Naive T cell homeostasis: from awareness of space to a sense of place (original) (raw)
Dorfman, J. R. & Germain, R. N. MHC-dependent survival of naive T cells? A complicated answer to a simple question. Microbes Infect.4, 547–554 (2002). ArticleCASPubMed Google Scholar
Jameson, S. C. Maintaining the norm: T-cell homeostasis. Nature Rev. Immunol.2, 547–556 (2002). ArticleCAS Google Scholar
Almeida, A. R., Rocha, B., Freitas, A. A. & Tanchot, C. Homeostasis of T cell numbers: from thymus production to peripheral compartmentalization and the indexation of regulatory T cells. Semin. Immunol.17, 239–249 (2005). ArticleCASPubMed Google Scholar
Surh, C. D. & Sprent, J. Homeostasis of naive and memory T cells. Immunity29, 848–862 (2008). ArticleCASPubMed Google Scholar
Starr, T. K., Jameson, S. C. & Hogquist, K. A. Positive and negative selection of T cells. Annu. Rev. Immunol.21, 139–176 (2003). ArticleCASPubMed Google Scholar
Davey, G. M. et al. Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells. J. Exp. Med.188, 1867–1874 (1998). ArticleCASPubMed CentralPubMed Google Scholar
Lucas, B., Stefanova, I., Yasutomo, K., Dautigny, N. & Germain, R. N. Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire. Immunity10, 367–376 (1999). ArticleCASPubMed Google Scholar
van Oers, N. S., Killeen, N. & Weiss, A. ZAP-70 is constitutively associated with tyrosine-phosphorylated TCRζ in murine thymocytes and lymph node T cells. Immunity1, 675–685 (1994). ArticleCASPubMed Google Scholar
Dorfman, J. R., Stefanova, I., Yasutomo, K. & Germain, R. N. CD4+ T cell survival is not directly linked to self-MHC-induced TCR signaling. Nature Immunol.1, 329–335 (2000). ArticleCAS Google Scholar
Witherden, D. et al. Tetracycline-controllable selection of CD4+ T cells: half-life and survival signals in the absence of major histocompatibility complex class II molecules. J. Exp. Med.191, 355–364 (2000). ArticleCASPubMed Google Scholar
Brocker, T. Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells. J. Exp. Med.186, 1223–1232 (1997). ArticleCASPubMed CentralPubMed Google Scholar
Kirberg, J., Berns, A. & von Boehmer, H. Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules. J. Exp. Med.186, 1269–1275 (1997). ArticleCASPubMed CentralPubMed Google Scholar
Nesic, D. & Vukmanovic, S. MHC class I is required for peripheral accumulation of CD8+ thymic emigrants. J. Immunol.160, 3705–3712 (1998). CASPubMed Google Scholar
Markiewicz, M. A., Brown, I. & Gajewski, T. F. Death of peripheral CD8+ T cells in the absence of MHC class I is Fas-dependent and not blocked by Bcl-xL . Eur. J. Immunol.33, 2917–2926 (2003). ArticleCASPubMed Google Scholar
Markiewicz, M. A. et al. Long-term T cell memory requires the surface expression of self-peptide/major histocompatibility complex molecules. Proc. Natl Acad. Sci. USA95, 3065–3070 (1998). ArticleCASPubMedPubMed Central Google Scholar
Murali-Krishna, K. et al. Persistence of memory CD8 T cells in MHC class I-deficient mice. Science286, 1377–1381 (1999). ArticleCASPubMed Google Scholar
Takeda, S., Rodewald, H. R., Arakawa, H., Bluethmann, H. & Shimizu, T. MHC class II molecules are not required for survival of newly generated CD4+ T cells, but affect their long-term life span. Immunity5, 217–228 (1996). ArticleCASPubMed Google Scholar
Tanchot, C., Lemonnier, F. A., Perarnau, B., Freitas, A. A. & Rocha, B. Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science276, 2057–2062 (1997). References 17 and 18 set the stage for appreciating a role for self-peptide–MHC complexes in maintaining naive T cell homeostasis. ArticleCASPubMed Google Scholar
Grandjean, I. et al. Are major histocompatibility complex molecules involved in the survival of naive CD4+ T cells? J. Exp. Med.198, 1089–1102 (2003). ArticleCASPubMed CentralPubMed Google Scholar
Clarke, S. R. & Rudensky, A. Y. Survival and homeostatic proliferation of naive peripheral CD4+ T cells in the absence of self peptide:MHC complexes. J. Immunol.165, 2458–2464 (2000). ArticleCASPubMed Google Scholar
Fischer, U. B. et al. MHC class II deprivation impairs CD4 T cell motility and responsiveness to antigen-bearing dendritic cells in vivo. Proc. Natl Acad. Sci. USA104, 7181–7186 (2007). ArticleCASPubMedPubMed Central Google Scholar
Martin, B., Becourt, C., Bienvenu, B. & Lucas, B. Self-recognition is crucial for maintaining the peripheral CD4+ T-cell pool in a nonlymphopenic environment. Blood108, 270–277 (2006). ArticleCASPubMed Google Scholar
Vugmeyster, Y. et al. Major histocompatibility complex (MHC) class I KbDb−/− deficient mice possess functional CD8+ T cells and natural killer cells. Proc. Natl Acad. Sci. USA95, 12492–12497 (1998). ArticleCASPubMed CentralPubMed Google Scholar
Takada, K. & Jameson, S. C. Self class-I MHC molecules support survival of naïve CD8 T cells but depress their functional sensitivity through regulation of CD8 expression levels. J. Exp. Med.206, 2253–2269 (2009). ArticleCASPubMed CentralPubMed Google Scholar
Hataye, J., Moon, J. J., Khoruts, A., Reilly, C. & Jenkins, M. K. Naive and memory CD4+ T cell survival controlled by clonal abundance. Science312, 114–116 (2006). A pioneering study that described the effects of precursor cell number on the maintenance of naive and memory T cells in non-lymphopenic hosts. ArticleCASPubMed Google Scholar
Moses, C. T., Thorstenson, K. M., Jameson, S. C. & Khoruts, A. Competition for self ligands restrains homeostatic proliferation of naive CD4 T cells. Proc. Natl Acad. Sci. USA100, 1185–1190 (2003). ArticleCASPubMedPubMed Central Google Scholar
Min, B., Foucras, G., Meier-Schellersheim, M. & Paul, W. E. Spontaneous proliferation, a response of naive CD4 T cells determined by the diversity of the memory cell repertoire. Proc. Natl Acad. Sci. USA101, 3874–3879 (2004). ArticleCASPubMedPubMed Central Google Scholar
Troy, A. E. & Shen, H. Cutting edge: homeostatic proliferation of peripheral T lymphocytes is regulated by clonal competition. J. Immunol.170, 672–676 (2003). ArticleCASPubMed Google Scholar
Leitao, C., Freitas, A. A. & Garcia, S. The role of TCR specificity and clonal competition during reconstruction of the peripheral T cell pool. J. Immunol.182, 5232–5239 (2009). ArticleCASPubMed Google Scholar
Moon, J. J. et al. Naive CD4+ T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Immunity27, 203–213 (2007). ArticleCASPubMed CentralPubMed Google Scholar
Kieper, W. C., Burghardt, J. T. & Surh, C. D. A role for TCR affinity in regulating naive T cell homeostasis. J. Immunol.172, 40–44 (2004). ArticleCASPubMed Google Scholar
Hao, Y., Legrand, N. & Freitas, A. A. The clone size of peripheral CD8 T cells is regulated by TCR promiscuity. J. Exp. Med.203, 1643–1649 (2006). ArticleCASPubMed CentralPubMed Google Scholar
Agenes, F., Dangy, J. P. & Kirberg, J. T cell receptor contact to restricting MHC molecules is a prerequisite for peripheral interclonal T cell competition. J. Exp. Med.205, 2735–2743 (2008). ArticleCASPubMed CentralPubMed Google Scholar
Polic, B., Kunkel, D., Scheffold, A. & Rajewsky, K. How αβ T cells deal with induced TCRα ablation. Proc. Natl Acad. Sci. USA98, 8744–8749 (2001). ArticleCASPubMedPubMed Central Google Scholar
Seddon, B., Legname, G., Tomlinson, P. & Zamoyska, R. Long-term survival but impaired homeostatic proliferation of naive T cells in the absence of p56lck. Science290, 127–131 (2000). References 36–38 helped to dissect the role of TCR interactions in promoting T cell maintenance and LIP. ArticleCASPubMed Google Scholar
Seddon, B. & Zamoyska, R. TCR signals mediated by Src family kinases are essential for the survival of naive T cells. J. Immunol.169, 2997–3005 (2002). ArticleCASPubMed Google Scholar
Stefanova, I., Dorfman, J. R. & Germain, R. N. Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes. Nature420, 429–434 (2002). ArticleCASPubMed Google Scholar
Krogsgaard, M. et al. Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity. Nature434, 238–243 (2005). ArticleCASPubMed Google Scholar
Yachi, P. P., Lotz, C., Ampudia, J. & Gascoigne, N. R. T cell activation enhancement by endogenous pMHC acts for both weak and strong agonists but varies with differentiation state. J. Exp. Med.204, 2747–2757 (2007). ArticleCASPubMed CentralPubMed Google Scholar
Tarakhovsky, A. et al. A role for CD5 in TCR-mediated signal transduction and thymocyte selection. Science269, 535–537 (1995). ArticleCASPubMed Google Scholar
Jabbari, A. & Harty, J. T. Cutting edge: differential self-peptide/MHC requirement for maintaining CD8 T cell function versus homeostatic proliferation. J. Immunol.175, 4829–4833 (2005). ArticleCASPubMed Google Scholar
Bhandoola, A. et al. Peripheral expression of self-MHC-II influences the reactivity and self-tolerance of mature CD4+ T cells: evidence from a lymphopenic T cell model. Immunity17, 425–436 (2002). ArticleCASPubMed Google Scholar
Marrack, P. & Kappler, J. Control of T cell viability. Annu. Rev. Immunol.22, 765–787 (2004). ArticleCASPubMed Google Scholar
Rathmell, J. C., Farkash, E. A., Gao, W. & Thompson, C. B. IL-7 enhances the survival and maintains the size of naive T cells. J. Immunol.167, 6869–6876 (2001). ArticleCASPubMed Google Scholar
Rochman, Y. & Leonard, W. J. The role of thymic stromal lymphopoietin in CD8+ T cell homeostasis. J. Immunol.181, 7699–7705 (2008). ArticleCASPubMed Google Scholar
Vivien, L., Benoist, C. & Mathis, D. T lymphocytes need IL-7 but not IL-4 or IL-6 to survive in vivo. Int. Immunol.13, 763–768 (2001). ArticleCASPubMed Google Scholar
Schluns, K. S., Kieper, W. C., Jameson, S. C. & Lefrancois, L. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nature Immunol.1, 426–432 (2000). ArticleCAS Google Scholar
Hassan, J. & Reen, D. J. IL-7 promotes the survival and maturation but not differentiation of human post-thymic CD4+ T cells. Eur. J. Immunol.28, 3057–3065 (1998). ArticleCASPubMed Google Scholar
Tan, J. T. et al. IL-7 is critical for homeostatic proliferation and survival of naive T cells. Proc. Natl Acad. Sci. USA98, 8732–8737 (2001). ArticleCASPubMedPubMed Central Google Scholar
Mertsching, E., Burdet, C. & Ceredig, R. IL-7 transgenic mice: analysis of the role of IL-7 in the differentiation of thymocytes in vivo and in vitro. Int. Immunol.7, 401–414 (1995). ArticleCASPubMed Google Scholar
Kieper, W. C. et al. Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells. J. Exp. Med.195, 1533–1539 (2002). ArticleCASPubMed CentralPubMed Google Scholar
Rochman, Y., Spolski, R. & Leonard, W. J. New insights into the regulation of T cells by γc family cytokines. Nature Rev. Immunol.9, 480–490 (2009). ArticleCAS Google Scholar
Jiang, Q. et al. Cell biology of IL-7, a key lymphotrophin. Cytokine Growth Factor Rev.16, 513–533 (2005). ArticleCASPubMed Google Scholar
Wojciechowski, S. et al. Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis. J. Exp. Med.204, 1665–1675 (2007). ArticleCAS Google Scholar
Akashi, K., Kondo, M., von Freeden-Jeffry, U., Murray, R. & Weissman, I. L. Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Cell89, 1033–1041 (1997). ArticleCASPubMed Google Scholar
Maraskovsky, E. et al. Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant _rag_-1−/− mice. Cell89, 1011–1019 (1997). ArticleCASPubMed Google Scholar
Pellegrini, M. et al. Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice. J. Exp. Med.200, 1189–1195 (2004). ArticleCASPubMed CentralPubMed Google Scholar
Wofford, J. A., Wieman, H. L., Jacobs, S. R., Zhao, Y. & Rathmell, J. C. IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival. Blood111, 2101–2111 (2008). ArticleCASPubMed CentralPubMed Google Scholar
Carlson, C. M. et al. Kruppel-like factor 2 regulates thymocyte and T-cell migration. Nature442, 299–302 (2006). ArticleCASPubMed Google Scholar
Sinclair, L. V. et al. Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking. Nature Immunol.9, 513–521 (2008). ArticleCAS Google Scholar
Kerdiles, Y. M. et al. Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nature Immunol.10, 176–184 (2009). ArticleCAS Google Scholar
Fry, T. J. & Mackall, C. L. The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance. J. Immunol.174, 6571–6576 (2005). ArticleCASPubMed Google Scholar
Goldrath, A. W. et al. Cytokine requirements for acute and basal homeostatic proliferation of naive and memory CD8+ T cells. J. Exp. Med.195, 1515–1522 (2002). ArticleCASPubMed CentralPubMed Google Scholar
Sportes, C. et al. Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets. J. Exp. Med.205, 1701–1714 (2008). ArticleCASPubMed CentralPubMed Google Scholar
Hassan, J. & Reen, D. J. Human recent thymic emigrants — identification, expansion, and survival characteristics. J. Immunol.167, 1970–1976 (2001). ArticleCASPubMed Google Scholar
Dardalhon, V. et al. IL-7 differentially regulates cell cycle progression and HIV-1-based vector infection in neonatal and adult CD4+ T cells. Proc. Natl Acad. Sci. USA98, 9277–9282 (2001). ArticleCASPubMed CentralPubMed Google Scholar
Opiela, S. J., Koru-Sengul, T. & Adkins, B. Murine neonatal recent thymic emigrants are phenotypically and functionally distinct from adult recent thymic emigrants. Blood113, 5635–5643 (2009). ArticleCASPubMed CentralPubMed Google Scholar
Swainson, L. et al. IL-7-induced proliferation of recent thymic emigrants requires activation of the PI3K pathway. Blood109, 1034–1042 (2007). ArticleCASPubMed Google Scholar
Park, J. H. et al. Suppression of IL7Rα transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival. Immunity21, 289–302 (2004). ArticleCASPubMed Google Scholar
Park, J. H. et al. 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. Nature Immunol.8, 1049–1059 (2007). References 75 and 76 revealed the influence that IL-7R signalling has on its own expression and that of the T cell co-receptor CD8. ArticleCAS Google Scholar
Lundmark, F. et al. Variation in interleukin 7 receptor α chain (IL7R) influences risk of multiple sclerosis. Nature Genet.39, 1108–1113 (2007). ArticleCASPubMed Google Scholar
Yucel, R., Karsunky, H., Klein-Hitpass, L. & Moroy, T. The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4/CD8 lineage decision in the thymus. J. Exp. Med.197, 831–844 (2003). ArticleCASPubMed CentralPubMed Google Scholar
Ouyang, W., Beckett, O., Flavell, R. A. & Li, M. O. An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance. Immunity30, 358–371 (2009). Along with references 65 and 66, this study revealed a key role for FOXO1 and PI3K activation (which negatively regulates FOXO1 expression) in T cell trafficking and IL-7 reactivity. ArticleCASPubMed CentralPubMed Google Scholar
Engelman, J. A., Luo, J. & Cantley, L. C. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nature Rev. Genet.7, 606–619 (2006). ArticleCASPubMed Google Scholar
Bajenoff, M. et al. Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity25, 989–1001 (2006). ArticleCASPubMed CentralPubMed Google Scholar
Mueller, S. N. & Germain, R. N. Stromal cell contributions to the homeostasis and functionality of the immune system. Nature Rev. Immunol.9, 618–629 (2009). ArticleCAS Google Scholar
Dai, Z. & Lakkis, F. G. Cutting edge: Secondary lymphoid organs are essential for maintaining the CD4, but not CD8, naive T cell pool. J. Immunol.167, 6711–6715 (2001). ArticleCASPubMed Google Scholar
Dummer, W., Ernst, B., LeRoy, E., Lee, D. & Surh, C. Autologous regulation of naive T cell homeostasis within the T cell compartment. J. Immunol.166, 2460–2468 (2001). ArticleCASPubMed Google Scholar
Link, A. et al. Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nature Immunol.8, 1255–1265 (2007). This groundbreaking report revealed the central role of the FRC network in naive T cell maintenance. ArticleCAS Google Scholar
Luther, S. A., Tang, H. L., Hyman, P. L., Farr, A. G. & Cyster, J. G. Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse. Proc. Natl Acad. Sci. USA97, 12694–12699 (2000). ArticleCASPubMed CentralPubMed Google Scholar
Okada, T. & Cyster, J. G. CC chemokine receptor 7 contributes to Gi-dependent T cell motility in the lymph node. J. Immunol.178, 2973–2978 (2007). ArticleCASPubMed Google Scholar
Worbs, T., Mempel, T. R., Bolter, J., von Andrian, U. H. & Forster, R. CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo. J. Exp. Med.204, 489–495 (2007). ArticleCAS Google Scholar
Cyster, J. G. Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annu. Rev. Immunol.23, 127–159 (2004). ArticleCAS Google Scholar
Pham, T. H., Okada, T., Matloubian, M., Lo, C. G. & Cyster, J. G. S1P1 receptor signaling overrides retention mediated by Gαi-coupled receptors to promote T cell egress. Immunity28, 122–133 (2008). ArticleCASPubMed Google Scholar
Guimond, M. et al. Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells. Nature Immunol.10, 149–157 (2009). This report uncovered surprising differences in the cell types that produce IL-7 for sustaining CD4+ versus CD8+ T cells and regulatory feedback loops in IL-7 production. ArticleCAS Google Scholar
Kim, J. W., Ferris, R. L. & Whiteside, T. L. Chemokine C receptor 7 expression and protection of circulating CD8+ T lymphocytes from apoptosis. Clin. Cancer Res.11, 7901–7910 (2005). ArticleCASPubMed Google Scholar
Cinalli, R. M. et al. T cell homeostasis requires G protein-coupled receptor-mediated access to trophic signals that promote growth and inhibit chemotaxis. Eur. J. Immunol.35, 786–795 (2005). ArticleCASPubMed CentralPubMed Google Scholar
Clarke, D., Katoh, O., Gibbs, R. V., Griffiths, S. D. & Gordon, M. Y. Interaction of interleukin 7 (IL-7) with glycosaminoglycans and its biological relevance. Cytokine7, 325–330 (1995). ArticleCASPubMed Google Scholar
Borghesi, L. A., Yamashita, Y. & Kincade, P. W. Heparan sulfate proteoglycans mediate interleukin-7-dependent B lymphopoiesis. Blood93, 140–148 (1999). CASPubMed Google Scholar
Rot, A. & von Andrian, U. H. Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Annu. Rev. Immunol.22, 891–928 (2004). ArticleCASPubMed Google Scholar
Cyster, J. G. Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annu. Rev. Immunol.23, 127–159 (2005). ArticleCASPubMed Google Scholar
Mempel, T. R., Junt, T. & von Andrian, U. H. Rulers over randomness: stroma cells guide lymphocyte migration in lymph nodes. Immunity25, 867–869 (2006). ArticleCASPubMed Google Scholar
Mueller, S. N. et al. Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection. Proc. Natl Acad. Sci. USA104, 15430–15435 (2007). ArticleCASPubMed CentralPubMed Google Scholar
Mueller, S. N. et al. Regulation of homeostatic chemokine expression and cell trafficking during immune responses. Science317, 670–674 (2007). This study revealed how inflammatory immune responses lead to loss of homeostatic chemokine expression in lymphoid sites, with a resulting breakdown in naive T cell trafficking. ArticleCASPubMed Google Scholar
Mueller, S. N. & Ahmed, R. Lymphoid stroma in the initiation and control of immune responses. Immunol. Rev.224, 284–294 (2008). ArticleCASPubMed Google Scholar
Scandella, E. et al. Restoration of lymphoid organ integrity through the interaction of lymphoid tissue-inducer cells with stroma of the T cell zone. Nature Immunol.9, 667–675 (2008). ArticleCAS Google Scholar
Cheng, M. H., Shum, A. K. & Anderson, M. S. What's new in the Aire? Trends Immunol.28, 321–327 (2007). ArticleCASPubMed Google Scholar
Lee, J. W. et al. Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self. Nature Immunol.8, 181–190 (2007). ArticleCAS Google Scholar
Berzins, S. P., Boyd, R. L. & Miller, J. F. The role of the thymus and recent thymic migrants in the maintenance of the adult peripheral lymphocyte pool. J. Exp. Med.187, 1839–1848 (1998). ArticleCASPubMed CentralPubMed Google Scholar
Schnell, F. J. & Kersh, G. J. Control of recent thymic emigrant survival by positive selection signals and early growth response gene 1. J. Immunol.175, 2270–2277 (2005). ArticleCASPubMed Google Scholar
Hakim, F. T. et al. Age-dependent incidence, time course, and consequences of thymic renewal in adults. J. Clin. Invest.115, 930–939 (2005). ArticleCASPubMed CentralPubMed Google Scholar
Nikolich-Zugich, J., Slifka, M. K. & Messaoudi, I. The many important facets of T-cell repertoire diversity. Nature Rev. Immunol.4, 123–132 (2004). ArticleCAS Google Scholar
Napolitano, L. A. et al. Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis. Nature Med.7, 73–79 (2001). ArticleCASPubMed Google Scholar
Boyman, O., Ramsey, C., Kim, D. M., Sprent, J. & Surh, C. D. IL-7/anti-IL-7 mAb complexes restore T cell development and induce homeostatic T Cell expansion without lymphopenia. J. Immunol.180, 7265–7275 (2008). ArticleCASPubMed Google Scholar
Boyman, O., Purton, J. F., Surh, C. D. & Sprent, J. Cytokines and T-cell homeostasis. Curr. Opin. Immunol.19, 320–326 (2007). ArticleCASPubMed Google Scholar
Capitini, C. M., Chisti, A. A. & Mackall, C. L. Modulating T-cell homeostasis with IL-7: preclinical and clinical studies. J. Intern. Med.266, 141–153 (2009). ArticleCASPubMed CentralPubMed Google Scholar
Calzascia, T. et al. CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity. Proc. Natl Acad. Sci. USA105, 2999–3004 (2008). ArticleCASPubMedPubMed Central Google Scholar