Advanced glycation end-product (original) (raw)
Konečné produkty pokročilé glykace (anglicky advanced glycation end products, AGEs) jsou bílkoviny nebo lipidy, které se při vystavení se cukrům stávají glykovanými. Tyto látky mohou být činitelem stárnutí a rozvoje či zhoršení mnoha degenerativních onemocnění, jako je cukrovka, ateroskleróza, chronické renální selhání a Alzheimerova choroba.
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| dbo:abstract | Konečné produkty pokročilé glykace (anglicky advanced glycation end products, AGEs) jsou bílkoviny nebo lipidy, které se při vystavení se cukrům stávají glykovanými. Tyto látky mohou být činitelem stárnutí a rozvoje či zhoršení mnoha degenerativních onemocnění, jako je cukrovka, ateroskleróza, chronické renální selhání a Alzheimerova choroba. (cs) Advanced glycation end products (AGEs) are proteins or lipids that become glycated as a result of exposure to sugars. They are a bio-marker implicated in aging and the development, or worsening, of many degenerative diseases, such as diabetes, atherosclerosis, chronic kidney disease, and Alzheimer's disease. (en) AGEs（エージス、エイジス、エイジズ、エージーイー）とは、Advanced Glycation End Productsの略語であり、終末糖化産物、後期糖化生成物などと訳される。タンパク質または脂質が糖へ曝露されることによる糖化反応（メイラード反応）によって作られた生成物の総称であり、身体の様々な老化に関与する物質（より正確に言えば、生体化学反応による生成物）と言える。現在判明しているだけでも、AGEsには数十種類の化合物があり、それぞれが多種多様な化学的性質を有する。AGEsの例としては、Nε-カルボキシメチルリシン(CML)、Nε-カルボキシエチルリシン(CEL)、アルグピリミジンなどが知られている。類似の概念に過酸化脂質に由来する（Advanced Lipoxidation End products、ALEs）がある。（ALEsについては脂質過酸化反応も参照の事） AGEsは糖尿病、アテローム性動脈硬化症、慢性腎不全、アルツハイマー型認知症などの変性疾患を悪化させると言われる。糖尿病の血管系合併症の原因ともされる。活性酸素による細胞障害を加速し、機能を変化させるという。 (ja) De term Advanced Glycation End Products (AGEs) zou vertaald kunnen worden met voortgeschreden-versuikeringseindproducten. Het is een verzamelnaam voor eiwitten die onherstelbaar beschadigd zijn, doordat er suikergroepen (zoals glucose) aan verankerd zijn en het eiwit is gedegenereerd. AGEs ontstaan onder invloed van onder andere hoge bloedsuikerspiegels. De hoeveelheid AGEs in een lichaam zou een maat kunnen zijn voor de schade die een patiënt door zijn stofwisseling heeft opgelopen. Daarmee is het een maat voor het risico op cardiovasculaire aandoeningen als hartaanval of beroerte. (nl) L'advanced glycation end-product, in sigla AGE (in italiano: prodotto finale della glicazione avanzata), è il risultato di una catena di reazioni chimiche successive alla reazione di glicazione iniziale. Prodotti intermedi sono conosciuti come il riarrangiamento di Amadori, la base di Schiff e i prodotti di Maillard, chiamati così dai ricercatori che per primi li hanno descritti. La letteratura è ancora indecisa sull'applicare questa terminologia. Per esempio i prodotti della reazione di Maillard sono talvolta considerati prodotti intermedi talvolta prodotti finali. Gli effetti collaterali generati nei passaggi intermedi derivano da agenti ossidanti (come il perossido di idrogeno) e non (come le proteine amiloidi beta).Il termine glicosilazione è talvolta usato per glicazione in letteratura, di solito come glicosilazione non enzimatica. Gli AGE si trovano sulle superfici dorate o abbrustolite di cibi fritti o grigliati, ed anche sulla crosta del pane. Oltre al colore, gli AGE conferiscono agli alimenti cotti anche il sapore caratteristico, tipico dei prodotti da forno. (it) Коне́чные проду́кты глики́рования (КПГ, англ. Advanced glycation end-products, AGEs) — это белки или липиды, которые подверглись гликированию углеводами. Они могут быть одним из факторов старения и развития или осложнения многих , таких как диабет, атеросклероз, хроническая болезнь почек и болезнь Альцгеймера. (ru) 糖化終產物（英語：Advanced glycation end products）是糖與蛋白質相互聚合、經過一系列的反應後產生的不可還原之物質。它也會改變及影響蛋白質的正常功能，與其他蛋白質連成大分子，降低蛋白質被代謝的機會；AGE也會使DNA產生移位現象，造成DNA損傷，影響DNA正常功能。 (zh) |
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| rdfs:comment | Konečné produkty pokročilé glykace (anglicky advanced glycation end products, AGEs) jsou bílkoviny nebo lipidy, které se při vystavení se cukrům stávají glykovanými. Tyto látky mohou být činitelem stárnutí a rozvoje či zhoršení mnoha degenerativních onemocnění, jako je cukrovka, ateroskleróza, chronické renální selhání a Alzheimerova choroba. (cs) Advanced glycation end products (AGEs) are proteins or lipids that become glycated as a result of exposure to sugars. They are a bio-marker implicated in aging and the development, or worsening, of many degenerative diseases, such as diabetes, atherosclerosis, chronic kidney disease, and Alzheimer's disease. (en) AGEs（エージス、エイジス、エイジズ、エージーイー）とは、Advanced Glycation End Productsの略語であり、終末糖化産物、後期糖化生成物などと訳される。タンパク質または脂質が糖へ曝露されることによる糖化反応（メイラード反応）によって作られた生成物の総称であり、身体の様々な老化に関与する物質（より正確に言えば、生体化学反応による生成物）と言える。現在判明しているだけでも、AGEsには数十種類の化合物があり、それぞれが多種多様な化学的性質を有する。AGEsの例としては、Nε-カルボキシメチルリシン(CML)、Nε-カルボキシエチルリシン(CEL)、アルグピリミジンなどが知られている。類似の概念に過酸化脂質に由来する（Advanced Lipoxidation End products、ALEs）がある。（ALEsについては脂質過酸化反応も参照の事） AGEsは糖尿病、アテローム性動脈硬化症、慢性腎不全、アルツハイマー型認知症などの変性疾患を悪化させると言われる。糖尿病の血管系合併症の原因ともされる。活性酸素による細胞障害を加速し、機能を変化させるという。 (ja) De term Advanced Glycation End Products (AGEs) zou vertaald kunnen worden met voortgeschreden-versuikeringseindproducten. Het is een verzamelnaam voor eiwitten die onherstelbaar beschadigd zijn, doordat er suikergroepen (zoals glucose) aan verankerd zijn en het eiwit is gedegenereerd. AGEs ontstaan onder invloed van onder andere hoge bloedsuikerspiegels. De hoeveelheid AGEs in een lichaam zou een maat kunnen zijn voor de schade die een patiënt door zijn stofwisseling heeft opgelopen. Daarmee is het een maat voor het risico op cardiovasculaire aandoeningen als hartaanval of beroerte. (nl) Коне́чные проду́кты глики́рования (КПГ, англ. Advanced glycation end-products, AGEs) — это белки или липиды, которые подверглись гликированию углеводами. Они могут быть одним из факторов старения и развития или осложнения многих , таких как диабет, атеросклероз, хроническая болезнь почек и болезнь Альцгеймера. (ru) 糖化終產物（英語：Advanced glycation end products）是糖與蛋白質相互聚合、經過一系列的反應後產生的不可還原之物質。它也會改變及影響蛋白質的正常功能，與其他蛋白質連成大分子，降低蛋白質被代謝的機會；AGE也會使DNA產生移位現象，造成DNA損傷，影響DNA正常功能。 (zh) L'advanced glycation end-product, in sigla AGE (in italiano: prodotto finale della glicazione avanzata), è il risultato di una catena di reazioni chimiche successive alla reazione di glicazione iniziale. Gli AGE si trovano sulle superfici dorate o abbrustolite di cibi fritti o grigliati, ed anche sulla crosta del pane. Oltre al colore, gli AGE conferiscono agli alimenti cotti anche il sapore caratteristico, tipico dei prodotti da forno. (it) |
| rdfs:label | Konečné produkty pokročilé glykace (cs) Advanced glycation end-product (en) Advanced glycation end-product (it) AGEs (ja) 최종 당화 산물 (ko) Advanced glycation end product (nl) Конечные продукты гликирования (ru) 糖化終產物 (zh) |
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