Sweet 'n' sour: the impact of differential glycosylation on T cell responses (original) (raw)

• Lowe, J.B. Glycosylation, immunity, and autoimmunity. Cell 104, 809–812 (2001).
  Article CAS PubMed Google Scholar
• Rudd, P.M. et al. Roles for glycosylation of cell surface receptors involved in cellular immune recognition. J. Mol. Biol. 293, 351–366 (1999).
  Article CAS PubMed Google Scholar
• Rudd, P.M., Elliott, T., Cresswell, P., Wilson, I.A. & Dwek, R.A. Glycosylation and the immune system. Science 291, 2370–2376 (2001).
  Article CAS PubMed Google Scholar
• Varki, A. et al. (eds.) Essentials of Glycobiology (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 1999).
  Google Scholar
• Crocker, P.R. & Varki, A. Siglecs, sialic acids and innate immunity. Trends Immunol. 22, 337–342 (2001).
  Article CAS PubMed Google Scholar
• Rabinovich, G.A. et al. Galectins and their ligands: amplifiers, silencers or tuners of the inflammatory response? Trends Immunol. 23, 313–320 (2002).
  Article CAS PubMed Google Scholar
• Grogan, M.J., Pratt, M.R., Marcaurelle, L.A. & Bertozzi, C.R. Homogeneous glycopeptides and glycoproteins for biological investigation. Annu. Rev. Biochem. 71, 593–634 (2002).
  Article CAS PubMed Google Scholar
• Marth, J.D. Will the transgenic mouse serve as a Rosetta Stone to glycoconjugate function? Glycocon. J. 11, 3–8 (1994).
  Article CAS Google Scholar
• Lowe, J.B. & Marth, J.D. Genetic approaches to carbohydrate function. Annu. Rev. Biochem. (in the press, 2003).
• Despont, J.P., Abel, C.A. & Grey, H.M. Sialic acids and sialyltransferases in murine lymphoid cells: indicators of T cell maturation. Cell. Immunol. 17, 487–494 (1975).
  Article CAS PubMed Google Scholar
• Reisner, Y., Linker-Isreali, M. & Sharon, N. Separation of mouse thymocytes into two subpopulations by the use of peanut agglutinin. Cell. Immunol. 25, 129–134 (1976).
  Article CAS PubMed Google Scholar
• Pink, J.R. Changes in T-lymphocyte glycoprotein structures associated with differentiation. Contemp. Top. Mol. Immunol. 9, 89–113 (1983).
  Article CAS PubMed Google Scholar
• Toporowicz, A. & Reisner, Y. Changes in sialyltransferase activity during murine T cell differentiation. Cell. Immunol. 100, 10–19 (1986).
  Article CAS PubMed Google Scholar
• Lefrancois, L. Expression of carbohydrate differentiation antigens during ontogeny of the murine thymus. J. Immunol. 139, 2220–2229 (1987).
  CAS PubMed Google Scholar
• Fowlkes, B.J. et al. Differential binding of fluorescein-labeled lectins to mouse thymocytes: subsets revealed by flow microfluorometry. J. Immunol. 125, 623–630 (1980).
  CAS PubMed Google Scholar
• Gillespie, W., Paulson, J.C., Kelm, S., Pang, M. & Baum, L.G. Regulation of α2,3-sialyltransferase expression correlates with conversion of peanut agglutinin (PNA)+ to PNA-phenotype in developing thymocytes. J. Biol. Chem. 268, 3801–3804 (1993).
  Article CAS PubMed Google Scholar
• Baum, L.G. et al. Characterization of terminal sialic acid linkages on human thymocytes. Correlation between lectin-binding phenotype and sialyltransferase expression. J. Biol. Chem. 271, 10793–10799 (1996).
  Article CAS PubMed Google Scholar
• Priatel, J.J. et al. The ST3Gal-I sialyltransferase controls CD8+ T lymphocyte homeostasis by modulating O-glycan biosynthesis. Immunity 12, 273–283 (2000).
  Article CAS PubMed Google Scholar
• Martin, L.T., Marth, J.D., Varki, A. & Varki, N.M. Genetically altered mice with different sialyltransferase deficiencies show tissue-specific alterations in sialylation and sialic acid 9-O-acetylation. J. Biol. Chem. 277, 32930–32938 (2002).
  Article CAS PubMed Google Scholar
• Tsuboi, S. & Fukuda, M. Roles of O-linked oligosaccharides in immune responses. Bioessays 23, 46–53 (2001).
  Article CAS PubMed Google Scholar
• Baum, L.G. et al. Human thymic epithelial cells express an endogenous lectin, galectin-1, which binds to core 2 O-glycans on thymocytes and T lymphoblastoid cells. J. Exp. Med. 181, 877–887 (1995).
  Article CAS PubMed Google Scholar
• Ellies, L.G., Tao, W., Fellinger, W., Teh, H.S. & Ziltener, H.J. The CD43 130-kD peripheral T-cell activation antigen is downregulated in thymic positive selection. Blood 88, 1725–1732 (1996).
  Article CAS PubMed Google Scholar
• Taira, S. & Nariuchi, H. Possible role of neuraminidase in activated T cells in the recognition of allogeneic Ia. J. Immunol. 141, 440–446 (1988).
  CAS PubMed Google Scholar
• Chervenak, R. & Cohen, J.J. Peanut lectin binding as a marker for activated T-lineage lymphocytes. Thymus 4, 61–67 (1982).
  CAS PubMed Google Scholar
• Landolfi, N.F., Leone, J., Womack, J.E. & Cook, R.G. Activation of T lymphocytes results in an increase in H-2-encoded neuraminidase. Immunogenetics 22, 159–167 (1985).
  Article CAS PubMed Google Scholar
• Piller, F., Piller, V., Fox, R.I. & Fukuda, M. Human T-lymphocyte activation is associated with changes in O-glycan biosynthesis. J. Biol. Chem. 263, 15146–15150 (1988).
  Article CAS PubMed Google Scholar
• Galvan, M., Murali-Krishna, K., Ming, L.L., Baum, L. & Ahmed, R. Alterations in cell surface carbohydrates on T cells from virally infected mice can distinguish effector/memory CD8+ T cells from naive cells. J. Immunol. 161, 641–648 (1998).
  CAS PubMed Google Scholar
• Kaufmann, M. et al. Identification of an α2,6-sialyltransferase induced early after lymphocyte activation. Int. Immunol. 11, 731–738 (1999).
  Article CAS PubMed Google Scholar
• Harrington, L.E., Galvan, M., Baum, L.G., Altman, J.D. & Ahmed, R. Differentiating between memory and effector CD8 T cells by altered expression of cell surface O-glycans. J. Exp. Med. 191, 1241–1246 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Siegelman, M.H., DeGrendele, H.C. & Estess, P. Activation and interaction of CD44 and hyaluronan in immunological systems. J. Leukoc. Biol. 66, 315–321 (1999).
  Article CAS PubMed Google Scholar
• Khan, A.A., Bose, C., Yam, L.S., Soloski, M.J. & Rupp, F. Physiological regulation of the immunological synapse by agrin. Science 292, 1681–1686 (2001).
  Article CAS PubMed Google Scholar
• Martin, P.T. Glycobiology of the synapse. Glycobiology 12, 1–7 (2002).
  Article Google Scholar
• Trautmann, A. & Vivier, E. Immunology. Agrin–a bridge between the nervous and immune systems. Science 292, 1667–1668 (2001).
  Article CAS PubMed Google Scholar
• Shaw, A.S. & Allen, P.M. Kissing cousins: immunological and neurological synapses. Nature Immunol. 2, 575–576 (2001).
  Article CAS Google Scholar
• Demetriou, M., Granovsky, M., Quaggin, S. & Dennis, J.W. Negative regulation of T-cell activation and autoimmunity by Mgat5N-glycosylation. Nature 409, 733–739 (2001).
  Article CAS PubMed Google Scholar
• Krishna, M. & Varki, A. 9-O-Acetylation of sialomucins: a novel marker of murine CD4 T cells that is regulated during maturation and activation. J. Exp. Med. 185, 1997–2013 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Carlow, D.A., Ardman, B. & Ziltener, H.J. A novel CD8 T cell-restricted CD45RB epitope shared by CD43 is differentially affected by glycosylation. J. Immunol. 163, 1441–1448 (1999).
  CAS PubMed Google Scholar
• Blander, J.M., Visintin, I., Janeway, C.A. Jr. & Medzhitov, R. A(1,3)-fucosyltransferase VII and α(2,3)-sialyltransferase IV are up-regulated in activated CD4 T cells and maintained after their differentiation into Th1 and migration into inflammatory sites. J. Immunol. 163, 3746–3752 (1999).
  CAS PubMed Google Scholar
• Lim, Y.C. et al. Expression of functional selectin ligands on Th cells is differentially regulated by IL-12 and IL-4. J. Immunol. 162, 3193–3201 (1999).
  CAS PubMed Google Scholar
• Lim, Y.C. et al. IL-12, STAT4-dependent up-regulation of CD4+ T cell core 2 β-1,6-n-acetylglucosaminyltransferase, an enzyme essential for biosynthesis of P-selectin ligands. J. Immunol. 167, 4476–4484 (2001).
  Article CAS PubMed Google Scholar
• Moody, A.M. et al. Developmentally regulated glycosylation of the CD8αβ coreceptor stalk modulates ligand binding. Cell 107, 501–512 (2001).
  Article CAS PubMed Google Scholar
• Ellies, L.G. et al. Core 2 oligosaccharide biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammation. Immunity 9, 881–890 (1998).
  Article CAS PubMed Google Scholar
• Tsuboi, S. & Fukuda, M. Branched O-linked oligosaccharides ectopically expressed in transgenic mice reduce primary T-cell immune responses. EMBO J. 16, 6364–6373 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Tsuboi, S. & Fukuda, M. Overexpression of branched O-linked oligosaccharides on T cell surface glycoproteins impairs humoral immune responses in transgenic mice. J. Biol. Chem. 273, 30680–30687 (1998).
  Article CAS PubMed Google Scholar
• Schwientek, T. et al. Control of O-glycan branch formation. Molecular cloning and characterization of a novel thymus-associated core 2 β1, 6-n-acetylglucosaminyltransferase. J. Biol. Chem. 275, 11106–11113 (2000).
  Article CAS PubMed Google Scholar
• Yeh, J.C., Ong, E. & Fukuda, M. Molecular cloning and expression of a novel β-1, 6-N-acetylglucosaminyltransferase that forms core 2, core 4, and I branches. J. Biol. Chem. 274, 3215–3221 (1999).
  Article CAS PubMed Google Scholar
• Chen, X.P., Enioutina, E.Y. & Daynes, R.A. The control of IL-4 gene expression in activated murine T lymphocytes: a novel role for neu-1 sialidase. J. Immunol. 158, 3070–3080 (1997).
  CAS PubMed Google Scholar
• Chen, X.P., Ding, X. & Daynes, R.A. Ganglioside control over IL-4 priming and cytokine production in activated T cells. Cytokine 12, 972–985 (2000).
  Article CAS PubMed Google Scholar
• Womack, J.E., Yan, D.L. & Potier, M. Gene for neuraminidase activity on mouse chromosome 17 near h-2: pleiotropic effects on multiple hydrolases. Science 212, 63–65 (1981).
  Article CAS PubMed Google Scholar
• Rottier, R.J., Bonten, E. & d'Azzo, A. A point mutation in the neu-1 locus causes the neuraminidase defect in the SM/J mouse. Hum. Mol. Genet. 7, 313–321 (1998).
  Article CAS PubMed Google Scholar
• Oh, S. & Eichelberger, M.C. Polarization of allogeneic T-cell responses by influenza virus-infected dendritic cells. J. Virol. 74, 7738–7744 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Todeschini, A.R. et al. Costimulation of host T lymphocytes by a trypanosomal trans-sialidase: involvement of CD43 signaling. J. Immunol. 168, 5192–5198 (2002).
  Article CAS PubMed Google Scholar
• Penninger, J.M., Irie-Sasaki, J., Sasaki, T. & Oliveira-dos-Santos, A.J. CD45: new jobs for an old acquaintance. Nature Immunol. 2, 389–396 (2001).
  Article CAS Google Scholar
• Janeway, C.A. Jr. The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation. Annu. Rev. Immunol. 10, 645–674 (1992).
  Article CAS PubMed Google Scholar
• Luqman, M. & Bottomly, K. Activation requirements for CD4+ T cells differing in CD45R expression. J. Immunol. 149, 2300–2306 (1992).
  CAS PubMed Google Scholar
• Chui, D., Ong, C.J., Johnson, P., Teh, H.S. & Marth, J.D. Specific CD45 isoforms differentially regulate T cell receptor signaling. EMBO J. 13, 798–807 (1994).
  Article CAS PubMed PubMed Central Google Scholar
• Leitenberg, D., Boutin, Y., Lu, D.D. & Bottomly, K. Biochemical association of CD45 with the T cell receptor complex: regulation by CD45 isoform and during T cell activation. Immunity 10, 701–711 (1999).
  Article CAS PubMed Google Scholar
• Majeti, R., Bilwes, A.M., Noel, J.P., Hunter, T. & Weiss, A. Dimerization-induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge. Science 279, 88–91 (1998).
  Article CAS PubMed Google Scholar
• Majeti, R. et al. An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity. Cell 103, 1059–1070 (2000).
  Article CAS PubMed Google Scholar
• Xu, Z. & Weiss, A. Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms. Nature Immunol. 3, 764–771 (2002).
  Article CAS Google Scholar
• Wu, W., Harley, P.H., Punt, J.A., Sharrow, S.O. & Kearse, K.P. Identification of CD8 as a peanut agglutinin (PNA) receptor molecule on immature thymocytes. J. Exp. Med. 184, 759–764 (1996).
  Article CAS PubMed Google Scholar
• Baldwin, T.A. & Ostergaard, H.L. Developmentally regulated changes in glucosidase II association with, and carbohydrate content of, the protein tyrosine phosphatase CD45. J. Immunol. 167, 3829–3835 (2001).
  Article CAS PubMed Google Scholar
• Nguyen, J.T. et al. CD45 modulates galectin-1-induced T cell death: regulation by expression of core 2 O-glycans. J. Immunol. 167, 5697–5707 (2001).
  Article CAS PubMed Google Scholar
• Hennet, T., Chui, D., Paulson, J.C. & Marth, J.D. Immune regulation by the ST6Gal sialyltransferase. Proc. Natl. Acad. Sci. USA 95, 4504–4509 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Fouillit, M. et al. Regulation of CD45-induced signaling by galectin-1 in Burkitt lymphoma B cells. Glycobiology 10, 413–419 (2000).
  Article CAS PubMed Google Scholar
• Dornan, S. et al. Differential association of CD45 isoforms with CD4 and CD8 regulates the actions of specific pools of p56lck tyrosine kinase in T cell antigen receptor signal transduction. J. Biol. Chem. 277, 1912–1918 (2002).
  Article CAS PubMed Google Scholar
• Kishimoto, H. & Sprent, J. Several different cell surface molecules control negative selection of medullary thymocytes. J. Exp. Med. 190, 65–73 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Higgins, E.A., Siminovitch, K.A., Zhuang, D.L., Brockhausen, I. & Dennis, J.W. Aberrant O-linked oligosaccharide biosynthesis in lymphocytes and platelets from patients with the Wiskott-Aldrich syndrome. J. Biol. Chem. 266, 6280–6290 (1991).
  Article CAS PubMed Google Scholar
• Ellies, L.G., Jones, A.T., Williams, M.J. & Ziltener, H.J. Differential regulation of CD43 glycoforms on CD4+ and CD8+ T lymphocytes in graft-_versus_-host disease. Glycobiology 4, 885–893 (1994).
  Article CAS PubMed Google Scholar
• Jones, A.T. et al. Characterization of the activation-associated isoform of CD43 on murine T lymphocytes. J. Immunol. 153, 3426–3439 (1994).
  CAS PubMed Google Scholar
• Manjunath, N., Correa, M., Ardman, M. & Ardman, B. Negative regulation of T-cell adhesion and activation by CD43. Nature 377, 535–538 (1995).
  Article CAS PubMed Google Scholar
• Ostberg, J.R., Barth, R.K. & Frelinger, J.G. The Roman god Janus: a paradigm for the function of CD43. Immunol. Today 19, 546–550 (1998).
  Article CAS PubMed Google Scholar
• He, Y.W. & Bevan, M.J. High level expression of CD43 inhibits T cell receptor/CD3-mediated apoptosis. J. Exp. Med. 190, 1903–1908 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Sperling, A.I. et al. CD43 is a murine T cell costimulatory receptor that functions independently of CD28. J. Exp. Med. 182, 139–146 (1995).
  Article CAS PubMed Google Scholar
• Sperling, A.I. et al. TCR signaling induces selective exclusion of CD43 from the T cell-antigen-presenting cell contact site. J. Immunol. 161, 6459–6462 (1998).
  CAS PubMed Google Scholar
• Stockton, B.M., Cheng, G., Manjunath, N., Ardman, B. & von Andrian, U.H. Negative regulation of T cell homing by CD43. Immunity 8, 373–381 (1998).
  Article CAS PubMed Google Scholar
• Onami, T.M. et al. Dynamic regulation of T cell immunity by CD43. J. Immunol. 168, 6022–6031 (2002).
  Article CAS PubMed Google Scholar
• Carlow, D.A., Corbel, S.Y. & Ziltener, H.J. Absence of CD43 fails to alter T cell development and responsiveness. J. Immunol. 166, 256–261 (2001).
  Article CAS PubMed Google Scholar
• Allenspach, E.J. et al. ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity 15, 739–750 (2001).
  Article CAS PubMed Google Scholar
• Delon, J., Kaibuchi, K. & Germain, R.N. Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin. Immunity 15, 691–701 (2001).
  Article CAS PubMed Google Scholar
• Roumier, A. et al. The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activation. Immunity 15, 715–728 (2001).
  Article CAS PubMed Google Scholar
• van den Berg, T.K. et al. Cutting edge: CD43 functions as a T cell counterreceptor for the macrophage adhesion receptor sialoadhesin (Siglec-1). J. Immunol. 166, 3637–3640 (2001).
  Article CAS PubMed Google Scholar
• Cyster, J.G., Shotton, D.M. & Williams, A.F. The dimensions of the T lymphocyte glycoprotein leukosialin and identification of linear protein epitopes that can be modified by glycosylation. EMBO J. 10, 893–902 (1991).
  Article CAS PubMed PubMed Central Google Scholar
• Fukuda, M. & Carlsson, S.R. Leukosialin, a major sialoglycoprotein on human leukocytes as differentiation antigens. Med. Biol. 64, 335–343 (1986).
  CAS PubMed Google Scholar
• Shaw, A.S. & Dustin, M.L. Making the T cell receptor go the distance: A topological view of T cell activation. Immunity 6, 361–369 (1997).
  Article CAS PubMed Google Scholar
• Casabo, L.G., Mamalaki, C., Kioussis, D. & Zamoyska, R. T cell activation results in physical modification of the mouse CD8β chain. J. Immunol. 152, 397–404 (1994).
  CAS PubMed Google Scholar
• Daniels, M.A. et al. CD8 binding to MHC class I molecules is influenced by T cell maturation and glycosylation. Immunity 15, 1051–1061 (2001).
  Article CAS PubMed Google Scholar
• O'Rourke, A.M. & Mescher, M.F. The roles of CD8 in cytotoxic T lymphocyte function. Immunol. Today 14, 183–188 (1993).
  Article CAS PubMed Google Scholar
• Nakayama, T. et al. Inhibition of T cell receptor expression and function in immature CD4+CD8+ cells by CD4. Science 249, 1558–1561 (1990).
  Article CAS PubMed Google Scholar
• Wiest, D.L. et al. Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules. J. Exp. Med. 178, 1701–1712 (1993).
  Article CAS PubMed Google Scholar
• Baldwin, K.K., Trenchak, B.P., Altman, J.D. & Davis, M.M. Negative selection of T cells occurs throughout thymic development. J. Immunol. 163, 689–698 (1999).
  CAS PubMed Google Scholar
• Baum, L.G. Developing a taste for sweets. Immunity 16, 5–8 (2002).
  Article CAS PubMed Google Scholar
• Gascoigne, N.R. T-cell differentiation: MHC class I's sweet tooth lost on maturity. Curr. Biol. 12, 99–101 (2002).
  Article Google Scholar
• Deck, M.B., Sjolin, P., Unanue, E.R. & Kihlberg, J. MHC-restricted, glycopeptide-specific T cells show specificity for both carbohydrate and peptide residues. J. Immunol. 162, 4740–4744 (1999).
  CAS PubMed Google Scholar
• Kronenberg, M. & Gapin, L. The unconventional lifestyle of NKT cells. Nature Rev. Immunol. 2, 557–568 (2002).
  Article CAS Google Scholar
• Pihlgren, M., Dubois, P.M., Tomkowiak, M., Sjogren, T. & Marvel, J. Resting memory CD8+ T cells are hyperreactive to antigenic challenge in vitro. J. Exp. Med. 184, 2141–2151 (1996).
  Article CAS PubMed PubMed Central Google Scholar
• Davey, G.M. et al. Pre-selection thymocytes are more sensitive to TCR stimulation than mature T cells. J. Exp. Med. 188, 1867–1874 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Curtsinger, J.M., Lins, D.C. & Mescher, M.F. CD8+ memory T cells (CD44high, Ly-6C+) are more sensitive than naive cells to (CD44low, Ly-6C−) to TCR/CD8 signaling in response to antigen. J. Immunol. 160, 3236–3243 (1998).
  CAS PubMed Google Scholar
• Lucas, B., Stefanova, I., Yasutomo, K., Dautigny, N. & Germain, R.N. Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire. Immunity 10, 367–376 (1999).
  Article CAS PubMed Google Scholar
• Knop, J. Effect of Vibrio cholerae neuraminidase on the mitogen response of T lymphocytes. I. Enhancement of macrophage T-lymphocyte cooperation in concanavalin-A-induced lymphocyte activation. Immunobiology 157, 474–485 (1980).
  Article CAS PubMed Google Scholar
• Cullen, S.E., Kindle, C.S., Shreffler, D.C. & Cowing, C. Differential glycosylation of murine B cell and spleen adherent cell Ia antigens. J. Immunol. 127, 1478–1484 (1981).
  CAS PubMed Google Scholar
• Cowing, C. & Chapdelaine, J.M. T cells discriminate between Ia antigens expressed on allogeneic accessory cells and B cells: a potential function for carbohydrate side chains on Ia molecules. Proc. Natl. Acad. Sci. USA 80, 6000–6004 (1983).
  Article CAS PubMed PubMed Central Google Scholar
• Hunig, T. The role of accessory cells in polyclonal T cell activation II. Induction of interleukin 2 responsiveness requires cell-cell contact. Eur J. Immunol. 13, 596–601 (1983).
  Article CAS PubMed Google Scholar
• Boog, C.J., Neefjes, J.J., Boes, J., Ploegh, H.L. & Melief, C.J. Specific immune responses restored by alteration in carbohydrate chains of surface molecules on antigen-presenting cells. Eur J. Immunol. 19, 537–542 (1989).
  Article CAS PubMed Google Scholar
• Powell, L.D., Whiteheart, S.W. & Hart, G.W. Cell surface sialic acid influences tumor cell recognition in the mixed lymphocyte reaction. J. Immunol. 139, 262–270 (1987).
  CAS PubMed Google Scholar
• Sprent, J. & Schaefer, M. Antigen-presenting cells for CD8+ T cells. Immunol. Rev. 117, 213–234 (1990).
  Article CAS PubMed Google Scholar
• Hebert, E. Endogenous lectins as cell surface transducers. Biosci. Rep. 20, 213–237 (2000).
  Article CAS PubMed Google Scholar
• Snapp, K.R., Heitzig, C.E., Ellies, L.G., Marth, J.D. & Kansas, G.S. Differential requirements for the O-linked branching enzyme core 2 β1-6-N-glucosaminyltransferase in biosynthesis of ligands for E-selectin and P-selectin. Blood 97, 3806–3811 (2001).
  Article CAS PubMed Google Scholar
• Sperandio, M. et al. Severe impairment of leukocyte rolling in venules of core 2 glucosaminyltransferase-deficient mice. Blood 97, 3812–3819 (2001).
  Article CAS PubMed Google Scholar
• Yeh, J.C. et al. Novel sulfated lymphocyte homing receptors and their control by a Core1 extension β1,3-_N_-acetylglucosaminyltransferase. Cell 105, 957–969 (2001).
  Article CAS PubMed Google Scholar
• Smithson, G. et al. Fuc-TVII is required for T helper 1 and T cytotoxic 1 lymphocyte selectin ligand expression and recruitment in inflammation, and together with Fuc-TIV regulates naive T cell trafficking to lymph nodes. J. Exp. Med. 194, 601–614 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Homeister, J.W. et al. The α(1,3)fucosyltransferases FucT-IV and FucT-VII exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homing. Immunity 15, 115–126 (2001).
  Article CAS PubMed Google Scholar
• Maly, P. et al. The α(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis. Cell 86, 643–653 (1996).
  Article CAS PubMed Google Scholar
• Weninger, W. et al. Specialized contributions by α(1,3)-fucosyltransferase-IV and FucT-VII during leukocyte rolling in dermal microvessels. Immunity 12, 665–676 (2000).
  Article CAS PubMed Google Scholar
• Wagers, A.J., Waters, C.M., Stoolman, L.M. & Kansas, G.S. Interleukin 12 and interleukin 4 control T cell adhesion to endothelial selectins through opposite effects on α1,3-fucosyltransferase VII gene expression. J. Exp. Med. 188, 2225–2231 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Carlow, D.A., Corbel, S.Y., Williams, M.J. & Ziltener, H.J. IL-2, -4, and -15 differentially regulate O-glycan branching and P-selectin ligand formation in activated CD8 T cells. J. Immunol. 167, 6841–6848 (2001).
  Article CAS PubMed Google Scholar
• Wagers, A.J. & Kansas, G.S. Potent induction of α(1,3)-fucosyltransferase VII in activated CD4+ T cells by TGF-β 1 through a p38 mitogen-activated protein kinase-dependent pathway. J. Immunol. 165, 5011–5016 (2000).
  Article CAS PubMed Google Scholar
• Crocker, P.R. & Varki, A. Siglecs in the immune system. Immunology 103, 137–145 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Cornall, R.J., Goodnow, C.C. & Cyster, J.G. Regulation of B cell antigen receptor signaling by the Lyn/CD22/SHP1 pathway. Curr. Top. Microbiol. Immunol. 244, 57–68 (1999).
  CAS PubMed Google Scholar
• Jin, L., McLean, P.A., Neel, B.G. & Wortis, H.H. Sialic acid binding domains of CD22 are required for negative regulation of B cell receptor signaling. J. Exp. Med. 195, 1199–1205 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Razi, N. & Varki, A. Masking and unmasking of the sialic acid-binding lectin activity of CD22 (Siglec-2) on B lymphocytes. Proc. Natl. Acad. Sci. USA 95, 7469–7474 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Kelm, S., Gerlach, J., Brossmer, R., Danzer, C.P. & Nitschke, L. The ligand-binding domain of CD22 is needed for inhibition of the B cell receptor signal, as demonstrated by a novel human CD22-specific inhibitor compound. J. Exp. Med. 195, 1207–1213 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Scholler, N., Hayden-Ledbetter, M., Hellstrom, K.E., Hellstrom, I. & Ledbetter, J.A. CD83 is a sialic acid-binding Ig-like lectin (Siglec) adhesion receptor that binds monocytes and a subset of activated CD8+ T cells. J. Immunol. 166, 3865–3872 (2001).
  Article CAS PubMed Google Scholar
• Cramer, S.O. et al. Activation-induced expression of murine CD83 on T cells and identification of a specific CD83 ligand on murine B cells. Int. Immunol. 12, 1347–1351 (2000).
  Article CAS PubMed Google Scholar
• Lechmann, M. et al. The extracellular domain of CD83 inhibits dendritic cell-mediated T cell stimulation and binds to a ligand on dendritic cells. J. Exp. Med. 194, 1813–1821 (2001).
  Article CAS PubMed PubMed Central Google Scholar
• Scholler, N. et al. Cutting edge: CD83 regulates the development of cellular immunity. J. Immunol. 168, 2599–2602 (2002).
  Article CAS PubMed Google Scholar
• Fujimoto, Y. et al. CD83 expression influences CD4+ T cell development in the thymus. Cell 108, 755–767 (2002).
  Article CAS PubMed Google Scholar
• Hughes, R.C. Galectins as modulators of cell adhesion. Biochimie 83, 667–676 (2001).
  Article CAS PubMed Google Scholar
• Perillo, N.L., Pace, K.E., Seilhamer, J.J. & Baum, L.G. Apoptosis of T cells mediated by galectin-1. Nature 378, 736–739 (1995).
  Article CAS PubMed Google Scholar
• Perillo, N.L., Uittenbogaart, C.H., Nguyen, J.T. & Baum, L.G. Galectin-1, an endogenous lectin produced by thymic epithelial cells, induces apoptosis of human thymocytes. J. Exp. Med. 185, 1851–1858 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Vespa, G.N. et al. Galectin-1 specifically modulates TCR signals to enhance TCR apoptosis but inhibit IL-2 production and proliferation. J. Immunol. 162, 799–806 (1999).
  CAS PubMed Google Scholar
• Chung, C.D., Lewis, L.A. & Miceli, M.C. T cell antigen receptor-induced IL-2 production and apoptosis have different requirements for Lck activities. J. Immunol. 159, 1758–1766 (1997).
  CAS PubMed Google Scholar
• Wada, J., Ota, K., Kumar, A., Wallner, E.I. & Kanwar, Y.S. Developmental regulation, expression, and apoptotic potential of galectin-9, a β-galactoside binding lectin. J. Clin. Invest. 99, 2452–2461 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Dennis, J.W., Warren, C.E., Granovsky, M. & Demetriou, M. Genetic defects in N-glycosylation and cellular diversity in mammals. Curr. Opin. Struct. Biol. 11, 601–607 (2001).
  Article CAS PubMed Google Scholar
• Poirier, F. & Robertson, E.J. Normal development of mice carrying a null mutation in the gene encoding the L14 S-type lectin. Development 119, 1229–1236 (1993).
  Article CAS PubMed Google Scholar
• Colnot, C., Fowlis, D., Ripoche, M.A., Bouchaert, I. & Poirier, F. Embryonic implantation in galectin 1/galectin 3 double mutant mice. Dev. Dyn. 211, 306–313 (1998).
  Article CAS PubMed Google Scholar
• Hsu, D.K. et al. Targeted disruption of the galectin-3 gene results in attenuated peritoneal inflammatory responses. Am. J. Pathol. 156, 1073–1083 (2000).
  Article CAS PubMed PubMed Central Google Scholar