Cancer gene therapy: fringe or cutting edge? (original) (raw)
Morin, P. J., Vogelstein, B. & Kinzler, K. W. Apoptosis and APC in colorectal tumorigenesis. Proc. Natl Acad. Sci. USA93, 7950–7954 (1996). ArticleCASPubMedPubMed Central Google Scholar
Nikitin, A. Y., Juarez-Perez, M. I., Li, S., Huang, L. & Lee, W. H. RB-mediated suppression of spontaneous multiple neuroendocrine neoplasia and lung metastases in Rb+/− mice. Proc. Natl Acad. Sci. USA96, 3916–3921 (1999). ArticleCASPubMedPubMed Central Google Scholar
Demers, G. W. et al. A recombinant adenoviral vector expressing full-length human retinoblastoma susceptibility gene inhibits human tumor cell growth. Cancer Gene Ther.5, 207–214 (1998). CASPubMed Google Scholar
Craig, C. et al. Effects of adenovirus-mediated p16INK4A expression on cell cycle arrest are determined by endogenous p16 and Rb status in human cancer cells. Oncogene16, 265–272 (1998). ArticleCASPubMed Google Scholar
Sumitomo, K., Shimizu, E., Shinohara, A., Yokota, J. & Sone, S. Activation of RB tumor suppressor protein and growth suppression of small cell lung carcinoma cells by reintroduction of p16INK4A gene. Int. J. Oncol.14, 1075–1080 (1999). CASPubMed Google Scholar
Tanaka, M. et al. MMAC1/PTEN inhibits cell growth and induces chemosensitivity to doxorubicin in human bladder cancer cells. Oncogene19, 5406–5412 (2000). ArticleCASPubMed Google Scholar
Minaguchi, T. et al. Growth suppression of human ovarian cancer cells by adenovirus-mediated transfer of the PTEN gene. Cancer Res.59, 6063–6067 (1999). CASPubMed Google Scholar
Sakurada, A. et al. Adenovirus-mediated delivery of the PTEN gene inhibits cell growth by induction of apoptosis in endometrial cancer. Int. J. Oncol.15, 1069–1074 (1999). CASPubMed Google Scholar
Cheney, I. W. et al. Suppression of tumorigenicity of glioblastoma cells by adenovirus-mediated MMAC1/PTEN gene transfer. Cancer Res.58, 2331–2334 (1998). CASPubMed Google Scholar
Yang, C. T. et al. Adenovirus-mediated p14ARF gene transfer in human mesothelioma cells. J. Natl Cancer Inst.92, 636–641 (2000). ArticleCASPubMed Google Scholar
Roth, J. A. et al. Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer. Nature Med.2, 985–991 (1996).First report of p53 delivery to cancer cells in humans. Expression of p53 and increased apoptosis in treated tumours was reported, with no evidence of toxicity. The retrovirus delivery system was not sufficiently efficient, but this paper proved the principle that delivery of p53 could kill cancer cellsin vivo. ArticleCASPubMed Google Scholar
Seth, P. et al. A recombinant adenovirus expressing wild type p53 induces apoptosis in drug-resistant human breast cancer cells: a gene therapy approach for drug-resistant cancers. Cancer Gene Ther.4, 383–390 (1997). CASPubMed Google Scholar
Holt, J. T. et al. Growth retardation and tumour inhibition by BRCA1. Nature Genet.12, 298–302 (1996). ArticleCASPubMed Google Scholar
Shao, N., Chai, Y. L., Shyam, E., Reddy, P. & Rao, V. N. Induction of apoptosis by the tumor suppressor protein BRCA1. Oncogene13, 1–7 (1996). CASPubMed Google Scholar
Tait, D. L. et al. A phase I trial of retroviral BRCA1sv gene therapy in ovarian cancer. Clin. Cancer Res.3, 1959–1968 (1997). CASPubMed Google Scholar
Vogelstein, B., Lane, D. & Levine, A. J. Surfing the p53 network. Nature408, 307–310 (2000). ArticleCASPubMed Google Scholar
Kaplan, K. B. et al. A role for the adenomatous polyposis coli protein in chromosome segregation. Nature Cell Biol.3, 429–432 (2001). ArticleCASPubMed Google Scholar
Fodde, R. et al. Mutations in the APC tumour suppressor gene cause chromosomal instability. Nature Cell Biol.3, 433–438 (2001). ArticleCASPubMed Google Scholar
Zhang, W. W. et al. High-efficiency gene transfer and high-level expression of wild-type p53 in human lung cancer cells mediated by recombinant adenovirus. Cancer Gene Ther.1, 5–13 (1994). PubMed Google Scholar
Nishizaki, M. et al. Recombinant adenovirus expressing wild-type p53 is antiangiogenic: a proposed mechanism for bystander effect. Clin. Cancer Res.5, 1015–102 (1999). CASPubMed Google Scholar
Bouvet, M. et al. Adenovirus-mediated wild-type p53 gene transfer down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human colon cancer. Cancer Res.58, 2288–2292 (1998). CASPubMed Google Scholar
Dameron, K. M., Volpert, O. V., Tainsky, M. A. & Bouck, N. The p53 tumor suppressor gene inhibits angiogenesis by stimulating the production of thrombospondin. Cold Spring Harb. Symp. Quant. Biol.59, 483–489 (1994).First connection between p53 and angiogenesis: the discovery that p53 regulates expression of the production of thrombospondin, a protein purified by Bouck and co-workers in an early biological assay for factors that block angiogenesis. ArticleCASPubMed Google Scholar
Buckbinder, L. et al. Induction of the growth inhibitor IGF-binding protein 3 by p53. Nature377, 646–649 (1995). ArticleCASPubMed Google Scholar
Mueller, H. Tumor necrosis factor as an antineoplastic agent: pitfalls and promises. Cell. Mol. Life Sci.54, 1291–1298 (1998). ArticleCASPubMed Google Scholar
Swisher, S. G. et al. Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer. J. Natl Cancer Inst.91, 763–771 (1999). ArticleCASPubMed Google Scholar
Clayman, G. L., Frank, D. K., Bruso, P. A. & Goepfert, H. Adenovirus-mediated wild-type p53 gene transfer as a surgical adjuvant in advanced head and neck cancers. Clin. Cancer Res.5, 1715–1722 (1999). CASPubMed Google Scholar
Nemunaitis, J. et al. Adenovirus-mediated p53 gene transfer in sequence with cisplatin to tumors of patients with non-small-cell lung cancer. J. Clin. Oncol.18, 609–622 (2000). ArticleCASPubMed Google Scholar
Chin, L. et al. Essential role for oncogenic Ras in tumour maintenance. Nature400, 468–472 (1999). ArticleCASPubMed Google Scholar
Barrington, R. E. et al. A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Mol. Cell Biol.18, 85–92 (1998). ArticleCASPubMedPubMed Central Google Scholar
Druker, B. J. et al. Efficacy and safety of a specific inhibitor of the BCR–ABL tyrosine kinase in chronic myeloid leukemia. N. Engl. J. Med.344, 1031–1037 (2001).One of a series of landmark papers from Druker and colleagues, showing the clinical effects of STI-571 (Gleevec) in clinical trials. First successful demonstration that small molecules that target oncogenes can have clinical benefit. ArticleCASPubMed Google Scholar
Sebolt-Leopold, J. S. et al. Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo. Nature Med.5, 810–816 (1999). ArticleCASPubMed Google Scholar
Mendelsohn, J. & Baselga, J. The EGF receptor family as targets for cancer therapy. Oncogene19, 6550–6565 (2000). ArticleCASPubMed Google Scholar
Moolten, F. L. Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res.46, 5276–5281 (1986).Early description of the concept of suicide gene therapy, in which HSV-tk is expressed in cells using viral vectors, and cells and their uninfected neighbours are killed by the approved clinical prodrug, ganciclovir. This system has been the most widely used of all suicide gene-therapy protocols. CASPubMed Google Scholar
Crystal, R. G. et al. Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine. Hum. Gene Ther.8, 985–1001 (1997). ArticleCASPubMed Google Scholar
Takayama, K. et al. Suppression of tumor angiogenesis and growth by gene transfer of a soluble form of vascular endothelial growth factor receptor into a remote organ. Cancer Res.60, 2169–2177 (2000). CASPubMed Google Scholar
Chen, Q. R., Kumar, D., Stass, S. A. & Mixson, A. J. Liposomes complexed to plasmids encoding angiostatin and endostatin inhibit breast cancer in nude mice. Cancer Res.59, 3308–3312 (1999). CASPubMed Google Scholar
Chen, C. T. et al. Antiangiogenic gene therapy for cancer via systemic administration of adenoviral vectors expressing secretable endostatin. Hum. Gene Ther.11, 1983–1996 (2000). ArticleCASPubMed Google Scholar
Regulier, E. et al. Adenovirus-mediated delivery of antiangiogenic genes as an antitumor approach. Cancer Gene Ther.8, 45–54 (2001). ArticleCASPubMed Google Scholar
Brand, K. et al. Treatment of colorectal liver metastases by adenoviral transfer of tissue inhibitor of metalloproteinase-2 into the liver tissue. Cancer Res.60, 5723–5730 (2000). CASPubMed Google Scholar
Rainov, N. G. A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme. Hum. Gene Ther.11, 2389–2401 (2000). ArticleCASPubMed Google Scholar
Sandmair, A. M. et al. Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses. Hum. Gene Ther.11, 2197–2205 (2000). ArticleCASPubMed Google Scholar
Aghi, M., Kramm, C. M., Chou, T. C., Breakefield, X. O. & Chiocca, E. A. Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies. J. Natl Cancer Inst.90, 370–380 (1998). ArticleCASPubMed Google Scholar
Touraine, R. L., Vahanian, N., Ramsey, W. J. & Blaese, R. M. Enhancement of the herpes simplex virus thymidine kinase/ganciclovir bystander effect and its antitumor efficacy in vivo by pharmacologic manipulation of gap junctions. Hum. Gene Ther.9, 2385–2391 (1998). ArticleCASPubMed Google Scholar
Sakai, Y. et al. Gene therapy for hepatocellular carcinoma using two recombinant adenovirus vectors with α-fetoprotein promoter and Cre/lox P system. J. Virol. Methods92, 5–17 (2001). ArticleCASPubMed Google Scholar
Kirn, D. H. & McCormick, F. Replicating viruses as selective cancer therapeutics. Mol. Med. Today2, 519–527 (1996). ArticleCASPubMed Google Scholar
Mineta, T., Rabkin, S. D., Yazaki, T., Hunter, W. D. & Martuza, R. L. Attenuated multi-mutated herpes simplex virus-1 for the treatment of malignant gliomas. Nature Med.1, 938–943 (1995).First use of a recombinant conditionally replicating virus to treat human cancer. This HSV mutant cannot replicate in quiescent cells because a key enzyme involved in DNA synthesis has been deleted. This mutant virus kills brain tumour cells selectively, because normal cells cannot support replication. ArticleCASPubMed Google Scholar
Markert, J. M. et al. Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial. Gene Ther.7, 867–874 (2000). ArticleCASPubMed Google Scholar
Randazzo, B. P., Bhat, M. G., Kesari, S., Fraser, N. W. & Brown, S. M. Treatment of experimental subcutaneous human melanoma with a replication-restricted herpes simplex virus mutant. J. Invest. Dermatol.108, 933–937 (1997). ArticleCASPubMed Google Scholar
MacKie, R. M., Stewart, B. & Brown, S. M. Intralesional injection of herpes simplex virus 1716 in metastatic melanoma. Lancet357, 525–526 (2001). ArticleCASPubMed Google Scholar
Rampling, R. et al. Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma. Gene Ther.7, 859–866 (2000). ArticleCASPubMed Google Scholar
Barker, D. D. & Berk, A. J. Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection. Virology156, 107–121 (1987). ArticleCASPubMed Google Scholar
Bischoff, J. R. et al. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science274, 373–376 (1996).First virus described for which replication depends on loss of p53. This adenovirus mutant grows selectively in tumour cells in which p53 is inactive, but also depends on other functions of tumour cells that are not fully understood for its efficient replication. In this paper, it was shown for the first time that a recombinant virus destroys human xenograft tumours in mouse models of cancer. ArticleCASPubMed Google Scholar
Dix, B. R., Edwards, S. J. & Braithwaite, A. W. Does the antitumor adenovirus ONYX-015/dl1520 selectively target cells defective in the p53 pathway? J. Virol.75, 5443–5447 (2001). ArticleCASPubMedPubMed Central Google Scholar
Heise, C. C., Williams, A., Olesch, J. & Kirn, D. H. Efficacy of a replication-competent adenovirus (ONYX-015) following intratumoral injection: intratumoral spread and distribution effects. Cancer Gene Ther.6, 499–504 (1999). ArticleCASPubMed Google Scholar
Goodrum, F. D. & Ornelles, D. A. p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection. J. Virol.72, 9479–9490 (1998). ArticleCASPubMedPubMed Central Google Scholar
Rothmann, T., Hengstermann, A., Whitaker, N. J., Scheffner, M. & zur Hausen, H. Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells. J. Virol.72, 9470–9478 (1998). ArticleCASPubMedPubMed Central Google Scholar
Turnell, A. S., Grand, R. J. A. & Gallimore, P. H. The replicative capacities of large E1B-null group A and group C adenoviruses are independent of host cell p53 status. J. Virol.73, 2074–2083 (1999). ArticleCASPubMedPubMed Central Google Scholar
Ries, S. J. et al. Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015). Nature Med.6, 1128–1133 (2000). ArticleCASPubMed Google Scholar
Harada, J. N. & Berk, A. J. p53-independent and -dependent requirements for E1B-55K in adenovirus type 5 replication. J. Virol.73, 5333–5344 (1999). ArticleCASPubMedPubMed Central Google Scholar
Nemunaitis, J. et al. Phase II trial of intratumoral administration of ONYX-015, a replication-selective adenovirus, in patients with refractory head and neck cancer. J. Clin. Oncol.19, 289–298 (2001). ArticleCASPubMed Google Scholar
Khuri, F. R. et al. A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer. Nature Med.6, 879–885 (2000). ArticleCASPubMed Google Scholar
Heise, C. et al. An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy. Nature Med.6, 1134–1139 (2000). ArticleCASPubMed Google Scholar
Fueyo, J. et al. A mutant oncolytic adenovirus targeting the RB pathway produces anti-glioma effect in vivo. Oncogene19, 2–12 (2000).A mutant adenovirus that cannot neutralize RB is shown to replicate selectively in cancer cells. This approach is similar to the approach of dl1520, ONYX-015. In this case, a small mutation was made to inactivate E1A's ability to neutralize RB, and other functions of E1A were left intact. ArticleCASPubMed Google Scholar
Doronin, K. et al. Tumor-specific, replication-competent adenovirus vectors overexpressing the adenovirus death protein. J. Virol.74, 6147–6155 (2000). ArticleCASPubMedPubMed Central Google Scholar
Doronin, K. et al. Tissue-specific, tumor-selective, replication-competent adenovirus vector for cancer gene therapy. J. Virol.75, 3314–3324 (2001). ArticleCASPubMedPubMed Central Google Scholar
Nevins, J. R. Adenovirus E1A-dependent trans-activation of transcription. Semin. Cancer Biol.1, 59–68 (1990).Description of E2F, the crucial transcription factor activity responsible for entry into S-phase of the cell cycle. This factor is misregulated in almost all cancers, and is also vital for adenovirus replication, through its effects on S-phase and on activation of the E2 region of the viral genome. CASPubMed Google Scholar
Rodriguez, R. et al. Prostate attenuated replication competent adenovirus (ARCA) CN706: a selective cytotoxic for prostate-specific antigen-positive prostate cancer cells. Cancer Res.57, 2559–2563 (1997). CASPubMed Google Scholar
Yu, D. C. et al. Antitumor synergy of CV787, a prostate cancer-specific adenovirus, and paclitaxel and docetaxel. Cancer Res.61, 517–525 (2001). CASPubMed Google Scholar
Brunori, M., Malerba, M., Kashiwazaki, H. & Iggo, R. Replicating adenoviruses that target tumors with constitutive activation of the wnt signaling pathway. J. Virol.75, 2857–2865 (2001). ArticleCASPubMedPubMed Central Google Scholar
Kurihara, T., Brough, D. E., Kovesdi, I. & Kufe, D. W. Selectivity of a replication-competent adenovirus for human breast carcinoma cells expressing the MUC1 antigen. J. Clin. Invest.106, 763–771 (2000). ArticleCASPubMedPubMed Central Google Scholar
Hallenbeck, P. L. Chang, Y.-N. & Chiang, Y. L. Vectors for tissue-specific replication. US Patent 5,998,205 (1999).
Freytag, S. O., Rogulski, K. R., Paielli, D. L., Gilbert, J. D. & Kim, J. H. A novel three-pronged approach to kill cancer cells selectively: concomitant viral, double suicide gene, and radiotherapy. Hum. Gene Ther.9, 1323–1333 (1998). ArticleCASPubMed Google Scholar
Wildner, O. et al. Adenoviral vectors capable of replication improve the efficacy of HSVtk/GCV suicide gene therapy of cancer. Gene Ther.6, 57–62 (1999). ArticleCASPubMed Google Scholar
Aghi, M., Chou, T. C., Suling, K., Breakefield, X. O. & Chiocca, E. A. Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P450 2B1 and ganciclovir/herpes simplex virus thymidine kinase gene therapies. Cancer Res.59, 3861–3865 (1999). CASPubMed Google Scholar
Raj, K., Ogston, P. & Beard, P. Virus-mediated killing of cells that lack p53 activity. Nature412, 914–917 (2001). ArticleCASPubMed Google Scholar
Kirn, D., Martuza, R. L. & Zwiebel, J. Replication-selective virotherapy for cancer: biological principles, risk management and future directions. Nature Med.7, 781–787 (2001). ArticleCASPubMed Google Scholar
Alemany, R., Suzuki, K. & Curiel, D. T. Blood clearance rates of adenovirus type 5 in mice. J. Gen. Virol.81, 2605–2609 (2000). ArticleCASPubMed Google Scholar
Bergelson, J. M. et al. The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses. J. Virol.72, 415–419 (1998).Identification of the cellular receptor for adenovirus, using an ingenious expression-cloning strategy. Identification of CAR has greatly increased our understanding of adenovirus infectivity and efficiency of vectors using adenoviruses to deliver genes or kill cells through replication. ArticleCASPubMedPubMed Central Google Scholar
Honda, T. et al. The coxsackievirus-adenovirus receptor protein as a cell adhesion molecule in the developing mouse brain. Brain Res. Mol. Brain Res.77, 19–28 (2000). ArticleCASPubMed Google Scholar
Fechner, H. et al. Expression of coxsackie adenovirus receptor and α-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers. Gene Ther.6, 1520–1535 (1999). ArticleCASPubMed Google Scholar
Okegawa, T. et al. The dual impact of coxsackie and adenovirus receptor expression on human prostate cancer gene therapy. Cancer Res.60, 5031–5036 (2000). CASPubMed Google Scholar
Li, Y. et al. Loss of adenoviral receptor expression in human bladder cancer cells: a potential impact on the efficacy of gene therapy. Cancer Res.59, 325–330 (1999). CASPubMed Google Scholar
Bewley, M. C., Springer, K., Zhang, Y. B., Freimuth, P. & Flanagan, J. M. Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR. Science286, 1579–1583 (1999). ArticleCASPubMed Google Scholar
Hoganson, D. K., Sosnowski, B. A., Pierce, G. F. & Doukas, J. Uptake of adenoviral vectors via fibroblast growth factor receptors involves intracellular pathways that differ from the targeting ligand. Mol. Ther.3, 105–112 (2001). ArticleCASPubMed Google Scholar
Cripe, T. P. et al. Fiber knob modifications overcome low, heterogeneous expression of the coxsackievirus-adenovirus receptor that limits adenovirus gene transfer and oncolysis for human rhabdomyosarcoma cells. Cancer Res.61, 2953–2960 (2001).A good example of retargeting adenovirus to infect cells through non-CAR-mediated interactions. These approaches are designed to overcome the fact that many cancer cells downregulate CAR expression, whereas CAR is abundantly expressed in many normal epithelial cells. CASPubMed Google Scholar
Shayakhmetov, D. M., Papayannopoulou, T., Stamatoyannopoulos, G. & Lieber, A. Efficient gene transfer into human CD34+ cells by a retargeted adenovirus vector. J. Virol.74, 2567–2583 (2000). ArticleCASPubMedPubMed Central Google Scholar
Fisher, K. D. et al. Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies. Gene Ther.8, 341–348 (2001). ArticleCASPubMed Google Scholar
Ikeda, K. et al. Oncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral responses. Nature Med.5, 881–887 (1999). ArticleCASPubMed Google Scholar
Chen, Y., Yu, D. C., Charlton, D. & Henderson, D. R. Pre-existent adenovirus antibody inhibits systemic toxicity and antitumor activity of CN706 in the nude mouse LNCaP xenograft model: implications and proposals for human therapy. Hum. Gene Ther.11, 1553–1567 (2000). ArticleCASPubMed Google Scholar
Grim, J. et al. Adenovirus-mediated delivery of p16 to p16-deficient human bladder cancer cells confers chemo-resistance to cisplatin and paclitaxel. Clin. Cancer Res.3, 2415–2423 (1997). CASPubMed Google Scholar
Patel, S. D. et al. The p53-independent tumoricidal activity of an adenoviral vector encoding a p27–p16 fusion tumor suppressor gene. Mol. Ther.2, 161–169 (2000). ArticleCASPubMed Google Scholar
Riley, D. J., Nikitin, A. Y. & Lee, W. H. Adenovirus-mediated retinoblastoma gene therapy suppresses spontaneous pituitary melanotroph tumors in Rb+/− mice. Nature Med.2, 1316–1321 (1996). ArticleCASPubMed Google Scholar
Claudio, P. P. et al. RB2/p130 gene-enhanced expression down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in vivo. Cancer Res.61, 462–468 (2001). CASPubMed Google Scholar
Kawabe, S. et al. Adenovirus-mediated wild-type p53 gene expression radiosensitizes non-small cell lung cancer cells but not normal lung fibroblasts. Int. J. Radiat. Biol.77, 185–194 (2001). ArticleCASPubMed Google Scholar
Nielsen, L. L. et al. Efficacy of p53 adenovirus-mediated gene therapy against human breast cancer xenografts. Cancer Gene Ther.4, 129–138 (1997). CASPubMed Google Scholar
Kataoka, M. et al. An agent that increases tumor suppressor transgene product coupled with systemic transgene delivery inhibits growth of metastatic lung cancer in vivo. Cancer Res.58, 4761–4765 (1998). CASPubMed Google Scholar
Spitz, F. R. et al. In vivo adenovirus-mediated p53 tumor suppressor gene therapy for colorectal cancer. Anticancer Res.16, 3415–3422 (1996). CASPubMed Google Scholar
Czubayko, F. et al. Adenovirus-mediated transduction of ribozymes abrogates HER2/neu and pleiotrophin expression and inhibits tumor cell proliferation. Gene Ther.4, 943–949 (1997). ArticleCASPubMed Google Scholar
Lui, V. W., He, Y. & Huang, L. Specific down-regulation of HER2/neu mediated by a chimeric U6 hammerhead ribozyme results in growth inhibition of human ovarian carcinoma. Mol. Ther.3, 169–177 (2001). ArticleCASPubMed Google Scholar
Suzuki, T. et al. Adenovirus-mediated ribozyme targeting of HER2/neu inhibits in vivo growth of breast cancer cells. Gene Ther.7, 241–248 (2000). ArticleCASPubMed Google Scholar
Tang, C. K. et al. Ribozyme-mediated down-regulation of ErbB4 in estrogen receptor-positive breast cancer cells inhibits proliferation both in vitro and in vivo. Cancer Res.59, 5315–5322 (1999). CASPubMed Google Scholar
Alemany, R. et al. Growth inhibitory effect of anti-KRAS adenovirus on lung cancer cells. Cancer Gene Ther.3, 296–301 (1996). CASPubMed Google Scholar
Tsuchida, T. et al. Adenovirus-mediated anti-KRAS ribozyme induces apoptosis and growth suppression of human pancreatic carcinoma. Cancer Gene Ther.7, 373–383 (2000). ArticleCASPubMed Google Scholar
Funato, T., Ishii, T., Kambe, M., Scanlon, K. J. & Sasaki, T. Anti-KRAS ribozyme induces growth inhibition and increased chemosensitivity in human colon cancer cells. Cancer Gene Ther.7, 495–500 (2000). ArticleCASPubMed Google Scholar
Zhang, Y. A., Nemunaitis, J., Scanlon, K. J. & Tong, A. W. Anti-tumorigenic effect of a KRAS ribozyme against human lung cancer cell line heterotransplants in nude mice. Gene Ther.7, 2041–2050 (2000). ArticleCASPubMed Google Scholar
Irie, A. et al. Therapeutic efficacy of an adenovirus-mediated anti-HRAS ribozyme in experimental bladder cancer. Antisense Nucleic Acid Drug Dev.9, 341–349 (1999). ArticleCASPubMed Google Scholar
Kunke, D. et al. Preclinical study on gene therapy of cervical carcinoma using adeno-associated virus vectors. Cancer Gene Ther.7, 766–777 (2000). ArticleCASPubMed Google Scholar
Potter, P. M. et al. Construction of adenovirus for high level expression of small RNAs in mammalian cells. Application to a BCL2 ribozyme. Mol. Biotechnol.15, 105–114 (2000). ArticleCASPubMed Google Scholar
Ludwig, A. et al. Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase. Cancer Res.61, 3053–3061 (2001). CASPubMed Google Scholar
Jiang, W. G. et al. A hammerhead ribozyme suppresses expression of hepatocyte growth factor/scatter factor receptor c-MET and reduces migration and invasiveness of breast cancer cells. Clin. Cancer Res.7, 2555–2562 (2001). CASPubMed Google Scholar
Cheng, J. et al. Inhibition of cell proliferation in HCC-9204 hepatoma cells by a c-MYC specific ribozyme. Cancer Gene Ther.7, 407–412 (2000). ArticleCASPubMed Google Scholar
Trinh, Q. T., Austin, E. A., Murray, D. M., Knick, V. C. & Huber, B. E. Enzyme/prodrug gene therapy: comparison of cytosine deaminase/5-fluorocytosine versus thymidine kinase/ganciclovir enzyme/prodrug systems in a human colorectal carcinoma cell line. Cancer Res.55, 4808–4812 (1995). CASPubMed Google Scholar
Hanna, N. N. et al. Virally directed cytosine deaminase/5-fluorocytosine gene therapy enhances radiation response in human cancer xenografts. Cancer Res.57, 4205–4209 (1997). CASPubMed Google Scholar
Bridgewater, J. A. et al. Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954. Eur. J. Cancer31A, 2362–2370 (1995). ArticleCASPubMed Google Scholar
Danks, M. K. et al. Overexpression of a rabbit liver carboxylesterase sensitizes human tumour cells to CPT-11. Cancer Res,58, 20–22 (1998). CAS Google Scholar
Waxman, D. J. et al. Cytochrome P450-based cancer gene therapy: recent advances and future prospects. Drug Metab. Rev.31, 503–522 (1999). ArticleCASPubMed Google Scholar
Sorcher, E. J. et al. Tumor cell bystander killing in colonic carcinoma utilizing the Escherichia coli DeoD gene to generate toxic purines. Gene Ther.4, 233–238 (1994). Google Scholar
Topf, N., Worgall, S., Hackett, N. R. & Crystal, R. G. Regional 'pro-drug' gene therapy: intravenous administration of an adenoviral vector expressing the E. coli cytosine deaminase gene and systemic administration of 5-fluorocytosine suppresses growth of hepatic metastasis of colon carcinoma. Gene Ther.5, 507–513 (1998). ArticleCASPubMed Google Scholar
Gnant, M. F., Puhlmann, M., Alexander, H. R., Jr & Bartlett, D. L. Systemic administration of a recombinant vaccinia virus expressing the cytosine deaminase gene and subsequent treatment with 5-fluorocytosine leads to tumor-specific gene expression and prolongation of survival in mice. Cancer Res.59, 3396–3403 (1999). CASPubMed Google Scholar
Block, A. et al. Gene therapy of metastatic colon carcinoma: regression of multiple hepatic metastases by adenoviral expression of bacterial cytosine deaminase. Cancer Gene Ther.7, 438–445 (2000). ArticleCASPubMed Google Scholar
Pandha, H. S. et al. Genetic prodrug activation therapy for breast cancer: a phase I clinical trial of ERBB2-directed suicide gene expression. J. Clin. Oncol.17, 2180–2189 (1999). ArticleCASPubMed Google Scholar
Suzuki, S., Tadakuma, T., Asano, T. & Hayakawa, M. Coexpression of the partial androgen receptor enhances the efficacy of prostate-specific antigen promoter-driven suicide gene therapy for prostate cancer cells at low testosterone concentrations. Cancer Res.61, 1276–1279 (2001). CASPubMed Google Scholar
Miyauchi, M. et al. Expression of herpes simplex virus-thymidine kinase gene controlled by a promoter region of the midkine gene confers selective cytotoxicity to ganciclovir in human carcinoma cells. Int. J. Cancer91, 723–727 (2001). ArticleCASPubMed Google Scholar
Ido, A. et al. Gene therapy targeting for hepatocellular carcinoma: selective and enhanced suicide gene expression regulated by a hypoxia-inducible enhancer linked to a human α-fetoprotein promoter. Cancer Res.61, 3016–3021 (2001). CASPubMed Google Scholar
Morimoto, E., Inase, N., Mlyake, S. & Yoshizawa, Y. Adenovirus-mediated suicide gene transfer to small cell lung carcinoma using a tumor-specific promoter. Anticancer Res.21, 329–331 (2001). CASPubMed Google Scholar
You, L., Yang, C. T. & Jablons, D. M. ONYX-015 works synergistically with chemotherapy in lung cancer cell lines and primary cultures freshly made from lung cancer patients. Cancer Res.60, 1009–1013 (2000). CASPubMed Google Scholar
Xie, X. et al. Robust prostate-specific expression for targeted gene therapy based on the human kallikrein 2 promoter. Hum. Gene Ther.12, 549–561 (2001). ArticleCASPubMed Google Scholar
Koeneman, K. S. et al. Osteocalcin-directed gene therapy for prostate-cancer bone metastasis. World J. Urol.18, 102–110 (2000). ArticleCASPubMed Google Scholar
Chen, R. H. & McCormick, F. Selective targeting to the hyperactive β-catenin/T-cell factor pathway in colon cancer cells. Cancer Res.61, 4445–4449 (2001). CASPubMed Google Scholar
Hernandez-Alcoceba, R., Pihalja, M., Wicha, M. S. & Clarke, M. F. A novel, conditionally replicative adenovirus for the treatment of breast cancer that allows controlled replication of E1a-deleted adenoviral vectors. Hum. Gene Ther.11, 2009–2024 (2000). ArticleCASPubMed Google Scholar
Majumdar, A. S. et al. The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promoters. Gene Ther.8, 568–578 (2001). ArticleCASPubMed Google Scholar
Zhang, R., Straus, F. H. & DeGroot, L. J. Adenoviral-mediated gene therapy for thyroid carcinoma using thymidine kinase controlled by thyroglobulin promoter demonstrates high specificity and low toxicity. Thyroid11, 115–123 (2001). ArticleCASPubMed Google Scholar
Nishino, K. et al. Adenovirus-mediated gene therapy specific for small cell lung cancer cells using a Myc–Max binding motif. Int. J. Cancer91, 851–856 (2001). ArticleCASPubMed Google Scholar
Ueda, K. et al. Enhanced selective gene expression by adenovirus vector using Cre/loxP regulation system for human carcinoembryonic antigen-producing carcinoma. Oncology59, 255–265 (2000). ArticleCASPubMed Google Scholar
Lan, K. H. et al. Tumor-specific gene expression in carcinoembryonic antigen-producing gastric cancer cells using adenovirus vectors. Gastroenterology111, 1241–1251 (1996). ArticleCASPubMed Google Scholar
Siders, W. M., Halloran, P. J. & Fenton, R. G. Transcriptional targeting of recombinant adenoviruses to human and murine melanoma cells. Cancer Res.56, 5638–5646 (1996). CASPubMed Google Scholar
Chen, J. et al. A glial-specific, repressible, adenovirus vector for brain tumor gene therapy. Cancer Res.58, 3504–3507 (1998). CASPubMed Google Scholar
Walton, T. et al. Endothelium-specific expression of an E-selectin promoter recombinant adenoviral vector. Anticancer Res.18, 1357–1360 (1998). CASPubMed Google Scholar
Manome, Y. et al. Transgene expression in malignant glioma using a replication-defective adenoviral vector containing the Egr-1 promoter: activation by ionizing radiation or uptake of radioactive iododeoxyuridine. Hum. Gene Ther.9, 1409–1417 (1998). ArticleCASPubMed Google Scholar
Gotoh, A. et al. Development of prostate-specific antigen promoter-based gene therapy for androgen-independent human prostate cancer. J. Urol.160, 220–229 (1998). ArticleCASPubMed Google Scholar
McKie, E. A., Graham, D. I. & Brown, S. M. Selective astrocytic transgene expression in vitro and in vivo from the GFAP promoter in a HSV RL1 null mutant vector—potential glioblastoma targeting. Gene Ther.5, 440–450 (1998). ArticleCASPubMed Google Scholar
Parr, M. J. et al. Tumor-selective transgene expression in vivo mediated by an E2F-responsive adenoviral vector. Nature Med.3, 1145–1149 (1997). ArticleCASPubMed Google Scholar
Miyao, Y. et al. Usefulness of a mouse myelin basic protein promoter for gene therapy of malignant glioma: myelin basic protein promoter is strongly active in human malignant glioma cells. Jpn J. Cancer Res.88, 678–686 (1997). ArticleCASPubMedPubMed Central Google Scholar
Ozaki, K. et al. Use of von Willebrand factor promoter to transduce suicidal gene to human endothelial cells, HUVEC. Hum. Gene Ther.7, 1483–1490 (1996). ArticleCASPubMed Google Scholar
Anderson, L. M., Krotz, S., Weitzman, S. A. & Thimmapaya, B. Breast cancer-specific expression of the Candida albicans cytosine deaminase gene using a transcriptional targeting approach. Cancer Gene Ther.7, 845–852 (2000). ArticleCASPubMed Google Scholar