MTPN (original) (raw)

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Protein coding gene in Homo sapiens

MTPN
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3AAA
Identifiers
Aliases	MTPN, GCDP, V-1, myotrophin
External IDs	OMIM: 606484; MGI: 99445; HomoloGene: 40607; GeneCards: MTPN; OMA:MTPN - orthologs
Gene location (Human)Chr.Chromosome 7 (human)[1]Band7q33Start135,926,760 bp[1]End135,977,359 bp[1]
Gene location (Mouse)Chr.Chromosome 6 (mouse)[2]Band6|6 B1Start35,485,841 bp[2]End35,516,823 bp[2]
RNA expression patternBgeeHuman Mouse (ortholog)Top expressed incardiac muscle tissue of right atriumskin of armmucosa of ileummyocardium of left ventriclesuperficial temporal arterymonocytelower lobe of lungtrabecular boneBrodmann area 46tibialis anterior muscleTop expressed inretinal pigment epitheliumRostral migratory streambarrel cortexciliary bodyepithelium of lensdorsal striatumendothelial cell of lymphatic vesselsubiculumprefrontal cortexpineal glandMore reference expression dataBioGPSMore reference expression data
Gene ontologyMolecular function sequence-specific DNA binding Cellular component cytoplasm F-actin capping protein complex axon perinuclear region of cytoplasm nucleus cytosol Biological process regulation of striated muscle tissue development catecholamine metabolic process positive regulation of cardiac muscle hypertrophy regulation of barbed-end actin filament capping cellular response to mechanical stimulus skeletal muscle tissue regeneration neuron differentiation striated muscle cell differentiation regulation of translation cerebellar granule cell differentiation positive regulation of NF-kappaB transcription factor activity positive regulation of cell growth positive regulation of macromolecule biosynthetic process regulation of cell size Sources:Amigo / QuickGO
OrthologsSpeciesHuman MouseEntrez13631914489EnsemblENSG00000105887ENSMUSG00000029840UniProtP58546P62774RefSeq (mRNA)NM_145808NM_008098RefSeq (protein)NP_665807NP_032124Location (UCSC)Chr 7: 135.93 – 135.98 MbChr 6: 35.49 – 35.52 MbPubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Myotrophin is a protein that in humans is encoded by the MTPN gene.[5][6]

MTPN has been shown to interact with RELA[7] and REL.[7]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105887 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029840 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Mitra S, Timur AA, Gupta S, Wang Q, Sen S (July 2001). "Assignment of myotrophin to human chromosome band 7q33→q35 by in situ hybridization". Cytogenet Cell Genet. 93 (1–2): 151–2. doi:10.1159/000056974. PMID 11474205. S2CID 30646120.
6. ^ "Entrez Gene: MTPN myotrophin".
7. ^ a b Knuefermann, Pascal; Chen Peter; Misra Arunima; Shi Shu-Ping; Abdellatif Maha; Sivasubramanian Natarajan (June 2002). "Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers". J. Biol. Chem. 277 (26). United States: 23888–97. doi:10.1074/jbc.M202937200. ISSN 0021-9258. PMID 11971907.

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