MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels (original) (raw)

• Glass, C.K. & Witztum, J.L. Atherosclerosis. the road ahead. Cell 104, 503–516 (2001).
  Article CAS PubMed Google Scholar
• Lusis, A.J. Atherosclerosis. Nature 407, 233–241 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Brown, M.S. & Goldstein, J.L. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89, 331–340 (1997).
  Article CAS PubMed Google Scholar
• Zelcer, N., Hong, C., Boyadjian, R. & Tontonoz, P. LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Science 325, 100–104 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Hua, X. et al. SREBP-2, a second basic-helix-loop-helix–leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proc. Natl. Acad. Sci. USA 90, 11603–11607 (1993).
  Article CAS PubMed PubMed Central Google Scholar
• Tontonoz, P., Kim, J.B., Graves, R.A. & Spiegelman, B.M. ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation. Mol. Cell. Biol. 13, 4753–4759 (1993).
  Article CAS PubMed PubMed Central Google Scholar
• Yokoyama, C. et al. SREBP-1, a basic-helix-loop-helix–leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Cell 75, 187–197 (1993).
  Article CAS PubMed Google Scholar
• Goldstein, J.L. & Brown, M.S. Regulation of the mevalonate pathway. Nature 343, 425–430 (1990).
  Article CAS PubMed Google Scholar
• Walker, A.K. et al. A conserved SREBP-1–phosphatidylcholine feedback circuit regulates lipogenesis in metazoans. Cell 147, 840–852 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Horton, J.D. et al. Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc. Natl. Acad. Sci. USA 100, 12027–12032 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Maxwell, K.N., Soccio, R.E., Duncan, E.M., Sehayek, E. & Breslow, J.L. Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice. J. Lipid Res. 44, 2109–2119 (2003).
  Article CAS PubMed Google Scholar
• Beaven, S.W. & Tontonoz, P. Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia. Annu. Rev. Med. 57, 313–329 (2006).
  Article CAS PubMed Google Scholar
• Ambros, V. The functions of animal microRNAs. Nature 431, 350–355 (2004).
  CAS PubMed Google Scholar
• Bartel, D.P. MicroRNAs: target recognition and regulatory functions. Cell 136, 215–233 (2009).
  CAS PubMed PubMed Central Google Scholar
• Filipowicz, W., Bhattacharyya, S.N. & Sonenberg, N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat. Rev. Genet. 9, 102–114 (2008).
  Article CAS PubMed Google Scholar
• Rayner, K.J. et al. MiR-33 contributes to the regulation of cholesterol homeostasis. Science 328, 1570–1573 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Najafi-Shoushtari, S.H. et al. MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis. Science 328, 1566–1569 (2010).
  Article CAS PubMed Google Scholar
• Jeon, T.I. et al. An SREBP-responsive microRNA operon contributes to a regulatory loop for intracellular lipid homeostasis. Cell Metab. 18, 51–61 (2013).
  Article CAS PubMed PubMed Central Google Scholar
• Rayner, K.J. et al. Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis. J. Clin. Invest. 121, 2921–2931 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Rayner, K.J. et al. Inhibition of miR-33a/b in nonhuman primates raises plasma HDL and lowers VLDL triglycerides. Nature 478, 404–407 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Rottiers, V. et al. Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR. Sci. Transl. Med. 5, 212ra162 (2013).
  Article CAS PubMed PubMed Central Google Scholar
• de Aguiar Vallim, T.Q. et al. MicroRNA-144 regulates hepatic ABCA1 and plasma HDL following activation of the nuclear receptor FXR. Circ. Res. 112, 1602–1612 (2013).
  Article CAS PubMed PubMed Central Google Scholar
• Ramírez, C.M. et al. Control of cholesterol metabolism and plasma HDL levels by miRNA-144. Circ. Res. 112, 1592–1601 (2013).
  Article CAS PubMed PubMed Central Google Scholar
• Vickers, K.C. et al. MicroRNA-223 coordinates cholesterol homeostasis. Proc. Natl. Acad. Sci. USA 111, 14518–14523 (2014).
  Article CAS PubMed PubMed Central Google Scholar
• Elmén, J. et al. LNA-mediated microRNA silencing in nonhuman primates. Nature 452, 896–899 (2008).
  Article CAS PubMed Google Scholar
• Elmén, J. et al. Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to upregulation of a large set of predicted target mRNAs in the liver. Nucleic Acids Res. 36, 1153–1162 (2008).
  Article CAS PubMed Google Scholar
• Esau, C. et al. miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metab. 3, 87–98 (2006).
  Article CAS PubMed Google Scholar
• Soh, J., Iqbal, J., Queiroz, J., Fernandez-Hernando, C. & Hussain, M.M. MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion. Nat. Med. 19, 892–900 (2013).
  Article CAS PubMed PubMed Central Google Scholar
• Brown, M.S., Dana, S.E. & Goldstein, J.L. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by lipoproteins. Proc. Natl. Acad. Sci. USA 70, 2162–2166 (1973).
  Article CAS PubMed PubMed Central Google Scholar
• Goldstein, J.L., Basu, S.K., Brunschede, G.Y. & Brown, M.S. Release of low-density lipoprotein from its cell surface receptor by sulfated glycosaminoglycans. Cell 7, 85–95 (1976).
  Article CAS PubMed Google Scholar
• Zhang, J.H., Chung, T.D. & Oldenburg, K.R. A simple statistical parameter for use in evaluation and validation of high-throughput screening assays. J. Biomol. Screen. 4, 67–73 (1999).
  Article CAS PubMed Google Scholar
• Birmingham, A. et al. Statistical methods for analysis of high-throughput RNA interference screens. Nat. Methods 6, 569–575 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Barad, O. et al. MicroRNA expression detected by oligonucleotide microarrays: system establishment and expression profiling in human tissues. Genome Res. 14, 2486–2494 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Landgraf, P. et al. A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 129, 1401–1414 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Vickers, K.C. et al. MicroRNA-27b is a regulatory hub in lipid metabolism and is altered in dyslipidemia. Hepatology 57, 533–542 (2013).
  Article CAS PubMed Google Scholar
• Arora, A. & Simpson, D.A. Individual mRNA expression profiles reveal the effects of specific microRNAs. Genome Biol. 9, R82 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Do, R. et al. Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat. Genet. 45, 1345–1352 (2013).
  Article CAS PubMed PubMed Central Google Scholar
• Global Lipids Genetics Consortium. et al. Discovery and refinement of loci associated with lipid levels. Nat. Genet. 45, 1274–1283 (2013).
• Huan, T. et al. Genome-wide identification of microRNA expression quantitative trait loci. Nat. Commun. 6, 6601 (2015).
  Article CAS PubMed Google Scholar
• Trajkovski, M. et al. MicroRNAs 103 and 107 regulate insulin sensitivity. Nature 474, 649–653 (2011).
  Article CAS PubMed Google Scholar
• Mercer, J. et al. RNAi screening reveals proteasome- and Cullin3-dependent stages in vaccinia virus infection. Cell Rep. 2, 1036–1047 (2012).
  Article CAS PubMed Google Scholar
• John, B. et al. Human MicroRNA targets. PLoS Biol. 2, e363 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Lewis, B.P., Burge, C.B. & Bartel, D.P. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120, 15–20 (2005).
  Article CAS PubMed Google Scholar
• Dweep, H., Gretz, N. & Sticht, C. miRWalk database for miRNA-target interactions. Methods Mol. Biol. 1182, 289–305 (2014).
  Article CAS PubMed Google Scholar
• Huang, D.W., Sherman, B.T. & Lempicki, R.A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 4, 44–57 (2009).
  Article CAS Google Scholar
• Szklarczyk, D. et al. The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Res. 39, D561–D568 (2011).
  Article CAS PubMed Google Scholar
• Thomas, P.D. et al. PANTHER: a library of protein families and subfamilies indexed by function. Genome Res. 13, 2129–2141 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Down, T.A. & Hubbard, T.J. Computational detection and location of transcription start sites in mammalian genomic DNA. Genome Res. 12, 458–461 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Saini, H.K., Griffiths-Jones, S. & Enright, A.J. Genomic analysis of human microRNA transcripts. Proc. Natl. Acad. Sci. USA 104, 17719–17724 (2007).
  Article PubMed PubMed Central Google Scholar
• Ernst, J. & Kellis, M. Discovery and characterization of chromatin states for systematic annotation of the human genome. Nat. Biotechnol. 28, 817–825 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Ernst, J. et al. Mapping and analysis of chromatin state dynamics in nine human cell types. Nature 473, 43–49 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Kent, W.J. et al. The human genome browser at UCSC. Genome Res. 12, 996–1006 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Shimomura, I., Bashmakov, Y. & Horton, J.D. Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. J. Biol. Chem. 274, 30028–30032 (1999).
  Article CAS PubMed Google Scholar
• Shimomura, I., Shimano, H., Horton, J.D., Goldstein, J.L. & Brown, M.S. Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. J. Clin. Invest. 99, 838–845 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Horton, J.D., Bashmakov, Y., Shimomura, I. & Shimano, H. Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice. Proc. Natl. Acad. Sci. USA 95, 5987–5992 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Peet, D.J. et al. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell 93, 693–704 (1998).
  Article CAS PubMed Google Scholar
• Yoshikawa, T. et al. Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter. Mol. Cell. Biol. 21, 2991–3000 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Dietschy, J.M., Turley, S.D. & Spady, D.K. Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans. J. Lipid Res. 34, 1637–1659 (1993).
  CAS PubMed Google Scholar
• Oram, J.F. & Vaughan, A.M. ABCA1-mediated transport of cellular cholesterol and phospholipids to HDL apolipoproteins. Curr. Opin. Lipidol. 11, 253–260 (2000).
  Article CAS PubMed Google Scholar
• Yang, M. et al. Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low density lipoprotein uptake. J. Lipid Res. 55, 226–238 (2014).
  Article CAS PubMed PubMed Central Google Scholar
• Ramírez, C.M. et al. MicroRNA 33 regulates glucose metabolism. Mol. Cell. Biol. 33, 2891–2902 (2013).
  Article CAS PubMed PubMed Central Google Scholar
• Dávalos, A. et al. miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling. Proc. Natl. Acad. Sci. USA 108, 9232–9237 (2011).
  Article PubMed PubMed Central Google Scholar
• Suárez, Y., Fernandez-Hernando, C., Pober, J.S. & Sessa, W.C. Dicer-dependent microRNAs regulate gene expression and functions in human endothelial cells. Circ. Res. 100, 1164–1173 (2007).
  Article CAS PubMed Google Scholar
• Goedeke, L. et al. A regulatory role for microRNA 33* in controlling lipid metabolism gene expression. Mol. Cell. Biol. 33, 2339–2352 (2013).
  Article CAS PubMed PubMed Central Google Scholar
• Allen, R.M., Marquart, T.J., Jesse, J.J. & Baldan, A. Control of very low–density lipoprotein secretion by _N_-ethylmaleimide–sensitive factor and miR-33. Circ. Res. 115, 10–22 (2014).
  Article CAS PubMed PubMed Central Google Scholar
• Calvo, D., Gomez-Coronado, D., Suarez, Y., Lasuncion, M.A. & Vega, M.A. Human CD36 is a high-affinity receptor for the native lipoproteins HDL, LDL and VLDL. J. Lipid Res. 39, 777–788 (1998).
  CAS PubMed Google Scholar
• Suárez, Y. et al. Synergistic upregulation of low-density lipoprotein receptor activity by tamoxifen and lovastatin. Cardiovasc. Res. 64, 346–355 (2004).
  Article CAS PubMed Google Scholar
• Chamorro-Jorganes, A., Araldi, E., Rotllan, N., Cirera-Salinas, D. & Suarez, Y. Autoregulation of glypican-1 by intronic microRNA-149 fine tunes the angiogenic response to FGF2 in human endothelial cells. J. Cell Sci. 127, 1169–1178 (2014).
  Article CAS PubMed PubMed Central Google Scholar
• Ramirez, C.M. et al. MicroRNA-758 regulates cholesterol efflux through post-transcriptional repression of ATP-binding cassette transporter A1. Arterioscler. Thromb. Vasc. Biol. 31, 2707–2714 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Wang, W. et al. Radixin is required to maintain apical canalicular membrane structure and function in rat hepatocytes. Gastroenterology 131, 878–884 (2006).
  Article CAS PubMed Google Scholar
• Mattison, J.A. et al. Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates. Cell Metab. 20, 183–190 (2014).
  Article CAS PubMed PubMed Central Google Scholar
• Goedeke, L. et al. Long-term therapeutic silencing of miR-33 increases circulating triglyceride levels and hepatic lipid accumulation in mice. EMBO Mol. Med. 6, 1133–1141 (2014).
  Article CAS PubMed PubMed Central Google Scholar
• Miller, A.M. et al. MiR-155 has a protective role in the development of non-alcoholic hepatosteatosis in mice. PLoS ONE 8, e72324 (2013).
  Article CAS PubMed PubMed Central Google Scholar