Notch signaling pathway (original) (raw)
Notch receptor je transmembránový protein a receptor živočišných buněk. V extracelulární části obsahuje opakující se , které vytváří pro vazbu Notch ligandu (např. proteinu u octomilek). Notch byl původně pojmenován u octomilek (Drosophila), u C. elegans se nachází dva Notch receptory ( a ), u člověka se gen nazývá TAN-1, u myši int-3 a u je to Xotch.
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| dbo:abstract | Notch receptor je transmembránový protein a receptor živočišných buněk. V extracelulární části obsahuje opakující se , které vytváří pro vazbu Notch ligandu (např. proteinu u octomilek). Notch byl původně pojmenován u octomilek (Drosophila), u C. elegans se nachází dva Notch receptory ( a ), u člověka se gen nazývá TAN-1, u myši int-3 a u je to Xotch. (cs) Der Notch-Signalweg ist ein weit verbreiteter und stark konservierter Signaltransduktionsweg, durch den Zellen auf äußere Signale reagieren können. Der Signalweg ist nach seinem Rezeptor „Notch“ benannt, welcher den membranständigen Liganden „Delta“ auf der Oberfläche einer anderen Zelle bindet. Notch ist ein Transmembranprotein mit nur einer Transmembrandomäne und einer großen extrazellulären Domäne. (de) La Ruta de Señalización Notch es un sistema de señalización celular altamente conservado en los animales, con el cometido principal de controlar los destinos celulares mediante la amplificación y consolidación de diferencias entre células adyacentes. La Ruta se basa en la proteína funcional NOTCH, proteína transmembranal que sirve como receptor de señales extracelulares. Esta proteína es un hetero-oligomero compuesto por dos porción extracelulares, una larga y una corta, asociadas por una interacción no covalente dependiente de calcio, y una porción intracelular corta. Los mamíferos cuentan con cuatro receptores NOTCH diferentes. La ruta de señalización Notch participa en procesos proliferativos en la neurogénesis y mantenimiento de nichos de célula madre. Su actividad es inhibida por Numb. (es) The Notch signaling pathway is a highly conserved cell signaling system present in most animals. Mammals possess four different notch receptors, referred to as NOTCH1, NOTCH2, NOTCH3, and NOTCH4. The notch receptor is a single-pass transmembrane receptor protein. It is a hetero-oligomer composed of a large extracellular portion, which associates in a calcium-dependent, non-covalent interaction with a smaller piece of the notch protein composed of a short extracellular region, a single transmembrane-pass, and a small intracellular region. Notch signaling promotes proliferative signaling during neurogenesis, and its activity is inhibited by Numb to promote neural differentiation. It plays a major role in the regulation of embryonic development. Notch signaling is dysregulated in many cancers, and faulty notch signaling is implicated in many diseases, including T-cell acute lymphoblastic leukemia (T-ALL), cerebral autosomal-dominant arteriopathy with sub-cortical infarcts and leukoencephalopathy (CADASIL), multiple sclerosis, Tetralogy of Fallot, and Alagille syndrome. Inhibition of notch signaling inhibits the proliferation of T-cell acute lymphoblastic leukemia in both cultured cells and a mouse model. (en) La voie de signalisation Notch est une cascade de signalisation conservée chez tous les métazoaires. Elle doit son nom au gène Notch, qui code le premier élément de la cascade, le récepteur transmembranaire Notch. La voie de signalisation Notch va permettre de déterminer le lignage d'une cellule. C'est une grande protéine encastrée dans la membrane et qui va être clivée pour ensuite s'intégrer dans une autre protéine, Delta. Le peptide restant de Notch est encore clivé et va aller dans le noyau pour réguler l'expression de certains gènes. (fr) Il Notch è un recettore di natura integrinica altamente conservato e presente in numerosi organismi multicellulari, tra cui tutti i metazoi. Nei vertebrati sono presenti quattro famiglie di recettori Notch, indicati con i numeri arabi da 1 a 4. Tale recettore fu scoperto da Thomas Hunt Morgan nel 1917, e fu così chiamato perché gli individui di Drosophila melanogaster le cui cellule lo presentavano mutato avevano delle piccole incisure sulle ali. (it) Notchシグナリング（ノッチシグナリング）もしくはNotch経路（ノッチけいろ、Notch pathway）は神経、造血、血管、体節などの様々な分化過程に関係する、ヒトを含め脊椎動物から節足動物まで多くの後生動物でよく保存された遺伝子調節（シグナル伝達）経路である。 NotchカスケードはNotchとNotch受容体、それと核へNotchシグナルを伝える細胞内タンパク質から成る。Notch/Lin-12/Glp-1受容体ファミリーはショウジョウバエとC.elegansの発生で細胞運命の特異化に関連していることが判明した。 哺乳類においては現在5種類のリガンドと4種類の受容体が発見されている。Notchの受容体は一回膜貫通型受容体である。Notchの受容体にリガンドが結合すると細胞表面のNotchタンパクはあるプロテアーゼに切断されて、細胞内ドメインが細胞質へ遊離して核内のCBF1と結合することで、標的遺伝子の転写活性が行なわれる。 興味深いことに、Notchシグナリング経路は青春期に達すると新しい細胞の成長を抑制し、成人では神経ネットワークを安定にする。 (ja) A via de sinalização Notch é uma via de sinalização celular, justácrina e altamente conservada de Drosophilas até humanos, que atua principalmente no desenvolvimento de células embrionárias, coordenando a diferenciação celular, proliferação celular e apoptose . Ela foi sugerida pela primeira vez em 1937 por Donald F. Poulson, quando estudava a ablação de partes do cromossomo X em Drosophila Melanogaster . Notch são proteínas transmembrânicas que ao se ligarem com proteínas, também transmembrânicas (como Delta, Jagged ou Serrate), da célula vizinha ativam uma cascata bioquímica. Elas estão envolvidas na formação de vários órgãos de vertebrados e são receptores extremamente importantes principalmente no sistema nervoso ditando a diferenciação celular . Uma célula indutora - normalmente com o ligante Delta - interage com uma célula vizinha portadora da proteína Notch, chamada de responsiva. Quando a proteína Delta, Jagged ou Serrate se liga a proteína Notch esta sofre mudança de conformação e parte do seu domínio citoplasmático é clivado pela protease presenilina 1. A parte clivada da proteína Notch entra no núcleo da célula e se liga ao fator de transcrição dormente da família CSL ativando genes alvo . (pt) Notch信号通路是大多数多细胞生物体中存在的高度保守的细胞信号转导系统。哺乳动物具有四种不同的，分别称为NOTCH1, NOTCH2, NOTCH3, NOTCH4。Notch受体是单跨膜的受体蛋白。它是由大的胞外部分构成的异源寡聚体，通过钙依赖性的非共价作用与包含有短的胞外结构域，一个跨膜区域和一小段膜内结构域的notch蛋白相互作用。 Notch信号通路提升了神经增殖过程中的增殖信号，而其活性被Numb所抑制，以促进神经分化。他在胚胎发育中起到重要的调控作用。 (zh) |
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| rdfs:comment | Notch receptor je transmembránový protein a receptor živočišných buněk. V extracelulární části obsahuje opakující se , které vytváří pro vazbu Notch ligandu (např. proteinu u octomilek). Notch byl původně pojmenován u octomilek (Drosophila), u C. elegans se nachází dva Notch receptory ( a ), u člověka se gen nazývá TAN-1, u myši int-3 a u je to Xotch. (cs) Der Notch-Signalweg ist ein weit verbreiteter und stark konservierter Signaltransduktionsweg, durch den Zellen auf äußere Signale reagieren können. Der Signalweg ist nach seinem Rezeptor „Notch“ benannt, welcher den membranständigen Liganden „Delta“ auf der Oberfläche einer anderen Zelle bindet. Notch ist ein Transmembranprotein mit nur einer Transmembrandomäne und einer großen extrazellulären Domäne. (de) La voie de signalisation Notch est une cascade de signalisation conservée chez tous les métazoaires. Elle doit son nom au gène Notch, qui code le premier élément de la cascade, le récepteur transmembranaire Notch. La voie de signalisation Notch va permettre de déterminer le lignage d'une cellule. C'est une grande protéine encastrée dans la membrane et qui va être clivée pour ensuite s'intégrer dans une autre protéine, Delta. Le peptide restant de Notch est encore clivé et va aller dans le noyau pour réguler l'expression de certains gènes. (fr) Il Notch è un recettore di natura integrinica altamente conservato e presente in numerosi organismi multicellulari, tra cui tutti i metazoi. Nei vertebrati sono presenti quattro famiglie di recettori Notch, indicati con i numeri arabi da 1 a 4. Tale recettore fu scoperto da Thomas Hunt Morgan nel 1917, e fu così chiamato perché gli individui di Drosophila melanogaster le cui cellule lo presentavano mutato avevano delle piccole incisure sulle ali. (it) Notchシグナリング（ノッチシグナリング）もしくはNotch経路（ノッチけいろ、Notch pathway）は神経、造血、血管、体節などの様々な分化過程に関係する、ヒトを含め脊椎動物から節足動物まで多くの後生動物でよく保存された遺伝子調節（シグナル伝達）経路である。 NotchカスケードはNotchとNotch受容体、それと核へNotchシグナルを伝える細胞内タンパク質から成る。Notch/Lin-12/Glp-1受容体ファミリーはショウジョウバエとC.elegansの発生で細胞運命の特異化に関連していることが判明した。 哺乳類においては現在5種類のリガンドと4種類の受容体が発見されている。Notchの受容体は一回膜貫通型受容体である。Notchの受容体にリガンドが結合すると細胞表面のNotchタンパクはあるプロテアーゼに切断されて、細胞内ドメインが細胞質へ遊離して核内のCBF1と結合することで、標的遺伝子の転写活性が行なわれる。 興味深いことに、Notchシグナリング経路は青春期に達すると新しい細胞の成長を抑制し、成人では神経ネットワークを安定にする。 (ja) Notch信号通路是大多数多细胞生物体中存在的高度保守的细胞信号转导系统。哺乳动物具有四种不同的，分别称为NOTCH1, NOTCH2, NOTCH3, NOTCH4。Notch受体是单跨膜的受体蛋白。它是由大的胞外部分构成的异源寡聚体，通过钙依赖性的非共价作用与包含有短的胞外结构域，一个跨膜区域和一小段膜内结构域的notch蛋白相互作用。 Notch信号通路提升了神经增殖过程中的增殖信号，而其活性被Numb所抑制，以促进神经分化。他在胚胎发育中起到重要的调控作用。 (zh) La Ruta de Señalización Notch es un sistema de señalización celular altamente conservado en los animales, con el cometido principal de controlar los destinos celulares mediante la amplificación y consolidación de diferencias entre células adyacentes. La ruta de señalización Notch participa en procesos proliferativos en la neurogénesis y mantenimiento de nichos de célula madre. Su actividad es inhibida por Numb. (es) The Notch signaling pathway is a highly conserved cell signaling system present in most animals. Mammals possess four different notch receptors, referred to as NOTCH1, NOTCH2, NOTCH3, and NOTCH4. The notch receptor is a single-pass transmembrane receptor protein. It is a hetero-oligomer composed of a large extracellular portion, which associates in a calcium-dependent, non-covalent interaction with a smaller piece of the notch protein composed of a short extracellular region, a single transmembrane-pass, and a small intracellular region. (en) A via de sinalização Notch é uma via de sinalização celular, justácrina e altamente conservada de Drosophilas até humanos, que atua principalmente no desenvolvimento de células embrionárias, coordenando a diferenciação celular, proliferação celular e apoptose . Ela foi sugerida pela primeira vez em 1937 por Donald F. Poulson, quando estudava a ablação de partes do cromossomo X em Drosophila Melanogaster . (pt) |
| rdfs:label | Notch receptor (cs) Notch-Signalweg (de) Ruta de señalización Notch (es) Jalur persinyalan Notch (in) Voie de signalisation Notch (fr) Notch (it) Notchシグナリング (ja) Notch signaling pathway (en) Via de sinalização Notch (pt) Notch信号通路 (zh) |
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