A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance (original) (raw)

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Acknowledgements

A full list of acknowledgments is provided in the Supplementary Note.

Author information

Author notes

1. Leena Peltonen Deceased.
2. Alisa K Manning, Marie-France Hivert and Robert A Scott: These authors contributed equally to this work.
3. James B Meigs and Claudia Langenberg: These authors jointly directed this work.

Authors and Affiliations

1. Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA
   Alisa K Manning, Han Chen, Ching-Ti Liu & Josée Dupuis
2. Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
   Alisa K Manning, Aarno Palotie, Richa Saxena, Benjamin F Voight & Jose C Florez
3. Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA
   Alisa K Manning
4. Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
   Alisa K Manning
5. General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, USA
   Marie-France Hivert, Jonna L Grimsby & James B Meigs
6. Department of Medicine, Universite de Sherbrooke, Sherbrooke, Québec, Canada
   Marie-France Hivert
7. Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK
   Robert A Scott, Daniel Barnes, Nita G Forouhi, Ruth J F Loos, Jian'an Luan, Ken K Ong, Nicholas J Wareham & Claudia Langenberg
8. Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
   Jonna L Grimsby, Jose C Florez & James B Meigs
9. Institut Pasteur de Lille, Lille, France
   Nabila Bouatia-Naji, Cecile Lecoeur, Elodie Eury, Philippe Froguel & Stéphane Lobbens
10. Université Lille Nord de France, Lille, France
    Nabila Bouatia-Naji, Cecile Lecoeur, Elodie Eury, Philippe Froguel & Stéphane Lobbens
11. Boston University Data Coordinating Center, Boston, Massachusetts, USA
    Denis Rybin
12. Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA
    Lawrence F Bielak, Min A Jhun, Sharon L R Kardia & Patricia A Peyser
13. Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK
    Inga Prokopenko, Vasiliki Lagou, Reedik Mägi & Mark I McCarthy
14. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Inga Prokopenko, Vasiliki Lagou, John R B Perry, Anuj Goel, Reedik Mägi, John F Peden, Hugh Watkins & Mark I McCarthy
15. Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Najaf Amin, Cornelia M van Duijn, Yurii Aulchenko, Albert Hofman, Andre G Uitterlinden, Sara M Willems & Jacqueline C M Witteman
16. Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, Ontario, Canada
    Gemma Cadby & Lyle J Palmer
17. Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada
    Gemma Cadby & Lyle J Palmer
18. Netherlands Twin Register, VU University, Amsterdam, The Netherlands
    Jouke-Jan Hottenga, Dorret I Boomsma, Eco de Geus & Gonneke Willemsen
19. Department of Biological Psychology, VU University, Amsterdam, The Netherlands
    Jouke-Jan Hottenga, Dorret I Boomsma, Eco de Geus & Gonneke Willemsen
20. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Erik Ingelsson, Patrik K E Magnusson, Nancy L Pedersen & Emil Rehnberg
21. Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    Anne U Jackson & Michael Boehnke
22. Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Toby Johnson
23. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.,
    Stavroula Kanoni, Panos Deloukas, Aarno Palotie, Leena Peltonen & Kathleen Stirrups
24. Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Malmö, Sweden
    Claes Ladenvall, Dmitry Shungin, Paul W Franks, Leif Groop, Ola Hansson & Valeriya Lyssenko
25. Lund University Diabetes Centre, Malmö, Sweden
    Claes Ladenvall, Dmitry Shungin, Paul W Franks, Leif Groop, Ola Hansson & Valeriya Lyssenko
26. Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland
    Jari Lahti & Katri Räikkönen
27. Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
    Yongmei Liu
28. Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain
    Maria Teresa Martinez-Larrad, Arturo Corbatón-Anchuelo & Manuel Serrano-Rios
29. Division of Endocrinology, Department of Medicine, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA
    May E Montasser, Jeff O'Connell & Alan R Shuldiner
30. MRC Human Genetics Unit, MRC Institute of Genetics & Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK
    Pau Navarro, Caroline Hayward, Veronique Vitart & Alan F Wright
31. Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK
    John R B Perry, Timothy M Frayling & Hanieh Yaghootkar
32. Department of Twin Research and Genetic Epidemiology, King's College London, London, UK
    John R B Perry & Kerrin S Small
33. Department of Preventive Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
    Laura J Rasmussen-Torvik
34. Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
    Perttu Salo, Antti Jula, Markus Perola & Veikko Salomaa
35. Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    Naveed Sattar
36. Department of Public Health & Clinical Medicine, Genetic Epidemiology & Clinical Research Group, Umeå University Hospital, Umeå, Sweden
    Dmitry Shungin & Paul W Franks
37. Department of Odontology, Umeå University, Umeå, Sweden
    Dmitry Shungin
38. Department of Medicine Solna, Atherosclerosis Research Unit, Karolinska Institutet, Stockholm, Sweden
    Rona J Strawbridge, Anders Hamsten, Maria Sabater-Lleal & Bengt Sennblad
39. Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA
    Toshiko Tanaka
40. Centre for Medical Systems Biology, Netherlands Genomics Initiative, The Hague, The Netherlands
    Cornelia M van Duijn
41. Netherlands Consortium for Healthy Aging, Netherlands Genomics Initiative, Rotterdam, The Netherlands
    Cornelia M van Duijn, Albert Hofman, Andre G Uitterlinden & Jacqueline C M Witteman
42. Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, Saint Louis, Missouri, USA
    Ping An, Ingrid B Borecki & Michael A Province
43. Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA
    Mariza de Andrade
44. Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA
    Jeanette S Andrews
45. Icelandic Heart Association, Kopavogur, Iceland
    Thor Aspelund, Gudny Eiriksdottir, Vilmundur Gudnason & Albert Vernon Smith
46. University of Iceland, Reykjavik, Iceland
    Thor Aspelund, Vilmundur Gudnason & Albert Vernon Smith
47. Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Kuopio, Finland
    Mustafa Atalay & Timo Lakka
48. Institut de la Santé et de la Recherche Médicale (INSERM), Centre de recherche en Épidémiologie et Santé des Populations (CESP) Centre for Research in Epidemiology and Population Health, Villejuif, France
    Beverley Balkau
49. University Paris–Sud 11, Unité Mixte de Recherche en Santé (UMRS) 1018, Villejuif, France
    Beverley Balkau
50. Geriatric Unit, Azienda Sanitaria di Firenze, Florence, Italy
    Stefania Bandinelli
51. Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland
    Jacques S Beckmann
52. Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Jacques S Beckmann
53. Department of Molecular Genetics, PathWest Laboratory of Western Australia, J Block, Queen Elizabeth II (QEII) Medical Centre, Nedlands, Western Australia, Australia
    John P Beilby & Jennie Hui
54. School of Pathology and Laboratory Medicine, The University of Western Australia, Nedlands, Western Australia, Australia
    John P Beilby
55. Busselton Population Medical Research Foundation, B Block, QEII Medical Centre, Nedlands, Western Australia, Australia
    John P Beilby & Joseph Hung
56. Texas Biomedical Research Institute, San Antonio, Texas, USA
    Claire Bellis & John Blangero
57. Department of Physiology & Biophysics, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
    Richard N Bergman & Richard M Watanabe
58. Department of Pharmacology, Faculty of Medicine, University of Split, Split, Croatia
    Mladen Boban & Danijela Budimir
59. Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA
    Eric Boerwinkle
60. Genome Technology Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA
    Lori L Bonnycastle, Peter S Chines, Francis S Collins, Michael R Erdos, Mario A Morken, Narisu Narisu & Amy J Swift
61. Integriertes Forschungs- und Behandlungszentrum (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany
    Yvonne Böttcher, Michael Stumvoll & Anke Tönjes
62. Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Claude Bouchard
63. Department of Epidemiology & Public Health, University College London, London, UK
    Eric Brunner, Mika Kivimaki & Michael Marmot
64. Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK
    Harry Campbell, Igor Rudan, Sarah H Wild, James F Wilson & Lina Zgaga
65. Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, Maryland, USA
    Olga Carlson & Josephine M Egan
66. Clinical Trial Service Unit, University of Oxford, Oxford, UK
    Robert Clarke
67. Department of Biostatistics, University of North Carolina Gillings School of Global Public Health, Chapel Hill, North Carolina, USA
    David Couper
68. Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Ulf de Faire, Bruna Gigante, Karin Leander & Max Vikström
69. Department of Nutrition–Dietetics, Harokopio University, Athens, Greece
    George V Dedoussis & Maria Dimitriou
70. Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland
    Johan G Eriksson
71. Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland
    Johan G Eriksson
72. Folkhalsan Research Centre, Helsinki, Finland
    Johan G Eriksson
73. Vaasa Central Hospital, Vaasa, Finland
    Johan G Eriksson
74. National Institute for Health and Welfare, Helsinki, Finland
    Johan G Eriksson & Jaakko Kaprio
75. Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA
    Luigi Ferrucci
76. Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK
    Ian Ford & Paul C D Johnson
77. National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA
    Caroline S Fox & Josée Dupuis
78. Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Caroline S Fox
79. Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Maria Grazia Franzosi
80. Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Paul W Franks
81. Institut National de la Recherche Agronomique, Université Paris, Bobigny Cedex, France.,
    Paul W Franks
82. Genomic Medicine, Hammersmith Hospital, Imperial College London, London, UK
    Philippe Froguel
83. INSERM, Université Paris, Bobigny Cedex, France
    Pilar Galan & Serge Hercberg
84. Department of Medicine, Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Massachusetts, USA
    Nicole L Glazer
85. Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA
    Nicole L Glazer
86. Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    Anuj Goel & John F Peden
87. Department of Public Health & Clinical Medicine, Nutrition Research, Umeå University, Umeå, Sweden
    Göran Hallmans & Hugh Watkins
88. Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA
    Tamara B Harris & Lenore J Launer
89. Centre National de Génotypage, Commissariat à l'Energie Atomique, Institut de Génomique, Evry, France
    Simon Heath, G Mark Lathrop & Diana Zelenika
90. Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy. (Affiliated Institute of the University Lübeck).,
    Andrew A Hicks & Peter P Pramstaller
91. Department of Epidemiology & Public Health, Genetic Epidemiology Group, University College London, London, UK
    Aroon Hingorani & Meena Kumari
92. School of Population Health, The University of Western Australia, Nedlands, Western Australia, Australia
    Jennie Hui
93. Sir Charles Gairdner Hospital Unit, School of Medicine & Pharmacology, University of Western Australia, Nedlands, Western Australia, Australia
    Joseph Hung
94. Department of Epidemiology and Biostatistics, School of Public Health, MRC–Health Protection Agency (HPA) Centre for Environment and Health, Faculty of Medicine, Imperial College London, London, UK
    Marjo-Riitta Jarvelin
95. Institute of Health Sciences, University of Oulu, Oulu, Finland
    Marjo-Riitta Jarvelin
96. Biocenter Oulu, University of Oulu, Oulu, Finland
    Marjo-Riitta Jarvelin
97. National Institute of Health and Welfare, Oulu, Finland
    Marjo-Riitta Jarvelin
98. Department of Cardiology C5-P, Leiden University Medical Center, Leiden, The Netherlands
    J Wouter Jukema & Stella Trompet
99. Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands
    J Wouter Jukema
100. Division of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland, USA
     W H Kao
101. Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
     Jaakko Kaprio, Aarno Palotie, Leena Peltonen & Elisabeth Widen
102. Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland
     Jaakko Kaprio
103. Faculty of Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland
     Sirkka Keinanen-Kiukaanniemi
104. Unit of General Practice, Oulu University Hospital, Oulu, Finland
     Sirkka Keinanen-Kiukaanniemi
105. Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia
     Ivana Kolcic & Ozren Polasek
106. Interdisciplinary Centre for Clinical Research, University of Leipzig, Leipzig, Germany
     Peter Kovacs
107. Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
     Johanna Kuusisto, Markku Laakso & Alena Stančáková
108. Institute of Regional Health Services Research, University of Southern Denmark, Odense, Denmark
     Kirsten Ohm Kyvik
109. Odense Patient data Explorative Network (OPEN), University of Southern Denmark, Odense, Denmark
     Kirsten Ohm Kyvik
110. Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
     Timo Lakka & Rainer Rauramaa
111. Department of Public Health and Caring Sciences, Uppsala University, Rudbecklaboratoriet, Uppsala, Sweden
     Lars Lannfelt
112. Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
     Guo Li & David S Siscovick
113. Department of Medical Sciences, University Hospital, Uppsala University, Uppsala, Sweden
     Lars Lind
114. Department of Chronic Disease Prevention, Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland
     Jaana Lindstrom & Jaakko Tuomilehto
115. Estonian Genome Center, University of Tartu, Tartu, Estonia
     Reedik Mägi
116. INSERM, Centre de Recherche des Cordeliers, Paris, France
     Pierre Meneton
117. Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA
     Karen L Mohlke
118. Division of Genetics, GlaxoSmithKline, Philadelphia, Pennsylvania, USA
     Vincent Mooser & Dawn M Waterworth
119. Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
     Iva Miljkovic
120. Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands
     Ben A Oostra
121. Department of Medical Genetics, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
     Aarno Palotie
122. Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA
     James S Pankow
123. Department of Biology, Faculty of Medicine, University of Split, Split, Croatia
     Marina Pehlic & Tatijana Zemunik
124. Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
     Brenda Penninx
125. Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
     Brenda Penninx
126. Department of Psychiatry, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
     Brenda Penninx & Johannes H Smit
127. Institute for Research in Extramural Medicine (EMGO Institute) for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
     Brenda Penninx
128. Institute for Anthropological Research, Zagreb, Croatia
     Marijana Pericic
129. Department of Preventive Medicine, Laval University, Quebec, Canada
     Louis Perusse
130. Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland
     Rainer Rauramaa
131. Department of Biostatistics, University of Washington, Seattle, Washington, USA
     Ken Rice
132. Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, Calfornia, USA
     Jerome I Rotter
133. Centre for Global Health, University of Split, Split, Croatia
     Igor Rudan
134. Institute of Clinical Medicine, University of Oulu, Oulu, Finland
     Aimo Ruokonen
135. Finnish Diabetes Association, Tampere, Finland
     Timo Saaristo
136. Pirkanmaa Hospital District and Diabetes Center, Tampere, Finland
     Timo Saaristo
137. Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK
     David B Savage & Ines Barroso
138. Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA
     Richa Saxena & Jose C Florez
139. Department of Medicine, Division Prevention and Care of Diabetes, University of Dresden, Dresden, Germany
     Peter Schwarz
140. Leibniz Institute for Arteriosclerosis Research, University of Munster, Munster, Germany
     Udo Seedorf
141. Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland, USA
     Alan R Shuldiner
142. Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
     Eric J G Sijbrands & Andre G Uitterlinden
143. Department of Medicine, University of Washington, Seattle, Washington, USA
     David S Siscovick & Nicholas L Smith
144. Department of Epidemiology, University of Washington, Seattle, Washington, USA
     David S Siscovick & Nicholas L Smith
145. Group Health Research Institute, Group Health Cooperative, Seattle, Washington, USA
     Nicholas L Smith
146. Seattle Epidemiologic Research and Information Center, Veterans Affairs Office of Research and Development, Seattle, Washington, USA
     Nicholas L Smith
147. Division of Endocrinology and Diabetes, Department of Medicine, University of Leipzig, Leipzig, Germany
     Michael Stumvoll & Anke Tönjes
148. Department of Epidemiology, Emory University, Atlanta, Georgia, USA
     Yan V Sun
149. South Ostrobothnia Central Hospital, Seinäjoki, Finland
     Jaakko Tuomilehto
150. Hospital Universitario La Paz, Madrid, Spain
     Jaakko Tuomilehto
151. Centre for Vascular Prevention, Danube–University Krems, Krems, Austria
     Jaakko Tuomilehto
152. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
     Matti Uusitupa
153. Research Unit, Kuopio University Hospital, Kuopio, Finland
     Matti Uusitupa
154. Department of Food Science and Nutrition, Laval University, Quebec, Canada
     Marie-Claude Vohl
155. Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
     Peter Vollenweider & Gerard Waeber
156. Metabolic Disease Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.,
     Eleanor Wheeler & Ines Barroso
157. Department of Medical Statistics, Epidemiology and Medical Informatics, University of Zagreb, Zagreb, Croatia
     Lina Zgaga
158. Oxford National Institute for Health Research (NIHR) Biomedical Research Centre, Churchill Hospital, Oxford, UK
     Mark I McCarthy
159. Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
     Richard M Watanabe
160. Diabetes Unit, Diabetes Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA
     Jose C Florez

Authors

1. Alisa K Manning
2. Marie-France Hivert
3. Robert A Scott
4. Jonna L Grimsby
5. Nabila Bouatia-Naji
6. Han Chen
7. Denis Rybin
8. Ching-Ti Liu
9. Lawrence F Bielak
10. Inga Prokopenko
11. Najaf Amin
12. Daniel Barnes
13. Gemma Cadby
14. Jouke-Jan Hottenga
15. Erik Ingelsson
16. Anne U Jackson
17. Toby Johnson
18. Stavroula Kanoni
19. Claes Ladenvall
20. Vasiliki Lagou
21. Jari Lahti
22. Cecile Lecoeur
23. Yongmei Liu
24. Maria Teresa Martinez-Larrad
25. May E Montasser
26. Pau Navarro
27. John R B Perry
28. Laura J Rasmussen-Torvik
29. Perttu Salo
30. Naveed Sattar
31. Dmitry Shungin
32. Rona J Strawbridge
33. Toshiko Tanaka
34. Cornelia M van Duijn
35. Ping An
36. Mariza de Andrade
37. Jeanette S Andrews
38. Thor Aspelund
39. Mustafa Atalay
40. Yurii Aulchenko
41. Beverley Balkau
42. Stefania Bandinelli
43. Jacques S Beckmann
44. John P Beilby
45. Claire Bellis
46. Richard N Bergman
47. John Blangero
48. Mladen Boban
49. Michael Boehnke
50. Eric Boerwinkle
51. Lori L Bonnycastle
52. Dorret I Boomsma
53. Ingrid B Borecki
54. Yvonne Böttcher
55. Claude Bouchard
56. Eric Brunner
57. Danijela Budimir
58. Harry Campbell
59. Olga Carlson
60. Peter S Chines
61. Robert Clarke
62. Francis S Collins
63. Arturo Corbatón-Anchuelo
64. David Couper
65. Ulf de Faire
66. George V Dedoussis
67. Panos Deloukas
68. Maria Dimitriou
69. Josephine M Egan
70. Gudny Eiriksdottir
71. Michael R Erdos
72. Johan G Eriksson
73. Elodie Eury
74. Luigi Ferrucci
75. Ian Ford
76. Nita G Forouhi
77. Caroline S Fox
78. Maria Grazia Franzosi
79. Paul W Franks
80. Timothy M Frayling
81. Philippe Froguel
82. Pilar Galan
83. Eco de Geus
84. Bruna Gigante
85. Nicole L Glazer
86. Anuj Goel
87. Leif Groop
88. Vilmundur Gudnason
89. Göran Hallmans
90. Anders Hamsten
91. Ola Hansson
92. Tamara B Harris
93. Caroline Hayward
94. Simon Heath
95. Serge Hercberg
96. Andrew A Hicks
97. Aroon Hingorani
98. Albert Hofman
99. Jennie Hui
100. Joseph Hung
101. Marjo-Riitta Jarvelin
102. Min A Jhun
103. Paul C D Johnson
104. J Wouter Jukema
105. Antti Jula
106. W H Kao
107. Jaakko Kaprio
108. Sharon L R Kardia
109. Sirkka Keinanen-Kiukaanniemi
110. Mika Kivimaki
111. Ivana Kolcic
112. Peter Kovacs
113. Meena Kumari
114. Johanna Kuusisto
115. Kirsten Ohm Kyvik
116. Markku Laakso
117. Timo Lakka
118. Lars Lannfelt
119. G Mark Lathrop
120. Lenore J Launer
121. Karin Leander
122. Guo Li
123. Lars Lind
124. Jaana Lindstrom
125. Stéphane Lobbens
126. Ruth J F Loos
127. Jian'an Luan
128. Valeriya Lyssenko
129. Reedik Mägi
130. Patrik K E Magnusson
131. Michael Marmot
132. Pierre Meneton
133. Karen L Mohlke
134. Vincent Mooser
135. Mario A Morken
136. Iva Miljkovic
137. Narisu Narisu
138. Jeff O'Connell
139. Ken K Ong
140. Ben A Oostra
141. Lyle J Palmer
142. Aarno Palotie
143. James S Pankow
144. John F Peden
145. Nancy L Pedersen
146. Marina Pehlic
147. Leena Peltonen
148. Brenda Penninx
149. Marijana Pericic
150. Markus Perola
151. Louis Perusse
152. Patricia A Peyser
153. Ozren Polasek
154. Peter P Pramstaller
155. Michael A Province
156. Katri Räikkönen
157. Rainer Rauramaa
158. Emil Rehnberg
159. Ken Rice
160. Jerome I Rotter
161. Igor Rudan
162. Aimo Ruokonen
163. Timo Saaristo
164. Maria Sabater-Lleal
165. Veikko Salomaa
166. David B Savage
167. Richa Saxena
168. Peter Schwarz
169. Udo Seedorf
170. Bengt Sennblad
171. Manuel Serrano-Rios
172. Alan R Shuldiner
173. Eric J G Sijbrands
174. David S Siscovick
175. Johannes H Smit
176. Kerrin S Small
177. Nicholas L Smith
178. Albert Vernon Smith
179. Alena Stančáková
180. Kathleen Stirrups
181. Michael Stumvoll
182. Yan V Sun
183. Amy J Swift
184. Anke Tönjes
185. Jaakko Tuomilehto
186. Stella Trompet
187. Andre G Uitterlinden
188. Matti Uusitupa
189. Max Vikström
190. Veronique Vitart
191. Marie-Claude Vohl
192. Benjamin F Voight
193. Peter Vollenweider
194. Gerard Waeber
195. Dawn M Waterworth
196. Hugh Watkins
197. Eleanor Wheeler
198. Elisabeth Widen
199. Sarah H Wild
200. Sara M Willems
201. Gonneke Willemsen
202. James F Wilson
203. Jacqueline C M Witteman
204. Alan F Wright
205. Hanieh Yaghootkar
206. Diana Zelenika
207. Tatijana Zemunik
208. Lina Zgaga
209. Nicholas J Wareham
210. Mark I McCarthy
211. Ines Barroso
212. Richard M Watanabe
213. Jose C Florez
214. Josée Dupuis
215. James B Meigs
216. Claudia Langenberg

Consortia

DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium

The Multiple Tissue Human Expression Resource (MUTHER) Consortium

Contributions

A.K.M., J.D. and J.B.M. conceived of the study, A.K.M. and R.A.S. performed the analysis, A.K.M., M.F.H. and R.A.S. wrote the manuscript, J.B.M. and C. Langenberg directed the work, and J.L.G., N.B.-N., H.C., D.R., C.-T.L., L.F.B., I.P., R.M.W., J.C.F., J.D., J.B.M. and C. Langenberg provided analytical advice and revised the manuscript.

Corresponding authors

Correspondence toJames B Meigs or Claudia Langenberg.

Ethics declarations

Competing interests

J.C.F. has received consulting fees from Novartis, Eli Lilly and Pfizer. I.B. and spouse own stock in GlaxoSmithKline and Incyte Ltd. A.R.S. is a consultant for Merck.

Additional information

A full list of members is provided in the Supplementary Note.

A full list of members is provided in the Supplementary Note.

Supplementary information

Supplementary Text and Figures

Supplementary Note and Supplementary Figures 1–3 (PDF 1606 kb)

Supplementary Table 1

Study descriptives of samples included in meta-analysis (XLS 106 kb)

Supplementary Table 2

Meta-analysis results of loci with known associations with glycemic traits (XLS 71 kb)

Supplementary Table 3

Meta-analysis results of fasting insulin and fasting glucose loci taken to the follow-up stage of analysis (XLS 225 kb)

Supplementary Table 4

Association results of index SNPs with other traits (HOMA-IR, HOMA-B, 2hr glucose, and HbA1c) in MAGIC (XLS 33 kb)

Supplementary Table 5

eQTL SNPs in linkage disequilibrium with fasting insulin index SNPs in gene expression database from liver tissue (XLS 41 kb)

Supplementary Table 6

Fasting insulin index SNPs in gene expression eQTL database from subcutaneous adipose tissue (MuTHER). (XLS 46 kb)

Supplementary Table 7

Details of coding SNPs (cSNPs) near index SNPs. (XLS 56 kb)

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Manning, A., Hivert, MF., Scott, R. et al. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.Nat Genet 44, 659–669 (2012). https://doi.org/10.1038/ng.2274

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• Received: 07 July 2011
• Accepted: 13 April 2012
• Published: 13 May 2012
• Issue date: June 2012
• DOI: https://doi.org/10.1038/ng.2274