Malonyl-CoA (original) (raw)
Malonil-CoA és un coenzim A derivat de l'àcid malònic.
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| dbo:abstract | Malonil-CoA és un coenzim A derivat de l'àcid malònic. (ca) El malonil-CoA (malonil coenzima A) es una molécula que se forma de la carboxilación de un acetil-CoA por parte del complejo enzimático acetil-CoA carboxilasa; este grupo carboxilo procede del bicarbonato. Esta es la primera reacción y la etapa limitante de la biosíntesis de ácidos grasos, es dependiente de biotina y consume ATP. (es) Malonyl-Coenzym A (kurz: Malonyl-CoA) ist ein Thioester der Malonsäure mit dem Coenzym A. Malonyl-CoA ist beim molekularen Mechanismus der Fettsäuresynthese erforderlich. Dort nimmt es eine zentrale Rolle als Fettsäurekettenverlängerer ein, ebenso bei der Biosynthese mehrfach ungesättigter Fettsäuren (z. B. Arachidonsäure aus Linolsäure). Hier bietet es seinen Kohlenstoffkettenanteil zur Fettsäureverlängerung (und damit Platzschaffung von Doppelbindungen) an. Zur Herstellung von Malonyl-CoA wird ein Biotin-abhängiges Enzym, die Acetyl-CoA-Carboxylase (ACC) benötigt. Malonyl-CoA entsteht also durch die Carboxylierung aus Acetyl-CoA (aktivierte Essigsäure) als Vorstufe der Entstehung von Fettsäuren. Die ACC ist das Schrittmacherenzym der Fettsäurebiosynthese. Der Einbau von CO2 verläuft unter einfachem ATP-Verbrauch. Die Fettsäurebiosynthese findet bei höheren Organismen überwiegend in der Leber statt. (de) Malonyl-CoA is a coenzyme A derivative of malonic acid. (en) La malonyl-coenzyme A, souvent écrite malonyl-CoA, est un thioester entre l'une des fonctions acide carboxylique de l'acide malonique et la fonction thiol de la coenzyme A. C'est une molécule clé dans la biosynthèse des acides gras et des polycétides. La malonyl-CoA sert aussi à transporter l'alpha-cétoglutarate à travers la membrane mitochondriale dans la matrice mitochondriale. (fr) 말로닐-CoA(영어: malonyl-CoA) 또는 말로닐 조효소 A(영어: malonyl coenzyme A)는 말론산의 조효소 A 유도체이다. (ko) マロニルCoA (マロニルコエンゼイムエー、マロニルコエー)は、マロニル補酵素Aの略であり、マロン酸の誘導体。補酵素Aの末端のチオール基がマロン酸とチオエステル結合した化合物で、脂肪酸やポリケチドの合成における出発物質（プライマー）である。生体内ではアセチルCoAカルボキシレース (ACC) によりアセチルCoAから生合成される。 脂肪酸合成では、マロニルCoAはまずマロニルCoA: ACP転移酵素（MCAT, MT）によりアシルキャリアタンパク質（ACP）と結合してマロニルACPとして活性化され、マロニルACPが実際のプライマーとなる。マロニルACPがアセチルACPに逐次結合することで脂肪酸の炭素鎖が炭素数2ずつ増加していく。また、マロニルCoAは脂肪酸とカルニチンの結合を阻害することで、脂肪酸のβ酸化の制御に関与している。 (ja) Il malonil-CoA è una molecola derivata dal coenzima A che si forma grazie ad una reazione di carbossilazione tra l'acetil-coenzima A e lo ione bicarbonato (HCO3-) catalizzata dalla acetil-CoA carbossilasi in presenza di ATP. Il coenzima A risulta dunque legato, mediante legame tiosterico, ad un'unità a 3 atomi di Carbonio (un malonile). (it) O malonil-CoA (malonil coenzima A) é uma molécula que se forma da de um acetil-CoA por parte do complexo enzimático acetil-CoA carboxilase; este grupo carboxilo procede do bicarbonato. Esta é a primeira reação e a etapa limitante da , é dependente de biotina e consome ATP. Dentre as funções podemos destacar que é uma molécula alongadora. (pt) 丙二酰辅酶A（英語：Malonyl-CoA，或称为丙二酸单酰辅酶A）是一种辅酶A的衍生物。 (zh) |
| dbo:iupacName | (9R)-1-[(2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]-3,5,9-trihydroxy-3,5,10,14,19-pentaoxo-8,8-dimethyl-2,4,6-trioxa-18-thia-11,15-diaza-3λ5,5λ5-diphosphahenicosan-21-oic acid (en) |
| dbo:thumbnail | wiki-commons:Special:FilePath/Malonyl-CoA2.svg?width=300 |
| dbo:wikiPageExternalLink | http://news.bbc.co.uk/1/hi/health/4608752.stm |
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| dbo:wikiPageWikiLink | dbr:Carnitine dbr:Beta-oxidation dbr:Bicarbonate dbc:Metabolism dbr:Coenzyme_A dbr:Mitochondria dbr:Malonic_acid dbr:Malonyl-CoA_decarboxylase dbr:Polyketide dbr:Acetyl-CoA dbr:Acetyl-CoA_carboxylase dbr:Acyl_carrier_protein dbr:Adenosine_triphosphate dbr:Fatty_acids dbc:Thioesters_of_coenzyme_A dbr:MCAT_(gene) dbr:Malonate dbr:Malonyl-CoA_decarboxylase_deficiency dbr:Polyketide_synthase dbr:Thiol dbr:Malonyl_coenzyme_A:acyl_carrier_protein_transacylase dbr:Carnitine_acyltransferase dbr:Fatty_acid_biosynthesis dbr:Fatty_acid_oxidation |
| dbp:imagefile | Malonyl-CoA2.svg (en) |
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| dcterms:subject | dbc:Metabolism dbc:Thioesters_of_coenzyme_A |
| gold:hypernym | dbr:Coenzyme |
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| rdfs:comment | Malonil-CoA és un coenzim A derivat de l'àcid malònic. (ca) El malonil-CoA (malonil coenzima A) es una molécula que se forma de la carboxilación de un acetil-CoA por parte del complejo enzimático acetil-CoA carboxilasa; este grupo carboxilo procede del bicarbonato. Esta es la primera reacción y la etapa limitante de la biosíntesis de ácidos grasos, es dependiente de biotina y consume ATP. (es) Malonyl-CoA is a coenzyme A derivative of malonic acid. (en) La malonyl-coenzyme A, souvent écrite malonyl-CoA, est un thioester entre l'une des fonctions acide carboxylique de l'acide malonique et la fonction thiol de la coenzyme A. C'est une molécule clé dans la biosynthèse des acides gras et des polycétides. La malonyl-CoA sert aussi à transporter l'alpha-cétoglutarate à travers la membrane mitochondriale dans la matrice mitochondriale. (fr) 말로닐-CoA(영어: malonyl-CoA) 또는 말로닐 조효소 A(영어: malonyl coenzyme A)는 말론산의 조효소 A 유도체이다. (ko) マロニルCoA (マロニルコエンゼイムエー、マロニルコエー)は、マロニル補酵素Aの略であり、マロン酸の誘導体。補酵素Aの末端のチオール基がマロン酸とチオエステル結合した化合物で、脂肪酸やポリケチドの合成における出発物質（プライマー）である。生体内ではアセチルCoAカルボキシレース (ACC) によりアセチルCoAから生合成される。 脂肪酸合成では、マロニルCoAはまずマロニルCoA: ACP転移酵素（MCAT, MT）によりアシルキャリアタンパク質（ACP）と結合してマロニルACPとして活性化され、マロニルACPが実際のプライマーとなる。マロニルACPがアセチルACPに逐次結合することで脂肪酸の炭素鎖が炭素数2ずつ増加していく。また、マロニルCoAは脂肪酸とカルニチンの結合を阻害することで、脂肪酸のβ酸化の制御に関与している。 (ja) Il malonil-CoA è una molecola derivata dal coenzima A che si forma grazie ad una reazione di carbossilazione tra l'acetil-coenzima A e lo ione bicarbonato (HCO3-) catalizzata dalla acetil-CoA carbossilasi in presenza di ATP. Il coenzima A risulta dunque legato, mediante legame tiosterico, ad un'unità a 3 atomi di Carbonio (un malonile). (it) O malonil-CoA (malonil coenzima A) é uma molécula que se forma da de um acetil-CoA por parte do complexo enzimático acetil-CoA carboxilase; este grupo carboxilo procede do bicarbonato. Esta é a primeira reação e a etapa limitante da , é dependente de biotina e consome ATP. Dentre as funções podemos destacar que é uma molécula alongadora. (pt) 丙二酰辅酶A（英語：Malonyl-CoA，或称为丙二酸单酰辅酶A）是一种辅酶A的衍生物。 (zh) Malonyl-Coenzym A (kurz: Malonyl-CoA) ist ein Thioester der Malonsäure mit dem Coenzym A. Malonyl-CoA ist beim molekularen Mechanismus der Fettsäuresynthese erforderlich. Dort nimmt es eine zentrale Rolle als Fettsäurekettenverlängerer ein, ebenso bei der Biosynthese mehrfach ungesättigter Fettsäuren (z. B. Arachidonsäure aus Linolsäure). Hier bietet es seinen Kohlenstoffkettenanteil zur Fettsäureverlängerung (und damit Platzschaffung von Doppelbindungen) an. Zur Herstellung von Malonyl-CoA wird ein Biotin-abhängiges Enzym, die Acetyl-CoA-Carboxylase (ACC) benötigt. Malonyl-CoA entsteht also durch die Carboxylierung aus Acetyl-CoA (aktivierte Essigsäure) als Vorstufe der Entstehung von Fettsäuren. Die ACC ist das Schrittmacherenzym der Fettsäurebiosynthese. Der Einbau von CO2 verläuft unte (de) |
| rdfs:label | Malonil-CoA (ca) Malonyl-CoA (de) Malonil-CoA (es) Malonyl-coenzyme A (fr) Malonil-CoA (it) Malonyl-CoA (en) 말로닐-CoA (ko) マロニルCoA (ja) Malonil-CoA (pt) 丙二酰辅酶A (zh) |
| owl:sameAs | freebase:Malonyl-CoA yago-res:Malonyl-CoA http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugs/DB04524 wikidata:Malonyl-CoA http://azb.dbpedia.org/resource/مالونیل-کوآ dbpedia-ca:Malonyl-CoA dbpedia-de:Malonyl-CoA dbpedia-es:Malonyl-CoA dbpedia-fa:Malonyl-CoA dbpedia-fr:Malonyl-CoA dbpedia-gl:Malonyl-CoA dbpedia-it:Malonyl-CoA dbpedia-ja:Malonyl-CoA dbpedia-ko:Malonyl-CoA dbpedia-pt:Malonyl-CoA dbpedia-sh:Malonyl-CoA dbpedia-sr:Malonyl-CoA dbpedia-zh:Malonyl-CoA https://global.dbpedia.org/id/2Y6ZS |
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