, Neurobiology Of Disease, Flow Cytometry, Treatment Outcome
- by Claudio Luders and +2
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- Kidney diseases, Chronic kidney disease, Cardiovascular disease, Humans

The first generation of troponin T ELISA (TnT 1) can yield false-positive results in patients with severe skeletal muscle injury. Therefore, a cardiac-specific second-generation troponin T ELISA (TnT 2) was developed, in which the cross-reactive antibody 1B10 has been replaced by a high-affinity cardiac-specific antibody M11.7. No cross-reactivity of TnT 2 was observed with purified skeletal muscle troponin T (1000 micrograms/L) or in test samples from 43 marathon runners and 24 patients with rhabdomyolysis and highly increased creatine kinase. TnT 2 was increased > 0.2 microgram/L in 5 of 40 patients with renal failure and in 4 of 20 muscular dystrophy patients. The detection limit is 0.012 microgram/L. Day-to-day imprecision (CV) within the range 0.19-14.89 micrograms/L was < 5.8%. In 4955 patients without myocardial damage, 99.6% had TnT < 0.10 microgram/L. Assay comparison (TnT 1 vs TnT 2) over the whole concentration range (i.e., in 323 samples from AMI-suspected patie...

- by Christoph Ebert
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- Skeletal muscle biology, Clinical Chemistry, Medical Biotechnology, Mice
- by L. Berardinelli
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- Kidney transplantation, Renal transplantation, Humans, Renal failure
- by Carsten Carlberg
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- Transcription Factors, Nuclear Receptor, Protein-DNA interaction, Humans
- by Giacomo Aletti
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- Risk, Treatment Outcome, Continuous Improvement, Cardiac Surgery
- by Peter Folb and +1
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- Kinetics, Humans, Kidney, Female

The seroprevalence of three bacterial re-emerging diseases namely brucellosis, leptospirosis and melioidosis was investigated in farmers and technical staff of Selangor and Negeri Sembilan. The study found that the highest seroprevalence for both Selangor and Negeri Sembilan was among the farmers with seroprevalence of 5.05% ± 2.15 and 5.88% ± 3.7 respectively. Among the technical staff, the highest seroprevalence for the disease was observed among the staff in Negeri Sembilan. Antibodies against Leptospira spp was the most commonly detected among the three pathogens. Knowledge of the mode of transmission of zoonotic infections may have been an advantage for the technical staff in preventing exposure to these pathogens.

Cardiac troponins are sensitive and specific indicators of myocardial injury and are traditionally used to support the diagnosis of myocardial infarction. However, raised cardiac troponins may also be found in a wide range of non-cardiac medical conditions. Examples include sepsis, neurological conditions, renal failure, burns and certain inflammatory and infiltrative diseases. Emergency physicians should consider these alternative diagnostic possibilities when faced with elevated cardiac troponins in the absence of other clinical and laboratory evidence to support a myocardial infarction. We report a case of a 29-year-old male who presented to the emergency department after an epileptic fit with a significantly elevated serum cardiac troponin. The association between seizures and raised cardiac troponins must be taken into account by emergency physicians to avoid misdiagnosing and over-investigating patients.

- by Jacobs Publishers
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- Renal failure, Sepsis, Seizures, Troponin
- by Paolo Zatta
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- Inorganic Chemistry, Free Radicals, Free Radical, Metal Ions
- by Peter Rhee
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- Nursing, Acute kidney injury, Humans, Female
- by roberto castro
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- Urology, Treatment Outcome, Humans, Child

Renal involvement is common in childhood polyarteritis nodosa (PAN). We report a retrospective analysis of the presentation and clinical course of 26 patients with PAN and renal involvement. The mean age was 9.3 years (range 1–14 years) and there were 12 boys and 14 girls. Renal symptoms at presentation were as follows: 3 had isolated proteinuria, 9 had nephritic syndrome, 2 had nephritic and nephrotic components, and 10 had renal failure with one of the above features. Two patients with isolated hypertension were diagnosed by angiography and classified as classical PAN. Patients either received prednisone p.o. alone (n=9), or prednisone plus cyclophosphamide p.o. (n=11), or pulse steroids with prednisone p.o. and cyclophosphamide (n=2); 4 did not receive any treatment. Patients who were given cyclophosphamide had a significantly better outcome than those who did not. We suggest that oral cyclophosphamide therapy and corticosteroids are effective in the treatment of PAN. The overall 1-year and 5-year survival rates of the patients were 72.5% and 60%, respectively. In conclusion, renal disease is a serious manifestation of PAN necessitating prompt and aggressive treatment.

- by Seza Ozen
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- Kidney diseases, Survival Analysis, Adolescent, Humans
- by Stephen Onufrak
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- Atherosclerosis, Risk, Phosphorus, Humans
- by Alper Azak
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- Treatment Outcome, Prospective studies, Humans, Female
- by Alexandre Pereira
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- Engineering, Genetics, Nutrition and Dietetics, Nutrition
- by Wladimiro Jiménez
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- Hepatology, Humans, Liver Cirrhosis, Hemodynamics
- by Ulrich Neyer
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- Kidney diseases, Chronic kidney disease, Adolescent, Prospective studies

Objective: to analyze intra-hospital results in patients undergoing elective off-pump total arterial revascularization and identify morbidity and mortality predictors using this surgical strategy. Methods: From May 1999 to February 2004, 203 myocardial revascularization procedures with total arterial revascularization without cardiopulmonary bypass (off-pump) were carried out in patients with multivessel disease (three vessels 81.7 %, one vessel disease was excluded). We report pre-surgical variables and co-morbidities: average age 63.9 ± 9.13 years, men 182 (89.5%), hypertension 132 (65%), smokers 125 (61%), hypercholesterolemia 152 (74.8%), previous myocardial infarction (> 30 days) 73 (35%), moderate to severe ventricular dysfunction 31 (15%), redo 5 (2.5%). Total arterial revascularization included T-grafts and sequential grafts with left internal mammary (100%), right internal mammary (56.6%) and radial (63%) arteries. The total number of distal anastomosis was 576 (mean of ...

- by Guillermo Vaccarino
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- Statistical Analysis, Logistic Regression, Operating Room, Renal failure
- by Roberto Bonaudo and +1
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- Pediatrics, Natural History, Adolescent, Italy
- by Carlota Saldanha
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- Electron Microscopy, Cell Cycle, Inflammation, Cryopreservation
- by Hideo Nagai
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- Nutrition, Treatment Outcome, Colorectal cancer, Malnutrition
- by M. Giannella
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- Respiratory Medicine, Colombia, Developing Countries, Risk assessment
- by Ajay Singh
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- Facial Paralysis, Magnetic Resonance Imaging, Atherosclerosis, Rheumatoid Arthritis

Page 1. 6 Renal Disease and Pregnancy Marius Craina, Elena Bernad, Răzvan Niţu, Paul Stanciu, Cosmin Cîtu, Zoran Popa, Corina Şerban and Rodica Mihăescu University of Medicine and Pharmacy “Victor Babeş” Timişoara Romania 1. Introduction... more

- by Marius Craina
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- Kidney diseases, Medicine, Pregnancy, Humans
- by Matheus Raffael
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- Vascular Surgery, Cerebrospinal Fluid, Spinal Cord, Renal failure
- by Steven Kravet
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- Fluorescence Microscopy, Biopsy, Humans, Renal failure
- by Makiko Osawa
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- Informed Consent, Treatment Outcome, Brain development, Tacrolimus
- by Christian Chillou
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- Treatment Outcome, Coma, Cardiac arrest, Humans
- by Vincent Launay-vacher
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- Kidney diseases, Acute kidney injury, Crystallization, Humans
- by Philippe Brunet
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- Radiation Protection, Humans, Hemodialysis, Renal failure
- by Linda Shortliffe
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- Laparoscopic Surgery, Humans, Child, Renal failure
- by Ersilia Satta
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- Gene regulation, Cardiovascular disease, Platelet aggregation, Renal failure
- by Adenekan Oyefeso and +2
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- Psychology, Cognitive Science, Drug interactions, Human
- by Javier Rejas and +2
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- Pharmaceutical Care, Medicine, Renal failure, Nursing Home
- by Ola Hammarsten
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- Inflammation, Heart Failure, Humans, Female
- by Richard Cohn
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- Adolescent, Biopsy, Multivariate Analysis, Humans
- by Fenella Kirkham
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- Cerebral Palsy, Comorbidity, Down Syndrome, Movement disorders

Charles (Chuck) Fleming's acute illness developed on June 12, 2000 induced by the ingestion of toxic doses of creatine monohydrate and high levels of propylene glycol (PEG). Chuck was taking several medications contained PEG that increased creatine bioavability and caused acute renal failure, severe hypophosphatemia, and ketoacidosis. Chuck's serum phosphorous level was 0.1 mg/dL (normal range: 2.8-4.9 mg/dL) and his

- by Mohammed al-Bayati
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- Acute renal failure, Sudden Death, Hemodialysis, Renal failure