Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors (original) (raw)

• Dykxhoorn, D.M. & Lieberman, J. The Silent Revolution: RNA interference as basic biology, research tool and therapeutic. Annu. Rev. Med. 56, 401–423 (2005).
  Article CAS PubMed Google Scholar
• Sledz, C.A., Holko, M., de Veer, M.J., Silverman, R.H. & Williams, B.R. Activation of the interferon system by short-interfering RNAs. Nat. Cell Biol. 5, 834–839 (2003).
  Article CAS PubMed Google Scholar
• Jackson, A.L. et al. Expression profiling reveals off-target gene regulation by RNAi. Nat. Biotechnol. 21, 635–637 (2003).
  Article CAS PubMed Google Scholar
• Kariko, K., Bhuyan, P., Capodici, J. & Weissman, D. Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3. J. Immunol. 172, 6545–6549 (2004).
  Article CAS PubMed Google Scholar
• Bitko, V., Musiyenko, A., Shulyayeva, O. & Barik, S. Inhibition of respiratory viruses by nasally administered siRNA. Nat. Med. 11, 50–55 (2005).
  Article CAS PubMed Google Scholar
• Song, E. et al. RNA interference targeting Fas protects mice from fulminant hepatitis. Nat. Med. 9, 347–351 (2003).
  Article CAS PubMed Google Scholar
• Chen, S.Y., Khouri, Y., Bagley, J. & Marasco, W.A. Combined intra- and extracellular immunization against human immunodeficiency virus type 1 infection with a human anti-gp120 antibody. Proc. Natl. Acad. Sci. USA 91, 5932–5936 (1994).
  Article CAS PubMed PubMed Central Google Scholar
• Chen, S.Y., Zani, C., Khouri, Y. & Marasco, W.A. Design of a genetic immunotoxin to eliminate toxin immunogenicity. Gene Ther. 2, 116–123 (1995).
  CAS PubMed Google Scholar
• Chen, T.H. et al. Structure of pp32, an acidic nuclear protein which inhibits oncogene- induced formation of transformed foci. Mol. Biol. Cell 7, 2045–2056 (1996).
  Article CAS PubMed PubMed Central Google Scholar
• Li, X., Stuckert, P., Bosch, I., Marks, J.D. & Marasco, W.A. Single-chain antibody-mediated gene delivery into ErbB2-positive human breast cancer cells. Cancer Gene Ther. 8, 555–565 (2001).
  Article CAS PubMed Google Scholar
• Layzer, J.M. et al. In vivo activity of nuclease-resistant siRNAs. RNA 10, 766–771 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Soutschek, J. et al. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 432, 173–178 (2004).
  Article CAS PubMed Google Scholar
• Song, E. et al. Sustained Small Interfering RNA-Mediated Human Immunodeficiency Virus Type 1 Inhibition in Primary Macrophages. J. Virol. 77, 7174–7181 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Slamon, D.J. et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235, 177–182 (1987).
  Article CAS PubMed Google Scholar
• Sorensen, D.R., Leirdal, M. & Sioud, M. Gene silencing by systemic delivery of synthetic siRNAs in adult mice. J. Mol. Biol. 327, 761–766 (2003).
  Article CAS PubMed Google Scholar
• Zhang, X. et al. Small interfering RNA targeting heme oxygenase-1 enhances ischemia-reperfusion-induced lung apoptosis. J. Biol. Chem. 279, 10677–10684 (2004).
  Article CAS PubMed Google Scholar
• Massaro, D., Massaro, G.D. & Clerch, L.B. Noninvasive delivery of small inhibitory RNA and other reagents to pulmonary alveoli in mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 287, L1066–L1070 (2004).
  Article CAS PubMed Google Scholar
• McCaffrey, A.P. et al. Inhibition of hepatitis B virus in mice by RNA interference. Nat. Biotechnol. 21, 639–644 (2003).
  Article CAS PubMed Google Scholar
• McCaffrey, A.P. et al. RNA interference in adult mice. Nature 418, 38–39 (2002).
  Article CAS PubMed Google Scholar
• Hamar, P. et al. Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury. Proc. Natl. Acad. Sci. USA 101, 14883–14888 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Contreras, J.L. et al. Caspase-8 and caspase-3 small interfering RNA decreases ischemia/reperfusion injury to the liver in mice. Surgery 136, 390–400 (2004).
  Article PubMed Google Scholar
• Minakuchi, Y. et al. Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo. Nucleic Acids Res. 32, e109 (2004).
  Article PubMed PubMed Central Google Scholar
• Schiffelers, R.M. et al. Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle. Nucleic Acids Res. 32, e149 (2004).
  Article PubMed PubMed Central Google Scholar
• Hassani, Z. et al. Lipid-mediated siRNA delivery down-regulates exogenous gene expression in the mouse brain at picomolar levels. J. Gene Med. (2004).
• Ge, Q. et al. Inhibition of influenza virus production in virus-infected mice by RNA interference. Proc. Natl. Acad. Sci. USA 101, 8676–8681 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Zhang, Y. et al. Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer. Clin. Cancer Res. 10, 3667–3677 (2004).
  Article CAS PubMed Google Scholar
• Hung, L. & Kumar, V. Specific inhibition of gene expression and transactivation functions of hepatitis B virus X protein and c-myc by small interfering RNAs. FEBS Lett. 560, 210–214 (2004).
  Article CAS PubMed Google Scholar
• Reich, S.J. et al. Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model. Mol. Vis. 9, 210–216 (2003).
  CAS PubMed Google Scholar
• Brody, J.R. et al. pp32 reduction induces differentiation of TSU-Pr1 cells. Am. J. Pathol. 164, 273–283 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Stewart, S.A. et al. Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA 9, 493–501 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Muthumani, K. et al. Novel engineered HIV-1 East African Clade-A gp160 plasmid construct induces strong humoral and cell-mediated immune responses in vivo. Virology 314, 134–146 (2003).
  Article CAS PubMed Google Scholar