| dbo:abstract |
معزر التنشيط القائم على التيروزين (ITAM) هو تسلسل محفوظ لأربعة أحماض أمينية تتكرر مرتين في لمستقبلات التيروزين الفسفورية غير الحفزية، وهي بروتينات سطح الخلية الموجودة في الخلايا المناعية.إنه مكون لا يتجزأ من بدء مسار الإشارات ومن ثم تنشيط الخلايا المناعية. (ar) ITAM (z anglického immunoreceptor tyrosine-based activation motif) je konzervovaná sekvence čtyř aminokyselin, která se dvakrát opakuje v intracelulárních částech nekatalytických receptorů, jejichž funkce je závislá na fosforylaci tyrosinu. Tyto receptory se nejčastěji nachází na buňkách imunitního systému. Jejich hlavní role je jejich integrální účast na spuštění celé řady signálních drah a následné aktivaci imunitní buňky. Hrají ovšem také klíčovou roli při signalizaci v jiných buněčných typech, jako například při zrání osteoklastů. (cs) An immunoreceptor tyrosine-based activation motif (ITAM) is a conserved sequence of four amino acids that is repeated twice in the cytoplasmic tails of non-catalytic tyrosine-phosphorylated receptors, cell-surface proteins found mainly on immune cells. Its major role is being an integral component for the initiation of a variety of signaling pathway and subsequently the activation of immune cells, although different functions have been described, for example an osteoclast maturation. (en) Un Motif d’Activation des récepteurs Immuns basé sur la Tyrosine (ITAM en anglais) est une séquence conservée de quatre acides aminés qui est répété deux fois dans les queues cytoplasmiques de certaines protéines de surface exprimées par des cellules du système immunitaire. Son antagoniste est le motif ITIM, pour motif d’inhibition des récepteurs immuns basé sur la tyrosine. (fr) I motivi ITAM (acronimo inglese di Immunoreceptor Tyrosine-based Activation Motif) contengono due volte una sequenza formata da una tirosina separata da una leucina o isoleucina da 2 amminoacidi (Tyr-X-X-Leu) e queste due sequenze sono solitamente separate da 6-8 altri amminoacidi. I motivi ITAM sono importanti per la trasduzione del segnale nelle cellule del sistema immunitario. Per questo motivo si trovano spesso all'estremità di molecole importanti per la comunicazione cellulare come per esempio la CD3 o la catena ζ dei T-cell receptor, le catene alfa e beta della CD79 dei B-cell receptor e alcuni recettori Fc. Il residuo di tirosina viene fosforilato a seguito dell'interazione fra il ligando e le molecole del recettore e forma siti di legame per altre proteine coinvolte nelle vie di segnalazione della cellula. Gli antagonisti si chiamano profili ITIM. (it) 免疫受体酪氨酸活化基序（英語：immunoreceptor tyrosine-based activation motif，缩写ITAM）是一个由十多个氨基酸构成的保守序列，常出现在免疫系统某些细胞的跨膜蛋白的胞内区。 (zh) |
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معزر التنشيط القائم على التيروزين (ITAM) هو تسلسل محفوظ لأربعة أحماض أمينية تتكرر مرتين في لمستقبلات التيروزين الفسفورية غير الحفزية، وهي بروتينات سطح الخلية الموجودة في الخلايا المناعية.إنه مكون لا يتجزأ من بدء مسار الإشارات ومن ثم تنشيط الخلايا المناعية. (ar) ITAM (z anglického immunoreceptor tyrosine-based activation motif) je konzervovaná sekvence čtyř aminokyselin, která se dvakrát opakuje v intracelulárních částech nekatalytických receptorů, jejichž funkce je závislá na fosforylaci tyrosinu. Tyto receptory se nejčastěji nachází na buňkách imunitního systému. Jejich hlavní role je jejich integrální účast na spuštění celé řady signálních drah a následné aktivaci imunitní buňky. Hrají ovšem také klíčovou roli při signalizaci v jiných buněčných typech, jako například při zrání osteoklastů. (cs) An immunoreceptor tyrosine-based activation motif (ITAM) is a conserved sequence of four amino acids that is repeated twice in the cytoplasmic tails of non-catalytic tyrosine-phosphorylated receptors, cell-surface proteins found mainly on immune cells. Its major role is being an integral component for the initiation of a variety of signaling pathway and subsequently the activation of immune cells, although different functions have been described, for example an osteoclast maturation. (en) Un Motif d’Activation des récepteurs Immuns basé sur la Tyrosine (ITAM en anglais) est une séquence conservée de quatre acides aminés qui est répété deux fois dans les queues cytoplasmiques de certaines protéines de surface exprimées par des cellules du système immunitaire. Son antagoniste est le motif ITIM, pour motif d’inhibition des récepteurs immuns basé sur la tyrosine. (fr) 免疫受体酪氨酸活化基序（英語：immunoreceptor tyrosine-based activation motif，缩写ITAM）是一个由十多个氨基酸构成的保守序列，常出现在免疫系统某些细胞的跨膜蛋白的胞内区。 (zh) I motivi ITAM (acronimo inglese di Immunoreceptor Tyrosine-based Activation Motif) contengono due volte una sequenza formata da una tirosina separata da una leucina o isoleucina da 2 amminoacidi (Tyr-X-X-Leu) e queste due sequenze sono solitamente separate da 6-8 altri amminoacidi. I motivi ITAM sono importanti per la trasduzione del segnale nelle cellule del sistema immunitario. Per questo motivo si trovano spesso all'estremità di molecole importanti per la comunicazione cellulare come per esempio la CD3 o la catena ζ dei T-cell receptor, le catene alfa e beta della CD79 dei B-cell receptor e alcuni recettori Fc. Il residuo di tirosina viene fosforilato a seguito dell'interazione fra il ligando e le molecole del recettore e forma siti di legame per altre proteine coinvolte nelle vie di se (it) |
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معزز التنشيط القائم على التيروزين المناعي (ar) ITAM (cs) ITAM (it) Immunoreceptor tyrosine-based activation motif (en) Motif d’activation des récepteurs immuns basé sur la tyrosine (fr) 免疫受体酪氨酸活化基序 (zh) |
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