Steiniger, B. & Barth, P. Microanatomy and function of the spleen. Adv. Anat. Embryol. Cell Biol.151, III–IX; 1–101 (2000). CASPubMed Google Scholar
Groom, A. C., Schmidt, E. E. & MacDonald, I. C. Microcirculatory pathways and blood flow in spleen: new insights from washout kinetics, corrosion casts, and quantitative intravital videomicroscopy. Scanning Microsc.5, 159–174 (1991). CASPubMed Google Scholar
Drenckhahn, D. & Wagner, J. Stress fibers in the splenic sinus endothelium in situ: molecular structure, relationship to the extracellular matrix, and contractility. J. Cell Biol.102, 1738–1747 (1986). ArticleCASPubMed Google Scholar
MacDonald, I. C., Ragan, D. M., Schmidt, E. E. & Groom, A. C. Kinetics of red blood cell passage through interendothelial slits into venous sinuses in rat spleen, analyzed by in vivo microscopy. Microvasc. Res.33, 118–134 (1987). ArticleCASPubMed Google Scholar
Bratosin, D. et al. Cellular and molecular mechanisms of senescent erythrocyte phagocytosis by macrophages. A review. Biochimie80, 173–195 (1998). ArticleCASPubMed Google Scholar
Stewart, I. B. & McKenzie, D. C. The human spleen during physiological stress. Sports Med.32, 361–369 (2002). ArticlePubMed Google Scholar
Knutson, M. & Wessling-Resnick, M. Iron metabolism in the reticuloendothelial system. Crit. Rev. Biochem. Mol. Biol.38, 61–88 (2003). ArticleCASPubMed Google Scholar
Maines, M. D. The heme oxygenase system: a regulator of second messenger gases. Annu. Rev. Pharmacol. Toxicol.37, 517–554 (1997). ArticleCASPubMed Google Scholar
Kristiansen, M. et al. Identification of the haemoglobin scavenger receptor. Nature409, 198–201 (2001). This paper shows that CD163, which is expressed at the cell surface of macrophages, is a scavenger receptor for haemoglobin and haptoglobin-bound haemoglobin. This provides insight into a molecular mechanism of iron recycling by macrophages. ArticleCASPubMed Google Scholar
Gruenheid, S. et al. The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes. J. Exp. Med.189, 831–841 (1999). ArticleCASPubMedPubMed Central Google Scholar
Gruenheid, S. & Gros, P. Genetic susceptibility to intracellular infections: Nramp1, macrophage function and divalent cations transport. Curr. Opin. Microbiol.3, 43–48 (2000). ArticleCASPubMed Google Scholar
Hackam, D. J. et al. Host resistance to intracellular infection: mutation of natural resistance-associated macrophage protein 1 (Nramp1) impairs phagosomal acidification. J. Exp. Med.188, 351–364 (1998). ArticleCASPubMedPubMed Central Google Scholar
Ratledge, C. & Dover, L. G. Iron metabolism in pathogenic bacteria. Annu. Rev. Microbiol.54, 881–941 (2000). ArticleCASPubMed Google Scholar
Flo, T. H. et al. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature432, 917–921 (2004). The authors of this paper describe a new mechanism of the control of bacterial growth by macrophages, the increased production of lipocalin-2 after bacterial encounter. This molecule sequesters iron and thereby limits the growth of bacteria. ArticleCASPubMed Google Scholar
Sze, D. M., Toellner, K. M., Garcia de Vinuesa, C., Taylor, D. R. & MacLennan, I. C. Intrinsic constraint on plasmablast growth and extrinsic limits of plasma cell survival. J. Exp. Med.192, 813–821 (2000). ArticleCASPubMedPubMed Central Google Scholar
Hargreaves, D. C. et al. A coordinated change in chemokine responsiveness guides plasma cell movements. J. Exp. Med.194, 45–56 (2001). ArticleCASPubMedPubMed Central Google Scholar
Garcia De Vinuesa, C. et al. Dendritic cells associated with plasmablast survival. Eur. J. Immunol.29, 3712–3721 (1999). ArticleCASPubMed Google Scholar
Leenen, P. J. M. et al. Heterogeneity of mouse spleen dendritic cells: in vivo phagocytic activity, expression of macrophage markers, and subpopulation turnover. J. Immunol.160, 2166–2173 (1998). CASPubMed Google Scholar
Ansel, K. M. et al. A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature406, 309–314 (2000). ArticleCASPubMed Google Scholar
Gunn, M. D. et al. Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J. Exp. Med.189, 451–460 (1999). ArticleCASPubMedPubMed Central Google Scholar
Förster, R. et al. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell99, 23–33 (1999). ArticlePubMed Google Scholar
Ngo, V. N. et al. Lymphotoxin α/β and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. J. Exp. Med.189, 403–412 (1999). ArticleCASPubMedPubMed Central Google Scholar
Matsumoto, M. et al. Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers. Science271, 1289–1291 (1996). ArticleCASPubMed Google Scholar
Mebius, R. E., Van Tuijl, S., Weissman, I. L. & Randall, T. D. Transfer of primitive stem/progenitor bone marrow cells from LT-α−/− donors to wild-type hosts: implications for the generation of architectural events in lymphoid B cell domains. J. Immunol.161, 3836–3843 (1998). CASPubMed Google Scholar
Endres, R. et al. Mature follicular dendritic cell networks depend on expression of lymphotoxin β receptor by radioresistant stromal cells and of lymphotoxin β and tumor necrosis factor by B cells. J. Exp. Med.189, 159–168 (1999). ArticleCASPubMedPubMed Central Google Scholar
Luther, S. A., Tang, H. L., Hyman, P. L., Farr, A. G. & Cyster, J. G. Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse. Proc. Natl Acad. Sci. USA97, 12694–12699 (2000). ArticleCASPubMedPubMed Central Google Scholar
Tumanov, A. et al. Distinct role of surface lymphotoxin expressed by B cells in the organization of secondary lymphoid tissues. Immunity17, 239–250 (2002). ArticleCASPubMed Google Scholar
Cyster, J. G. & Goodnow, C. C. Pertussis toxin inhibits migration of B and T lymphocytes into splenic white pulp cords. J. Exp. Med.182, 581–586 (1995). In this paper, the authors show that entry of lymphocytes to the white pulp depends on signalling through G-protein-coupled receptors. ArticleCASPubMed Google Scholar
Johnston, B. & Butcher, E. C. Chemokines in rapid leukocyte adhesion triggering and migration. Semin. Immunol.14, 83–92 (2002). ArticleCASPubMed Google Scholar
Kang, Y. S. et al. The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide of Streptococcus pneumoniae in the marginal zone of mouse spleen. Proc. Natl Acad. Sci. USA101, 215–220 (2004). ArticleCASPubMed Google Scholar
Kang, Y. S. et al. SIGN-R1, a novel C-type lectin expressed by marginal zone macrophages in spleen, mediates uptake of the polysaccharide dextran. Int. Immunol.15, 177–186 (2003). ArticleCASPubMed Google Scholar
Geijtenbeek, T. B. et al. Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens in vivo. Blood100, 2908–2916 (2002). This paper shows that expression of the mouse homologue of DC-SIGN, SIGNR1, is restricted in the spleen to marginal-zone macrophages. It functions there as a pattern-recognition receptor for blood-borne antigens. ArticleCASPubMed Google Scholar
Elomaa, O. et al. Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages. Cell80, 603–609 (1995). ArticleCASPubMed Google Scholar
Munday, J., Floyd, H. & Crocker, P. R. Sialic acid binding receptors (siglecs) expressed by macrophages. J. Leukoc. Biol.66, 705–711 (1999). ArticleCASPubMed Google Scholar
Yu, P. et al. B cells control the migration of a subset of dendritic cells into B cell follicles via CXC chemokine ligand 13 in a lymphotoxin-dependent fashion. J. Immunol.168, 5117–5123 (2002). ArticleCASPubMed Google Scholar
Martin, F. & Kearney, J. F. Marginal-zone B cells. Nature Rev. Immunol.2, 323–335 (2002). ArticleCAS Google Scholar
Nolte, M. A. et al. B cells are crucial for both development and maintenance of the splenic marginal zone. J. Immunol.172, 3620–3627 (2004). ArticleCASPubMed Google Scholar
Crowley, M. T., Reilly, C. R. & Lo, D. Influence of lymphocytes on the presence and organization of dendritic cell subsets in the spleen. J. Immunol.163, 4894–4900 (1999). CASPubMed Google Scholar
Cupedo, T. et al. Initiation of cellular organization in lymph nodes is regulated by non-B cell-derived signals and is not dependent on CXC chemokine ligand 13. J. Immunol.173, 4889–4896 (2004). ArticleCASPubMed Google Scholar
Cupedo, T. et al. Presumptive lymph node organizers are differentially represented in developing mesenteric and peripheral nodes. J. Immunol.173, 2968–2975 (2004). ArticleCASPubMed Google Scholar
Ato, M., Nakano, H., Kakiuchi, T. & Kaye, P. M. Localization of marginal zone macrophages is regulated by C-C chemokine ligands 21/19. J. Immunol.173, 4815–4820 (2004). ArticleCASPubMed Google Scholar
Karlsson, M. C. et al. Macrophages control the retention and trafficking of B lymphocytes in the splenic marginal zone. J. Exp. Med.198, 333–340 (2003). ArticleCASPubMedPubMed Central Google Scholar
Matloubian, M. et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature427, 355–360 (2004). ArticleCASPubMed Google Scholar
Allende, M. L., Dreier, J. L., Mandala, S. & Proia, R. L. Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration. J. Biol. Chem.279, 15396–15401 (2004). ArticleCASPubMed Google Scholar
Cinamon, G. et al. Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone. Nature Immunol.5, 713–720 (2004). This paper shows that S1P1is required for retention of marginal-zone B cells in the marginal zone, 'overwriting' the effects of the chemoattractant CXCL13, which is produced in B-cell follicles. This finding adds another level of complexity to the regulation of the integrity of the marginal zone. ArticleCAS Google Scholar
Girkontaite, I. et al. The sphingosine-1-phosphate (S1P) lysophospholipid receptor S1P3 regulates MAdCAM-1+ endothelial cells in splenic marginal sinus organization. J. Exp. Med.200, 1491–1501 (2004). ArticleCASPubMedPubMed Central Google Scholar
Graeler, M., Shankar, G. & Goetzl, E. J. Suppression of T cell chemotaxis by sphingosine 1-phosphate. J. Immunol.169, 4084–4087 (2002). ArticleCASPubMed Google Scholar
Goetzl, E. J., Wang, W., McGiffert, C., Huang, M. C. & Graler, M. H. Sphingosine 1-phosphate and its G protein-coupled receptors constitute a multifunctional immunoregulatory system. J. Cell. Biochem.92, 1104–1114 (2004). ArticleCASPubMedPubMed Central Google Scholar
Lu, T. T. & Cyster, J. G. Integrin-mediated long-term B cell retention in the splenic marginal zone. Science297, 409–412 (2002). ArticleCASPubMed Google Scholar
Guinamard, R., Okigaki, M., Schlessinger, J. & Ravetch, J. V. Absence of marginal zone B cells in Pyk-2 deficient mice defines their role in the humoral response. Nature Immunol.1, 31–36 (2000). ArticleCAS Google Scholar
Gordon, S. Pattern recognition receptors: doubling up for the innate immune response. Cell111, 927–930 (2002). ArticleCASPubMed Google Scholar
Koppel, E. A. et al. Identification of the mycobacterial carbohydrate structure that binds the C-type lectins DC-SIGN, L-SIGN and SIGNR1. Immunobiology209, 117–127 (2004). ArticleCASPubMed Google Scholar
Marzi, A. et al. DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus. J. Virol.78, 12090–12095 (2004). ArticleCASPubMedPubMed Central Google Scholar
Oehen, S. et al. Marginal zone macrophages and immune responses against viruses. J. Immunol.169, 1453–1458 (2002). ArticleCASPubMed Google Scholar
Crocker, P. R. & Varki, A. Siglecs, sialic acids and innate immunity. Trends Immunol.22, 337–342 (2001). ArticleCASPubMed Google Scholar
Jones, C., Virji, M. & Crocker, P. R. Recognition of sialylated meningococcal lipopolysaccharide by siglecs expressed on myeloid cells leads to enhanced bacterial uptake. Mol. Microbiol.49, 1213–1225 (2003). ArticleCASPubMed Google Scholar
Eloranta, M. L. & Alm, G. V. Splenic marginal metallophilic macrophages and marginal zone macrophages are the major interferon-α/β producers in mice upon intravenous challenge with herpes simplex virus. Scand. J. Immunol.49, 391–394 (1999). ArticleCASPubMed Google Scholar
Van Rooijen, N. Antigen processing and presentation in vivo: the microenvironment as a crucial factor. Immunol. Today11, 436–439 (1990). ArticleCASPubMed Google Scholar
Lopes-Carvalho, T. & Kearney, J. F. Development and selection of marginal zone B cells. Immunol. Rev.197, 192–205 (2004). ArticlePubMed Google Scholar
Attanavanich, K. & Kearney, J. F. Marginal zone, but not follicular B cells, are potent activators of naive CD4 T cells. J. Immunol.172, 803–811 (2004). ArticleCASPubMed Google Scholar
Ato, M., Stager, S., Engwerda, C. R. & Kaye, P. M. Defective CCR7 expression on dendritic cells contributes to the development of visceral leishmaniasis. Nature Immunol.3, 1185–1191 (2002). ArticleCAS Google Scholar
Amlot, P. L. & Hayes, A. E. Impaired human antibody response to the thymus-independent antigen, DNP–Ficoll, after splenectomy. Implications for post-splenectomy infections. Lancet1, 1008–1011 (1985). ArticleCASPubMed Google Scholar
Nolte, M. A., Hoen, E. N., van Stijn, A., Kraal, G. & Mebius, R. E. Isolation of the intact white pulp. Quantitative and qualitative analysis of the cellular composition of the splenic compartments. Eur. J. Immunol.30, 626–634 (2000). This paper shows, by isolation of intact white pulp, that the cellular composition and organization of the lymphoid compartment of the spleen is highly similar to that of lymph nodes. ArticleCASPubMed Google Scholar
Balazs, M., Martin, F., Zhou, T. & Kearney, J. Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses. Immunity17, 341–352 (2002). ArticleCASPubMed Google Scholar
Ansel, K. M., McHeyzer-Williams, L. J., Ngo, V. N., McHeyzer-Williams, M. G. & Cyster, J. G. _In vivo_-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines. J. Exp. Med.190, 1123–1134 (1999). ArticleCASPubMedPubMed Central Google Scholar
Reif, K. et al. Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position. Nature416, 94–99 (2002). ArticlePubMed Google Scholar
Garside, P. et al. Visualization of specific B and T lymphocyte interactions in the lymph node. Science281, 96–99 (1998). ArticleCASPubMed Google Scholar
Pape, K. A. et al. Visualization of the genesis and fate of isotype-switched B cells during a primary immune response. J. Exp. Med.197, 1677–1687 (2003). ArticleCASPubMedPubMed Central Google Scholar
Gretz, J. E., Norbury, C. C., Anderson, A. O., Proudfoot, A. E. I. & Shaw, S. Lymph-borne chemokines and other low molecular weight molecules reach high endothelial venules via specialized conduits while a functional barrier limits access to the lymphocyte microenvironments in lymph node cortex. J. Exp. Med.192, 1425–1440 (2000). The authors show that there is a fine tubular network in the lymph nodes that allows rapid transport of small molecules. Others have shown that this conduit system is important for the transport of chemokines and that it is also present in the spleen. ArticleCASPubMedPubMed Central Google Scholar
Nolte, M. A. et al. A conduit system distributes chemokines and small blood-borne molecules through the splenic white pulp. J. Exp. Med.198, 505–512 (2003). ArticleCASPubMedPubMed Central Google Scholar
Palframan, R. T. et al. Inflammatory chemokine transport and presentation in HEV: a remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues. J. Exp. Med.194, 1361–1373 (2001). ArticleCASPubMedPubMed Central Google Scholar
Baekkevold, E. S. et al. The CCR7 ligand ELC (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitment. J. Exp. Med.193, 1105–1112 (2001). ArticleCASPubMedPubMed Central Google Scholar
Sixt, M. et al. The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node. Immunity22, 19–29 (2005). ArticleCASPubMed Google Scholar
Katakai, T., Hara, T., Sugai, M., Gonda, H. & Shimizu, A. Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes. J. Exp. Med.200, 783–795 (2004). ArticleCASPubMedPubMed Central Google Scholar
Dejardin, E. et al. The lymphotoxin-β receptor induces different patterns of gene expression via two NF-κB pathways. Immunity17, 525–535 (2002). ArticleCASPubMed Google Scholar
Unsoeld, H., Voehringer, D., Krautwald, S. & Pircher, H. Constitutive expression of CCR7 directs effector CD8 T cells into the splenic white pulp and impairs functional activity. J. Immunol.173, 3013–3019 (2004). ArticleCASPubMed Google Scholar
Mitchell, J. Lymphocyte circulation in the spleen. Marginal zone bridging channels and their possible role in cell traffic. Immunology24, 93–107 (1973). CASPubMedPubMed Central Google Scholar
Green, M. C. A defect of the splanchnic mesoderm caused by the mutant gene dominant hemimelia in the mouse. Dev. Biol.15, 62–89 (1967). ArticleCASPubMed Google Scholar
Hecksher-Sorensen, J. et al. The splanchnic mesodermal plate directs spleen and pancreatic laterality, and is regulated by Bapx1/Nkx3.2. Development131, 4665–4675 (2004). ArticleCASPubMed Google Scholar
Roberts, C. W., Shutter, J. R. & Korsmeyer, S. J. Hox11 controls the genesis of the spleen. Nature368, 747–749 (1994). ArticleCASPubMed Google Scholar
Lu, J. et al. The basic helix–loop–helix transcription factor capsulin controls spleen organogenesis. Proc. Natl Acad. Sci. USA97, 9525–9530 (2000). ArticleCASPubMedPubMed Central Google Scholar
Herzer, U., Crocoll, A., Barton, D., Howells, N. & Englert, C. The Wilms tumor suppressor gene WT1 is required for development of the spleen. Curr. Biol.9, 837–840 (1999). ArticleCASPubMed Google Scholar
Seifert, M. F. & Marks, S. C. J. The regulation of hemopoiesis in the spleen. Experientia41, 192–199 (1985). ArticleCASPubMed Google Scholar
Mebius, R., Rennert, P. D. & Weissman, I. L. Developing lymph nodes collect CD4+CD3− LTβ+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells. Immunity7, 493–504 (1997). ArticleCASPubMed Google Scholar
Mebius, R. E. Organogenesis of lymphoid tissues. Nature Rev. Immunol.3, 292–303 (2003). ArticleCAS Google Scholar
Saito, T. et al. Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Immunity18, 675–685 (2003). ArticleCASPubMed Google Scholar
Quong, M. W. et al. Receptor editing and marginal zone B cell development are regulated by the helix–loop–helix protein, E2A. J. Exp. Med.199, 1101–1112 (2004). ArticleCASPubMedPubMed Central Google Scholar
Tanigaki, K. et al. Notch–RBP-J signaling is involved in cell fate determination of marginal zone B cells. Nature Immunol.3, 443–450 (2002). ArticleCAS Google Scholar
Kuroda, K. et al. Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway. Immunity18, 301–312 (2003). ArticleCASPubMed Google Scholar
Cariappa, A. et al. The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21. Immunity14, 603–615 (2001). ArticleCASPubMed Google Scholar
Loder, F. et al. B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals. J. Exp. Med.190, 75–89 (1999). References 90–95 provide evidence that the differentiation of B cells into marginal-zone B cells or follicular B cells is a cell-fate decision that is regulated by many factors. ArticleCASPubMedPubMed Central Google Scholar
Makowska, A., Faizunnessa, N. N., Anderson, P., Midtvedt, T. & Cardell, S. CD1high B cells: a population of mixed origin. Eur. J. Immunol.29, 3285–3294 (1999). ArticleCASPubMed Google Scholar
Pillai, S., Cariappa, A. & Moran, S. T. Marginal zone B cells. Annu. Rev. Immunol.23, 161–196 (2005). ArticleCASPubMed Google Scholar
Steiniger, B., Ruttinger, L. & Barth, P. J. The three-dimensional structure of human splenic white pulp compartments. J. Histochem. Cytochem.51, 655–664 (2003). ArticleCASPubMed Google Scholar
Steiniger, B., Barth, P. & Hellinger, A. The perifollicular and marginal zones of the human splenic white pulp: do fibroblasts guide lymphocyte immigration? Am. J. Pathol.159, 501–512 (2001). ArticleCASPubMedPubMed Central Google Scholar
De Togni, P. et al. Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science264, 703–707 (1994). ArticleCASPubMed Google Scholar
Banks, T. A. et al. Lymphotoxin-α-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness. J. Immunol.155, 1685–1693 (1995). CASPubMed Google Scholar
Koni, P. A. et al. Distinct roles in lymphoid organogenesis for lymphotoxins α and β revealed in lymphotoxin β-deficient mice. Immunity6, 491–500 (1997). ArticleCASPubMed Google Scholar
Alexopoulou, L., Pasparakis, M. & Kollias, G. Complementation of lymphotoxin α knockout mice with tumor necrosis factor-expressing transgenes rectifies defective splenic structure and function. J. Exp. Med.188, 745–754 (1998). ArticleCASPubMedPubMed Central Google Scholar
Pasparakis, M., Kousteni, S., Peschon, J. & Kollias, G. Tumor necrosis factor and the p55TNF receptor are required for optimal development of the marginal sinus and for migration of follicular dendritic cell precursors into splenic follicles. Cell. Immunol.201, 33–41 (2000). ArticleCASPubMed Google Scholar
Kuprash, D. V. et al. TNF and lymphotoxin β cooperate in the maintenance of secondary lymphoid tissue microarchitecture but not in the development of lymph nodes. J. Immunol.163, 6575–6580 (1999). CASPubMed Google Scholar
Alimzhanov, M. et al. Abnormal development of secondary lymphoid tissues in lymphotoxin β-deficient mice. Proc. Natl Acad. Sci. USA94, 9302–9307 (1997). ArticleCASPubMedPubMed Central Google Scholar
Kuprash, D. V. et al. Redundancy in tumor necrosis factor (TNF) and lymphotoxin (LT) signaling in vivo: mice with inactivation of the entire TNF/LT locus versus single-knockout mice. Mol. Cell. Biol.22, 8626–8634 (2002). ArticleCASPubMedPubMed Central Google Scholar
Futterer, A., Mink, K., Luz, A., Kosco-Vilbois, M. H. & Pfeffer, K. The lymphotoxin β receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. Immunity9, 59–70 (1998). ArticleCASPubMed Google Scholar
Scheu, S. et al. Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin β in mesenteric lymph node genesis. J. Exp. Med.195, 1613–1624 (2002). ArticleCASPubMedPubMed Central Google Scholar
Pasparakis, M. et al. Peyer's patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor. Proc. Natl Acad. Sci. USA94, 6319–6323 (1997). ArticleCASPubMedPubMed Central Google Scholar
Pasparakis, M., Alexopoulou, L., Episkopou, V. & Kollias, G. Immune and inflammatory responses in TNFα-deficient mice: a critical requirement for TNFα in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J. Exp. Med.184, 1397–1411 (1996). ArticleCASPubMed Google Scholar
Körner, H. et al. Distinct role for lymphotoxin-α and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue. Eur. J. Immunol.27, 2600–2609 (1997). ArticlePubMed Google Scholar
Pfeffer, K. et al. Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell73, 457–467 (1993). ArticleCASPubMed Google Scholar
Erickson, S. L. et al. Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice. Nature372, 560–563 (1994). ArticleCASPubMed Google Scholar
Koike, R. et al. The splenic marginal zone is absent in alymphoplastic aly mutant mice. Eur. J. Immunol.26, 669–675 (1996). ArticleCASPubMed Google Scholar
Matsumoto, M. et al. Involvement of distinct cellular compartments in the abnormal lymphoid organogenesis in lymphotoxin-α-deficient mice and alymphoplasia (aly) mice defined by the chimeric analysis. J. Immunol.163, 1584–1591 (1999). CASPubMed Google Scholar
Shinkura, R. et al. Alymphoplasia is caused by a point mutation in the mouse gene encoding NF-κB-inducing kinase. Nature Genet.22, 74–77 (1999). ArticleCASPubMed Google Scholar
Yamada, T. et al. Abnormal immune function of hemopoietic cells from alymphoplasia (aly) mice, a natural strain with mutant NF-κB-inducing kinase. J. Immunol.165, 804–812 (2000). ArticleCASPubMed Google Scholar
Weih, F. & Caamano, J. Regulation of secondary lymphoid organ development by the nuclear factor-κB signal transduction pathway. Immunol. Rev.195, 91–105 (2003). ArticleCASPubMed Google Scholar
Cariappa, A., Liou, H. C., Horwitz, B. H. & Pillai, S. Nuclear factor κB is required for the development of marginal zone B lymphocytes. J. Exp. Med.192, 1175–1182 (2000). ArticleCASPubMedPubMed Central Google Scholar
Franzoso, G. et al. Mice deficient in nuclear factor (NF)-κB/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture. J. Exp. Med.187, 147–159 (1998). ArticleCASPubMedPubMed Central Google Scholar
Poljak, L., Carlson, L., Cunningham, K., Kosco-Vilbois, M. H. & Siebenlist, U. Distinct activities of p52/NF-κB required for proper secondary lymphoid organ microarchitecture: functions enhanced by Bcl-3. J. Immunol.163, 6581–6588 (1999). CASPubMed Google Scholar
Weih, D., Yilmaz, Z. & Weih, F. Essential role of RelB in germinal center and marginal zone formation and proper expression of homing chemokines. J. Immunol.167, 1909–1919 (2001). ArticleCASPubMed Google Scholar
Franzoso, G. et al. Critical roles for the Bcl-3 oncoprotein in T cell-mediated immunity, splenic microarchitecture, and germinal center reactions. Immunity6, 479–490 (1997). ArticleCASPubMed Google Scholar
Pabst, O., Förster, R., Lipp, M., Engel, H. & Arnold, H. H. NKX2.3 is required for MAdCAM-1 expression and homing of lymphocytes in spleen and mucosa-associated lymphoid tissue. EMBO J.19, 2015–2023 (2000). ArticleCASPubMedPubMed Central Google Scholar