Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation (original) (raw)

• Campbell, K.S. Signal transduction from the B cell antigen-receptor. Curr. Opin. Immunol. 11, 256–264 (1999).
  Article CAS PubMed Google Scholar
• Peng, S.L. et al. NFATc1 and NFATc2 together control both T and B cell activation and differentiation. Immunity 14, 13–20 (2001).
  Article CAS PubMed Google Scholar
• Schulze-Luehrmann, J. & Ghosh, S. Antigen-receptor signaling to nuclear factor κB. Immunity 25, 701–715 (2006).
  Article CAS PubMed Google Scholar
• Huo, L. & Rothstein, T.L. Receptor-specific induction of individual AP-1 components in B lymphocytes. J. Immunol. 154, 3300–3309 (1995).
  CAS PubMed Google Scholar
• Li, Q. & Verma, I.M. NF-κB regulation in the immune system. Nat. Rev. Immunol. 2, 725–734 (2002).
  Article CAS PubMed Google Scholar
• Norvell, A., Mandik, L. & Monroe, J.G. Engagement of the antigen-receptor on immature murine B-lymphocytes results in death by apoptosis. J. Immunol. 154, 4404–4413 (1995).
  CAS PubMed Google Scholar
• McHeyzer-Williams, L.J. & McHeyzer-Williams, M.G. Antigen-specific memory B cell development. Annu. Rev. Immunol. 23, 487–513 (2005).
  Article CAS PubMed Google Scholar
• Osmond, D.G. The turnover of B-cell populations. Immunol. Today 14, 34–37 (1993).
  Article CAS PubMed Google Scholar
• Gallo, E.M., Cante-Barrett, K. & Crabtree, G.R. Lymphocyte calcium signaling from membrane to nucleus. Nat. Immunol. 7, 25–32 (2006).
  Article CAS PubMed Google Scholar
• Winslow, M.M. et al. The calcineurin phosphatase complex modulates immunogenic B cell responses. Immunity 24, 141–152 (2006).
  Article CAS PubMed Google Scholar
• Ranger, A.M. et al. Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development. Immunity 9, 627–635 (1998).
  Article CAS PubMed Google Scholar
• Hodge, M.R. et al. Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice. Immunity 4, 397–405 (1996).
  Article CAS PubMed Google Scholar
• Macian, F., Lopez-Rodriguez, C. & Rao, A. Partners in transcription: NFAT and AP-1. Oncogene 20, 2476–2489 (2001).
  Article CAS PubMed Google Scholar
• Yang, T.T.C. & Chow, C.W. Transcription cooperation by NFAT.C/EBP composite enhancer complex. J. Biol. Chem. 278, 15874–15885 (2003).
  Article CAS PubMed Google Scholar
• Rengarajan, J. et al. Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression. J. Exp. Med. 195, 1003–1012 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Blaeser, F. et al. Ca2+-dependent gene expression mediated by MEF2 transcription factors. J. Biol. Chem. 275, 197–209 (2000).
  Article CAS PubMed Google Scholar
• Youn, H.D., Chatila, T.A. & Liu, J.O. Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis. EMBO J. 19, 4323–4331 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Edmondson, D.G. et al. Mef2 gene-expression marks the cardiac and skeletal-muscle lineages during mouse embryogenesis. Development 120, 1251–1263 (1994).
  CAS PubMed Google Scholar
• Molkentin, J.D. et al. Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2C. Mol. Cell. Biol. 16, 2627–2636 (1996).
  Article CAS PubMed PubMed Central Google Scholar
• Molkentin, J.D. et al. Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins. Cell 83, 1125–1136 (1995).
  Article CAS PubMed Google Scholar
• Black, B.L. et al. Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family. J. Biol. Chem. 271, 26659–26663 (1996).
  Article CAS PubMed Google Scholar
• Morin, S. et al. GATA-dependent recruitment of MEF2 proteins to target promoters. EMBO J. 19, 2046–2055 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Miska, E.A. et al. HDAC4 deacetylase associates with and represses the MEF2 transcription factor. EMBO J. 18, 5099–5107 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Zhao, M. et al. Regulation of the MEF2 family of transcription factors by p38. Mol. Cell. Biol. 19, 21–30 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Lynch, J. et al. Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade. J. Cell Biol. 170, 37–47 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Youn, H.D., Grozinger, C.M. & Liu, J.O. Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4. J. Biol. Chem. 275, 22563–22567 (2000).
  Article CAS PubMed Google Scholar
• Lin, Q. et al. Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science 276, 1404–1407 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Lin, Q. et al. Requirement of the MADS-box transcription factor MEF2C for vascular development. Development 125, 4565–4574 (1998).
  CAS PubMed Google Scholar
• Potthoff, M.J. & Olson, E.N. MEF2: a central regulator of diverse developmental programs. Development 134, 4131–4140 (2007).
  Article CAS PubMed Google Scholar
• Arnold, M.A. et al. MEF2C transcription factor controls chondrocyte hypertrophy and bone development. Dev. Cell 12, 377–389 (2007).
  Article CAS PubMed Google Scholar
• Rickert, R.C., Roes, J. & Rajewsky, K. B lymphocyte-specific, Cre-mediated mutagenesis in mice. Nucleic Acids Res. 25, 1317–1318 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Vong, L. et al. MEF2C is required for the normal allocation of cells between the ventricular and sinoatrial precursors of the primary heart field. Dev. Dyn. 235, 1809–1821 (2006).
  Article CAS PubMed Google Scholar
• Swanson, B.J., Jack, H.M. & Lyons, G.E. Characterization of myocyte enhancer factor 2 (MEF2) expression in B and T cells: MEF2C is a B cell-restricted transcription factor in lymphocytes. Mol. Immunol. 35, 445–458 (1998).
  Article CAS PubMed Google Scholar
• Vong, L.H., Ragusa, M.J. & Schwarz, J.J. Generation of conditional _Mef2c_loxP/loxP mice for temporal- and tissue-specific analyses. Genesis 43, 43–48 (2005).
  Article CAS PubMed Google Scholar
• Hardy, R.R. & Hayakawa, K. B cell development pathways. Annu. Rev. Immunol. 19, 595–621 (2001).
  Article CAS PubMed Google Scholar
• Allman, D. et al. Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation. J. Immunol. 167, 6834–6840 (2001).
  Article CAS PubMed Google Scholar
• Yazawa, N. et al. CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes. Blood 102, 1374–1380 (2003).
  Article CAS PubMed Google Scholar
• Chan, V.W.F. et al. The molecular mechanism of B cell activation by toll-like receptor protein RP-105. J. Exp. Med. 188, 93–101 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Nakagawa, O. et al. Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2. Genes Dev. 19, 2066–2077 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Rao, S. et al. Myocyte enhancer factor-related B-MEF2 is developmentally expressed in B cells and regulates the immunoglobulin J chain promoter. J. Biol. Chem. 273, 26123–26129 (1998).
  Article CAS PubMed Google Scholar
• Fang, W. et al. Cloning and molecular characterization of mouse bcl-x in B and T lymphocytes. J. Immunol. 153, 4388–4398 (1994).
  CAS PubMed Google Scholar
• Solvason, N. et al. Cyclin D2 is essential for BCR-mediated proliferation and CD5 B cell development. Int. Immunol. 12, 631–638 (2000).
  Article CAS PubMed Google Scholar
• Stief, A. et al. Mice deficient in Cd23 reveal its modulatory role in IgE production but no role in T-cell and B-cell development. J. Immunol. 152, 3378–3390 (1994).
  CAS PubMed Google Scholar
• Yu, P. et al. Negative feedback-regulation of Ige synthesis by murine Cd23. Nature 369, 753–756 (1994).
  Article CAS PubMed Google Scholar
• Hodgkin, P.D., Lee, J.H. & Lyons, A.B. B cell differentiation and isotype switching is related to division cycle number. J. Exp. Med. 184, 277–281 (1996).
  Article CAS PubMed Google Scholar
• McHeyzer-Williams, L.J., Malherbe, L.P. & McHeyzer-Williams, M.G. Checkpoints in memory B-cell evolution. Immunol. Rev. 211, 255–268 (2006).
  Article CAS PubMed Google Scholar
• Deming, P.B. & Rathmell, J.C. Mitochondria, cell death, and B cell tolerance. Curr. Dir. Autoimmun. 9, 95–119 (2006).
  CAS PubMed Google Scholar
• Wurster, A.L. et al. Interleukin-4-mediated protection of primary B cells from apoptosis through Stat6-dependent up-regulation of Bcl-xL. J. Biol. Chem. 277, 27169–27175 (2002).
  Article CAS PubMed Google Scholar
• Grillot, D.A.M. et al. Bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice. J. Exp. Med. 183, 381–391 (1996).
  Article CAS PubMed Google Scholar
• Do, R.K.G. et al. Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response. J. Exp. Med. 192, 953–964 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Hsu, B.L. et al. Cutting edge: BLyS enables survival of transitional and mature B cells through distinct mediators. J. Immunol. 168, 5993–5996 (2002).
  Article CAS PubMed Google Scholar
• Takahashi, Y. et al. Relaxed negative selection in germinal centers and impaired affinity maturation in Bcl-xL transgenic mice. J. Exp. Med. 190, 399–409 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Huntington, N.D. et al. CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers. Nat. Immunol. 7, 190–198 (2006).
  Article CAS PubMed Google Scholar
• Murray, A.W. Recycling the cell cycle: cyclins revisited. Cell 116, 221–234 (2004).
  Article CAS PubMed Google Scholar
• Chiles, T.C. Regulation and function of cyclin D2 in B lymphocyte subsets. J. Immunol. 173, 2901–2907 (2004).
  Article CAS PubMed Google Scholar
• Han, J. et al. Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation. Nature 386, 296–299 (1997).
  Article CAS PubMed Google Scholar
• Wu, H. et al. MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type. EMBO J. 19, 1963–1973 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Glynne, R. et al. B-lymphocyte quiescence, tolerance and activation as viewed by global gene expression profiling on microarrays. Immunol. Rev. 176, 216–246 (2000).
  Article CAS PubMed Google Scholar
• Goodnow, C.C. et al. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 334, 676–682 (1988).
  Article CAS PubMed Google Scholar
• Fang, W. et al. Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editing. Immunity 9, 35–45 (1998).
  Article CAS PubMed Google Scholar
• Kato, Y. et al. BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C. EMBO J. 16, 7054–7066 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• McKinsey, T.A., Zhang, C.L. & Olson, E.N. Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14–3-3 to histone deacetylase 5. Proc. Natl. Acad. Sci. USA 97, 14400–14405 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Lu, J.R. et al. Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases. Mol. Cell 6, 233–244 (2000).
  Article CAS PubMed Google Scholar
• McKinsey, T.A. et al. Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature 408, 106–111 (2000).
  Article CAS PubMed PubMed Central Google Scholar